Page last updated: 2024-08-21

isoxazoles and Pain

isoxazoles has been researched along with Pain in 83 studies

Research

Studies (83)

TimeframeStudies, this research(%)All Research%
pre-19908 (9.64)18.7374
1990's5 (6.02)18.2507
2000's42 (50.60)29.6817
2010's26 (31.33)24.3611
2020's2 (2.41)2.80

Authors

AuthorsStudies
Gao, L; Wang, C; Wu, Z; Xu, H; Yao, Y; Zheng, F; Zhou, J1
Ahmed, S; Anwar, T; Arif, M; Khan, A; Nadeem, H; Naureen, H; Sarwar, S1
Aikawa, Y; Ito, H; Kawaguchi, Y; Kimura, T; Makino, H; Motomura, H; Nogami, M; Sainoh, T; Seki, S; Shiozawa, S; Tsumaki, N; Watanabe, K; Yahara, Y; Yamazaki, M1
Duan, XL; He, YT; Hu, XD; Liu, JP; Suo, ZW; Yang, X1
Song, ZS; Sun, JY; Xiao, XY; Zhang, XP1
Bartzatt, R1
Li, H; Liu, Y; Rui, Q; Shu, L; Si, T; Su, Y; Zhang, H1
Kong, Y; Yang, X1
Mejia, GL; Pasteris, RJ; Pember, SO; Price, TJ1
Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM1
Brack, A; Broscheit, JA; Rittner, HL; Roewer, N; Sauer, RS; Shityakov, S; Sohajda, T1
Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS1
Bhatti, R; Gupta, V; Mahajan, A; Singh Ishar, MP; Singh, G; Singh, P1
Murakami, T; Ono, H; Tanabe, M1
Herrndobler, F; Koppert, W; Maihöfner, C; Ringler, R1
Abbadie, C; Felix, JP; Gao, YD; Garcia, ML; Kaczorowski, GJ; Li, X; Lyons, KA; Martin, WJ; McGowan, E; McMasters, DR; Parsons, WH; Priest, BT; Shao, PP; Smith, MM; Weber, AE; Williams, BS; Ye, F2
Angst, MS; Bradshaw, MH; Felden, L; Geisslinger, G; Greer, JJ; Johnson, S; Lötsch, J; Oertel, BG; Schmidt, H; Tran, PV; Varney, MA1
Li, XX; Peng, YZ; Wang, YW1
Mateos, JL1
Bala, I; Ghai, B; Makkar, JK; Wig, J1
Gopal, S; Herben, V; Kusumakar, V; Lim, P; Lindenmayer, JP; Lull, J; Palumbo, J; Pandina, GJ; Yuen, E1
Perrone, MG; Scilimati, A; Simone, L; Vitale, P1
Gao, ZY; Gong, N; Hashimoto, K; Huang, JL; Li, XY; Wang, YC; Wang, YX1
Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A1
Abernethy, L; Clarkson, T; Dempster, M; Easson, AM; Edwards, D; Everett, K; Feilden, H; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Nimz, O; Nisbet, LA; Palin, R; Ratcliffe, P; Tracey, H; Walker, G1
Arvidsson, PI; Besidski, Y; Bueters, T; Bylund, J; Eriksson, AB; Ginman, T; Gravenfors, Y; Lund, PE; Macsari, I; Sandberg, L; Venyike, E1
Gong, N; Lu, JM; Wang, YC; Wang, YX1
Gong, N; Hashimoto, K; Ma, AN; Wang, HL; Wang, YC; Wang, YX1
Liu, J; Xiang, Y; Zhang, Y1
Chen, XL; Guo, C; Huang, JL; Wang, YX1
Carroll, FI; Damaj, MI; Freitas, K1
Bible, R; Findlay, JW; Karim, A; Yang, DC; Yuan, JJ; Zhang, JY1
Backonja, MM1
Ormrod, D; Wagstaff, AJ; Wellington, K1
Hayes, EC; Rock, JA1
Rowbotham, DJ1
Korttila, K1
Alsalameh, S; Burian, M; Geisslinger, G; Mahr, G; Woodcock, BG1
Amara, I; Cohen, S; Crawford, B; Felson, D; Koch, G; Pincus, T; Strand, V; Wolfe, F1
Goldstein, JL; Kent, JD; Kivitz, AJ; Palmer, RC; Recker, DP; Verburg, KM1
Burian, M; Geisslinger, G1
Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L1
Granados, J; Jakez-Ocampo, J; Llorente, L; Richaud-Patin, Y; Sánchez-Guerrero, J1
Jain, NK; Kulkarni, SK; Padi, SS; Singh, S1
Hashimoto, K; Takahashi, Y; Tsuji, S1
Hasegawa, H1
Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR1
Boggie, DT; Delattre, ML; Morreale, AP; Plowman, BK; Schaefer, MG; Tran, F1
Guay, DR1
Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A1
Taéron, C1
Querna, E1
Joshi, GP1
Dalpiaz, AS; Peterson, D1
Lang, L1
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M1
Zareba, G1
Bouhassira, D; Chauvin, M; Fletcher, D; Martin, F1
Bey, M; Kohles, JD; Pan, S; Sanner, KM; Schachtel, BP; Schachtel, EP1
Anagnostou, T; Gravas, S; Karatzas, A; Melekos, MD; Mitsogiannis, IC; Poulakis, V; Tzortzis, V1
Czugler, M; Erdélyi, P; Fischer, J; Fodor, T; Gere, A; Varga, AK1
Sawynok, J1
Kjaer, M; Nielsen, H1
Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H1
Clark, WG; Menon, MK; Vivonia, C1
Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS1
Kusuhara, H; Matsuyuki, H; Okumoto, T1
Goto, K; Imayoshi, T; Kusuhara, H; Matsuyuki, H; Ochi, H; Okumoto, T; Yasunaga, Y1
Ghanipoor, N; Parvini, S; Rezayat, M; Zarrindast, MR1
Parvini, S; Pirali, M; Rezayat, M; Tabarrai, E; Zarrindast, MR1
Debroe, S; Hewitson, PJ; McBride, A; Milne, R1
Cheer, SM; Goa, KL1
Baum, D; Desjardins, PJ; Dhadda, S; Grossman, EH; Hubbard, RC; Kuss, ME; Talwalker, S1
Hiida, M; Hoshi, K1
Dafny, N; Enna, SJ; Reyes-Vazquez, C1
Enna, SJ; Zorn, SH1
Drower, EJ; Hammond, DL1
Pelley, KA; Vaught, JL1

Reviews

14 review(s) available for isoxazoles and Pain

ArticleYear
[Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review].
    Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46 Suppl A

    Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Administration Routes; Evidence-Based Medicine; Humans; Inflammation; Isoxazoles; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship; Sulfonamides; Treatment Outcome

2010
Selective COX-1 inhibition: A therapeutic target to be reconsidered.
    Current medicinal chemistry, 2010, Volume: 17, Issue:32

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Female; Humans; Isoxazoles; Neoplasms; Nervous System Diseases; Obstetric Labor, Premature; Pain; Pregnancy

2010
Use of anticonvulsants for treatment of neuropathic pain.
    Neurology, 2002, Sep-10, Volume: 59, Issue:5 Suppl 2

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nervous System Diseases; Pain; Phenytoin; Triazines; Zonisamide

2002
Valdecoxib.
    Drugs, 2002, Volume: 62, Issue:14

    Topics: Arthritis; Clinical Trials as Topic; Dysmenorrhea; Female; Humans; Isoxazoles; Pain; Sulfonamides

2002
COX-2 inhibitors and their role in gynecology.
    Obstetrical & gynecological survey, 2002, Volume: 57, Issue:11

    Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Administration Schedule; Dysmenorrhea; Endometriosis; Female; Genital Diseases, Female; Humans; Infertility, Female; Isoenzymes; Isoxazoles; Labor, Obstetric; Membrane Proteins; Menorrhagia; Menstrual Cycle; Ovary; Ovulation; Pain; Polycystic Ovary Syndrome; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides

2002
COX-2-selective inhibitors: clinical relevance in surgical and acute pain.
    European journal of anaesthesiology. Supplement, 2002, Volume: 25

    Topics: Acute Disease; Analgesics; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides

2002
Review article: The pharmacological properties and clinical use of valdecoxib, a new cyclo-oxygenase-2-selective inhibitor.
    Alimentary pharmacology & therapeutics, 2003, Feb-15, Volume: 17, Issue:4

    Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Availability; Bone Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Dysmenorrhea; Female; Humans; Isoenzymes; Isoxazoles; Liver Diseases; Male; Membrane Proteins; Middle Aged; Mouth Diseases; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides

2003
[Clinical pharmacology of the selective COX-2 inhibitors].
    Der Orthopade, 2003, Volume: 32, Issue:12

    Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones

2003
Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain.
    The American journal of geriatric pharmacotherapy, 2003, Volume: 1, Issue:1

    Topics: Aged; Analgesics, Non-Narcotic; Animals; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fructose; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Pain; Peripheral Nervous System Diseases; Piracetam; Topiramate; Zonisamide

2003
Valdecoxib for the management of chronic and acute pain.
    Expert review of neurotherapeutics, 2005, Volume: 5, Issue:1

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Drug Evaluation; Expert Testimony; Humans; Isoxazoles; Narcotics; Pain; Product Surveillance, Postmarketing; Sulfonamides

2005
Parecoxib: a shift in pain management?
    Expert review of neurotherapeutics, 2004, Volume: 4, Issue:2

    Topics: Animals; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Pain; Pain Measurement

2004
Zonisamide: review of its use in epilepsy therapy.
    Drugs of today (Barcelona, Spain : 1998), 2005, Volume: 41, Issue:9

    Topics: Animals; Anticonvulsants; Biological Availability; Child; Child, Preschool; Drug Interactions; Epilepsy; Half-Life; Humans; Infant; Isoxazoles; Migraine Disorders; Pain; Parkinson Disease; Randomized Controlled Trials as Topic; Tissue Distribution; Zonisamide

2005
Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications.
    Journal of clinical pharmacy and therapeutics, 2000, Volume: 25, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Disease Progression; Drug Costs; Humans; Isoxazoles; Leflunomide; Pain; Treatment Outcome

2000
[Rheumatic pain].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59, Issue:9

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Cytokines; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Neoplasm Proteins; Pain; Pain Management; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Steroids; Tumor Necrosis Factor Decoy Receptors

2001

Trials

18 trial(s) available for isoxazoles and Pain

ArticleYear
Efficacy and Safety of COX-2 Inhibitor Parecoxib for Rigid Cystoscopy-related Pain Management in Male Patients: A Prospective, Randomized and Controlled Study.
    Current medical science, 2019, Volume: 39, Issue:1

    Topics: Ambulatory Care Facilities; Cyclooxygenase 2 Inhibitors; Cystoscopy; Double-Blind Method; Humans; Injections, Intramuscular; Isoxazoles; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Prospective Studies; Tetracaine; Treatment Outcome

2019
Pharmacokinetics and tolerability of paliperidone palmitate injection in Chinese subjects.
    Human psychopharmacology, 2014, Volume: 29, Issue:2

    Topics: Antipsychotic Agents; Asian People; Chromatography, High Pressure Liquid; Constipation; Dose-Response Relationship, Drug; Female; Humans; Injections, Intramuscular; Isoxazoles; Linear Models; Male; Middle Aged; Pain; Paliperidone Palmitate; Palmitates; Prolactin; Schizophrenia; Tandem Mass Spectrometry; Time Factors; Treatment Outcome; Tremor

2014
[Study on the preemptive analgesia effects of both the parecoxib sodium and the pentazocine in patients undergoing nasal endoscopic surgery].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2014, Volume: 28, Issue:17

    Topics: Analgesia; Analgesics; Double-Blind Method; Endoscopy; Humans; Isoxazoles; Nasal Surgical Procedures; Nose; Pain; Pain, Postoperative; Pentazocine

2014
[Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study].
    Schmerz (Berlin, Germany), 2009, Volume: 23, Issue:2

    Topics: Acute Disease; Adult; Analgesics; Aspirin; Brain Mapping; Cerebral Cortex; Cyclooxygenase Inhibitors; Dominance, Cerebral; Double-Blind Method; Female; Frontal Lobe; Gyrus Cinguli; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Isoxazoles; Magnetic Resonance Imaging; Male; Motor Cortex; Pain; Pain Measurement; Pain Threshold; Parietal Lobe; Psychophysics; Somatosensory Cortex

2009
Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia.
    Clinical pharmacology and therapeutics, 2010, Volume: 87, Issue:2

    Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Humans; Hypercapnia; Isoxazoles; Male; Naloxone; Narcotic Antagonists; Oxygen; Pain; Respiratory Insufficiency; Young Adult

2010
Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study.
    Journal of clinical anesthesia, 2010, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Anesthetics, Intravenous; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain; Pain Measurement; Propofol; Prospective Studies; Tourniquets; Treatment Outcome; Young Adult

2010
A randomized, placebo-controlled study to assess the efficacy and safety of 3 doses of paliperidone palmitate in adults with acutely exacerbated schizophrenia.
    Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:3

    Topics: Acute Disease; Adult; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Male; Pain; Paliperidone Palmitate; Palmitates; Schizophrenia; Treatment Outcome; Young Adult

2010
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Remifentanil; Time Factors; Young Adult

2011
Prevention of pain on injection of rocuronium: a comparison of lidocaine with different doses of parecoxib.
    Journal of clinical anesthesia, 2012, Volume: 24, Issue:6

    Topics: Academic Medical Centers; Adult; Androstanols; Anesthetics, Local; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections; Isoxazoles; Lidocaine; Male; Middle Aged; Neuromuscular Nondepolarizing Agents; Pain; Pain Measurement; Prospective Studies; Rocuronium; Severity of Illness Index

2012
Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:9

    Topics: Acute Disease; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Feces; Glucuronidase; Humans; Isoenzymes; Isoxazoles; Male; Mass Spectrometry; Membrane Proteins; Pain; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2002
An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in
    Arthritis and rheumatism, 2003, Volume: 48, Issue:3

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Pain; Pain Measurement; Placebos; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome

2003
A comparison of the upper gastrointestinal mucosal effects of valdecoxib, naproxen and placebo in healthy elderly subjects.
    Alimentary pharmacology & therapeutics, 2003, Jul-01, Volume: 18, Issue:1

    Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Isoxazoles; Naproxen; Osteoarthritis; Pain; Risk Factors; Sulfonamides

2003
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
    Journal of clinical gastroenterology, 2004, Volume: 38, Issue:7

    Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Treatment Outcome

2004
Therapeutic interchange involving replacement of rofecoxib or celecoxib with valdecoxib.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2004, Jul-01, Volume: 61, Issue:13

    Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Celecoxib; Chronic Disease; Cost Savings; Cyclooxygenase 2; Drug Utilization Review; Endpoint Determination; Female; Hospitals, Veterans; Humans; Isoenzymes; Isoxazoles; Lactones; Male; Membrane Proteins; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Therapeutic Equivalency

2004
Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2004, Volume: 11, Issue:12

    Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Combinations; Emergency Medicine; Female; Humans; Isoxazoles; Male; Musculoskeletal Diseases; Oxycodone; Pain; Pain Measurement; Prospective Studies; Sulfonamides; Treatment Outcome

2004
Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.
    Anesthesiology, 2007, Volume: 106, Issue:5

    Topics: Adult; Cross-Over Studies; Cyclooxygenase 2; Double-Blind Method; Female; Humans; Isoxazoles; Male; Pain; Pain Threshold; Reflex; Spinal Cord

2007
Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:7

    Topics: Adolescent; Adult; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Models, Biological; Pain; Pain Measurement; Pharyngitis; Sensitivity and Specificity; Sulfonamides

2007
Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium.
    Journal of endourology, 2008, Volume: 22, Issue:4

    Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Female; Fentanyl; Humans; Isoxazoles; Lithotripsy; Male; Middle Aged; Pain

2008

Other Studies

51 other study(ies) available for isoxazoles and Pain

ArticleYear
Nano-Carbon-Based Application of Parecoxib Sodium Combined with Hydromorphone in Preventing Anesthesia Hyperalgesia Caused by Remifentanil after Thyroidectomy.
    Cellular and molecular biology (Noisy-le-Grand, France), 2022, Mar-31, Volume: 68, Issue:3

    Topics: Analgesics, Opioid; Anesthesia; Humans; Hydromorphone; Hyperalgesia; Isoxazoles; Pain; Piperidines; Remifentanil; Thyroidectomy

2022
Investigation of antioxidant and anti-nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies.
    Drug development research, 2020, Volume: 81, Issue:7

    Topics: Analgesics; Animals; Antioxidants; Biphenyl Compounds; Isoxazoles; Mice; Molecular Docking Simulation; Pain; Picrates; Pyrazolones

2020
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.
    Scientific reports, 2017, 12-05, Volume: 7, Issue:1

    Topics: Animals; Benzophenones; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Intervertebral Disc Degeneration; Isoxazoles; Mice, Inbred C57BL; Molecular Targeted Therapy; Nucleus Pulposus; Pain; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Transcription Factor AP-1

2017
Enhanced Activities of δ Subunit-containing GABA
    Neuroscience, 2018, 02-10, Volume: 371

    Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; GABA-A Receptor Agonists; Isoxazoles; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; Pain; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord; Synapses

2018
Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2014, Volume: 13, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Computer Simulation; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Design; Humans; Isoxazoles; Models, Molecular; Neoplasms; Pain; Sulfonamides

2014
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.
    Bioorganic & medicinal chemistry letters, 2016, 06-15, Volume: 26, Issue:12

    Topics: Amidohydrolases; Analgesics; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Pain; Pain Measurement; Piperidines; Structure-Activity Relationship; Thiazoles

2016
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
    Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraperitoneal; Isoxazoles; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship

2016
A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.
    Anesthesia and analgesia, 2017, Volume: 124, Issue:2

    Topics: Animals; beta-Cyclodextrins; Computer Simulation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Electrophoresis, Capillary; Hyperalgesia; Inflammation; Inflammation Mediators; Isoxazoles; Male; Methylation; Pain; Pain Measurement; Pain Threshold; Postural Balance; Rats; Rats, Wistar

2017
[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2016, 12-18, Volume: 48, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Arthritis; Cyclophosphamide; Disease Progression; Female; Hematologic Diseases; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Middle Aged; Pain; Prognosis; Raynaud Disease; Recurrence; Scleritis; Serositis; Treatment Outcome; Triamcinolone Acetonide; Uveitis; Vision Disorders

2016
Rationally designed benzopyran fused isoxazolidines and derived β
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Amino Alcohols; Analgesics; Animals; Benzopyrans; Cell Line; Chemistry Techniques, Synthetic; Drug Design; Female; Humans; Isoxazoles; Male; Mice; Molecular Docking Simulation; Pain; Prostaglandin-Endoperoxide Synthases; Protein Conformation; Receptors, Opioid

2017
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.
    Journal of pharmacological sciences, 2008, Volume: 107, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Inflammation; Isoxazoles; Male; Mice; Pain; Streptozocin; Zonisamide

2008
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
    Bioorganic & medicinal chemistry letters, 2009, Sep-15, Volume: 19, Issue:18

    Topics: Animals; Isoxazoles; Models, Molecular; Molecular Structure; Pain; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spinal Nerves; Structure-Activity Relationship

2009
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
    Bioorganic & medicinal chemistry letters, 2009, Sep-15, Volume: 19, Issue:18

    Topics: Animals; Cell Line; Chronic Disease; Humans; Isoxazoles; Pain; Rats; Sodium Channel Blockers; Sodium Channels; Spinal Nerves; Structure-Activity Relationship

2009
Effects of Parecoxib and Fentanyl on nociception-induced cortical activity.
    Molecular pain, 2010, Jan-21, Volume: 6

    Topics: Action Potentials; Analgesics, Opioid; Animals; Arousal; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Electroencephalography; Electrophysiology; Evoked Potentials; Fentanyl; Gyrus Cinguli; Heart Rate; Isoxazoles; Neurons; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Respiration; Somatosensory Cortex

2010
A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 336, Issue:1

    Topics: Animals; Benzoic Acid; D-Amino-Acid Oxidase; Enzyme Inhibitors; Formaldehyde; Isoxazoles; Male; Pain; Pain Measurement; Rats; Rats, Wistar

2011
Identification of potent, soluble, and orally active TRPV1 antagonists.
    Bioorganic & medicinal chemistry letters, 2011, Apr-15, Volume: 21, Issue:8

    Topics: Administration, Oral; Amides; Animals; Disease Models, Animal; Humans; Isoxazoles; Pain; Rats; TRPV Cation Channels

2011
Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Administration, Oral; Animals; Carbamates; Humans; Infusion Pumps; Inhibitory Concentration 50; Isoxazoles; Molecular Structure; Pain; Rats; Sodium Channel Blockers; Structure-Activity Relationship

2011
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
    British journal of pharmacology, 2012, Volume: 165, Issue:6

    Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hyperalgesia; Isoxazoles; Male; Mice; Pain; Rats; Rats, Wistar; Serine; Spine

2012
Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia.
    Neuropharmacology, 2012, Volume: 63, Issue:3

    Topics: Analgesics, Opioid; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Injections, Subcutaneous; Isoxazoles; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate

2012
Contributions of spinal D-amino acid oxidase to bone cancer pain.
    Amino acids, 2012, Volume: 43, Issue:5

    Topics: Analgesia; Analgesics, Opioid; Animals; Astrocytes; Bone Neoplasms; Carcinoma 256, Walker; D-Amino-Acid Oxidase; Enzyme Inhibitors; Female; Gene Expression; Hyperalgesia; Injections, Spinal; Isoxazoles; Morphine; Nerve Tissue Proteins; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord; Tibia

2012
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Butadienes; Cholinergic Agents; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Injections, Spinal; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Nitriles; Pain; Pain Measurement; Phenylurea Compounds; Physical Stimulation; Postural Balance; Reaction Time; Receptors, Nicotinic

2013
[Rapid and safe pain management. Promising new cyclooxygenase inhibitor].
    MMW Fortschritte der Medizin, 2002, Jul-26, Volume: 144, Issue:29-30

    Topics: Clinical Trials as Topic; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Humans; Isoxazoles; Pain; Sulfonamides

2002
Concluding remarks. C0X-2-selective inhibition: a new advance in pain management.
    European journal of anaesthesiology. Supplement, 2002, Volume: 25

    Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Premedication; Prostaglandin-Endoperoxide Synthases

2002
[Adverse effect-free analgesia. New COX-2 inhibitor is even more selective].
    MMW Fortschritte der Medizin, 2003, May-01, Volume: 145, Issue:18

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Treatment Outcome

2003
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
    Pain, 2004, Volume: 107, Issue:1-2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Isoenzymes; Isoxazoles; Organic Chemicals; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Radiology; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Tumor Cells, Cultured

2004
Weekly leflunomide as monotherapy for recent-onset rheumatoid arthritis.
    Arthritis and rheumatism, 2004, Feb-15, Volume: 51, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Joints; Leflunomide; Male; Outpatients; Pain; Treatment Outcome

2004
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach

2004
Successful use of zonisamide for central poststroke pain.
    The journal of pain, 2004, Volume: 5, Issue:3

    Topics: Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebral Infarction; Diabetes Complications; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Pain; Stroke; Zonisamide

2004
Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital.
    Current medical research and opinion, 2004, Volume: 20, Issue:5

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Chronic Disease; Epilepsy; Humans; Isoxazoles; Male; Middle Aged; Pain; Retrospective Studies; Treatment Outcome; Zonisamide

2004
[Review of analgesics].
    Revue de l'infirmiere, 2004, Issue:106

    Topics: Analgesics; Delayed-Action Preparations; Drug and Narcotic Control; Drug Prescriptions; Drug Therapy; France; Humans; Isoxazoles; Oxycodone; Pain; Patient Selection; Tramadol

2004
Another popular painkiller gets the government's hook.
    U.S. news & world report, 2005, Apr-18, Volume: 138, Issue:14

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug and Narcotic Control; Drug Labeling; Humans; Isoxazoles; Pain; Sulfonamides; United States; United States Food and Drug Administration

2005
Parecoxib: renal failure.
    Prescrire international, 2005, Volume: 14, Issue:76

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Australia; Humans; Isoxazoles; Middle Aged; Pain; Renal Insufficiency

2005
Pfizer withdraws Bextra in South Africa.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2005, Volume: 95, Issue:5

    Topics: Cyclooxygenase Inhibitors; Drug Industry; Humans; Isoxazoles; Pain; South Africa; Sulfonamides

2005
Valdecoxib withdrawal leaves pain relief treatment gap.
    Gastroenterology, 2005, Volume: 128, Issue:7

    Topics: Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Decision Making; Drug Industry; Humans; Isoxazoles; Pain; Public Policy; Risk Factors; Sulfonamides; United States; United States Food and Drug Administration

2005
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:2

    Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide

2005
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
    Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Rabbits; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Sulfonamides; Time Factors

2008
GABAergic mechanisms in antinociception.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin

1984
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:5

    Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain

1983
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1

    Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds

1983
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Motor Activity; Muscimol; Pain; Phencyclidine; Reflex

1980
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission

1997
Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
    Prostaglandins & other lipid mediators, 1998, Volume: 55, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Pain; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; RNA, Messenger

1998
Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
    Prostaglandins & other lipid mediators, 1998, Volume: 56, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Inbred Strains; Pain; Prostaglandin-Endoperoxide Synthases; Time Factors

1998
Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test.
    Pharmacology & toxicology, 1998, Volume: 83, Issue:4

    Topics: Animals; Baclofen; Benzodiazepinones; Devazepide; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; Isoxazoles; Male; Mice; Motor Activity; Pain; Pain Measurement; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Tail

1998
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Cholecystokinin

1999
Parecoxib (parecoxib sodium).
    Drugs, 2001, Volume: 61, Issue:8

    Topics: Abdominal Pain; Cyclooxygenase Inhibitors; Dizziness; Headache; Humans; Infusions, Intravenous; Injections, Intramuscular; Isoxazoles; Nausea; Pain; Randomized Controlled Trials as Topic

2001
The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:3

    Topics: Adolescent; Adult; Analgesics; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Molar, Third; Oral Surgical Procedures; Pain; Pain Measurement; Pain, Postoperative; Preoperative Care; Prostaglandin-Endoperoxide Synthases; Tooth Extraction

2001
The parafasciculus thalami as a site for mediating the antinociceptive response to GABAergic drugs.
    Brain research, 1986, Sep-24, Volume: 383, Issue:1-2

    Topics: Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Synaptic Transmission; Thalamic Nuclei

1986
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
    Neuropharmacology, 1987, Volume: 26, Issue:5

    Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission

1987
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
    Brain research, 1988, May-31, Volume: 450, Issue:1-2

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds

1988
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
    Neuropharmacology, 1987, Volume: 26, Issue:4

    Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Motor Activity; Pain; Pyrans; Pyrones

1987