ritonavir and Pain

ritonavir has been researched along with Pain* in 3 studies

Trials

1 trial(s) available for ritonavir and Pain

Article	Year
Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir. European journal of clinical pharmacology, 2010, Volume: 66, Issue:10 this study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain.. a randomized crossover study design with three phases at intervals of 4 weeks was conducted in 12 healthy volunteers. Ritonavir 300 mg, lopinavir/ritonavir 400/100 mg, or placebo b.i.d. for 4 days was given to the subjects. On day 3, 10 mg oxycodone hydrochloride was administered orally. Plasma concentrations of oxycodone, noroxycodone, oxymorphone, and noroxymorphone were determined for 48 h. Pharmacokinetic parameters were calculated with standard noncompartmental methods. Behavioral effects and experimental cold pain analgesia were assessed for 12 h. ANOVA for repeated measures was used for statistical analysis.. ritonavir and lopinavir/ritonavir increased the area under the plasma concentration-time curve of oral oxycodone by 3.0-fold (range 1.9- to 4.3-fold; P <0.001) and 2.6-fold (range 1.9- to 3.3-fold; P <0.001). The mean (± SD) elimination half-life increased after ritonavir and lopinavir/ritonavir from 3.6 ± 0.6 to 5.6 ± 0.9 h (P <0.001) and 5.7 ± 0.9 h (P <0.001), respectively. Both ritonavir (P <0.001) and lopinavir/ritonavir (P <0.05) increased the self-reported drug effect of oxycodone.. ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects. Topics: Adult; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Finland; HIV Infections; HIV Protease Inhibitors; Humans; Linear Models; Lopinavir; Male; Oxycodone; Pain; Pyrimidinones; Reference Values; Ritonavir; Time Factors; Young Adult	2010

Article

Year

Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir.

European journal of clinical pharmacology, 2010, Volume: 66, Issue:10

this study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain.. a randomized crossover study design with three phases at intervals of 4 weeks was conducted in 12 healthy volunteers. Ritonavir 300 mg, lopinavir/ritonavir 400/100 mg, or placebo b.i.d. for 4 days was given to the subjects. On day 3, 10 mg oxycodone hydrochloride was administered orally. Plasma concentrations of oxycodone, noroxycodone, oxymorphone, and noroxymorphone were determined for 48 h. Pharmacokinetic parameters were calculated with standard noncompartmental methods. Behavioral effects and experimental cold pain analgesia were assessed for 12 h. ANOVA for repeated measures was used for statistical analysis.. ritonavir and lopinavir/ritonavir increased the area under the plasma concentration-time curve of oral oxycodone by 3.0-fold (range 1.9- to 4.3-fold; P <0.001) and 2.6-fold (range 1.9- to 3.3-fold; P <0.001). The mean (± SD) elimination half-life increased after ritonavir and lopinavir/ritonavir from 3.6 ± 0.6 to 5.6 ± 0.9 h (P <0.001) and 5.7 ± 0.9 h (P <0.001), respectively. Both ritonavir (P <0.001) and lopinavir/ritonavir (P <0.05) increased the self-reported drug effect of oxycodone.. ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects.

Topics: Adult; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Finland; HIV Infections; HIV Protease Inhibitors; Humans; Linear Models; Lopinavir; Male; Oxycodone; Pain; Pyrimidinones; Reference Values; Ritonavir; Time Factors; Young Adult

2010

Other Studies

2 other study(ies) available for ritonavir and Pain

Article	Year
Burning Pain in the Legs. The New England journal of medicine, 2020, Jul-23, Volume: 383, Issue:4 Topics: Adult; Computed Tomography Angiography; Cytochrome P-450 CYP3A Inhibitors; Ergotamine; Ergotism; Female; HIV Infections; Humans; Ischemia; Leg; Migraine Disorders; Pain; Ritonavir	2020
Ritonavir-associated hyperparathyroidism, osteopenia and bone pain. AIDS (London, England), 2002, Jul-26, Volume: 16, Issue:11 Topics: Antiretroviral Therapy, Highly Active; Bone and Bones; Bone Diseases, Metabolic; Female; HIV Infections; Humans; Hyperparathyroidism; Middle Aged; Pain; Ritonavir	2002