Page last updated: 2024-08-07 17:09:36

Neuropeptide Y receptor type 5

A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761]

Synonyms

NPY5-R;
NPY-Y5 receptor;
NPYY5-R;
Y5 receptor

Research

Bioassay Publications (12)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's7 (58.33)29.6817
2010's4 (33.33)24.3611
2020's0 (0.00)2.80

Compounds (8)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
benextramineHomo sapiens (human)Ki5.000011
bibp 3226Homo sapiens (human)Ki10.000011
cgp 71683 aHomo sapiens (human)IC500.002544
n-(4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochlorideHomo sapiens (human)IC502.700011
mk-0557Homo sapiens (human)IC500.001322
mk-0557Homo sapiens (human)Ki0.001611
neuropeptide y (24-36) amide, n-acetyl-(leu(28,31))-Homo sapiens (human)Ki1.000022
lu aa33810Homo sapiens (human)IC500.001811
lu aa33810Homo sapiens (human)Ki0.001511

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bms 193885Homo sapiens (human)Kb1.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
neuropeptide Y receptor activitymolecular functionCombining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606]
pancreatic polypeptide receptor activitymolecular functionCombining with pancreatic polypeptide PP to initiate a change in cell activity. [PMID:9315606]
peptide YY receptor activitymolecular functionCombining with gut peptide YY to initiate a change in cell activity. [PMID:9315606]
neuropeptide bindingmolecular functionInteracting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
presynapsecellular componentThe part of a synapse that is part of the presynaptic cell. [GOC:dos]
GABA-ergic synapsecellular componentA synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
positive regulation of acute inflammatory responsebiological processAny process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]
negative regulation of acute inflammatory response to antigenic stimulusbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]
outflow tract morphogenesisbiological processThe process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]
cardiac left ventricle morphogenesisbiological processThe process in which the left cardiac ventricle is generated and organized. [GOC:mtg_heart]
neuropeptide signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
negative regulation of glutamate secretionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]
negative regulation of synaptic transmission, GABAergicbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]
eating behaviorbiological processThe specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of smooth muscle cell proliferationbiological processAny process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
generation of ovulation cycle rhythmbiological processThe process which controls the timing of the type of sexual cycle seen in female mammals. [GOC:dph]
positive regulation of ERK1 and ERK2 cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
synaptic signaling via neuropeptidebiological processCell-cell signaling to or from a synapse, mediated by a peptide. [GOC:dos]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]