Neuropeptide Y receptor type 5

A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761]

Synonyms

NPY5-R;
NPY-Y5 receptor;
NPYY5-R;
Y5 receptor

Research

Bioassay Publications (12)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	7 (58.33)	29.6817
2010's	4 (33.33)	24.3611
2020's	0 (0.00)	2.80

Compounds (8)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benextramine	Homo sapiens (human)	Ki	5.0000	1	1
bibp 3226	Homo sapiens (human)	Ki	10.0000	1	1
cgp 71683 a	Homo sapiens (human)	IC50	0.0025	4	4
n-(4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride	Homo sapiens (human)	IC50	2.7000	1	1
mk-0557	Homo sapiens (human)	IC50	0.0013	2	2
mk-0557	Homo sapiens (human)	Ki	0.0016	1	1
neuropeptide y (24-36) amide, n-acetyl-(leu(28,31))-	Homo sapiens (human)	Ki	1.0000	2	2
lu aa33810	Homo sapiens (human)	IC50	0.0018	1	1
lu aa33810	Homo sapiens (human)	Ki	0.0015	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bms 193885	Homo sapiens (human)	Kb	1.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
neuropeptide Y receptor activity	molecular function	Combining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606]
pancreatic polypeptide receptor activity	molecular function	Combining with pancreatic polypeptide PP to initiate a change in cell activity. [PMID:9315606]
peptide YY receptor activity	molecular function	Combining with gut peptide YY to initiate a change in cell activity. [PMID:9315606]
neuropeptide binding	molecular function	Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]
GABA-ergic synapse	cellular component	A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
positive regulation of acute inflammatory response	biological process	Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]
negative regulation of acute inflammatory response to antigenic stimulus	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. [GOC:add]
outflow tract morphogenesis	biological process	The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]
cardiac left ventricle morphogenesis	biological process	The process in which the left cardiac ventricle is generated and organized. [GOC:mtg_heart]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
negative regulation of glutamate secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]
negative regulation of synaptic transmission, GABAergic	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]
eating behavior	biological process	The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of smooth muscle cell proliferation	biological process	Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
generation of ovulation cycle rhythm	biological process	The process which controls the timing of the type of sexual cycle seen in female mammals. [GOC:dph]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
synaptic signaling via neuropeptide	biological process	Cell-cell signaling to or from a synapse, mediated by a peptide. [GOC:dos]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]

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