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dka 9

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

DKA 9: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID39876
CHEMBL ID6937
SCHEMBL ID677776
MeSH IDM0047990

Synonyms (14)

Synonym
dka-9
dka 9
3-biphenylacetic acid, 4'-chloro-5-methoxy-
(1,1'-biphenyl)-3-acetic acid, 4'-chloro-5-methoxy-
4'-chloro-5-methoxy(1,1'-biphenyl)-3-acetic acid
4'-chloro-5-methoxy-(1,1'-biphenyl)-3-acetic acid
4'-chloro-5-methoxy-3-biphenylacetic acid
brn 2217175
2-[3-(4-chlorophenyl)-5-methoxyphenyl]acetic acid
CHEMBL6937
51028-89-8
3-methoxy-5-(p-chlorophenyl)phenylacetic acid
SCHEMBL677776
DTXSID50199034
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID182125Percent inhibition of carrageenan induced rat paw edema 3 hr after a peroral administration of 10 mg/kg1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
Nonsteroidal antiinflammatory agents. 3. Synthesis of the positional isomers of 4'-chloro-5-methoxy-3-biphenylylacetic acid and their antiinflammatory and analgesic activities.
AID116879Acute toxicity was determined 168 hr after a single ip injection to groups of four male ddY mice.1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Nonsteroidal antiinflammatory agents. 2. Synthesis of 4',5-disubstituted 3-biphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities.
AID1136186Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema administered 30 mins prior challenge measured after 3 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agenst.
AID183913Inhibitory activity on carrageenan-induced paw edema in rats 3h after po administration of 50 mg/kg1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Nonsteroidal antiinflammatory agents. 2. Synthesis of 4',5-disubstituted 3-biphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities.
AID114542Tested for inhibitory activity after administration of compound at 50 mg/kg perorally using AcOH writhing method1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
Nonsteroidal antiinflammatory agents. 3. Synthesis of the positional isomers of 4'-chloro-5-methoxy-3-biphenylylacetic acid and their antiinflammatory and analgesic activities.
AID183911Inhibitory activity on carrageenan-induced paw edema in rats 3h after po administration of 20 mg/kg1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Nonsteroidal antiinflammatory agents. 2. Synthesis of 4',5-disubstituted 3-biphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities.
AID184568Tested for inhibition of edema growth in rat1980Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
Structure-activity study of antiulcerous and antiinflammatory drugs by discriminant analysis.
AID182126Percent inhibition of carrageenan induced rat paw edema 3 hr after a peroral administration of 20 mg/kg1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
Nonsteroidal antiinflammatory agents. 3. Synthesis of the positional isomers of 4'-chloro-5-methoxy-3-biphenylylacetic acid and their antiinflammatory and analgesic activities.
AID177770Analgesic activity against AcOH writhing after po administration.1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Nonsteroidal antiinflammatory agents. 2. Synthesis of 4',5-disubstituted 3-biphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities.
AID183910Inhibitory activity on carrageenan-induced paw edema in rats 3h after po administration of 10 mg/kg1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Nonsteroidal antiinflammatory agents. 2. Synthesis of 4',5-disubstituted 3-biphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities.
AID23674Partition coefficient (logP)1980Journal of medicinal chemistry, Apr, Volume: 23, Issue:4
Structure-activity study of antiulcerous and antiinflammatory drugs by discriminant analysis.
AID182127Percent inhibition of carrageenan induced rat paw edema 3 hr after a peroral administration of 50 mg/kg1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
Nonsteroidal antiinflammatory agents. 3. Synthesis of the positional isomers of 4'-chloro-5-methoxy-3-biphenylylacetic acid and their antiinflammatory and analgesic activities.
AID117227Tested for acute toxicity after administration of compound at 50 mg/kg intraperitoneally in mice1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
Nonsteroidal antiinflammatory agents. 3. Synthesis of the positional isomers of 4'-chloro-5-methoxy-3-biphenylylacetic acid and their antiinflammatory and analgesic activities.
AID1136187Acute toxicity in ip dosed ddY mouse measured after 168 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agenst.
AID1136188Analgesic activity in ip dosed ddY mouse assessed as prevention of pseudoavoidance reflex co-administered with 5 mg/kg, sc morphine hydrochloride by tail pinch method1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agenst.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]