| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years. | 0 | 2.25 | 1 | 0 |
Cancer of Lung
[description not available] | 0 | 2.25 | 1 | 0 |
Malignant Melanoma
[description not available] | 0 | 2.98 | 4 | 0 |
Benign Meningeal Neoplasms
[description not available] | 0 | 2.25 | 1 | 0 |
Cancer of Skin
[description not available] | 0 | 2.25 | 1 | 0 |
Lung Neoplasms
Tumors or cancer of the LUNG. | 0 | 2.25 | 1 | 0 |
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) | 0 | 2.98 | 4 | 0 |
Meningeal Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord. | 0 | 2.25 | 1 | 0 |
Skin Neoplasms
Tumors or cancer of the SKIN. | 0 | 2.25 | 1 | 0 |
Uveal Neoplasms
Tumors or cancer of the UVEA. | 0 | 2.25 | 1 | 0 |
Blood Pressure, High
[description not available] | 0 | 3.82 | 11 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 3.82 | 11 | 0 |
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES. | 0 | 2.75 | 3 | 0 |
Cirrhosis
[description not available] | 0 | 2.1 | 1 | 0 |
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. | 0 | 2.1 | 1 | 0 |
Neointima
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement. | 0 | 2.49 | 2 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 3.64 | 9 | 0 |
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. | 0 | 2.44 | 2 | 0 |
Cardiac Failure
[description not available] | 0 | 2.93 | 4 | 0 |
Cardiomyopathies, Primary
[description not available] | 0 | 2.04 | 1 | 0 |
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. | 0 | 2.93 | 4 | 0 |
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). | 0 | 2.04 | 1 | 0 |
Glial Cell Tumors
[description not available] | 0 | 2.45 | 2 | 0 |
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 2.45 | 2 | 0 |
Constriction, Pathological
[description not available] | 0 | 2.05 | 1 | 0 |
Allodynia
[description not available] | 0 | 2.94 | 4 | 0 |
Constriction, Pathologic
The condition of an anatomical structure's being constricted beyond normal dimensions. | 0 | 2.05 | 1 | 0 |
Cruveilhier-Baumgarten Syndrome
Liver cirrhosis with intrahepatic portal obstruction, HYPERTENSION, and patent UMBILICAL VEINS. | 0 | 2.05 | 1 | 0 |
Cirrhoses, Experimental Liver
[description not available] | 0 | 2.05 | 1 | 0 |
Hypertension, Portal
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN. | 0 | 2.05 | 1 | 0 |
Hypovolemic
[description not available] | 0 | 2.05 | 1 | 0 |
Hypovolemia
An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK). | 0 | 2.05 | 1 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 2.05 | 1 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 2.05 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 2.05 | 1 | 0 |
Facial Pain, Referred
[description not available] | 0 | 2.05 | 1 | 0 |
Colicky Pain
[description not available] | 0 | 2.05 | 1 | 0 |
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. | 0 | 2.05 | 1 | 0 |
Abdominal Pain
Sensation of discomfort, distress, or agony in the abdominal region. | 0 | 2.05 | 1 | 0 |
Acute Kidney Failure
[description not available] | 0 | 2.43 | 2 | 0 |
Acute Kidney Injury
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. | 0 | 2.43 | 2 | 0 |
Left Ventricular Dysfunction
[description not available] | 0 | 2.44 | 2 | 0 |
Injury, Myocardial Reperfusion
[description not available] | 0 | 2.72 | 3 | 0 |
Ventricular Dysfunction, Left
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall. | 0 | 2.44 | 2 | 0 |
Diabetes Mellitus, Adult-Onset
[description not available] | 0 | 2.74 | 3 | 0 |
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. | 0 | 2.74 | 3 | 0 |
Vascular Injuries
[description not available] | 0 | 2.07 | 1 | 0 |
Central Nervous System Neoplasm
[description not available] | 0 | 2.07 | 1 | 0 |
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges. | 0 | 2.07 | 1 | 0 |
Acute Edematous Pancreatitis
[description not available] | 0 | 2.01 | 1 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 2.7 | 3 | 0 |
Pancreatitis
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis. | 0 | 2.01 | 1 | 0 |
Acute Respiratory Distress Syndrome
[description not available] | 0 | 2.01 | 1 | 0 |
Respiratory Distress Syndrome
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA. | 0 | 2.01 | 1 | 0 |
Arterial Obstructive Diseases
[description not available] | 0 | 2.01 | 1 | 0 |
Arterial Occlusive Diseases
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency. | 0 | 2.01 | 1 | 0 |
Hypokalemia
Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed) | 0 | 2.01 | 1 | 0 |
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES. | 0 | 2.01 | 1 | 0 |
Hypertrophy
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA). | 0 | 2.01 | 1 | 0 |
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues. | 0 | 2.01 | 1 | 0 |
Cancer of Prostate
[description not available] | 0 | 2.02 | 1 | 0 |
Prostatic Neoplasms
Tumors or cancer of the PROSTATE. | 0 | 2.02 | 1 | 0 |
Bone Cancer
[description not available] | 0 | 2.02 | 1 | 0 |
Ache
[description not available] | 0 | 2.7 | 3 | 0 |
Sarcoma, Epithelioid
[description not available] | 0 | 2.02 | 1 | 0 |
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES. | 0 | 2.02 | 1 | 0 |
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. | 0 | 2.7 | 3 | 0 |
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant. | 0 | 2.02 | 1 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 2.42 | 2 | 0 |
Hypertrophy, Right Ventricular
Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality. | 0 | 2.41 | 2 | 0 |
Cardiac Hypertrophy
Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. | 0 | 2.71 | 3 | 0 |
Pulmonary Hypertension
[description not available] | 0 | 2.7 | 3 | 0 |
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. | 0 | 2.71 | 3 | 0 |
Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. | 0 | 2.7 | 3 | 0 |
Hypermyotonia
[description not available] | 0 | 2.02 | 1 | 0 |
Cardiomyopathy, Congestive
[description not available] | 0 | 2.43 | 2 | 0 |
Cardiomyopathy, Dilated
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein. | 0 | 2.43 | 2 | 0 |
Heart Disease, Ischemic
[description not available] | 0 | 2.02 | 1 | 0 |
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). | 0 | 2.02 | 1 | 0 |
Air Embolism
[description not available] | 0 | 2.02 | 1 | 0 |
Right Ventricular Dysfunction
[description not available] | 0 | 2.02 | 1 | 0 |
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures. | 0 | 2.02 | 1 | 0 |
Entrapment Neuropathies
[description not available] | 0 | 2.03 | 1 | 0 |
Epileptiform Neuralgia
[description not available] | 0 | 2.03 | 1 | 0 |
Trigeminal Neuralgia
A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187) | 0 | 2.03 | 1 | 0 |
Diabetic Angiopathies
VASCULAR DISEASES that are associated with DIABETES MELLITUS. | 0 | 2.04 | 1 | 0 |
Anoxemia
[description not available] | 0 | 2 | 1 | 0 |
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms. | 0 | 2 | 1 | 0 |
Dermatitis
Any inflammation of the skin. | 0 | 2 | 1 | 0 |
Endotoxin Shock
[description not available] | 0 | 2 | 1 | 0 |
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status. | 0 | 2 | 1 | 0 |
Alloxan Diabetes
[description not available] | 0 | 2 | 1 | 0 |
Asymmetric Diabetic Proximal Motor Neuropathy
[description not available] | 0 | 2 | 1 | 0 |
Diabetic Neuropathies
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325) | 0 | 2 | 1 | 0 |
Injury, Ischemia-Reperfusion
[description not available] | 0 | 2.41 | 2 | 0 |
Ischemia
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. | 0 | 2 | 1 | 0 |
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. | 0 | 2.41 | 2 | 0 |
Cardiovascular Stroke
[description not available] | 0 | 2 | 1 | 0 |
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). | 0 | 2 | 1 | 0 |
Compensatory Hyperinsulinemia
A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin. | 0 | 2 | 1 | 0 |
Insulin Sensitivity
[description not available] | 0 | 2 | 1 | 0 |
Hyperinsulinism
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS. | 0 | 2 | 1 | 0 |
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. | 0 | 2 | 1 | 0 |
Hypertension, Renal
Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN. | 0 | 2 | 1 | 0 |
Cancer of Liver
[description not available] | 0 | 2 | 1 | 0 |
Experimental Neoplasms
[description not available] | 0 | 2 | 1 | 0 |
Colorectal Cancer
[description not available] | 0 | 2 | 1 | 0 |
Liver Neoplasms
Tumors or cancer of the LIVER. | 0 | 2 | 1 | 0 |
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI. | 0 | 2 | 1 | 0 |