fenclonine has been researched along with Pain in 53 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of aspirin or 5-hydroxytryptamine (5-HT)-related drugs on the dental pain induced by electrical stimulation of tooth pulp afferent fibers were assessed in conscious monkeys." | 7.67 | Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey. ( Lin, MT; Shyu, KW; Wu, TC, 1984) |
| " Parachlorophenylalanine chronic administration in migraine-headache sufferers lowered the pain threshold so far as to provoke (in 20% of cases) spontaneous pains in the trunk, legs and arms." | 5.25 | 5-Hydroxytryptamine and pain modulation in man: a clinical pharmacological approach with tryptophan and parachlorophenylalanine. ( Anselmi, B; Del Bene, E; Galli, P; Sicuteri, F, 1975) |
| "The effects of aspirin or 5-hydroxytryptamine (5-HT)-related drugs on the dental pain induced by electrical stimulation of tooth pulp afferent fibers were assessed in conscious monkeys." | 3.67 | Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey. ( Lin, MT; Shyu, KW; Wu, TC, 1984) |
| " In this study, we investigated the antinociceptive action of neurotropin in relation to the serotonergic system, a pain inhibitory system, and substance P, a pain transmitter; we also attempted to determine whether it acts at the spinal or supraspinal level in mice." | 3.67 | Analgesic mechanism of neurotropin: relation to the serotonergic system and influence of spinal cord transection. ( Hata, T; Itoh, E, 1989) |
| "The tail flick assay was used to evaluate pain perception in mice treated acutely with either of the two classical antidepressant drugs (AD) imipramine or amitriptyline, or the atypical antidepressant iprindole." | 3.67 | Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin. ( de Ceballos, ML; de Felipe, MC; Fuentes, JA, 1986) |
| " After chronic administration (2 or 5 mg/kg for 18 consecutive days) tolerance to the effect of metitepin (0." | 1.27 | Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice. ( Berge, OG; Eide, PK; Hole, K, 1988) |
| "Four approaches were used to alter transmission in monoamine pathways." | 1.25 | Monoaminergic mechanisms of stimulation-produced analgesia. ( Akil, H; Liebeskind, JC, 1975) |
| " Parachlorophenylalanine chronic administration in migraine-headache sufferers lowered the pain threshold so far as to provoke (in 20% of cases) spontaneous pains in the trunk, legs and arms." | 1.25 | 5-Hydroxytryptamine and pain modulation in man: a clinical pharmacological approach with tryptophan and parachlorophenylalanine. ( Anselmi, B; Del Bene, E; Galli, P; Sicuteri, F, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (67.92) | 18.7374 |
| 1990's | 8 (15.09) | 18.2507 |
| 2000's | 4 (7.55) | 29.6817 |
| 2010's | 5 (9.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nie, TW | 1 |
| Shukkoor, MS | 1 |
| Nair, RS | 1 |
| Amiruddin, FK | 1 |
| Ramasamy, S | 1 |
| Nakamoto, K | 1 |
| Nishinaka, T | 1 |
| Sato, N | 1 |
| Aizawa, F | 1 |
| Yamashita, T | 1 |
| Mankura, M | 1 |
| Koyama, Y | 1 |
| Kasuya, F | 1 |
| Tokuyama, S | 1 |
| Takayama, B | 1 |
| Kikuchi, S | 1 |
| Konno, S | 1 |
| Sekiguchi, M | 1 |
| Mazzardo-Martins, L | 1 |
| Martins, DF | 1 |
| Marcon, R | 1 |
| Dos Santos, UD | 1 |
| Speckhann, B | 1 |
| Gadotti, VM | 1 |
| Sigwalt, AR | 1 |
| Guglielmo, LG | 1 |
| Santos, AR | 1 |
| Qin, HY | 1 |
| Luo, JL | 1 |
| Qi, SD | 1 |
| Xu, HX | 1 |
| Sung, JJ | 1 |
| Bian, ZX | 1 |
| Eto, K | 1 |
| Kim, SK | 1 |
| Nabekura, J | 1 |
| Ishibashi, H | 1 |
| Marchand, F | 1 |
| Alloui, A | 1 |
| Chapuy, E | 1 |
| Jourdan, D | 1 |
| Pelissier, T | 1 |
| Ardid, D | 1 |
| Hernandez, A | 1 |
| Eschalier, A | 1 |
| Miranda, HF | 1 |
| Lemus, I | 1 |
| Pinardi, G | 1 |
| Berge, OG | 3 |
| Hole, K | 3 |
| Ogren, SO | 1 |
| Shyu, KW | 1 |
| Lin, MT | 1 |
| Wu, TC | 1 |
| Bodnar, RJ | 2 |
| Kordower, JH | 2 |
| Reches, A | 1 |
| Wallace, MM | 2 |
| Fahn, S | 1 |
| Carstens, E | 1 |
| Fraunhoffer, M | 1 |
| Zimmermann, M | 1 |
| Moreau, JL | 1 |
| Cohen, E | 1 |
| Lieblich, I | 1 |
| Le Bars, D | 1 |
| Rivot, JP | 1 |
| Dickenson, AH | 2 |
| Chaouch, A | 1 |
| Besson, JM | 1 |
| Tamir, H | 1 |
| Roliński, Z | 1 |
| Herbut, M | 1 |
| Alamo, C | 1 |
| Arias, A | 1 |
| Cuenca, E | 1 |
| Takeshita, N | 1 |
| Ohkubo, Y | 1 |
| Yamaguchi, I | 1 |
| Nicolodi, M | 1 |
| Sicuteri, F | 4 |
| Uzbay, IT | 1 |
| Cinar, MG | 1 |
| Aytemir, M | 1 |
| Tuglular, I | 1 |
| Srikiatkhachorn, A | 1 |
| Anuntasethakul, T | 1 |
| Phansuwan-Pujito, P | 1 |
| Patumraj, S | 1 |
| Kasantikul, V | 1 |
| Wang, JK | 1 |
| Akil, H | 1 |
| Liebeskind, JC | 1 |
| Harvey, JA | 4 |
| Schlosberg, AJ | 2 |
| Yunger, LM | 3 |
| Sheard, MH | 1 |
| Davis, M | 1 |
| Anselmi, B | 2 |
| Del Bene, E | 1 |
| Galli, P | 1 |
| Semenova, TP | 1 |
| Vekshina, NL | 1 |
| Lorens, SA | 1 |
| Telner, J | 2 |
| Lepore, F | 2 |
| Guillemot, JP | 2 |
| Beani, L | 1 |
| Siniscalchi, A | 1 |
| Sarto, G | 1 |
| Cui, R | 1 |
| Ma, C | 1 |
| Wang, X | 1 |
| Tian, Y | 1 |
| Hoffmann, P | 1 |
| Skarphedinsson, JO | 1 |
| Delle, M | 1 |
| Thorén, P | 1 |
| Calvino, B | 1 |
| Cooley, JE | 1 |
| Villarosa, GA | 1 |
| Lombardo, TW | 1 |
| Moss, RA | 1 |
| Fowler, SC | 1 |
| Sult, S | 1 |
| Tura, B | 1 |
| Tura, SM | 1 |
| Steinman, JL | 1 |
| Carlton, SM | 1 |
| Haber, B | 1 |
| Willis, WD | 1 |
| Itoh, E | 1 |
| Hata, T | 1 |
| de Felipe, MC | 1 |
| de Ceballos, ML | 1 |
| Fuentes, JA | 1 |
| Beardwood, CJ | 1 |
| Abrahams, A | 1 |
| Jordi, PM | 1 |
| Eide, PK | 2 |
| Broch, OJ | 1 |
| Goldsmith, G | 1 |
| Contreras, E | 1 |
| Quijada, L | 1 |
| Tamayo, L | 1 |
| Reinhold, K | 1 |
| Bläsig, J | 1 |
| Herz, A | 1 |
| Fibiger, HC | 1 |
| Mertz, PH | 1 |
| Campbell, BA | 1 |
| Lints, CE | 1 |
| Franchi, G | 1 |
| Fanciullacci, M | 1 |
| Del Bianco, PL | 1 |
| Azmitia, EC | 1 |
| McEwen, BS | 1 |
| Giardina, WJ | 1 |
2 reviews available for fenclonine and Pain
| Article | Year |
|---|---|
Behavioral correlates of serotonin depletion.
Topics: 5-Hydroxytryptophan; Acetylcholine; Amygdala; Animals; Behavior, Animal; Brain; Dihydroxyphenylalani | 1975 |
Some behavioral effects of serotonin depletion depend on method: a comparison of 5,7-dihydroxytryptamine, p-chlorophenylalanine, p-choloroamphetamine, and electrolytic raphe lesions.
Topics: 5,7-Dihydroxytryptamine; Animals; Avoidance Learning; Behavior, Animal; Brain Stem; Electrolysis; Fe | 1978 |
51 other studies available for fenclonine and Pain
| Article | Year |
|---|---|
Involvement of opioidergic and serotonergic systems in the analgesic activity of Cissus quadrangularis L. stem extract in mice.
Topics: Analgesics; Animals; Cissus; Dose-Response Relationship, Drug; Fenclonine; Mice; Naloxone; Pain; Phe | 2015 |
The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system.
Topics: Animals; Fenclonine; Formaldehyde; Male; Methylamines; Mice; Mice, Inbred Strains; Pain; Pain Measur | 2015 |
An immunohistochemical study of the antinociceptive effect of calcitonin in ovariectomized rats.
Topics: Analgesics; Animals; Biomarkers; Calcitonin; Central Nervous System; Disease Models, Animal; Female; | 2008 |
High-intensity extended swimming exercise reduces pain-related behavior in mice: involvement of endogenous opioids and the serotonergic system.
Topics: Acetic Acid; Animals; Behavior, Animal; Fenclonine; Irritants; Male; Mice; Naloxone; Narcotic Antago | 2010 |
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
Topics: Animals; Capsaicin; Colon; Fenclonine; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Male; Pain; | 2010 |
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
Topics: Adrenergic Agents; Animals; Biogenic Monoamines; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats.
Topics: alpha-Methyltyrosine; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Ani | 2003 |
Effect of the inhibition of serotonin biosynthesis on the antinociception induced by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Interaction | 2003 |
Attenuation of morphine-induced analgesia by p-chlorophenylalanine and p-chloroamphetamine: test-dependent effects and evidence for brainstem 5-hydroxytryptamine involvement.
Topics: Amphetamines; Analgesia; Animals; Brain Stem; Dose-Response Relationship, Drug; Drug Antagonism; Fen | 1983 |
Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey.
Topics: 5,7-Dihydroxytryptamine; Animals; Aspirin; Cyproheptadine; Dental Pulp; Fenclonine; Macaca; Male; Pa | 1984 |
Reductions in pain thresholds and morphine analgesia following intracerebroventricular parachlorophenylalanine.
Topics: Animals; Behavior, Animal; Brain Chemistry; Fenclonine; Injections, Intraventricular; Male; Morphine | 1984 |
Serotonergic mediation of descending inhibition from midbrain periaqueductal gray, but not reticular formation, or spinal nociceptive transmission in the cat.
Topics: Animals; Brain Mapping; Cats; Fenclonine; Hot Temperature; Mesencephalon; Methysergide; Neural Inhib | 1981 |
Ventral tegmental analgesia in two strains of rats: effects of amphetamine, naloxone and parachlorophenylalanine.
Topics: Amphetamine; Animals; Dopamine; Endorphins; Fenclonine; Male; Naloxone; Pain; Rats; Rats, Inbred Str | 1984 |
[Role of serotonin in the diffuse inhibitory controls induced by nociceptive stimulation].
Topics: Animals; Fenclonine; Male; Neural Inhibition; Neural Pathways; Neurons; Pain; Rats; Serotonin; Spina | 1980 |
Stress and morphine analgesia: alterations following p-chlorophenylalanine.
Topics: Animals; Brain Chemistry; Cold Temperature; Deoxyglucose; Fenclonine; Male; Morphine; Pain; Rats; Re | 1981 |
The role of the serotonergic system in foot shock-induced behavior in mice.
Topics: Aggression; Animals; Behavior, Animal; Brain Chemistry; Electroshock; Fenclonine; Humans; Male; Mice | 1981 |
[Involvement of serotoninergic mechanisms in the analgesic action of TRH].
Topics: Analgesics; Animals; Female; Fenclonine; Mice; Pain; Serotonin; Thyrotropin-Releasing Hormone; Trypt | 1981 |
Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism.
Topics: Animals; Central Nervous System; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dopamine An | 1995 |
Eosinophilia myalgia syndrome. The role of contaminants, the role of serotonergic metabolism set up.
Topics: Drug Contamination; Eosinophilia-Myalgia Syndrome; Female; Fenclonine; Fever; Humans; Male; Migraine | 1996 |
Analgesic effect of tianeptine in mice.
Topics: Analgesics; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Drug Interactions; Fenc | 1999 |
Effect of serotonin depletion on nitric oxide induced cerebrovascular nociceptive response.
Topics: Animals; Brain Stem; Cerebrovascular Circulation; Fenclonine; Fluorescent Dyes; Immunohistochemistry | 2001 |
Pain relief by intrathecal injection of serotonin or morphine.
Topics: Animals; Fenclonine; Humans; Injections, Spinal; Morphine; Naloxone; Pain; Rats; Serotonin; Serotoni | 1978 |
Monoaminergic mechanisms of stimulation-produced analgesia.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Apomorphine; Brain; Cerebral Aqueduct; Disulfiram; Dopamine | 1975 |
Shock elicited fighting in rats: importance of intershock interval upon the effect of p-chlorophenylalanine (PCPA).
Topics: Aggression; Animals; Electroshock; Fenclonine; Humans; Male; Pain; Rats; Serotonin; Time Factors | 1976 |
5-Hydroxytryptamine and pain modulation in man: a clinical pharmacological approach with tryptophan and parachlorophenylalanine.
Topics: 5-Hydroxytryptophan; Animals; Fenclonine; Headache; Humans; Pain; Serotonin; Tryptophan | 1975 |
[Effect of blockers of serotonin and noradrenaline synthesis on learning with emotionally different reinforcement in rats].
Topics: Animals; Brain; Conditioning, Classical; Disulfiram; Emotions; Fenclonine; Food; Learning; Male; Nor | 1978 |
Effects of serotonin content on pain sensitivity in the rat.
Topics: Animals; Avoidance Learning; Brain; Electroshock; Fenclonine; Male; Pain; Raphe Nuclei; Rats; Seroto | 1979 |
Monoamines modulation of morphine action on pain threshold and cortical acetylcholine outflow.
Topics: Acetylcholine; Animals; Biogenic Amines; Cerebral Cortex; Dextroamphetamine; Female; Fenclonine; Gui | 1979 |
Effects of serotonin on sensitivity and reactivity during various states of vigilance.
Topics: Animals; Arousal; Brain Chemistry; Cats; Fenclonine; Pain; Sensory Thresholds; Serotonin; Sleep; Sle | 1979 |
[The influence of P-chlorophenylalanine on the analgesia of electro-acupuncture and the level of SP in CNS of rats].
Topics: Acupuncture Analgesia; Animals; Central Nervous System; Electroacupuncture; Fenclonine; Nociceptors; | 1990 |
Electrical stimulation of the gastrocnemius muscle in the spontaneously hypertensive rat increases the pain threshold: role of different serotonergic receptors.
Topics: Analgesia; Animals; Drug Administration Schedule; Electric Stimulation; Fenclonine; Male; Muscles; P | 1990 |
Hypoalgesia induced by counter-irritation is not affected by pCPA pretreatment.
Topics: Animals; Fenclonine; Male; Pain; Rats; Rats, Inbred Strains; Reaction Time; Serotonin | 1990 |
Effect of pCPA on nicotine-induced analgesia.
Topics: Analgesia; Animals; Drug Interactions; Fenclonine; Male; Mecamylamine; Naloxone; Nicotine; Pain; Rat | 1990 |
The analgesic effect of tricyclic antidepressants.
Topics: Amitriptyline; Analgesia; Analgesics; Animals; Fenclonine; Imipramine; Male; Pain; Rats; Rats, Inbre | 1990 |
Differential effects of p-chlorophenylalanine on indoleamines in brainstem nuclei and spinal cord of rats. I. Biochemical and behavioral analysis.
Topics: 5-Hydroxytryptophan; Animals; Brain Stem; Female; Fenclonine; Hydroxyindoleacetic Acid; Organ Specif | 1987 |
Analgesic mechanism of neurotropin: relation to the serotonergic system and influence of spinal cord transection.
Topics: Analgesics; Animals; Behavior, Animal; Cisterna Magna; Cyproheptadine; Decerebrate State; Fenclonine | 1989 |
Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin.
Topics: Amitriptyline; Animals; Antidepressive Agents; Dibenzazepines; Drug Tolerance; Endorphins; Fenclonin | 1986 |
The effect of exposure to positive space charge on aversive responses to noxious stimuli in rats.
Topics: Analgesia; Animals; Atmosphere Exposure Chambers; Avoidance Learning; Brain; Electromagnetic Phenome | 1986 |
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; | 1988 |
Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Dibenzothiepins; Dihydroxytryptamines; Fenclonine; Male; Methiothe | 1988 |
Evidence for a role of 5-hydroxytryptamine in the responses of rat raphe magnus neurones to peripheral noxious stimuli.
Topics: Animals; Evoked Potentials; Fenclonine; Male; Metergoline; Pain; Raphe Nuclei; Rats; Rats, Inbred St | 1986 |
Headache as possible expression of deficiency of brain 5-hydroxytryptamine (central denervation supersensitivity).
Topics: Adult; Brain Chemistry; Female; Fenclonine; Headache; Humans; Migraine Disorders; Pain; Serotonin | 1972 |
A comparative study of the effects of reserpine and p-chlorophenylalanine on morphine analgesia in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Dihydroxyphenylalanine; Drug Synergism; Fenclonine; Male; M | 1973 |
Effect of lesions in the medial forebrain bundle on three measures of pain sensitivity and noise-elicited startle.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Avoidance Learning; Brain Chemistry; Electroshoc | 1973 |
Changes in brain concentration of biogenic amines and the antinociceptive effect of morphine in rats.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Catecholamines; Dopamine; Dopamine beta-Hydrox | 1973 |
The effect of para-chlorophenylalanine on aversion thresholds and reactivity to foot shock.
Topics: Animals; Avoidance Learning; Differential Threshold; Electroshock; Escape Reaction; Fenclonine; Hous | 1972 |
Lesions in the medial forebrain bundle: relationship between pain sensitivity and telencephalic content of serotonin.
Topics: 5-Hydroxytryptophan; Animals; Body Weight; Brain; Brain Chemistry; Brain Stem; Electroshock; Escape | 1971 |
[5-Hydroxytryptamine and physiopathology of pain; on a polyalgic syndrome in the course of therapy with para-chlorophenylalanine].
Topics: Catecholamines; Eosinophilia; Fenclonine; Fever; Headache; Humans; Migraine Disorders; Pain; Seroton | 1972 |
Effect of p-chlorophenylalanine and brain lesions on pain sensitivity and morphine analgesia in the rat.
Topics: Analgesia; Animals; Brain; Circadian Rhythm; Darkness; Escape Reaction; Fenclonine; Light; Morphine; | 1974 |
Adrenalcortical influence on rat brain tryptophan hydroxylase activity.
Topics: Adrenal Glands; Anesthesia, General; Animals; Brain; Circadian Rhythm; Cold Temperature; Corticoster | 1974 |
Analgesic properties of phenylethylamine and phenylethanolamine in mice.
Topics: Animals; Disulfides; Ethanolamines; Fenclonine; Imidazoles; Injections, Intraperitoneal; Male; Metho | 1974 |