Compounds > quadazocine
Page last updated: 2024-09-24

quadazocine

Description

quadazocine: RN given refers to (2 alpha,6 alpha,11S*)-(+-)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID115077
SCHEMBL ID990529
MeSH IDM0109859

Synonyms (10)

Synonym
(-)-win 44,441
(-)-quadazocine
gtpl1633
quadazocine
69924-29-4
SCHEMBL990529
1-cyclopentyl-5-(8-hydroxy-3,6,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11-yl)pentan-3-one
DTXSID30990187
Q7268283
1-cyclopentyl-5-[(1s,9r)-4-hydroxy-1,10,13-trimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-13-yl]pentan-3-one

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1346364Human mu receptor (Opioid receptors)1998NIDA research monograph, Mar, Volume: 178Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
AID1346329Human kappa receptor (Opioid receptors)1998NIDA research monograph, Mar, Volume: 178Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
AID1346361Human delta receptor (Opioid receptors)1998NIDA research monograph, Mar, Volume: 178Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (81)

TimeframeStudies, This Drug (%)All Drugs %
pre-199042 (51.85)18.7374
1990's32 (39.51)18.2507
2000's7 (8.64)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other81 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
fentanyl[no description available]medium60anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic
enkephalin, leucine[no description available]medium10peptide
etonitazene[no description available]medium10
levomethadone[no description available]medium106-(dimethylamino)-4,4-diphenylheptan-3-oneantitussive;
mu-opioid receptor agonist;
NMDA receptor antagonist;
opioid analgesic
enkephalin, d-penicillamine (2,5)-[no description available]medium40heterodetic cyclic peptidedelta-opioid receptor agonist
u 69593[no description available]medium50monocarboxylic acid amide;
N-alkylpyrrolidine;
organic heterobicyclic compound;
oxaspiro compound		anti-inflammatory agent;
diuretic;
kappa-opioid receptor agonist
enkephalin, ser(2), leu(5), thr(6)-[no description available]medium10oligopeptide
morphiceptin, n-me-phe(3)-[no description available]medium10
pentazocine[no description available]medium10benzazocine
diprenorphine[no description available]medium60morphinane alkaloid
buprenorphine[no description available]medium20morphinane alkaloiddelta-opioid receptor antagonist;
kappa-opioid receptor antagonist;
mu-opioid receptor agonist;
opioid analgesic
u-50488[no description available]medium140dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist
dynorphin (1-11)[no description available]medium10
codeine[no description available]medium20morphinane alkaloid;
organic heteropentacyclic compound		antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic
nalmefene[no description available]medium20morphinane alkaloid
nalorphine[no description available]medium10morphinane alkaloid
naloxone[no description available]medium270morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
morphine[no description available]medium200morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
beta-funaltrexamine[no description available]medium70morphinane alkaloid
dihydromorphine[no description available]medium10morphinane alkaloid
naltrexone[no description available]medium230cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound		antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium10peptide
normorphine[no description available]medium20morphinane alkaloid
norbinaltorphimine[no description available]medium40isoquinolines
naltrindole benzofuran[no description available]medium10morphinane alkaloid
naltrindole[no description available]medium40isoquinolines
naloxone benzoylhydrazone[no description available]medium20
7-benzylidenenaltrexone[no description available]medium10
enkephalin, leucine-2-alanine[no description available]medium50
dynorphin (1-17)[no description available]medium10
deltorphin ii, ala(2)-[no description available]medium10
beta-endorphin[no description available]medium40
rimorphin[no description available]medium20
dynorphins[no description available]medium20
enkephalin-leu, ala(2)-arg(6)-[no description available]medium10
gr 89696[no description available]medium10acetamides
2'-hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan[no description available]medium30
lofentanil[no description available]medium10methyl ester;
piperidines;
tertiary amino compound;
tertiary carboxamide		mu-opioid receptor agonist;
opioid analgesic
butorphanol[no description available]medium20morphinane alkaloidantitussive;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic
colforsin[no description available]medium20acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
etorphine[no description available]medium10
phenazocine[no description available]medium40
hydromorphone[no description available]medium20morphinane alkaloid;
organic heteropentacyclic compound		mu-opioid receptor agonist;
opioid analgesic
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium40
heroin[no description available]medium50morphinane alkaloidmu-opioid receptor agonist;
opioid analgesic;
prodrug
endomorphin 2[no description available]medium10
endomorphin 1[no description available]medium10oligopeptide
cyclazocine[no description available]medium70
ethylketocyclazocine[no description available]medium110
bremazocine[no description available]medium70
mr 2266[no description available]medium70
morphinans[no description available]medium30isoquinoline alkaloid fundamental parent;
morphinane alkaloid
enkephalin, leucine[no description available]medium130pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite
dynorphins[no description available]medium90
morphiceptin[no description available]medium10oligopeptide
cocaine[no description available]medium30benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
dinoprostone[no description available]medium20prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
tolmetin[no description available]medium10aromatic ketone;
monocarboxylic acid;
pyrroles		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug
bradykinin[no description available]medium10oligopeptidehuman blood serum metabolite;
vasodilator agent
ketorolac[no description available]medium10amino acid;
aromatic ketone;
monocarboxylic acid;
pyrrolizines;
racemate		analgesic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug
nalbuphine[no description available]medium20organic heteropentacyclic compoundmu-opioid receptor antagonist;
opioid analgesic
alfentanil[no description available]medium40monocarboxylic acid amide;
piperidines		central nervous system depressant;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic;
peripheral nervous system drug
spiradoline[no description available]medium30
enadoline[no description available]medium10
benzofurans[no description available]medium10
mr 2034[no description available]medium10
medetomidine[no description available]medium10imidazoles
xylazine[no description available]medium101,3-thiazine;
methylbenzene;
secondary amino compound		alpha-adrenergic agonist;
analgesic;
emetic;
muscle relaxant;
sedative
clonidine[no description available]medium20clonidine;
imidazoline
idazoxan[no description available]medium20benzodioxine;
imidazolines		alpha-adrenergic antagonist
bicuculline[no description available]medium20benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
u 54494a[no description available]medium20
bw 373u86[no description available]medium10diarylmethane
pyrroles[no description available]medium10pyrrole;
secondary amine
tifluadom[no description available]medium10benzodiazepine
pd 117302[no description available]medium10
thiophenes[no description available]medium10mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
14-thioglycolamido-7,8-dihydromorphinone[no description available]medium10
flupenthixol[no description available]medium20thioxanthenes
capsaicin[no description available]medium30capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
clocinnamox[no description available]medium10
phencyclidine[no description available]medium10benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide[no description available]medium10diarylmethane
1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)[no description available]medium10
ici 204448[no description available]medium10monocarboxylic acid
prazosin[no description available]medium10aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
glutamic acid[no description available]medium10glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
levorphanol[no description available]medium20morphinane alkaloid
n,n-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine[no description available]medium10
corticosterone[no description available]medium3011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
motilin[no description available]medium10
bethanechol[no description available]medium10carbamate ester;
quaternary ammonium ion		muscarinic agonist
melatonin[no description available]medium10acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
methadone[no description available]medium10benzenes;
diarylmethane;
ketone;
tertiary amino compound
ketazocine[no description available]medium10
1-octanol[no description available]medium10octanol;
primary alcohol		antifungal agent;
bacterial metabolite;
fuel additive;
kairomone;
plant metabolite
ici 154129[no description available]medium20
pyro(l-alpha-aminoadipyl)-l-histidyl-l-thiazolidine-4-carboxamide[no description available]medium10
thiazolidines[no description available]medium10thiazolidine
mr 1452[no description available]medium10
naloxonazine[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low10
Absence Seizures0low10
Ache0low50
Acute Brain Injuries0low20
Addiction, Opioid0low10
Alcohol Drinking0low10
Allodynia0low20
Allodynia, Mechanical0low20
Allodynia, Tactile0low20
Allodynia, Thermal0low20
Anaphylactic Reaction0low10
Anaphylactoid Reaction0low10
Anaphylactoid Shock0low10
Anaphylaxis0low10
Anterior Choroidal Artery Infarction0low10
Atonic Absence Seizure0low10
Atonic Absence Seizures0low10
Atonic Seizure0low10
Atonic Seizures0low10
Brain Injuries0low20
Brain Injuries, Acute0low20
Brain Injuries, Focal0low20
Brain Ischemia0low20
Brain Lacerations0low20
Brain Vascular Disorders0low10
Cerebral Infarct0low10
Cerebral Infarction0low10
Cerebral Infarction, Left Hemisphere0low10
Cerebral Infarction, Right Hemisphere0low10
Cerebral Ischemia0low20
Cerebral, Left Hemisphere, Infarction0low10
Cerebral, Right Hemisphere, Infarction0low10
Cerebrovascular Diseases0low10
Cerebrovascular Disorders0low10
Cerebrovascular Insufficiency0low10
Cerebrovascular Occlusion0low10
Chemical Dependence0low30
Clonic Seizure0low10
Clonic Seizures0low10
Cocaine Abuse0low10
Cocaine Addiction0low10
Cocaine Dependence0low10
Cocaine-Related Disorders0low10
Complex Partial Seizure0low10
Complex Partial Seizures0low10
Convulsion0low10
Convulsion, Non-Epileptic0low10
Convulsions0low10
Convulsive Seizure0low10
Convulsive Seizures0low10
Coronary Disease0low10
Coronary Heart Disease0low10
Decerebrate Posturing0low30
Decerebrate State0low30
Decorticate Rigidity0low30
Decorticate State0low30
Dependence, Opioid0low10
Disease Models, Animal0low30
Drug Abuse0low30
Drug Addiction0low30
Drug Dependence0low30
Drug Habituation0low30
Drug Use Disorders0low30
Drug Withdrawal Symptoms0low10
Encephalopathy, Ischemic0low20
Endotoxin Shock0low10
Epileptic Seizure0low10
Epileptic Seizures0low10
Focal Brain Injuries0low20
Generalized Absence Seizure0low10
Generalized Absence Seizures0low10
Generalized Tonic-Clonic Seizures0low10
Hemorrhagic Shock0low10
Heroin Abuse0low10
Heroin Addiction0low10
Heroin Dependence0low10
Heroin Smoking0low10
Hyperalgesia0low20
Hyperalgesia, Mechanical0low20
Hyperalgesia, Primary0low20
Hyperalgesia, Secondary0low20
Hyperalgesia, Tactile0low20
Hyperalgesia, Thermal0low20
Hyperalgesic Sensations0low20
Hyperalgia0low20
Hyperalgia, Mechanical0low20
Hyperalgia, Primary0low20
Hyperalgia, Secondary0low20
Infarction, Cerebral0low10
Infarction, Cerebral, Left Hemisphere0low10
Infarction, Cerebral, Right Hemisphere0low10
Infarction, Left Hemisphere, Cerebral0low10
Infarction, Right Hemisphere, Cerebral0low10
Inflammation0low10
Injuries, Acute Brain0low20
Injuries, Brain0low20
Injuries, Spinal Cord0low30
Injury, Myocardial Reperfusion0low10
Innate Inflammatory Response0low10
Intracranial Vascular Disorders0low10
Ischemia0low10
Ischemia, Cerebral0low20
Ischemic Encephalopathy0low20
Jacksonian Seizure0low10
Left Hemisphere, Cerebral Infarction0low10
Left Hemisphere, Infarction, Cerebral0low10
Mechanical Allodynia0low20
Mechanical Hyperalgesia0low20
Muscle Contraction0low10
Muscle Relaxation0low30
Myelopathy, Traumatic0low30
Myocardial Ischemic Reperfusion Injury0low10
Myocardial Reperfusion Injury0low10
Myoclonic Seizure0low10
Myoclonic Seizures0low10
Non-Epileptic Seizure0low10
Non-Epileptic Seizures0low10
Nonepileptic Seizure0low10
Nonepileptic Seizures0low10
Obesity0low10
Opiate Abuse0low10
Opiate Addiction0low10
Opiate Dependence0low10
Opioid Abuse0low10
Opioid Addiction0low10
Opioid Dependence0low10
Opioid Misuse0low10
Opioid Use Disorder0low10
Opioid-Related Disorders0low10
Organic Mental Disorders, Substance-Induced0low30
Pain0low50
Pain, Burning0low50
Pain, Crushing0low50
Pain, Migratory0low50
Pain, Radiating0low50
Pain, Splitting0low50
Partial Seizure0low10
Partial Seizures0low10
Petit Mal Convulsion0low10
Post-Traumatic Myelopathy0low30
Posterior Choroidal Artery Infarction0low10
Prescription Drug Abuse0low30
Prescription Opioid Abuse0low10
Prescription Opioid Misuse0low10
Reperfusion Injury, Myocardial0low10
Respiration Disorders0low10
Right Hemisphere, Cerebral Infarction0low10
Right Hemisphere, Infarction, Cerebral0low10
Rigidity, Decerebrate0low30
Rigidity, Decorticate0low30
Seizure0low10
Seizures0low10
Seizures, Auditory0low10
Seizures, Clonic0low10
Seizures, Convulsive0low10
Seizures, Epileptic0low10
Seizures, Focal0low10
Seizures, Generalized0low10
Seizures, Gustatory0low10
Seizures, Motor0low10
Seizures, Olfactory0low10
Seizures, Sensory0low10
Seizures, Somatosensory0low10
Seizures, Tonic0low10
Seizures, Tonic-Clonic0low10
Seizures, Vertiginous0low10
Seizures, Vestibular0low10
Seizures, Visual0low10
Septic Shock0low10
Shock, Anaphylactic0low10
Shock, Endotoxic0low10
Shock, Hemorrhagic0low10
Shock, Septic0low10
Shock, Toxic0low10
Single Seizure0low10
Spinal Cord Contusion0low30
Spinal Cord Injuries0low30
Spinal Cord Laceration0low30
Spinal Cord Transection0low30
Spinal Cord Trauma0low30
Subcortical Infarction0low10
Substance Abuse0low30
Substance Addiction0low30
Substance Dependence0low30
Substance Use0low30
Substance Use Disorders0low30
Substance Withdrawal Syndrome0low10
Substance-Related Disorders0low30
Suffering, Physical0low50
Tactile Allodynia0low20
Thermal Allodynia0low20
Tonic Clonic Seizure0low10
Tonic Seizure0low10
Tonic Seizures0low10
Tonic-Clonic Seizure0low10
Tonic-Clonic Seizures0low10
Toxic Shock0low10
Toxic Shock Syndrome0low10
Vascular Diseases, Intracranial0low10
Withdrawal Symptoms0low10

Research Highlights

Long-term Use (1)

ArticleYear
Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists.
Bulletin of experimental biology and medicine, Volume: 145, Issue: 6		2008
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (4)

ArticleYear
The effects of heroin on prolactin levels in male rhesus monkeys: use of cumulative-dosing procedures.
Psychoneuroendocrinology, Volume: 27, Issue: 3		2002
Antinociceptive action of intracerebroventricularly administered dynorphin and other opioid peptides in the rat.
The Journal of pharmacology and experimental therapeutics, Volume: 246, Issue: 2		1988
Reinforcing effect of alfentanil is mediated by mu opioid receptors: apparent pA2 analysis.
The Journal of pharmacology and experimental therapeutics, Volume: 251, Issue: 2		1989
Effects of intracerebroventricular administration of opiate receptor antagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol-treated rats.
Life sciences, Volume: 49, Issue: 24		1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
The Journal of pharmacology and experimental therapeutics, Volume: 271, Issue: 3		1994
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]