Page last updated: 2024-10-21

5-dimethylamiloride and Pain

5-dimethylamiloride has been researched along with Pain in 3 studies

5-dimethylamiloride: has anti-HIV-1 activity

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

Excerpt	Relevance	Reference
"A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain."	3.75	Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3). ( Bilodeau, MT; Bock, MG; Cato, MJ; Chang, RK; Cook, SP; Di Marco, CN; Dipardo, RM; Hartman, GD; Jovanovska, A; Kane, SA; Kuduk, SD; Leitl, M; Spencer, RH; Urban, MO, 2009)

3 other studies available for 5-dimethylamiloride and Pain

Article	Year
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorganic & medicinal chemistry letters, 2009, May-01, Volume: 19, Issue:9 Topics: Acid Sensing Ion Channels; Acidosis; Amiloride; Amines; Animals; Chemistry, Pharmaceutical; Drug Des	2009
Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception. Neuroscience, 2009, Apr-21, Volume: 160, Issue:1 Topics: Amiloride; Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Female; G	2009
Role of the spinal Na+/H+ exchanger in formalin-induced nociception. Neuroscience letters, 2011, Aug-21, Volume: 501, Issue:1 Topics: Amiloride; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Guanid	2011