| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Congenital Zika Syndrome
[description not available] | 0 | 2.25 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 3.32 | 6 | 0 |
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME. | 0 | 2.25 | 1 | 0 |
Idiopathic Parkinson Disease
[description not available] | 0 | 2.41 | 1 | 0 |
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) | 0 | 2.41 | 1 | 0 |
Alloxan Diabetes
[description not available] | 0 | 3.66 | 8 | 0 |
Amnesia-Memory Loss
[description not available] | 0 | 2.55 | 2 | 0 |
Behavior Disorders
[description not available] | 0 | 2.21 | 1 | 0 |
Amnesia
Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7) | 0 | 2.55 | 2 | 0 |
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures. | 0 | 2.21 | 1 | 0 |
Mental Disorders
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function. | 0 | 2.21 | 1 | 0 |
Hyperglycemia, Postprandial
Abnormally high BLOOD GLUCOSE level after a meal. | 0 | 2.55 | 2 | 0 |
Prediabetes
[description not available] | 0 | 2.21 | 1 | 0 |
Hyperglycemia
Abnormally high BLOOD GLUCOSE level. | 0 | 2.55 | 2 | 0 |
Prediabetic State
The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 2.21 | 1 | 0 |
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) | 0 | 2.25 | 1 | 0 |
Amentia
[description not available] | 0 | 2.31 | 1 | 0 |
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. | 0 | 2.31 | 1 | 0 |
Nerve Pain
[description not available] | 0 | 2.31 | 1 | 0 |
Neuralgia
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve. | 0 | 2.31 | 1 | 0 |
Insulin Sensitivity
[description not available] | 0 | 2.21 | 1 | 0 |
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. | 0 | 2.21 | 1 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 2.08 | 1 | 0 |
Ache
[description not available] | 0 | 2.08 | 1 | 0 |
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. | 0 | 2.08 | 1 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 2.97 | 4 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 2.97 | 4 | 0 |
Anoxia-Ischemia, Brain
[description not available] | 0 | 2.13 | 1 | 0 |
Hypoxia-Ischemia, Brain
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions. | 0 | 2.13 | 1 | 0 |
Brain Disorders
[description not available] | 0 | 2.71 | 3 | 0 |
Acute Brain Injuries
[description not available] | 0 | 2.72 | 3 | 0 |
Cognition Disorders
Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment. | 0 | 5.25 | 6 | 2 |
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. | 0 | 2.71 | 3 | 0 |
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. | 0 | 2.72 | 3 | 0 |
Acute Post-Traumatic Stress Disorder
[description not available] | 0 | 3.43 | 1 | 1 |
Stress Disorders, Post-Traumatic
A class of traumatic stress disorders with symptoms that last more than one month. | 0 | 3.43 | 1 | 1 |
Age-Related Memory Disorders
[description not available] | 0 | 2.93 | 4 | 0 |
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. | 0 | 2.93 | 4 | 0 |
Bodily Distress Disorder
[description not available] | 0 | 2.04 | 1 | 0 |
Anoxemia
[description not available] | 0 | 2.05 | 1 | 0 |
Cerebral Ischemia
[description not available] | 0 | 2.71 | 3 | 0 |
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms. | 0 | 2.05 | 1 | 0 |
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. | 0 | 2.71 | 3 | 0 |
Pulmonary Consumption
[description not available] | 0 | 2.05 | 1 | 0 |
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS. | 0 | 2.46 | 2 | 0 |
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung. | 0 | 2.05 | 1 | 0 |
Acute Onset Vascular Dementia
[description not available] | 0 | 2.05 | 1 | 0 |
Dementia, Vascular
An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44) | 0 | 2.05 | 1 | 0 |
Brain Vascular Disorders
[description not available] | 0 | 2.05 | 1 | 0 |
Blood Pressure, High
[description not available] | 0 | 2.05 | 1 | 0 |
Blood Pressure, Low
[description not available] | 0 | 2.05 | 1 | 0 |
Cerebrovascular Disorders
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others. | 0 | 2.05 | 1 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 2.05 | 1 | 0 |
Hypotension
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients. | 0 | 2.05 | 1 | 0 |
Craniocerebral Injuries
[description not available] | 0 | 2.06 | 1 | 0 |
Craniocerebral Trauma
Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage. | 0 | 2.06 | 1 | 0 |
Apoplexy
[description not available] | 0 | 3.45 | 1 | 1 |
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) | 0 | 3.45 | 1 | 1 |
Innate Inflammatory Response
[description not available] | 0 | 2.07 | 1 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 2.07 | 1 | 0 |
Brain Thrombosis
[description not available] | 0 | 2.42 | 2 | 0 |
47,XX,+21
[description not available] | 0 | 2.01 | 1 | 0 |
Down Syndrome
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213) | 0 | 2.01 | 1 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 2.01 | 1 | 0 |
Depression, Endogenous
[description not available] | 0 | 2.03 | 1 | 0 |
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. | 0 | 2.03 | 1 | 0 |
Delayed Hypersensitivity
[description not available] | 0 | 2.03 | 1 | 0 |
Academic Disorder, Developmental
[description not available] | 0 | 1.99 | 1 | 0 |
Learning Disabilities
Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA. | 0 | 1.99 | 1 | 0 |
Brain Emboli
[description not available] | 0 | 2 | 1 | 0 |