| Assay ID | Title | Year | Journal | Article |
|---|
| AID1629756 | Agonist activity at mouse mu opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1610024 | Inhibition of delta opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1610026 | Inhibition of kappa opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1610021 | Inhibition of mu opioid receptor (unknown origin) in presence of DAMGO by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629789 | Antinociceptive activity in MOR-1 7TM/E1 splice variant knock out sc dosed C57BL/6 mouse assessed as increase in reaction time by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID222753 | activity evaluated by its ability to inhibit the electrically induced twitch contraction in guinea pig ileum, which is reversed by naloxone (300 nM) (P < 0.001) | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID149837 | Relative affinity evaluated for Opioid receptor kappa 1 | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629767 | Antinociceptive activity in sc dosed CD-1 mouse assessed as increase in reaction time measured 15 mins post dose by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629774 | Antinociceptive activity in CD-1 mouse assessed as time required for peak effect at 1.5 mg/kg, sc by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629770 | Antinociceptive activity in po dosed CD-1 mouse assessed as increase in reaction time administered through gavage measured 15 mins post dose by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID149845 | Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor kappa 1 using [3H]- U-69,593 as radioligand | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629811 | Toxicity in C57BL/6 mouse assessed as decrease in respiratory rate at 3 mg/kg, sc measured at 15 to 35 mins post dose relative to control | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629752 | Antagonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of DPDPE-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629766 | Inhibition of DAMGO-induced beta-arrestin-2 recruitment at mu opioid receptor-1 (unknown origin) expressed in CHO cells preincubated for 30 mins followed by DAMGO addition measured after 90 mins by beta-galactosidase complementation assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629776 | Antinociceptive activity in 129Sv6 mouse assessed as increase in reaction time at 0.1 to 10 mg/kg, sc measured 15 mins post dose by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629800 | Toxicity in CD-1 mouse assessed as physical dependence by measuring number of jumps at 1.5 mg/kg, sc bid for 5 days followed by opioid antagonist naloxone injection on day 5 measured for 15 mins post last dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID222419 | Relative inhibitory activity expressed as the percentage of the maximum inhibition by the compound against that of morphine | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629793 | Antinociceptive activity in sc dosed CD-1 mouse assessed as increase in reaction time administered twice daily at dosing intervals of 12 hrs for 5 days by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629810 | Toxicity in C57BL/6 mouse assessed as decrease in respiratory rate at 1.2 mg/kg, sc measured at 15 to 35 mins post dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629790 | Antinociceptive activity in sc dosed C57BL/6 mouse assessed as increase in reaction time by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1610023 | Inhibition of mu opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629763 | Displacement of [3H]rauwolscine from recombinant human adrenergic alpha2A receptor expressed in MDCK cell membrane after 90 mins by microbeta scintillation counting method | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629798 | Antinociceptive activity in sc dosed CD-1 mouse assessed as increase in AUC of reaction time administered twice daily at dosing intervals of 12 hrs for 29 days by radiant heat tail flick assay relative to morphine | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1610030 | Inhibition of kappa opioid receptor (unknown origin) in presence of DAMGO by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629797 | Ratio of ED50 for sc dosed CD-1 mouse administered twice daily at dosing intervals of 12 hrs for 29 days to ED50 for sc dosed CD-1 mouse measured 15 mins post dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629768 | Potency index, ratio of morphine ED50 to compound ED50 in sc dosed CD-1 mouse | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629796 | Ratio of ED50 for sc dosed CD-1 mouse administered twice daily at dosing intervals of 12 hrs for 5 days to ED50 for sc dosed CD-1 mouse measured 15 mins post dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629779 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc measured 15 mins post dose in presence of opioid antagonist naloxone by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629761 | Antinociceptive activity in MOR-1 6TM/E11 splice variant knock out sc dosed C57BL/6 mouse assessed as increase in reaction time by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629806 | Toxicity in CD-1 mouse assessed as inhibition of gastrointestinal transit by measuring distance traveled by charcoal at 4 mg/kg, sc followed by charcoal meal administration measured after 30 mins | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID222285 | % maximum inhibition is elicited when the response reaches plateau, calculated regarding electrically induced contraction in guinea pig ileum as 100% | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629759 | Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629780 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc measured 15 mins post dose in presence of delta opioid receptor antagonist NTI by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1610022 | Inhibition of delta opioid receptor (unknown origin) in presence of DAMGO by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1610029 | Inhibition of delta opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629762 | Displacement of [3H]LSD from recombinant human 5HT7A receptor expressed in HEK cell membrane after 90 mins by microbeta scintillation counting method | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629775 | Potency index, ratio of morphine ED50 to compound ED50 in icv dosed CD-1 mouse | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629799 | Antinociceptive activity in sc dosed CD-1 mouse assessed as increase in reaction time administered four times per day for 5 days by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID754475 | Binding affinity to delta opioid receptor (unknown origin) | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Orally active opioid compounds from a non-poppy source. |
| AID1629782 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc measured 15 mins post dose in presence of adrenergic alpha2 receptor antagonist yohimbine by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629814 | Toxicity in C57BL/6 mouse assessed as conditioned place preference at 1.3 to 3.2 mg/kg/day, ip measured for 30 mins post dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629801 | Toxicity in CD-1 mouse assessed as physical dependence by measuring number of jumps at 1.5 mg/kg, sc bid for 22 days followed by opioid antagonist naloxone injection on day 22 measured for 15 mins post last dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629783 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc administered on day 6 after MOR1-exon1 antisense oligodeoxynucleotide injection on day 1, 3 and 5 by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629778 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc measured 15 mins post dose in presence of mu opioid receptor antagonist beta-FNA by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629769 | Antinociceptive activity in icv dosed CD-1 mouse assessed as increase in reaction time measured 15 mins post dose by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629792 | Toxicity in CD-1 mouse assessed as time for drug tolerance at 1.5 mg/kg, sc bid at dosing intervals of 12 hrs | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1610028 | Inhibition of mu opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629765 | Activation of mu opioid receptor-1 (unknown origin) expressed in CHO cells assessed as beta-arrestin-2 recruitment at 10 uM after 90 mins by beta-galactosidase complementation assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629794 | Antinociceptive activity in sc dosed CD-1 mouse assessed as increase in reaction time administered twice daily at dosing intervals of 12 hrs for 29 days by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629786 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc administered on day 6 after KOR1-exon2 antisense oligodeoxynucleotide injection on day 1, 3 and 5 by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629781 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc measured 15 mins post dose in presence of kappa opioid receptor antagonist norBNI by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID148190 | Relative affinity evaluated for Opioid receptor mu 1 | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629753 | Displacement of [125I]-IBNtxA from mouse mu opioid receptor-1 expressed in CHO cell membranes incubated for 90 mins | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID754477 | Binding affinity to kappa opioid receptor (unknown origin) | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Orally active opioid compounds from a non-poppy source. |
| AID1610025 | Inhibition of kappa opioid receptor (unknown origin) in presence of DAMGO by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629772 | Antinociceptive activity in sc dosed CD-1 mouse assessed as increase in latency latency to respond with hind paw lick or shake/flutter measured 15 mins post dose by hot plate test | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1610031 | Inhibition of kappa opioid receptor (unknown origin) in presence of DPDPE by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID754478 | Binding affinity to mu opioid receptor (unknown origin) | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12
| Orally active opioid compounds from a non-poppy source. |
| AID1629757 | Agonist activity at mouse mu opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis relative to DAMGO | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID150051 | Relative affinity evaluated for Opioid receptor delta 1 | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID148204 | Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor mu 1 using [3H]- DAMGO as radioligand | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629815 | Toxicity in C57BL/6 mouse assessed as conditioned place aversion at 1.3 to 3.2 mg/kg/day, ip measured for 30 mins post dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629754 | Displacement of [125I]-IBNtxA from mouse kappa opioid receptor-1 expressed in CHO cell membranes incubated for 90 mins | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID222586 | Relative potency expressed as the percentage of the pD2 value against that of morphine | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1629777 | Antinociceptive activity in C57BL/6 mouse assessed as increase in reaction time at 0.1 to 10 mg/kg, sc measured 15 mins post dose by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629804 | Toxicity in CD-1 mouse assessed as inhibition of gastrointestinal transit by measuring distance traveled by charcoal at 1.5 mg/kg, sc followed by charcoal meal administration measured after 30 mins | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629755 | Displacement of [125I]-IBNtxA from mouse delta opioid receptor-1 expressed in CHO cell membranes incubated for 90 mins | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629802 | Toxicity in CD-1 mouse assessed as physical dependence by measuring number of jumps at 1.5 mg/kg, sc bid for 29 days followed by opioid antagonist naloxone injection on day 29 measured for 15 mins post last dose | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID150056 | Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor delta 1 using [3H]DPDPE as radioligand | 2002 | Journal of medicinal chemistry, Apr-25, Volume: 45, Issue:9
| Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
| AID1610027 | Inhibition of delta opioid receptor (unknown origin) in presence of DAMGO by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1629764 | Displacement of [3H]rauwolscine from recombinant human adrenergic alpha2C receptor expressed in MDCK cell membrane after 90 mins by microbeta scintillation counting method | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| AID1629785 | Antinociceptive activity in CD-1 mouse assessed as increase in reaction time at 1.5 mg/kg, sc administered on day 6 after DOR1-exon3 antisense oligodeoxynucleotide injection on day 1, 3 and 5 by radiant heat tail flick assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |