Proteins > Corticosteroid 11-beta-dehydrogenase isozyme 2
Page last updated: 2024-08-07 13:22:08
Corticosteroid 11-beta-dehydrogenase isozyme 2
An 11-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of mouse. [OMA:P51661, PRO:DNx]
Synonyms
EC 1.1.1.-;
11-beta-hydroxysteroid dehydrogenase type 2;
11-DH2;
11-beta-HSD2;
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| carbenoxolone | Mus musculus (house mouse) | EC50 | 0.0820 | 1 | 1 |
Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 22, Issue:8, 2012
Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11β-hydroxysteroid dehydrogenases.Journal of natural products, , Apr-27, Volume: 75, Issue:4, 2012
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Medicinal chemistry of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008