Page last updated: 2024-12-08

pectolinarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pectolinarin: antihemorrhagic principle from Chinese plant Cirsium japonicum DC. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

pectolinarin : A disaccharide derivative that consists of pectolinarigenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
CirsiumgenusA plant genus of the family ASTERACEAE. Members contain pectolinarin (a flavonoid glycoside).[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Cirsium japonicumspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID168849
CHEMBL ID445978
CHEBI ID156327
SCHEMBL ID14916947
MeSH IDM0149731

Synonyms (30)

Synonym
bdbm50046953
pectolinarin
pectolinarigenin-7-o-rutinoside
28978-02-1
5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside
CHEBI:156327 ,
5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4h-chromen-7-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside
CHEMBL445978
5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
unii-by44l9o1rr
7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one
by44l9o1rr ,
4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-
S9054
SCHEMBL14916947
pectolinaroside
AKOS030489916
pectolinarin [inci]
4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-
7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one
HY-N0314
Q15425291
4h-1-benzopyran-4-one, 7-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-
STL564430
CCG-270258
CS-0008812
DTXSID70951590
5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(6-deoxyhexopyranosyl)hexopyranoside
AS-78048
4h-1-benzopyran-4-one, 7-[[6-o-(6-deoxy-a-l-mannopyranosyl)-ss-d-glucopyranosyl]oxy]-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (6)

RoleDescription
apoptosis inducerAny substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
anti-inflammatory agentAny compound that has anti-inflammatory effects.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitorAn EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
antioxidantA substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
dimethoxyflavoneAny methoxyflavone with two methoxy substituents.
rutinoside
glycosyloxyflavoneA member of the class of flavones having one or more glycosyl residues attached at unspecified positions.
disaccharide derivativeA carbohydrate derivative that is formally obtained from a disaccharide.
monohydroxyflavanoneAny hydroxyflavanone carrying a single hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC50 (µMol)38.00000.00022.45859.9600AID1845461
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Peroxisome proliferator-activated receptor gammaMus musculus (house mouse)EC50 (µMol)100.00000.00031.654210.0000AID1180479
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
3'-5'-RNA exonuclease activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoestersReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
protein guanylyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
double membrane vesicle viral factory outer membraneReplicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2
nucleoplasmPeroxisome proliferator-activated receptor gammaMus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID255957In vitro inhibitory concentration against human colorectal adenocarcinoma Caco-2 cells in the presence of vinblastine sulfate salt2005Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
AID1180479Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.
AID1180480Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector assessed as fold activation after 24 hrs by dual-luciferase reporter assay2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.
AID388892Antiproliferative activity against human ACHN cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID338974Inhibition of cow milk xanthine oxidase at 50 ug/mL
AID255956In vitro inhibitory concentration against human hepatocellular carcinoma HepG-2 cells in the presence of vinblastine sulfate salt2005Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
AID255916In vitro inhibitory concentration against renal adenocarcinoma cell line (ACHN) in the presence of taxol2005Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
AID1717777Inhibition of SARS-CoV 3C-like protease expressed in Escherichia coli BL21 (DE3) using ABCYL-KTSAVLQSGFRKME-EDANS as substrate preincubated for 1 hr followed by substrate addition and measured after 16 hrs by FRET assay2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
AID388888Antiproliferative activity against human 142BR cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID388896Partition coefficient, log P of the compound2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID255940In vitro inhibitory concentration against human carcinoma COR-L23 cells in the presence of vinblastine sulfate salt2005Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
AID1845461Inhibition of SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using DABCYLKTSAVLQSGFRKME-EDANS as substrate preincubated for 1 hr followed by substrate addition and measured after 16 hrs by FRET assay2021Journal of natural products, 01-22, Volume: 84, Issue:1
Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2.
AID388891Antiproliferative activity against human COR-L23 cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID255944In vitro inhibitory concentration against human fetal lung MRC-5 cell line in the presence of vinblastine sulfate salt2005Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
AID388894Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID255955In vitro inhibitory concentration against human amelanotic melanoma cell line (C32) in the presence of vinblastine sulfate salt2005Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf.
AID388895Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID388890Antiproliferative activity against human Caco-2 cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID388889Antiproliferative activity against human Huh-7D12 cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID388893Antiproliferative activity against human C32 cells after 48 hrs by sulforhodamine B assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (8.33)18.7374
1990's1 (4.17)18.2507
2000's5 (20.83)29.6817
2010's9 (37.50)24.3611
2020's7 (29.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.29 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index5.25 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (11.54%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (88.46%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]