Compounds > 2-hydroxypropyl methacrylate
Page last updated: 2024-11-05

2-hydroxypropyl methacrylate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Hydroxypropyl methacrylate (HPMA) is a monomer used in the synthesis of various polymers, including hydrogels, biomaterials, and drug delivery systems. It is known for its biocompatibility and ability to form hydrophilic polymers. HPMA can be synthesized through a variety of methods, such as esterification of methacrylic acid with 2-hydroxypropyl alcohol. The resulting polymer exhibits interesting properties, such as tunable biodegradability and controlled release of incorporated drugs or other bioactive molecules. HPMA polymers are studied for their potential applications in tissue engineering, drug delivery, and bioimaging. They are also investigated for their ability to modify the surface properties of materials, improving their biocompatibility and promoting cell adhesion.'

2-hydroxypropyl methacrylate : An enoate ester that is the 1-methacryloyl derivative of propane-1,2-diol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID13539
CHEMBL ID1873783
CHEBI ID53440
SCHEMBL ID19017
MeSH IDM0094420

Synonyms (62)

Synonym
unii-v9b8s034aw
v9b8s034aw ,
2-hydroxypropyl methacrylate
beta-hydroxypropyl methacrylate
brn 1752228
acryester hp
methacrylic acid, 2-hydroxypropyl ester
2-hydroxypropylmethacrylate
einecs 213-090-3
2-hydroxypropyl 2-methyl-2-propenoate
propylene glycol monomethacrylate
25703-79-1
NCGC00090806-01
923-26-2
2-propenoic acid, 2-methyl-, 2-hydroxypropyl ester
2-hydroxypropyl 2-methylacrylate
CHEBI:53440 ,
methacrylic acid 2-hydroxypropyl ester
2-hydroxypropyl 2-methylprop-2-enoate
FT-0694519
M0512
2-hpma
2-hydroxy-3-propyl methacrylate
hpma
2hpma
2-hydroxy-n-propyl methacrylate
NCGC00090806-02
NCGC00090806-03
NCGC00260080-01
dsstox_gsid_25934
dtxsid1029629 ,
dtxcid805934
tox21_201232
dsstox_gsid_27936
cas-27813-02-1
dsstox_rid_77971
cas-25703-79-1
NCGC00258784-01
tox21_200694
dsstox_cid_5934
dsstox_rid_78619
cas-923-26-2
NCGC00258248-01
tox21_202531
EPITOPE ID:131322
AKOS015899917
SCHEMBL19017
.beta.-hydroxypropyl methacrylate
hydroxypropyl methacrylate [inci]
blemmer p
2-hydroxypropyl 2-methylacrylate #
1,2-propanediol, 1-methacrylate
W-100292
CHEMBL1873783
AS-59279
2-hydroxyproyl methacrylate
Q27124054
D93082
2-propenoic acid,2-methyl-,2-hydroxypropyl ester
CBA81302
CS-W011008
hydroxypropyl methacrylate, mixture of isomers
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
polymerisation monomerAny compound used as a monomer for a polymerisation process. The term is generally used in relation to industrial polymerisation processes.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
enoate esterAn alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency29.30170.000221.22318,912.5098AID1259247; AID588515; AID743042
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency3.90810.003041.611522,387.1992AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency6.81090.001530.607315,848.9004AID1259401
pregnane X nuclear receptorHomo sapiens (human)Potency69.49740.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency0.01860.000229.305416,493.5996AID743075
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency45.74370.001024.504861.6448AID588534; AID743212; AID743227
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency52.29550.023723.228263.5986AID743222; AID743241
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.003119.739145.978464.9432AID1159509
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency13.86660.000323.4451159.6830AID743065
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (20.00)18.7374
1990's0 (0.00)18.2507
2000's5 (25.00)29.6817
2010's11 (55.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 44.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index44.46 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index64.08 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (44.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies4 (20.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		1.9610beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
penicillanic acid
Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration.		1.9610penicillanic acids
ethylene dimethacrylate
ethylene glycol dimethacrylate : The enoate ester that is the 1,2-bis(methacryloyl) derivative of ethylene glycol.		2.5520enoate esterallergen;
cross-linking reagent;
polymerisation monomer
glycidyl methacrylate
glycidyl methacrylate: RN given refers to monomer. glycidyl methacrylate : An enoate ester obtained by formal condensation of the carboxy group of methacrylic acid with the hydroxy group of glycidol.		2.0610enoate ester;
epoxide
tert-butylacrylamide
tert-butylacrylamide: structure in first source		2.0510
triethylene glycol dimethacrylate
[no description available]		1.9610
glycol monoacetate
[no description available]		2.0210
aminopenicillanic acid
aminopenicillanic acid: RN given refers to parent cpd; structure. 6-aminopenicillanic acid : A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics.		1.9610amino acid zwitterion;
penicillanic acids		allergen
2-hydroxyethyl acrylate
[no description available]		2.1310
hydroxyethyl methacrylate
hydroxyethyl methacrylate: many of cited refs are for gel which refers to polymeric form of above cpd: POLYHYDROXYETHYL METHACRYLATE. 2-hydroxyethyl methacrylate : An enoate ester that is the monomethacryloyl derivative of ethylene glycol.		340enoate esterallergen;
polymerisation monomer
bisphenol a-glycidyl methacrylate
Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.		1.9610diarylmethane
2-(dimethylamino)ethyl methacrylate
2-(dimethylamino)ethyl methacrylate: reducing agent; structure given in first source		2.1510
daunorubicin
Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.		1.9610aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
n-(2-hydroxypropyl)methacrylamide
Duxon: RN given refers to unlabeled cpd		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Contact Dermatitis
[description not available]		08.1650
Dermatitis, Occupational
A recurrent contact dermatitis caused by substances found in the work place.		03.1250
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		03.1650
Hepatocellular Carcinoma
[description not available]		02.110
Cancer of Liver
[description not available]		02.110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.110
Arteriovenous Malformations
Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.		02.0510
Ache
[description not available]		02.0110
Hand Dermatosis
[description not available]		02.3920
Hand Dermatoses
Skin diseases involving the HANDS.		02.3920
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0110
Adjuvant Arthritis
[description not available]		02.0210
Contact Dermatitis
[description not available]		01.9610
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		01.9610