n-methylaspartate has been researched along with Pain in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.25) | 18.7374 |
| 1990's | 55 (35.71) | 18.2507 |
| 2000's | 68 (44.16) | 29.6817 |
| 2010's | 20 (12.99) | 24.3611 |
| 2020's | 6 (3.90) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, D; Lou, W; Mao, X | 1 |
| Guo, X; Hao, N; Li, HF; Li, JG; Ma, Y; Qin, GH; Shi, Y; Zhang, C; Zhang, Y; Zhao, X | 1 |
| Chen, M; Chen, R; Li, X; Ling, R; Min, C; Xia, D | 1 |
| McNearney, TA; Westlund, KN | 1 |
| da Cunha, JM; Godoi, MM; Junior, HZ; Zanoveli, JM | 1 |
| Gao, YJ; Li, ZZ; Luo, C; Ma, SB; Shen, SN; Wu, SX; Xian, H; Xie, RG; Xing, JL; Zhang, H | 1 |
| Beitz, AJ; Kaang, BK; Kim, YH; Ko, HG; Kwon, SG; Lee, JH; Oh, SB; Roh, DH; Yeo, JH; Yoon, SY | 1 |
| Chung, W; Hong, J; Hsu, TM; Kim, DW; Kim, JJ; Ko, Y; Lee, SY; Lee, W; Lim, K; Nan, Y; Shin, N; Xu, Y; Yin, Y; Zhang, E | 1 |
| Coimbra, NC; da Silva Soares, R; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL | 1 |
| Fabris, D; Genaro, K; Prado, WA | 1 |
| Mizoguchi, H; Sakurada, S; Sakurada, T; Sato, T; Takagi, H; Watanabe, C; Yonezawa, A | 1 |
| Borszcz, GS; Spuz, CA; Tomaszycki, ML | 1 |
| Ghasemzadeh, Z; Ghazvini, H; Rezayof, A; Zarrindast, MR | 1 |
| Endo, Y; Nemoto, W; Shima, K; Sugawara, S; Takano-Yamamoto, T; Tan-No, K; Tsuchiya, M | 1 |
| Genaro, K; Prado, WA | 1 |
| Bujalska-Zadrożny, M; Kieć-Kononowicz, K; Leśniak, A; Sacharczuk, M; Wolińska, R; Żochowska, M | 1 |
| Chambers, JP; Johnson, CB; Lizarraga, I | 1 |
| Mendes-Gomes, J; Nunes-de-Souza, RL | 1 |
| Chiu, HY; Lai, CC; Lin, HH | 1 |
| Gordh, T; Miclescu, A | 1 |
| McNulty, JP | 1 |
| Autié, A; Braha, S; Januel, D; Montreuil, M; Moulier, V; Wojakiewicz, A | 1 |
| Cairns, BE; Dong, XD; Svensson, P | 1 |
| Mokha, SS; Nag, S | 2 |
| Beitz, AJ; Han, HJ; Lee, JH; Roh, DH; Seo, HS; Song, S; Yoon, SY | 1 |
| Beitz, AJ; Kang, SY; Lee, JH; Moon, JY; Roh, DH; Seo, HS; Song, S; Yoon, SY | 1 |
| Akcali, D; Bolay, H; Sara, Y; Sayin, A | 1 |
| Amaral, VC; Mendes-Gomes, J; Nunes-de-Souza, RL | 1 |
| Berrocoso, E; Garzón, J; Rodríguez-Muñoz, M; Sánchez-Blázquez, P; Vicente-Sánchez, A | 1 |
| Chung, JM; Chung, K; Cui, L; Kim, HY; Kim, SJ; Lee, KY; Lu, Y; Wang, J | 1 |
| Cao, H; Ren, WH; Zhang, YQ; Zhao, ZQ; Zhu, MY | 1 |
| Plunkett, AR; Turabi, A | 1 |
| Gong, N; Hashimoto, K; Ma, AN; Wang, HL; Wang, YC; Wang, YX | 1 |
| Xiao, X; Zhang, XM; Zhang, Y; Zhang, YQ; Zhao, ZQ | 1 |
| Clark, JD; Li, X | 1 |
| Baker, AK; Hoffmann, VL; Meert, TF | 1 |
| Coppini, DV; Potter, J; Spruce, MC | 1 |
| Calo, G; Inoue, A; Inoue, M; Kawashima, T; Nakata, Y; Takeshima, H; Ueda, H | 1 |
| Kuno, Y; Sato, E; Sato, I; Takano, M; Takano, Y | 1 |
| Bogulavsky, J; Drake, CT; Gage, FH; Hegarty, D; Heinemann, SF; Horner, P; Inturrisi, CE; Jenab, S; Kaspar, BK; Kohno, T; Malkmus, S; Masuyama, T; Ohata, M; Sailer, AW; South, SM; Vissel, B; Woolf, CJ; Yaksh, TL | 1 |
| Arendt-Nielsen, L; Sumikura, H | 1 |
| Chen, JG; Guan, BC; Li, ZW; Liu, CJ; Wu, ZZ; Yang, Q | 1 |
| Ennes, HS; Li, J; Mayer, EA; McRoberts, JA; Nie, J | 1 |
| Baba, A; Hashimoto, H; Ito, S; Mabuchi, T; Matsumura, S; Minami, T; Muratani, T; Okuda-Ashitaka, E; Shintani, N | 1 |
| Davis, AM; Inturrisi, CE; Monaghan, DT; Shimoyama, M; Shimoyama, N | 1 |
| Adriaensen, HF; Heylen, RJ; Hoffmann, VL; Meert, TF; Vissers, KC | 1 |
| Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ | 1 |
| An, TH; Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH | 1 |
| Zhang, L; Zhang, Y; Zhao, ZQ | 1 |
| Cahill, CM; Henry, JL; Ménard, HA; Ribeiro-da-Silva, A; Sharif Naeini, R | 1 |
| Cao, H; Guo, JD; Ji, RR; Ren, WH; Sha, H; Wang, H; Wang, PF; Zhang, YQ; Zhao, ZQ | 1 |
| Miguel, TT; Nunes-de-Souza, RL | 1 |
| Chizh, BA; Christoph, T; Englberger, W; Parsons, CG; Schiene, K | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Barrett, AC; Lomas, LM; Lysle, DT; Picker, MJ; Terner, JM | 1 |
| Chai, SC; Wang, CC; Wang, HC; Wu, YS | 1 |
| Komatsu, T; Kuwahata, H; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M; Watanabe, C | 1 |
| Cheevers, CV; Donello, JE; Gil, DW | 1 |
| Ando, K; Fujita, I; Hattori, K; Hirota, M; Hizue, M; Kawai, M; Kawamura, M; Matsumoto, Y; Mizutani, M; Nakamura, H; Ohta, A; Sakurada, I; Sudo, M; Takashima, T; Watanabe, S | 1 |
| Coluzzi, F; Mattia, C | 1 |
| Furuta, K; Ito, S; Mabuchi, T; Maeda, M; Minami, T; Soen, M; Suzuki, M; Tatsumi, S | 1 |
| Gracias, NG; Gu, G; Hua, XY; Nazarian, A; Vasko, MR; Wilkinson, K; Yaksh, TL | 1 |
| Chen, T; Hong, Y; Hu, Z; Quirion, R | 1 |
| Angelotti, T; Mokha, SS; Nag, S; Thompson, AD | 1 |
| Colvin, L; Fallon, M | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kim, KW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Azdad, K; d'Exaerde, Ade K; Dumont, H; Gall, D; Guntz, E; Pastijn, E; Schiffmann, SN; Sosnowski, M | 1 |
| de Vente, J; Garthwaite, J; Gittins, SR; Morris, R; Southam, E | 1 |
| Lücke, T; Neugebauer, V; Schaible, HG | 1 |
| Fukui, S; Hasegawa, T; Iyo, M; Maeda, Y; Nabeshima, T; Yamada, K | 1 |
| Cumberbatch, MJ; Headley, PM; Herrero, JF | 1 |
| Arendt-Nielsen, L; Bak, P; Bjerring, P; Fischer, M; Petersen-Felix, S; Zbinden, AM | 1 |
| Sagen, J; Siegan, JB | 1 |
| Alhaider, AA; Wilcox, GL | 1 |
| Dykstra, CL; Gebhart, GF; Meller, ST | 1 |
| Gebhart, GF; Kolhekar, R; Meller, ST | 1 |
| Gebhart, GF; Kolhekar, R | 1 |
| Murray, M; Nag, S; Riopelle, RJ; Zochodne, DW | 1 |
| Berge, OG; Karlsson, U; Näsström, J | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Dykstra, C; Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS | 1 |
| Yaksh, TL; Yamamoto, T | 3 |
| Dickenson, AH | 2 |
| Manning, BH; Mayer, DJ | 1 |
| Bonasera, L; Carlton, SM; Zhou, S | 1 |
| Ishikawa, T; Yaksh, TL | 1 |
| Hole, K; Kjørsvik, A; Størkson, RV; Tjølsen, A | 1 |
| Hayaishi, O; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E | 1 |
| Cashman, JN | 1 |
| Arendt-Nielsen, L; Nielsen, J; Petersen-Felix, S; Schnider, TW; Zbinden, AM | 1 |
| Bach, FW | 1 |
| Hole, K; Kjørsvik, A; Størkson, R; Tjølsen, A | 1 |
| Basbaum, AI; Liu, H; Mantyh, PW | 1 |
| Eisenach, J | 1 |
| Baamonde, A; Hidalgo, A; Menéndez, L | 1 |
| Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL | 1 |
| Budai, D; Fields, HL | 1 |
| Fallon, MT; O'Neill, B | 1 |
| Ellershaw, JE; Makin, MK | 1 |
| Nishiyama, T; Weber, E; Yaksh, TL | 1 |
| Farrer, K; Oxenham, D | 1 |
| Manning, BH | 1 |
| Alvarez-Vega, M; Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L | 1 |
| Kitto, KF; Laughlin, TM; Wilcox, GL | 1 |
| Song, XJ; Zhao, ZQ | 1 |
| Chen, J; Li, H; Li, Z; Luo, C; Zheng, J | 1 |
| Feuerstein, TJ; Fischer, W; Kiefer, G | 1 |
| Jensen, TS; Sindrup, SH | 1 |
| Haddad, E; Hassan, A; Johns, RA; Tao, YX | 1 |
| Davis, MA; Garry, MG; Malik, S; Yang, J; Yu, J | 1 |
| Asai, T; Ikeda, H; Murase, K | 1 |
| Johns, RA; Tao, YX | 1 |
| Pollard, M | 1 |
| Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD | 1 |
| Choi, MR; Chung, KM; Huh, SO; Kim, YH; Lee, KC; Song, DK; Suh, HW | 1 |
| Dubner, R; Guan, Y; Ren, K; Terayama, R | 1 |
| Giovengo, SL; Larson, AA; Michalek, JE; Russell, JI | 1 |
| Brewer, KL; Fairbanks, CA; Grocholski, BM; Kehl, LJ; Kitto, KF; Nguyen, HO; Regunathan, S; Reis, DJ; Schreiber, KL; Shoeman, DW; Stone, LS; Wilcox, GL; Yezierski, RP; Yu, CG | 1 |
| Chizh, BA; Englberger, W; Scheede, M; Schlütz, H | 1 |
| Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H | 1 |
| Chabot, JG; Coderre, TJ; Dray, A; Fundytus, ME; Henry, JL; Lefebvre, CD; Osborne, MG; Yashpal, K | 1 |
| Chung, JM; Gerber, G; Isaev, D; Park, SK; Randik, M | 1 |
| Imai, S; Kamei, J; Nagase, H; Narita, M; Suzuki, T; Tsuda, M; Yajima, Y | 1 |
| Ito, S; Matsumura, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Shimamoto, K | 1 |
| Alvarez-Vega, M; Baamonde, A; Hidalgo, A; Menéndez, L | 1 |
| Flores, CA; Mokha, SS; Wang, XM; Zhang, KM | 1 |
| Ben-Abraham, R; Weinbroum, AA | 1 |
| Luccarini, P; Sessle, BJ; Woda, A | 1 |
| Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Toriyabe, M | 1 |
| Ahmadi, S; Lippross, S; Neuhuber, WL; Zeilhofer, HU | 1 |
| Kaneko, H; Kawashima, T; Suzuki, SS; Takita, M; Yokoi, H | 1 |
| Gibb, AJ; Green, GM | 1 |
| Biella, GE; Sotgiu, ML | 1 |
| Berge, OG; Hole, K; Lund, A; Mjellem-Joly, N | 1 |
| Eide, PK; Lund, A; Mjellem, N; Størkson, R; Tjølsen, A | 1 |
| Jensen, TS; Yaksh, TL | 1 |
| Dykstra, C; Gebhart, GF; Meller, ST | 1 |
| Chapman, V; Dickenson, AH | 1 |
| Coderre, TJ; Melzack, R | 1 |
| Larson, AA; Skilling, SR; Smullin, DH | 1 |
| Cowan, A; Larson, AA; Murray, CW | 1 |
| Chai, CY; Kao, MC; Lee, HK; Wang, Y | 1 |
| Mitchell, D; Sher, GD | 1 |
| Urca, G; Urca, R | 1 |
| DeLander, GE; Wahl, JJ | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Jacquet, YF | 1 |
| Raigorodsky, G; Urca, G | 1 |
| Caudle, RM; Isaac, L | 1 |
12 review(s) available for n-methylaspartate and Pain
| Article | Year |
|---|---|
Pluripotential GluN1 (NMDA NR1): Functional Significance in Cellular Nuclei in Pain/Nociception.
Topics: Cell Nucleus; Excitatory Amino Acid Agonists; Humans; N-Methylaspartate; Nociception; Pain; Receptors, N-Methyl-D-Aspartate | 2023 |
Nitric oxide and pain: 'Something old, something new'.
Topics: Animals; Biopterins; Cyclic AMP; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nociceptors; omega-N-Methylarginine; Pain; Prostaglandin-Endoperoxide Synthases; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction | 2009 |
[Pain and schizophrenia: myth and reality].
Topics: Brain; Communication; Denial, Psychological; Emotions; Humans; Mythology; N-Methylaspartate; Pain; Pain Threshold; Reality Testing; Schizophrenia; Schizophrenic Psychology; Social Environment | 2009 |
The application of genomic and molecular data in the treatment of chronic cancer pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Autonomic Nerve Block; Catechol O-Methyltransferase; Chronic Disease; Genetic Therapy; Humans; N-Methylaspartate; Neoplasms; Pain; Pain Management; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Somatosensory Cortex; Translational Research, Biomedical | 2012 |
The pathogenesis and management of painful diabetic neuropathy: a review.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Antidepressive Agents; Blood Glucose; Capsaicin; Diabetic Foot; Diabetic Neuropathies; Humans; N-Methylaspartate; Pain; Selective Serotonin Reuptake Inhibitors; Transcutaneous Electric Nerve Stimulation | 2003 |
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Clinical Trials as Topic; Diabetic Neuropathies; Glycine; Humans; Indans; Monoamine Oxidase Inhibitors; N-Methylaspartate; Pain | 2007 |
Neurophysiology of opioid poorly responsive pain.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Clonidine; Dextromethorphan; Dextrorphan; Dynorphins; Humans; Morphine; N-Methylaspartate; Neoplasms; Neurophysiology; Neuroprotective Agents; Pain; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sympatholytics | 1994 |
The mechanisms of action of NSAIDs in analgesia.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase; Lipoxygenase Inhibitors; N-Methylaspartate; Pain; Prostaglandin-Endoperoxide Synthases; Rats | 1996 |
Beta-endorphin in the brain. A role in nociception.
Topics: Animals; beta-Endorphin; Brain; Capsaicin; Electric Stimulation; Excitatory Amino Acid Agonists; Humans; N-Methylaspartate; Pain | 1997 |
Update on spinal cord pharmacology in pain.
Topics: Acute Disease; Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell- and Tissue-Based Therapy; Cholinesterase Inhibitors; Chromaffin Cells; Chronic Disease; Delayed-Action Preparations; Humans; Muscarinic Agonists; N-Methylaspartate; Nerve Fibers; Neurotransmitter Agents; Nitric Oxide Synthase; Nociceptors; Norepinephrine; Pain; Rats; Receptors, Adrenergic, alpha; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Tachykinin; Spinal Cord | 1997 |
Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Carbamazepine; Diabetic Neuropathies; Humans; N-Methylaspartate; Narcotics; Neuralgia; Pain; Polyneuropathies; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors | 1999 |
Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Dexmedetomidine; Dextromethorphan; Humans; N-Methylaspartate; Pain; Pain, Postoperative; Premedication; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate | 2001 |
2 trial(s) available for n-methylaspartate and Pain
| Article | Year |
|---|---|
The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study.
Topics: Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Electromyography; Evoked Potentials; Humans; Ketamine; Lasers; N-Methylaspartate; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Placebos; Pressure; Receptors, N-Methyl-D-Aspartate; Reflex; Sural Nerve | 1995 |
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
Topics: Adult; Anesthetics, Dissociative; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Hot Temperature; Humans; Ketamine; N-Methylaspartate; Pain; Pain Threshold; Physical Stimulation; Pressure; Reaction Time; Skin Temperature; Stereoisomerism | 1996 |
140 other study(ies) available for n-methylaspartate and Pain
| Article | Year |
|---|---|
Music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on GRIK5.
Topics: Animals; Depression; Glutamic Acid; Hippocampus; Mice; Music; N-Methylaspartate; Pain; Pain Perception; Serotonin | 2022 |
Activation of δ-opioid Receptors in Anterior Cingulate Cortex Alleviates Affective Pain in Rats.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Freund's Adjuvant; Gyrus Cinguli; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 2022 |
Enriched environment rescues neonatal pain induced cognitive deficits and the impaired hippocampal synaptic plasticity later in life.
Topics: Animals; Cognition; Hippocampus; Humans; Infant, Newborn; Infant, Premature; N-Methylaspartate; Nerve Growth Factors; Neuronal Plasticity; Pain; Rats; Receptors, N-Methyl-D-Aspartate | 2022 |
Mu-opioid and CB1 cannabinoid receptors of the dorsal periaqueductal gray interplay in the regulation of fear response, but not antinociception.
Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; N-Methylaspartate; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Somatostatin | 2020 |
Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina II Neurons.
Topics: Animals; Chemokine CCL2; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Pain; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substantia Gelatinosa | 2020 |
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Flavonoids; Hyperalgesia; Imidazoles; MAP Kinase Signaling System; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Nociception; Pain; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Spinal Cord | 2017 |
High Omega-3 Polyunsaturated Fatty Acids in fat-1 Mice Reduce Inflammatory Pain.
Topics: Animals; Dietary Supplements; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Pain; Receptors, N-Methyl-D-Aspartate; Spinal Cord Dorsal Horn | 2017 |
5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal activation in the central nucleus of the inferior colliculus.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fear; Freezing Reaction, Cataleptic; Inferior Colliculi; Male; N-Methylaspartate; Neurons; Nociception; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Statistics, Nonparametric | 2019 |
The antinociceptive effect of anterior pretectal nucleus stimulation is mediated by distinct neurotransmitter mechanisms in descending pain pathways.
Topics: Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Male; Methysergide; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptors; Pain; Pain Management; Pain Measurement; Pedunculopontine Tegmental Nucleus; Pretectal Region; Rats; Rats, Wistar | 2019 |
Involvement of multiple µ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission.
Topics: Analgesics; Animals; Capsaicin; Male; Mice; N-Methylaspartate; Nociception; Oligopeptides; Pain; Presynaptic Terminals; Receptors, Opioid, mu; Somatostatin; Substance P; Synaptic Transmission | 2014 |
N-methyl-D-aspartate receptor agonism and antagonism within the amygdaloid central nucleus suppresses pain affect: differential contribution of the ventrolateral periaqueductal gray.
Topics: Animals; Central Amygdaloid Nucleus; Dose-Response Relationship, Drug; Electroshock; Male; N-Methylaspartate; Narcotic Antagonists; Pain; Pain Perception; Peptide Fragments; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Random Allocation; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Reflex; Somatostatin; Valine; Vocalization, Animal | 2014 |
μ-Opioid and N-methyl-D-aspartate receptors in the amygdala contribute to minocycline-induced potentiation of morphine analgesia in rats.
Topics: Amygdala; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Hot Temperature; Injections, Intraperitoneal; Male; Minocycline; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2015 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaicin; Clodronic Acid; Etidronic Acid; Excitatory Amino Acid Agonists; Foscarnet; Glutamic Acid; Lumbar Vertebrae; Mice; Mice, Inbred BALB C; N-Methylaspartate; Pain; Sodium-Phosphate Cotransporter Proteins; Spinal Cord; Substance P | 2016 |
Neural Correlates of the Antinociceptive Effects of Stimulating the Anterior Pretectal Nucleus in Rats.
Topics: Analgesics; Animals; Brain Mapping; Electric Stimulation; Excitatory Amino Acid Agonists; Functional Laterality; Male; Microinjections; N-Methylaspartate; Pain; Pain Management; Pulvinar; Rats; Rats, Wistar | 2016 |
Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain.
Topics: Acute Pain; Analgesics; Animals; Dizocilpine Maleate; Histamine Antagonists; Indoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4 | 2017 |
Prevention of N-methyl-D-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Injections, Spinal; Ketamine; Ketoprofen; N-Methylaspartate; Pain; Sheep; Xylans | 2008 |
Anxiolytic-like effects produced by bilateral lesion of the periaqueductal gray in mice: Influence of concurrent nociceptive stimulation.
Topics: Animals; Anxiety; Exploratory Behavior; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Periaqueductal Gray | 2009 |
Potentiation of spinal NMDA-mediated nociception by cocaine- and amphetamine-regulated transcript peptide via PKA and PKC signaling pathways in rats.
Topics: Animals; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; N-Methylaspartate; Nerve Tissue Proteins; Pain; Phosphorylation; Phosphoserine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spine | 2009 |
Chronic pain: levorphanol, methadone, and the N-methyl-D-aspartate receptor.
Topics: Analgesics, Opioid; Chronic Disease; Hospice Care; Humans; Levorphanol; Methadone; N-Methylaspartate; Narcotics; Pain; Palliative Care; Receptors, N-Methyl-D-Aspartate | 2009 |
The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Biophysics; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Injections, Intramuscular; Isoquinolines; Male; Musculoskeletal Diseases; N-Methylaspartate; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Time Factors | 2009 |
Testosterone is essential for alpha(2)-adrenoceptor-induced antinociception in the trigeminal region of the male rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Catheterization; Clonidine; Estradiol; Estrogens; Hormone Replacement Therapy; Hot Temperature; Male; N-Methylaspartate; Orchiectomy; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Testosterone; Testosterone Propionate; Time Factors; Trigeminal Nuclei; Yohimbine | 2009 |
Activation of spinal alpha-2 adrenoceptors, but not mu-opioid receptors, reduces the intrathecal N-methyl-D-aspartate-induced increase in spinal NR1 subunit phosphorylation and nociceptive behaviors in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immunohistochemistry; Injections, Spinal; Male; N-Methylaspartate; Pain; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2010 |
An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor.
Topics: Analysis of Variance; Animals; Cyclic AMP-Dependent Protein Kinases; Dehydroepiandrosterone Sulfate; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Pain; Phosphorylation; Protein Kinase C; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spinal Cord | 2010 |
Does single cortical spreading depression elicit pain behaviour in freely moving rats?
Topics: Animals; Behavior, Animal; Brain; Cortical Spreading Depression; Electroencephalography; Excitatory Amino Acid Agonists; Immunohistochemistry; Male; Migraine Disorders; Movement; N-Methylaspartate; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Vocalization, Animal | 2010 |
Ventrolateral periaqueductal gray lesion attenuates nociception but does not change anxiety-like indices or fear-induced antinociception in mice.
Topics: Animals; Anxiety; Behavior, Animal; Excitatory Amino Acid Agonists; Fear; Formaldehyde; Male; Maze Learning; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Periaqueductal Gray | 2011 |
The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; G-Protein-Coupled Receptor Kinase 2; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; N-Methylaspartate; Neurons; Pain; Periaqueductal Gray; Phosphorylation; Protein Kinase C; Receptor Aggregation; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2012 |
Mitochondrial Ca(2+) uptake is essential for synaptic plasticity in pain.
Topics: Animals; Calcium; Calcium Signaling; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Electrophysiological Phenomena; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mitochondria; N-Methylaspartate; Nerve Tissue Proteins; Neuronal Plasticity; Nuclear Proteins; Pain; Patch-Clamp Techniques; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Superoxides; Synapses | 2011 |
Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Glycine; Gyrus Cinguli; Male; N-Methylaspartate; Pain; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2012 |
Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia.
Topics: Analgesics, Opioid; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Injections, Subcutaneous; Isoxazoles; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2012 |
Estrogen facilitates spinal cord synaptic transmission via membrane-bound estrogen receptors: implications for pain hypersensitivity.
Topics: Animals; Biotinylation; Electrophysiology; Estrogens; Female; Long-Term Potentiation; Male; N-Methylaspartate; Nociception; Pain; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Spinal Cord; Synaptic Transmission | 2012 |
Spinal cord heme oxygenase participates in glutamate-induced pain-related behaviors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heme Oxygenase (Decyclizing); In Vitro Techniques; Injections, Spinal; Male; Mesoporphyrins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Protoporphyrins; Spinal Cord | 2002 |
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Clonidine; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Ketamine; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Piperazines; Reaction Time; Receptors, Opioid | 2002 |
In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord.
Topics: Animals; Blotting, Western; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hot Temperature; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pressure; Receptors, Neurokinin-1; Reflex; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Substance P; Synaptic Membranes; Synaptic Transmission | 2003 |
Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.
Topics: Animals; Carrageenan; Dizocilpine Maleate; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Kaolin; Male; N-Methylaspartate; Pain; Pain Measurement; Phenols; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain.
Topics: Animals; Binding Sites; Dependovirus; Excitatory Postsynaptic Potentials; Female; Formaldehyde; Genetic Vectors; Hyperalgesia; In Vitro Techniques; Integrases; Introns; Lumbosacral Region; Male; Mice; Mice, Mutant Strains; Motor Activity; N-Methylaspartate; Pain; Pain Measurement; Patch-Clamp Techniques; Posterior Horn Cells; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Transduction, Genetic; Viral Proteins | 2003 |
MAC reduction after intrathecal coadministration of GABA(A) agonist and glutamate antagonist in rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Inhalation; Animals; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Agonists; Imidazoles; Injections, Spinal; Male; Methyl Ethers; Muscimol; N-Methylaspartate; Pain; Pulmonary Alveoli; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sevoflurane | 2003 |
Sustained potentiation by substance P of NMDA-activated current in rat primary sensory neurons.
Topics: Animals; Benzylamines; Calcium Signaling; Cell Membrane; Cells, Cultured; Chelating Agents; Chronic Disease; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Ganglia, Spinal; Membrane Potentials; Models, Biological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Sulfonamides | 2004 |
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glycine; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Visceral Afferents | 2004 |
Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.
Topics: Animals; Cell Membrane; Inflammation; Mice; Mice, Knockout; N-Methylaspartate; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Transport; Spinal Cord | 2004 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Hyperalgesia; Indoles; Injections, Spinal; Morphine; N-Methylaspartate; Narcotics; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Spinal Cord | 2005 |
Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy.
Topics: Animals; Cold Temperature; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy | 2005 |
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bradykinin; Drug Synergism; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Spinal Cord; Synaptic Transmission | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; N-Methylaspartate; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley | 2005 |
Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus.
Topics: Animals; Dose-Response Relationship, Radiation; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Functional Laterality; Gyrus Cinguli; Homocysteine; Male; Microinjections; N-Methylaspartate; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Pathways; Nociceptors; Pain; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reticular Formation; Time Factors | 2005 |
Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ankle; Arthritis; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Freund's Adjuvant; Functional Laterality; Immunohistochemistry; Iontophoresis; Male; Microscopy, Immunoelectron; N-Methylaspartate; Neuronal Plasticity; Neurons; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors | 2005 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission | 2006 |
Defensive-like behaviors and antinociception induced by NMDA injection into the periaqueductal gray of mice depend on nitric oxide synthesis.
Topics: Analysis of Variance; Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Freezing Reaction, Cataleptic; Male; Mice; N-Methylaspartate; Nitric Oxide Synthase; Pain; Pain Measurement; Periaqueductal Gray; Reaction Time; Running | 2006 |
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cold Temperature; Constriction, Pathologic; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fentanyl; Iontophoresis; Ketamine; Male; Motor Activity; N-Methylaspartate; Pain; Peripheral Nervous System Diseases; Phthalazines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Activation of alpha2-adrenoceptors in the trigeminal region produces sex-specific modulation of nociception in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Catecholamines; Dose-Response Relationship, Drug; Estradiol; Female; Hot Temperature; Male; N-Methylaspartate; Nociceptors; Ovariectomy; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sex Characteristics; Synaptic Transmission; Trigeminal Caudal Nucleus | 2006 |
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation; Injections, Intraventricular; Injections, Subcutaneous; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid; Sex Factors | 2007 |
Does the medial thalamus play a role in the negative affective component of visceral pain in rats?
Topics: Acetic Acid; Affect; Animals; Avoidance Learning; Excitatory Amino Acid Agonists; Injections, Intraperitoneal; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Long-Evans; Thalamic Nuclei | 2007 |
Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Male; Morphine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitrites; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Memantine; Mice; Mice, Inbred C57BL; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System; Phenylephrine; Piperazines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reproducibility of Results; Spinal Cord; Spinal Nerves; Time Factors | 2008 |
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Ether-A-Go-Go Potassium Channels; Inhibitory Concentration 50; Molecular Structure; N-Methylaspartate; Pain; Piperidines; Quinolones; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P.
Topics: Animals; Calcitonin Gene-Related Peptide; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Image Processing, Computer-Assisted; Male; Microscopy, Confocal; N-Methylaspartate; Neurons, Afferent; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P | 2008 |
Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Formaldehyde; Gene Expression Regulation; Male; N-Methylaspartate; NADP; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cytoplasmic and Nuclear; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells | 2008 |
Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Castration; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Estrogens; Female; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sex Characteristics; Testosterone; Time Factors; Yohimbine | 2008 |
Challenges in cancer pain management--bone pain.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Bone Diseases; Bone Neoplasms; Diphosphonates; Drug Administration Routes; Endothelin-1; Humans; Lidocaine; N-Methylaspartate; Osteoprotegerin; Pain; Receptors, Vitronectin | 2008 |
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Pain; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Signal Processing, Computer-Assisted; Signal Transduction; Spinal Cord; Time Factors | 2008 |
Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Glycine; Lumbosacral Region; Membrane Potentials; N-Methylaspartate; Pain; Patch-Clamp Techniques; Phenethylamines; Posterior Horn Cells; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Substantia Gelatinosa | 2008 |
The NO-cGMP pathway in neonatal rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Animals, Newborn; Arginine; Biomarkers; Cyclic GMP; Female; Glutathione; Male; N-Methylaspartate; NADPH Dehydrogenase; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Nitroso Compounds; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Second Messenger Systems; Signal Transduction; Spinal Cord | 1994 |
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Cycloleucine; Inflammation; Knee Joint; Male; N-Methylaspartate; Neurons; Pain; Pressure; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids.
Topics: Afferent Pathways; Animals; Calcitonin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intraventricular; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tail | 1994 |
Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Hot Temperature; Kainic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1994 |
Attenuation of NMDA-induced spinal hypersensitivity by adrenal medullary transplants.
Topics: Adrenal Medulla; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; N-Methylaspartate; Naloxone; Nociceptors; Pain; Phentolamine; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 1995 |
Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Male; Mice; Morphine; N-Methylaspartate; Pain; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Substance P; Synaptic Transmission | 1993 |
Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Hot Temperature; Ibotenic Acid; Male; N-Methylaspartate; Neurotoxins; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Spinal Cord | 1993 |
Characterization of the role of spinal N-methyl-D-aspartate receptors in thermal nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Behavior, Animal; Cold Temperature; Hot Temperature; Male; Methysergide; N-Methylaspartate; Nitroarginine; Nociceptors; Pain; Phentolamine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord | 1993 |
NMDA and quisqualate modulation of visceral nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Colon; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Nociceptors; Pain; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Rectum | 1994 |
A segmental chronic pain syndrome in rats associated with intrathecal infusion of NMDA: evidence for selective action in the dorsal horn.
Topics: Animals; Anterior Horn Cells; Axons; Behavior, Animal; Chronic Disease; Electrophysiology; Injections, Spinal; Magnesium Sulfate; Male; Motor Neurons; N-Methylaspartate; Nerve Fibers; Nerve Fibers, Myelinated; Neural Conduction; Neural Pathways; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Systemic or intracerebroventricular injection of NMDA receptor antagonists attenuates the antinociceptive activity of intrathecally administered NMDA receptor antagonists.
Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Mice; Mice, Inbred Strains; N-Methylaspartate; Pain; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Skin Temperature; Spinal Cord; Time Factors | 1993 |
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats.
Topics: Analgesics; Animals; Arginine; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Ethanol dose-dependently attenuates NMDA-mediated thermal hyperalgesia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex | 1993 |
Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801.
Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; Nerve Crush; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine | 1993 |
The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Hot Temperature; Lidocaine; Male; Morphine; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Tail | 1995 |
Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hindlimb; Kainic Acid; Logistic Models; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
[Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonists].
Topics: Amino Acids; Animals; Bicuculline; GABA Antagonists; Glycine Agents; Injections, Spinal; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine; Touch | 1996 |
Lumbar catheterization of the spinal subarachnoid space in the rat.
Topics: Animals; Atlanto-Occipital Joint; Behavior, Animal; Catheterization; Excitatory Amino Acid Agonists; Injections, Spinal; Male; Movement; N-Methylaspartate; Pain; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Spinal Cord; Subarachnoid Space; Technetium Tc 99m Pentetate | 1996 |
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
Topics: Adrenergic Agonists; Animals; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Hydantoins; Male; Mice; N-Methylaspartate; Pain; Prostaglandin D2; Spinal Cord; Wakefulness | 1996 |
NMDA receptor antagonists: interactions with opioids.
Topics: Analgesics, Opioid; Animals; Drug Synergism; Humans; N-Methylaspartate; Pain; Receptors, N-Methyl-D-Aspartate | 1997 |
Differential effects of activation of lumbar and thoracic 5-HT2A/2C receptors on nociception in rats.
Topics: Amphetamines; Analysis of Variance; Animals; Excitatory Amino Acid Agonists; Injections, Spinal; Ketanserin; Lumbosacral Region; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Thorax | 1997 |
NMDA-receptor regulation of substance P release from primary afferent nociceptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Injections, Spinal; N-Methylaspartate; Neurons, Afferent; Nociceptors; Pain; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Presynaptic; Spinal Cord; Substance P | 1997 |
Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Male; N-Methylaspartate; Neurokinin A; Pain; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Sulfonamides | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
Substitution of another opioid for morphine. Opioid toxicity should be managed initially by decreasing the opioid dose.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Morphine; N-Methylaspartate; Pain; Practice Guidelines as Topic | 1998 |
Substitution of another opioid for morphine. Methadone can be used to manage neuropathic pain related to cancer.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Methadone; N-Methylaspartate; Neoplasms; Pain | 1998 |
Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Hot Temperature; Morphine; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Methadone: opioid, N-methyl-D-aspartate antagonist or both?
Topics: Analgesics, Opioid; Humans; Methadone; N-Methylaspartate; Narcotics; Pain; Receptors, N-Methyl-D-Aspartate | 1998 |
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fear; Formaldehyde; GABA Agonists; Hindlimb; Hyperalgesia; Locomotion; Male; Morphine; Muscimol; N-Methylaspartate; Narcotics; Nociceptors; Pain; Rats; Rats, Sprague-Dawley | 1998 |
Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-D-aspartate- and septide-induced nociceptive behaviour.
Topics: Analgesics; Animals; Bupivacaine; Imidazoles; Male; Morphine; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P | 1998 |
Redox manipulation of NMDA receptors in vivo: alteration of acute pain transmission and dynorphin-induced allodynia.
Topics: Acute Disease; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dynorphins; Excitatory Amino Acid Agonists; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxidation-Reduction; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Reducing Agents; Signal Transduction; Spinal Cord; Sulfhydryl Reagents; Synaptic Transmission | 1999 |
Involvement of NMDA and non-NMDA receptors in transmission of spinal visceral nociception in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Excitatory Amino Acid Agonists; Female; Kainic Acid; Male; N-Methylaspartate; Nociceptors; Pain; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Splanchnic Nerves; Viscera | 1999 |
Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bee Venoms; Cats; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Injections, Subcutaneous; Male; N-Methylaspartate; Nociceptors; Pain; Posterior Horn Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Caudate Nucleus; Chronic Disease; Clozapine; Doxepin; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Pain; Putamen; Rats; Rats, Wistar | 1999 |
Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord.
Topics: Animals; Antibodies; Behavior, Animal; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Guanylate Cyclase; Hyperalgesia; Male; Myelitis; N-Methylaspartate; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Thionucleotides | 2000 |
Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat.
Topics: Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Formaldehyde; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Measurement; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Robust changes of afferent-induced excitation in the rat spinal dorsal horn after conditioning high-frequency stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chlorides; Conditioning, Psychological; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Optics and Photonics; Pain; Posterior Horn Cells; Potassium; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Strychnine | 2000 |
Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Injections, Spinal; Male; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thionucleotides | 2000 |
Ionotropic glutamate receptor-mediated responses in the rat primary somatosensory cortex evoked by noxious and innocuous cutaneous stimulation in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Antagonists; Hot Temperature; Male; N-Methylaspartate; Neurons; Pain; Piperazines; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, Glutamate; Skin; Somatosensory Cortex; Synapses; Time Factors | 2000 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indomethacin; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice.
Topics: Adjuvants, Immunologic; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Excitatory Amino Acid Agonists; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Pain; Pertussis Toxin; Spinal Cord; Virulence Factors, Bordetella | 2000 |
Activity-induced plasticity in brain stem pain modulatory circuitry after inflammation.
Topics: Animals; Behavior, Animal; Efferent Pathways; Electric Stimulation; Excitatory Amino Acid Agonists; Hot Temperature; Inflammation; Male; Medulla Oblongata; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Glutamate; Stimulation, Chemical; Synaptic Transmission | 2000 |
Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways.
Topics: Adult; Aged; Analysis of Variance; Asparagine; Excitatory Amino Acids; Female; Fibromyalgia; Glutamine; Humans; Male; Middle Aged; N-Methylaspartate; Nitric Oxide; Pain; Pain Measurement; Signal Transduction | 2000 |
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.
Topics: Agmatine; Analgesics; Animals; Immunohistochemistry; Inflammation; Male; Mice; N-Methylaspartate; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2000 |
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methadone; N-Methylaspartate; Naloxone; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.
Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2001 |
Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Cold Temperature; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Morphine; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Sciatic Nerve; Touch | 2001 |
Facilitation of NMDA-induced currents and Ca2+ transients in the rat substantia gelatinosa neurons after ligation of L5-L6 spinal nerves.
Topics: Animals; Calcium Signaling; Cell Membrane; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; Lumbar Vertebrae; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Nerves; Substantia Gelatinosa; Synaptic Transmission | 2000 |
Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord.
Topics: Analgesics; Animals; Baclofen; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; Injections, Spinal; Male; Mice; N-Methylaspartate; Pain; Quinolines; Receptors, GABA-B; Spinal Cord | 2000 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Behavior, Animal; Calcium; Calcium-Transporting ATPases; Dantrolene; Enzyme Inhibitors; Male; Muscle Relaxants, Central; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Thapsigargin | 2001 |
Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Drug Interactions; Estrogens; Estrous Cycle; Excitatory Amino Acid Agonists; Female; Male; N-Methylaspartate; Neurons; Nociceptin; Nociceptin Receptor; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Sex Characteristics; Trigeminal Caudal Nucleus | 2001 |
Superficial and deep convergent nociceptive neurons are differentially affected by N-methyl-D-aspartate applied on the brainstem surface of the rat medullary dorsal horn.
Topics: Animals; Brain Stem; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Injections, Spinal; Male; Medulla Oblongata; N-Methylaspartate; Nerve Fibers; Neurons; Pain; Rats; Rats, Sprague-Dawley; Trigeminal Nuclei | 2001 |
Involvement of capsaicin-sensitive fibers in spinal NMDA-induced glutamate release.
Topics: Animals; Animals, Newborn; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lumbar Vertebrae; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Electrophysiology; Female; gamma-Aminobutyric Acid; Glycine; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Male; N-Methylaspartate; Pain; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, Prostaglandin; Synaptic Transmission | 2002 |
Sensitization of glutamate release and N-methyl-D-aspartate receptor response by transient dopamine pretreatment in prefrontal cortex of rats.
Topics: Animals; Avoidance Learning; Calcium Signaling; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Agonists; Glutamic Acid; Habituation, Psychophysiologic; Immobilization; Memory; Microdialysis; Microscopy, Video; N-Methylaspartate; Pain; Perfusion; Prefrontal Cortex; Rats; Receptors, N-Methyl-D-Aspartate; Reserpine; Septum Pellucidum; Stress, Physiological; Synaptic Transmission; Tetrodotoxin | 2002 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord.
Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Nociceptors; Pain; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
NMDA and strychnine diversely modulate spinal dorsal horn noxious responsiveness in normal rats: potential significance to sensory disorders in neuropathic pain.
Topics: Animals; Excitatory Amino Acid Agonists; Glycine Agents; Hyperalgesia; Male; N-Methylaspartate; Neurons, Afferent; Pain; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensation Disorders; Strychnine | 2002 |
Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test.
Topics: Animals; Formaldehyde; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Substance P | 1992 |
Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Hot Temperature; Hyperesthesia; Injections, Spinal; Male; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Cord; Time Factors | 1992 |
The role of 5-HT1A and 5-HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Spinal; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Skin Temperature; Spinal Cord; Synaptic Transmission | 1992 |
The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Brain Stem; Diencephalon; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Medulla Oblongata; Mesencephalon; Microinjections; N-Methylaspartate; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Reticular Formation; Stereotaxic Techniques | 1992 |
Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Enzyme Activation; Guanylate Cyclase; Male; N-Methylaspartate; Nitric Oxide; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Reflex | 1992 |
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Injections, Spinal; Kynurenic Acid; Morphine; N-Methylaspartate; Naloxone; Nerve Fibers; Neurons; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1992 |
Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat.
Topics: Animals; Dizocilpine Maleate; Injections, Spinal; Male; Morphine; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 1992 |
Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Capsaicin; Functional Laterality; Hot Temperature; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neuronal Plasticity; Neuropeptides; Pain; Quinoxalines; Rats; Reflex; Time Factors | 1991 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Nociceptors; Pain; Peptide Fragments; Reaction Time; Substance P; Urethane | 1991 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occlusive Diseases; Blood Pressure; Carotid Arteries; Carotid Artery Diseases; Cerebral Ventricles; Hypertension; Injections, Intraventricular; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Pain; Phencyclidine; Pressoreceptors; Rats; Rats, Inbred Strains; Reflex; Vagotomy | 1991 |
Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Injections, Spinal; Male; N-Methylaspartate; Neural Inhibition; Neurons; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Spinal Cord | 1990 |
Neurotoxic effects of excitatory amino acids in the mouse spinal cord: quisqualate and kainate but not N-methyl-D-aspartate induce permanent neural damage.
Topics: 2-Amino-5-phosphonovalerate; Aggression; Animals; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; N-Methylaspartate; Neurons; Neurotoxins; Pain; Paralysis; Quisqualic Acid; Spinal Cord | 1990 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Narcotics; Nociceptors; Oxadiazoles; Pain; Phencyclidine; Phentolamine; Quisqualic Acid; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1987 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; N-Methylaspartate; Oxadiazoles; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State; Injections, Spinal; Male; N-Methylaspartate; Nociceptors; Pain; Rats; Valine | 1987 |
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dipeptides; Dynorphins; Hot Temperature; Kinetics; Male; N-Methylaspartate; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |