pioglitazone has been researched along with Pain in 6 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the safety of the peroxisome proliferator-activated receptor gamma agonist pioglitazone in nondiabetic patients with Alzheimer disease (AD) and to explore treatment effect sizes on clinical outcomes." | 9.15 | A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. ( Fritsch, T; Geldmacher, DS; Landreth, G; McClendon, MJ, 2011) |
| "We found that pioglitazone appeared to mitigate the contralateral hemorrhage-induced thalamic pain while inhibiting inflammatory responses." | 8.31 | Peroxisome proliferator-activated receptor gamma agonist pioglitazone alleviates hemorrhage-induced thalamic pain and neuroinflammation. ( Ai, Y; He, L; Li, D; Yang, JJ; Yuan, C, 2023) |
| "Fenofibrate did not inhibit mechanical allodynia or paw edema induced by phorbol-12,13-didecanoate (PDD), a protein kinase C activator, in rats." | 5.34 | Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma. ( Bertollo, CM; Coelho, MM; Costa, KA; Nascimento, EB; Oliveira, AC; Rocha, LT, 2007) |
| "To evaluate the safety of the peroxisome proliferator-activated receptor gamma agonist pioglitazone in nondiabetic patients with Alzheimer disease (AD) and to explore treatment effect sizes on clinical outcomes." | 5.15 | A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. ( Fritsch, T; Geldmacher, DS; Landreth, G; McClendon, MJ, 2011) |
| "We found that pioglitazone appeared to mitigate the contralateral hemorrhage-induced thalamic pain while inhibiting inflammatory responses." | 4.31 | Peroxisome proliferator-activated receptor gamma agonist pioglitazone alleviates hemorrhage-induced thalamic pain and neuroinflammation. ( Ai, Y; He, L; Li, D; Yang, JJ; Yuan, C, 2023) |
| "Chronic pain is a common complication of diabetes." | 1.42 | Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. ( Byrne, FM; Chapman, V; Cheetham, S; Vickers, S, 2015) |
| "Naloxone was administrated 2 h after the morphine last dose, and withdrawal symptoms were recorded for 45 min." | 1.40 | Pioglitazone prevents morphine antinociception tolerance and withdrawal symptoms in rats. ( Azarfardian, A; Charkhpour, M; Ghasami, S; Ghavimi, H; Hassanzadeh, K; Maleki-Dizaji, N; Zolali, E, 2014) |
| " However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction." | 1.40 | Analgesic tolerance to morphine is regulated by PPARγ. ( Ciccocioppo, R; de Guglielmo, G; Demopulos, G; Gaitanaris, G; Kallupi, M; Scuppa, G; Stopponi, S, 2014) |
| "Fenofibrate did not inhibit mechanical allodynia or paw edema induced by phorbol-12,13-didecanoate (PDD), a protein kinase C activator, in rats." | 1.34 | Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma. ( Bertollo, CM; Coelho, MM; Costa, KA; Nascimento, EB; Oliveira, AC; Rocha, LT, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, D | 1 |
| He, L | 1 |
| Yuan, C | 1 |
| Ai, Y | 1 |
| Yang, JJ | 1 |
| Ghavimi, H | 1 |
| Hassanzadeh, K | 1 |
| Maleki-Dizaji, N | 1 |
| Azarfardian, A | 1 |
| Ghasami, S | 1 |
| Zolali, E | 1 |
| Charkhpour, M | 1 |
| de Guglielmo, G | 1 |
| Kallupi, M | 1 |
| Scuppa, G | 1 |
| Stopponi, S | 1 |
| Demopulos, G | 1 |
| Gaitanaris, G | 1 |
| Ciccocioppo, R | 1 |
| Byrne, FM | 1 |
| Cheetham, S | 1 |
| Vickers, S | 1 |
| Chapman, V | 1 |
| Geldmacher, DS | 1 |
| Fritsch, T | 1 |
| McClendon, MJ | 1 |
| Landreth, G | 1 |
| Oliveira, AC | 1 |
| Bertollo, CM | 1 |
| Rocha, LT | 1 |
| Nascimento, EB | 1 |
| Costa, KA | 1 |
| Coelho, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pioglitazone in Alzheimer Disease Progression[NCT00982202] | Phase 2 | 25 participants (Actual) | Interventional | 2002-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pioglitazone and Pain
| Article | Year |
|---|---|
A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Glucose; Double-Blind Method; Female; Humans; Male | 2011 |
5 other studies available for pioglitazone and Pain
| Article | Year |
|---|---|
Peroxisome proliferator-activated receptor gamma agonist pioglitazone alleviates hemorrhage-induced thalamic pain and neuroinflammation.
Topics: Animals; Hemorrhage; Mice; Neuroinflammatory Diseases; NF-kappa B; Pain; Pioglitazone; PPAR gamma; P | 2023 |
Pioglitazone prevents morphine antinociception tolerance and withdrawal symptoms in rats.
Topics: Analgesics, Opioid; Anilides; Animals; Behavior, Animal; Drug Tolerance; Male; Morphine; Motor Activ | 2014 |
Analgesic tolerance to morphine is regulated by PPARγ.
Topics: Analgesics, Opioid; Anilides; Animals; Body Temperature; Drug Tolerance; Hot Temperature; Male; Mice | 2014 |
Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.
Topics: Animal Feed; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neu | 2015 |
Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Re | 2007 |