Compounds > substance p, sar(9)-met(o2)(11)-
Page last updated: 2024-09-26

substance p, sar(9)-met(o2)(11)-

Description

substance P, Sar(9)-Met(O2)(11)-: a neurokinin-1 receptor agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID163829
CHEMBL ID1651026
MeSH IDM0173220

Synonyms (28)

Synonym
substance p [sar9,met(o2)11]
bdbm50335566
[sar...9...,met(o..2..)...11...]substance p
NCGC00167322-01
substance p, 9-(n-methylglycine)-11-(4-(methylsulfonyl)-l-2-aminobutanamide)-
9-sar-substance p sulfone
(sar(9))sp sulfone
bolton hunter-9-sar-11-met(02)-substance p
substance p, sarcosyl(9)-methionine(o2)(11)-
substance p, sar(9)-met(o2)(11)-
sarcosyl(9)-substance p sulfone
9-sar-11-met(o2)-substance p
9-sarcosyl-11-methionine(o2)-substance p
bolton-hunter reagent-substance p. sar(9)-met(02)(11)
substance p, sar(9) sulfone
substance p, sarcosyl(9)-methionine(02)(11)-bhr
(sar(9),met(o2)(11))sp
bhsar-sp
CHEMBL1651026 ,
(sar(9)kmet(o(2))(11))-substance p
8v0qafprxv ,
unii-8v0qafprxv
AKOS024456442
mfcd00076787
(sar9,met(o2)11)-substance p
sar9, met (o2)11-substance p
DB05875
[sar9,met(o2)11]-substance-p

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Substance-P receptorHomo sapiens (human)IC50 (µMol)0.00060.00000.09526.8130AID1285641; AID1336336; AID566270; AID751872; AID752234
Substance-P receptorHomo sapiens (human)Ki0.00010.00000.79368.7470AID751872
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (38)

Processvia Protein(s)Taxonomy
aggressive behaviorSubstance-P receptorHomo sapiens (human)
positive regulation of leukocyte migrationSubstance-P receptorHomo sapiens (human)
angiotensin-mediated drinking behaviorSubstance-P receptorHomo sapiens (human)
inflammatory responseSubstance-P receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwaySubstance-P receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationSubstance-P receptorHomo sapiens (human)
tachykinin receptor signaling pathwaySubstance-P receptorHomo sapiens (human)
long-term memorySubstance-P receptorHomo sapiens (human)
associative learningSubstance-P receptorHomo sapiens (human)
detection of abiotic stimulusSubstance-P receptorHomo sapiens (human)
response to ozoneSubstance-P receptorHomo sapiens (human)
positive regulation of epithelial cell migrationSubstance-P receptorHomo sapiens (human)
response to auditory stimulusSubstance-P receptorHomo sapiens (human)
regulation of smooth muscle cell migrationSubstance-P receptorHomo sapiens (human)
positive regulation of synaptic transmission, cholinergicSubstance-P receptorHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicSubstance-P receptorHomo sapiens (human)
response to estradiolSubstance-P receptorHomo sapiens (human)
response to progesteroneSubstance-P receptorHomo sapiens (human)
response to nicotineSubstance-P receptorHomo sapiens (human)
operant conditioningSubstance-P receptorHomo sapiens (human)
sperm ejaculationSubstance-P receptorHomo sapiens (human)
eating behaviorSubstance-P receptorHomo sapiens (human)
positive regulation of vascular permeabilitySubstance-P receptorHomo sapiens (human)
response to ethanolSubstance-P receptorHomo sapiens (human)
positive regulation of action potentialSubstance-P receptorHomo sapiens (human)
positive regulation of blood pressureSubstance-P receptorHomo sapiens (human)
positive regulation of ossificationSubstance-P receptorHomo sapiens (human)
positive regulation of vasoconstrictionSubstance-P receptorHomo sapiens (human)
positive regulation of hormone secretionSubstance-P receptorHomo sapiens (human)
behavioral response to painSubstance-P receptorHomo sapiens (human)
regulation of smooth muscle cell proliferationSubstance-P receptorHomo sapiens (human)
positive regulation of lymphocyte proliferationSubstance-P receptorHomo sapiens (human)
positive regulation of epithelial cell proliferationSubstance-P receptorHomo sapiens (human)
positive regulation of stress fiber assemblySubstance-P receptorHomo sapiens (human)
response to electrical stimulusSubstance-P receptorHomo sapiens (human)
smooth muscle contraction involved in micturitionSubstance-P receptorHomo sapiens (human)
positive regulation of uterine smooth muscle contractionSubstance-P receptorHomo sapiens (human)
positive regulation of flagellated sperm motilitySubstance-P receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
tachykinin receptor activitySubstance-P receptorHomo sapiens (human)
protein bindingSubstance-P receptorHomo sapiens (human)
substance P receptor activitySubstance-P receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Processvia Protein(s)Taxonomy
plasma membraneSubstance-P receptorHomo sapiens (human)
cell surfaceSubstance-P receptorHomo sapiens (human)
dendriteSubstance-P receptorHomo sapiens (human)
sperm flagellumSubstance-P receptorHomo sapiens (human)
cell bodySubstance-P receptorHomo sapiens (human)
sperm headSubstance-P receptorHomo sapiens (human)
sperm midpieceSubstance-P receptorHomo sapiens (human)
plasma membraneSubstance-P receptorHomo sapiens (human)
sperm midpieceSubstance-P receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID752234Binding affinity to human NK1 receptor by radioligand displacement assay2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
AID751872Binding affinity to human NK1 receptor by radioligand displacement assay2013European journal of medicinal chemistry, May, Volume: 63Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
AID566270Inhibition of human tachykinin NK1 receptor2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
AID1285641Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells2016Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
AID1336336Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting method2017Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (148)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (0.68)18.7374
1990's100 (67.57)18.2507
2000's39 (26.35)29.6817
2010's8 (5.41)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other151 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid[no description available]medium60amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
gallopamil[no description available]medium50benzenes;
organic amino compound
1,3-dipropyl-8-cyclopentylxanthine[no description available]medium50oxopurineadenosine A1 receptor antagonist;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
atenolol[no description available]medium60ethanolamines;
monocarboxylic acid amide;
propanolamine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic
cimetidine[no description available]medium50aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
diazepam[no description available]medium501,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
vanoxerine[no description available]medium10ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor
glyburide[no description available]medium10monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
haloperidol[no description available]medium70aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
ici 118551[no description available]medium40indanes
imipramine[no description available]medium50dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
ketanserin[no description available]medium50aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist
clorgyline[no description available]medium10aromatic ether;
dichlorobenzene;
terminal acetylenic compound;
tertiary amino compound		antidepressant;
EC 1.4.3.4 (monoamine oxidase) inhibitor
nipecotic acid[no description available]medium10beta-amino acid;
piperidinemonocarboxylic acid
nitrendipine[no description available]medium10C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent
pirenzepine[no description available]medium50pyridobenzodiazepineanti-ulcer drug;
antispasmodic drug;
muscarinic antagonist
prazosin[no description available]medium50aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
protriptyline[no description available]medium50carbotricyclic compoundantidepressant
pyrilamine[no description available]medium50aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
triiodothyronine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
veratridine[no description available]medium40steroidsodium channel modulator
neostigmine bromide[no description available]medium10bromide salt
framycetin[no description available]medium10aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
yohimbine[no description available]medium50methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
kainic acid[no description available]medium10dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
selegiline[no description available]medium10selegiline;
terminal acetylenic compound		geroprotector
glutamic acid[no description available]medium40glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
butaclamol[no description available]medium30amino alcohol;
organic heteropentacyclic compound;
tertiary alcohol;
tertiary amino compound		dopaminergic antagonist
diltiazem[no description available]medium105-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
colforsin[no description available]medium40acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
selfotel[no description available]medium10non-proteinogenic alpha-amino acid
nicotine[no description available]medium103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
methoctramine[no description available]medium10hydrochloridemuscarinic antagonist
alpha-methylhistamine[no description available]medium10aralkylamino compound;
imidazoles		H3-receptor agonist
atropine[no description available]medium70
monoiodotyrosine[no description available]medium10amino acid zwitterion;
L-tyrosine derivative;
monoiodotyrosine;
non-proteinogenic L-alpha-amino acid		EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor;
human metabolite;
mouse metabolite
strychnine[no description available]medium10monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
picrotoxinin[no description available]medium50epoxide;
gamma-lactone;
organic heteropentacyclic compound;
picrotoxane sesquiterpenoid;
tertiary alcohol		GABA antagonist;
plant metabolite;
serotonergic antagonist
adenosine-5'-(n-ethylcarboxamide)[no description available]medium50adenosines;
monocarboxylic acid amide		adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
4-diphenylacetoxy-n-methylpiperidine methiodide[no description available]medium50iodide salt;
quaternary ammonium salt		cholinergic antagonist;
muscarinic antagonist
sch 23390[no description available]medium10benzazepine
leukotriene d4[no description available]medium10dipeptide;
leukotriene;
organic sulfide		bronchoconstrictor agent;
human metabolite;
mouse metabolite
(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone[no description available]medium10morpholines;
naphthyl ketone;
organic heterotricyclic compound;
synthetic cannabinoid		analgesic;
apoptosis inhibitor;
neuroprotective agent
saralasin[no description available]medium50oligopeptide
nociceptin[no description available]medium40organic molecular entity;
polypeptide		human metabolite;
rat metabolite
clozapine[no description available]medium50benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound		adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic
melatonin[no description available]medium50acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
8-hydroxy-2-(di-n-propylamino)tetralin[no description available]medium40phenols;
tertiary amino compound;
tetralins		serotonergic antagonist
4-iodo-2,5-dimethoxyphenylisopropylamine[no description available]medium40amphetamines;
dimethoxybenzene;
organoiodine compound
pk 11195[no description available]medium40aromatic amide;
isoquinolines;
monocarboxylic acid amide;
monochlorobenzenes		antineoplastic agent
methoctramine[no description available]medium10aromatic ether;
tetramine		muscarinic antagonist
rosiglitazone[no description available]medium40aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
alpha,beta-methyleneadenosine 5'-triphosphate[no description available]medium50nucleoside triphosphate analogue
cp-55,940[no description available]medium40
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine[no description available]medium30adenosines;
monocarboxylic acid amide;
organoiodine compound		adenosine A3 receptor agonist
1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine[no description available]medium401-benzothiophenes;
piperidines;
tertiary amino compound		dopamine uptake inhibitor
neurokinin a (4-10), nle(10)-[no description available]medium100
2'-deoxyadenosine 5'-o-(1-thiotriphosphate)[no description available]medium30
bemesetron[no description available]medium40
u-50488[no description available]medium40dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist
rs 102221[no description available]medium40aromatic ketone
dinoprostone[no description available]medium40prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
iloprost[no description available]medium40carbobicyclic compound;
monocarboxylic acid;
secondary alcohol		platelet aggregation inhibitor;
vasodilator agent
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium40peptide
dizocilpine maleate[no description available]medium20maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
sb 222200[no description available]medium50quinolines
vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(o- methyl-l-tyrosine)-8-l-arginine-[no description available]medium40
somatostatin[no description available]medium40heterodetic cyclic peptide;
peptide hormone
msh, 4-nle-7-phe-alpha-[no description available]medium40polypeptidedermatologic drug
bombesin[no description available]medium30
neurotensin[no description available]medium40peptide hormonehuman metabolite;
mitogen;
neurotransmitter;
vulnerary
endothelins[no description available]medium20
pituitary adenylate cyclase activating polypeptide 38[no description available]medium30
donepezil[no description available]medium10aromatic ether;
indanones;
piperidines;
racemate		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
nootropic agent
arg-3-hyp-7-phe-bradykinin[no description available]medium30oligopeptidebradykinin receptor antagonist
pre 084[no description available]medium10morpholines
fentanyl[no description available]medium10anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic
mexiletine[no description available]medium10aromatic ether;
primary amino compound		anti-arrhythmia drug
7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol[no description available]medium20benzazepine;
organochlorine compound;
tertiary amino compound		dopaminergic antagonist
4-nitroquinoline-1-oxide[no description available]medium10C-nitro compound;
quinoline N-oxide		carcinogenic agent
butaclamol[no description available]medium10organic heteropentacyclic compound
enkephalin, d-penicillamine (2,5)-[no description available]medium20heterodetic cyclic peptidedelta-opioid receptor agonist
dizocilpine[no description available]medium20secondary amino compound;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
sincalide[no description available]medium20oligopeptide
endothelin-1[no description available]medium20
carbamazepine[no description available]medium10dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic
valproic acid[no description available]medium10branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
angiotensin ii[no description available]medium10amino acid zwitterion;
angiotensin II		human metabolite
ici 118551[no description available]medium10aromatic ether;
indanes;
secondary alcohol;
secondary amino compound		beta-adrenergic antagonist
substance p[no description available]medium1460peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
piperidines[no description available]medium400
l 733060[no description available]medium10piperidines
gr 73632[no description available]medium50
senktide[no description available]medium230
neurokinin a[no description available]medium600
cp 99994[no description available]medium130
neurokinin a(4-10), tyr(5)-trp(6,8,9)-lys(10)-[no description available]medium80
oxytocin[no description available]medium10heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
substance p (6-11), tyr(6)-d-phe(7)-d-his(9)-[no description available]medium30
3-nitrotyrosine[no description available]medium102-nitrophenols;
C-nitro compound;
nitrotyrosine;
non-proteinogenic alpha-amino acid
tyrosine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
methamphetamine[no description available]medium10amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
win 51708[no description available]medium30
gr 82334[no description available]medium100
physalaemin[no description available]medium130
bicuculline[no description available]medium10benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
cgp 52432[no description available]medium10dichlorobenzene
ryanodine[no description available]medium10
bisindolylmaleimide i[no description available]medium10
nicardipine[no description available]medium10benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound
iberiotoxin[no description available]medium10
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole[no description available]medium20ether;
imidazoles;
monomethoxybenzene		TRP channel blocker
neurokinin a (3-10), lysyl(3)-glycyl(8)-r-lactam-leucine(9)-[no description available]medium40
neurokinin b[no description available]medium130polypeptide
phentolamine[no description available]medium10imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent
sr 142801[no description available]medium50
sr 140333[no description available]medium140
quinuclidines[no description available]medium150quinuclidines;
saturated organic heterobicyclic parent
nan 190[no description available]medium10N-alkylpiperazine;
N-arylpiperazine;
phthalimides		serotonergic antagonist
7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one[no description available]medium60
eledoisin[no description available]medium40peptide
mezlocillin[no description available]medium10
bufokinin[no description available]medium10
capsaicin[no description available]medium130capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
phenyl acetate[no description available]medium20benzenes;
phenyl acetates
neurokinin a (4-10), beta-ala(8)-[no description available]medium270
sr 48968[no description available]medium140
pituitrin[no description available]medium20
p-methoxy-n-methylphenethylamine[no description available]medium10aromatic ether;
secondary amino compound		metabolite
tetrodotoxin[no description available]medium70azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
sr140333b[no description available]medium10
aprepitant[no description available]medium10(trifluoromethyl)benzenes;
cyclic acetal;
morpholines;
triazoles		antidepressant;
antiemetic;
neurokinin-1 receptor antagonist;
peripheral nervous system drug;
substance P receptor antagonist
inositol 1,4,5-trisphosphate[no description available]medium20myo-inositol trisphosphatemouse metabolite
2-aminoethoxydiphenyl borate[no description available]medium10organoboron compound;
primary amino compound		calcium channel blocker;
IP3 receptor antagonist;
potassium channel opener
septide[no description available]medium160
pyrrolidonecarboxylic acid[no description available]medium1705-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
substance p, pro(9)-[no description available]medium30
substance p[no description available]medium20
substance p (5-11)[no description available]medium10
l 668169[no description available]medium10
cp 96345[no description available]medium220
dipropizine[no description available]medium10piperazines
evans blue[no description available]medium40organic sodium saltfluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent
1-hexadecyl-2-acetyl-glycero-3-phosphocholine[no description available]medium202-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
diphenhydramine hydrochloride[no description available]medium10hydrochloride;
organoammonium salt		anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative
taurine[no description available]medium10amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
methacholine chloride[no description available]medium20quaternary ammonium salt
nifedipine[no description available]medium30C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
toluene 2,4-diisocyanate[no description available]medium10toluene meta-diisocyanateallergen;
hapten
isoproterenol[no description available]medium30catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
vasoactive intestinal peptide[no description available]medium20
ro 31-8220[no description available]medium20imidothiocarbamic ester;
indoles;
maleimides		EC 2.7.11.13 (protein kinase C) inhibitor
okadaic acid[no description available]medium10ketal
gr 94800[no description available]medium30
amphetamine[no description available]medium10primary amine
naxagolide[no description available]medium10organic heterotricyclic compound;
phenols;
tertiary amino compound		anticonvulsant;
antiparkinson drug;
dopamine agonist
substance p (5-11), asp(5,6)-mephe(8)-[no description available]medium20
sch 32615[no description available]medium10
nitroarginine[no description available]medium30guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
adenosine diphosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
indomethacin[no description available]medium20aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
arginine[no description available]medium10arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
suramin[no description available]medium10naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
guanethidine[no description available]medium10azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent
adp beta s[no description available]medium10
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
quinolinic acid[no description available]medium10pyridinedicarboxylic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist
fk 224[no description available]medium10
fk 888[no description available]medium50peptide
neurokinin a(4-10)[no description available]medium60
bucladesine[no description available]medium103',5'-cyclic purine nucleotide
phorbol 12,13-dibutyrate[no description available]medium10butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone
sq-23377[no description available]medium10cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid		calcium ionophore;
metabolite
tetraethylammonium[no description available]medium10quaternary ammonium ion
calcimycin[no description available]medium20benzoxazole
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
meglumine[no description available]medium10hexosamine;
secondary amino compound
guanosine 5'-o-(3-thiotriphosphate)[no description available]medium30nucleoside triphosphate analogue
chlorine[no description available]medium10halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
1-oleoyl-2-acetylglycerol[no description available]medium101,2-diglyceride
dactinomycin[no description available]medium10actinomycinmutagen
cyclo(gln-trp-phe-gly-leu-met)[no description available]medium10
1-palmitoyl-2-oleoylglycero-3-phosphoglycerol[no description available]medium20phosphatidylglycerol
1-palmitoyl-2-oleoylphosphatidylcholine[no description available]medium20
phosphatidylcholines[no description available]medium201,2-diacyl-sn-glycero-3-phosphocholine
histamine[no description available]medium30aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
resiniferatoxin[no description available]medium10carboxylic ester;
diterpenoid;
enone;
monomethoxybenzene;
organic heteropentacyclic compound;
ortho ester;
phenols;
tertiary alpha-hydroxy ketone		analgesic;
neurotoxin;
plant metabolite;
TRPV1 agonist
3,4-dihydroxyphenylacetic acid[no description available]medium20catechols;
dihydroxyphenylacetic acid		human metabolite
l 703606[no description available]medium20
substance p, methyl ester-[no description available]medium20
guanosine triphosphate[no description available]medium10guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
bradykinin[no description available]medium10oligopeptidehuman blood serum metabolite;
vasodilator agent
interleukin-8[no description available]medium20
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tryptophan[no description available]medium10erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
pd 154075[no description available]medium10
carbachol[no description available]medium20ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
hexamethonium[no description available]medium20quaternary ammonium salt
men 11420[no description available]medium10
lysine[no description available]medium20aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
biocytin[no description available]medium20azabicycloalkane;
L-alpha-amino acid zwitterion;
L-lysine derivative;
monocarboxylic acid amide;
non-proteinogenic L-alpha-amino acid;
thiabicycloalkane;
ureas		mouse metabolite
fluorescein-5-isothiocyanate[no description available]medium10fluorescein isothiocyanate
phosphoramidon[no description available]medium10deoxyaldohexose phosphate;
dipeptide		bacterial metabolite;
EC 3.4.24.11 (neprilysin) inhibitor;
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
n-formylmethionine leucyl-phenylalanine[no description available]medium10tripeptide
2-amino-5-phosphonovalerate[no description available]medium20non-proteinogenic alpha-amino acidNMDA receptor antagonist
u 73122[no description available]medium20aromatic ether;
aza-steroid;
maleimides		EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline[no description available]medium20naphthalenes;
sulfonic acid derivative
quinoxalines[no description available]medium20mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
diazo-2[no description available]medium10
diphenhydramine[no description available]medium10ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
ly 306740[no description available]medium10
omega-n-methylarginine[no description available]medium10amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
chelerythrine[no description available]medium10benzophenanthridine alkaloid;
organic cation		antibacterial agent;
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
u 73343[no description available]medium10
thiorphan[no description available]medium10N-acyl-amino acid
captopril[no description available]medium10alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
ovalbumin[no description available]medium10
egtazic acid[no description available]medium10diether;
tertiary amino compound;
tetracarboxylic acid		chelator
substance p (6-11)[no description available]medium10
vofopitant[no description available]medium10
neuropeptide y[no description available]medium10
pentobarbital[no description available]medium10barbituratesGABAA receptor agonist
mk 912[no description available]medium10
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium10
promethazine[no description available]medium10phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative
b 3824[no description available]medium10
substance p, arg(1)-pro(2)-trp(7),(9)-leunh(2)(11)-[no description available]medium10
substance p, prolyl(2)-tryptophan(7,9)-[no description available]medium10
caffeine[no description available]medium10purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
n-succinimidyl-3-(4-hydroxyphenyl)propionate[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low10
Absence Seizures0low10
Ache0low20
Acquired Meningomyelocele0low10
Alcohol Drinking0low20
Allergic Reaction0low10
Allergy0low10
Allodynia0low20
Allodynia, Mechanical0low20
Allodynia, Tactile0low20
Allodynia, Thermal0low20
Alveolitis, Fibrosing0low10
Anaplastic Astrocytoma0low50
Anasarca0low10
Anesthesia0low10
Anoxemia0low10
Anoxia0low10
Anoxia, Brain0low10
Anoxia, Cerebral0low10
Anoxic Brain Damage0low10
Anoxic Encephalopathy0low10
Anxiety0low10
Arthritis, Rheumatoid0low10
Astrocytoma0low50
Astrocytoma, Grade I0low50
Astrocytoma, Grade II0low50
Astrocytoma, Grade III0low50
Astrocytoma, Grade IV0low10
Astrocytoma, Protoplasmic0low50
Astrocytoma, Subependymal Giant Cell0low50
Astroglioma0low50
Atonic Absence Seizure0low10
Atonic Absence Seizures0low10
Atonic Seizure0low10
Atonic Seizures0low10
Aura0low10
Awakening Epilepsy0low10
Benign Neoplasms, Brain0low10
Besnier-Boeck Disease0low10
Besnier-Boeck-Schaumann Syndrome0low10
Bladder Disorder, Neurogenic0low20
Bladder Neurogenesis0low20
Bladder, Neurogenic0low20
Blood Pressure, High0low10
Blood Pressure, Low0low20
Boeck Disease0low10
Boeck's Disease0low10
Boeck's Sarcoid0low10
Brain Anoxia0low10
Brain Cancer0low10
Brain Hypoxia0low10
Brain Metastases0low10
Brain Neoplasm, Primary0low10
Brain Neoplasms0low10
Brain Neoplasms, Benign0low10
Brain Neoplasms, Malignant0low10
Brain Neoplasms, Malignant, Primary0low10
Brain Neoplasms, Primary Malignant0low10
Brain Tumor, Primary0low10
Brain Tumor, Recurrent0low10
Brain Tumors0low10
Bronchial Hyperreactivity0low10
Bronchial Spasm0low30
Bronchospasm0low30
Cancer of Brain0low10
Cancer of the Brain0low10
Cerebral Anoxia0low10
Cerebral Astrocytoma0low50
Cerebral Hypoxia0low10
Childhood Cerebral Astrocytoma0low50
Clonic Seizure0low10
Clonic Seizures0low10
Complex Partial Seizure0low10
Complex Partial Seizures0low10
Convulsion0low10
Convulsion, Non-Epileptic0low10
Convulsions0low10
Convulsive Seizure0low10
Convulsive Seizures0low10
Cystitis0low10
Decerebrate Posturing0low10
Decerebrate State0low10
Decorticate Rigidity0low10
Decorticate State0low10
Deficiency, Oxygen0low10
Diarrhea0low10
Diffuse Parenchymal Lung Disease0low10
Diffuse Parenchymal Lung Diseases0low10
Disease Models, Animal0low20
Disease, Pulmonary0low10
Diseases, Pulmonary0low10
Dropsy0low10
Drug Withdrawal Symptoms0low10
Edema0low10
Emesis0low30
Encephalopathy, Hypoxic0low10
Epilepsy0low10
Epilepsy, Cryptogenic0low10
Epileptic Seizure0low10
Epileptic Seizures0low10
Extravasation of Contrast Media0low40
Extravasation of Diagnostic and Therapeutic Materials0low40
Extravasation of Diagnostic, Therapeutic Materials0low40
Fibrillary Astrocytoma0low50
Fibroses, Pulmonary0low10
Fibrosis, Pulmonary0low10
Gastric Ulcer0low10
Gemistocytic Astrocytoma0low50
Generalized Absence Seizure0low10
Generalized Absence Seizures0low10
Generalized Tonic-Clonic Seizures0low10
Giant Cell Glioblastoma0low10
Glioblastoma0low10
Glioblastoma Multiforme0low10
Glioma, Astrocytic0low50
Hydrops0low10
Hyperalgesia0low20
Hyperalgesia, Mechanical0low20
Hyperalgesia, Primary0low20
Hyperalgesia, Secondary0low20
Hyperalgesia, Tactile0low20
Hyperalgesia, Thermal0low20
Hyperalgesic Sensations0low20
Hyperalgia0low20
Hyperalgia, Mechanical0low20
Hyperalgia, Primary0low20
Hyperalgia, Secondary0low20
Hypersensitivity0low10
Hypertension0low10
Hypertension, Pulmonary0low10
Hypertrophy, Right Ventricular0low10
Hypotension0low20
Hypotension, Vascular0low20
Hypoxemia0low10
Hypoxia0low10
Hypoxia, Brain0low10
Hypoxia, Cerebral0low10
Hypoxic Brain Damage0low10
Hypoxic Encephalopathy0low10
Idiopathic Diffuse Interstitial Pulmonary Fibrosis0low10
Inflammation0low30
Innate Inflammatory Response0low30
Interstitial Lung Disease0low10
Interstitial Lung Diseases0low10
Intracranial Astrocytoma0low50
Intracranial Neoplasms0low10
Jacksonian Seizure0low10
Juvenile Pilocytic Astrocytoma0low50
Low Blood Pressure0low20
Lung Diseases0low10
Lung Diseases, Interstitial0low10
Malignant Neoplasms, Brain0low10
Malignant Primary Brain Neoplasms0low10
Malignant Primary Brain Tumors0low10
Mechanical Allodynia0low20
Mechanical Hyperalgesia0low20
Meningomyelocele0low10
Muscle Contraction0low250
Muscle Relaxation0low20
Myelocele0low10
Myelomeningocele0low10
Myelomeningocele, Acquired0low10
Myoclonic Seizure0low10
Myoclonic Seizures0low10
Nasal Catarrh0low10
Neoplasms, Brain0low10
Neoplasms, Brain, Benign0low10
Neoplasms, Brain, Malignant0low10
Neoplasms, Brain, Primary0low10
Neoplasms, Intracranial0low10
Nerve Pain0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neurodynia0low10
Neurogenic Bladder0low20
Neurogenic Bladder Disorder0low20
Neurogenic Bladder, Atonic0low20
Neurogenic Bladder, Spastic0low20
Neurogenic Bladder, Uninhibited0low20
Neurogenic Dysfunction of the Urinary Bladder0low20
Neurogenic Urinary Bladder Disorder0low20
Neurogenic Urinary Bladder, Atonic0low20
Neurogenic Urinary Bladder, Spastic0low20
Neurogenic Urinary Bladder, Uninhibited0low20
Neuropathic Bladder0low20
Neuropathic Pain0low10
Non-Epileptic Seizure0low10
Non-Epileptic Seizures0low10
Nonepileptic Seizure0low10
Nonepileptic Seizures0low10
Oligoastrocytoma, Mixed0low50
Oxygen Deficiency0low10
Pain0low20
Pain, Burning0low20
Pain, Crushing0low20
Pain, Migratory0low20
Pain, Radiating0low20
Pain, Splitting0low20
Paroxysmal Nerve Pain0low10
Partial Seizure0low10
Partial Seizures0low10
Petit Mal Convulsion0low10
Pilocytic Astrocytoma0low50
Pneumonia, Interstitial0low10
Pneumonitis, Interstitial0low10
Pregnancy0low10
Primary Brain Neoplasms0low10
Primary Malignant Brain Neoplasms0low10
Primary Malignant Brain Tumors0low10
Pulmonary Disease0low10
Pulmonary Diseases0low10
Pulmonary Fibroses0low10
Pulmonary Fibrosis0low10
Pulmonary Hypertension0low10
Rheumatoid Arthritis0low10
Rhinitis0low10
Right Ventricular Hypertrophy0low10
Rigidity, Decerebrate0low10
Rigidity, Decorticate0low10
Sarcoidosis0low10
Schaumann Disease0low10
Schaumann Syndrome0low10
Schaumann's Syndrome0low10
Seizure0low10
Seizure Disorder0low10
Seizures0low10
Seizures, Auditory0low10
Seizures, Clonic0low10
Seizures, Convulsive0low10
Seizures, Epileptic0low10
Seizures, Focal0low10
Seizures, Generalized0low10
Seizures, Gustatory0low10
Seizures, Motor0low10
Seizures, Olfactory0low10
Seizures, Sensory0low10
Seizures, Somatosensory0low10
Seizures, Tonic0low10
Seizures, Tonic-Clonic0low10
Seizures, Vertiginous0low10
Seizures, Vestibular0low10
Seizures, Visual0low10
Sensitivity and Specificity0low10
Single Seizure0low10
Stomach Ulcer0low10
Subependymal Giant Cell Astrocytoma0low50
Substance Withdrawal Syndrome0low10
Suffering, Physical0low20
Tachyarrhythmia0low10
Tachycardia0low10
Tactile Allodynia0low20
Thermal Allodynia0low20
Tonic Clonic Seizure0low10
Tonic Seizure0low10
Tonic Seizures0low10
Tonic-Clonic Seizure0low10
Tonic-Clonic Seizures0low10
Urinary Bladder Disorder, Neurogenic0low20
Urinary Bladder Neurogenesis0low20
Urinary Bladder Neurogenic Dysfunction0low20
Urinary Bladder, Neurogenic0low20
Vascular Hypotension0low20
Ventricular Hypertrophy, Right0low10
Vomiting0low30
Withdrawal Symptoms0low10

Research Highlights

Bioavailability (2)

ArticleYear
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue: 8		2016
The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret.
European journal of pharmacology, Feb-26, Volume: 321, Issue: 2		1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

ArticleYear
NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs.
The American review of respiratory disease, Volume: 148, Issue: 4 Pt 1		1993
Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum.
European journal of pharmacology, Aug-25, Volume: 282, Issue: 1-3		1995
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Peptides, Volume: 16, Issue: 4		1995
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]