Vitamin K-dependent gamma-carboxylase

A vitamin K-dependent gamma-carboxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P38435]

EC 4.1.1.90;
Gamma-glutamyl carboxylase;
Peptidyl-glutamate 4-carboxylase;
Vitamin K gamma glutamyl carboxylase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
menatetrenone	Homo sapiens (human)	Km	13.3000	1	1

This protein enables 2 target(s):

Target	Category	Definition
gamma-glutamyl carboxylase activity	molecular function	Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. [PMID:18374194]
vitamin binding	molecular function	Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]

This protein is located in 2 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is involved in 4 target(s):

Target	Category	Definition
blood coagulation	biological process	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128]
protein modification process	biological process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]
vitamin K metabolic process	biological process	The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
peptidyl-glutamic acid carboxylation	biological process	The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. [RESID:AA0032]