pirenzepine has been researched along with Pain in 11 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-eight of forty patients satisfactorily concluded a double-blind, placebo-controlled trial to study the effects of pirenzepine (100 mg/day) on duodenal ulcers." | 9.05 | Pirenzepine in duodenal ulcer. A six week, double-blind study. ( Daniotti, S; Do, D; Martelli, S, 1982) |
| "This open-label pilot study explored the antiemetic activity of olanzapine, an atypical antipsychotic, in patients with advanced cancer requiring opioid analgesics for pain." | 7.71 | A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. ( Cooper, M; Donaghy, K; Dugan, W; Holtsclaw, E; Kirsh, KL; Lundberg, J; Passik, SD; Theobald, D, 2002) |
| "The purpose of this study was to determine if pirenzepine and cimetidine given together was superior to cimetidine alone in inducing healing of refractory duodenal ulcers which remained unhealed after treatment with cimetidine or ranitidine for at least eight weeks." | 5.06 | Combined anti-muscarinic and H2 receptor blockade in the healing of refractory duodenal ulcer. A double blind study. ( Bardhan, KD; Bose, K; Crowe, J; Hinchliffe, RF; McCarthy, C; Thompson, M; Thompson, MH; Thomson, TJ; Walters, J; Weir, DG, 1987) |
| "Thirty-eight of forty patients satisfactorily concluded a double-blind, placebo-controlled trial to study the effects of pirenzepine (100 mg/day) on duodenal ulcers." | 5.05 | Pirenzepine in duodenal ulcer. A six week, double-blind study. ( Daniotti, S; Do, D; Martelli, S, 1982) |
| "This open-label pilot study explored the antiemetic activity of olanzapine, an atypical antipsychotic, in patients with advanced cancer requiring opioid analgesics for pain." | 3.71 | A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. ( Cooper, M; Donaghy, K; Dugan, W; Holtsclaw, E; Kirsh, KL; Lundberg, J; Passik, SD; Theobald, D, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Motta, PG | 1 |
| Perez, AC | 1 |
| Alves, DP | 1 |
| Duarte, ID | 1 |
| Chen, SR | 1 |
| Pan, HL | 1 |
| Gorski, ED | 1 |
| Willis, KC | 1 |
| Koga, K | 1 |
| Honda, K | 1 |
| Ando, S | 1 |
| Harasawa, I | 1 |
| Kamiya, HO | 1 |
| Takano, Y | 1 |
| Do, D | 1 |
| Martelli, S | 1 |
| Daniotti, S | 1 |
| Brunner, H | 1 |
| Khojainova, N | 1 |
| Santiago-Palma, J | 1 |
| Kornick, C | 1 |
| Breitbart, W | 1 |
| Gonzales, GR | 1 |
| Passik, SD | 1 |
| Lundberg, J | 1 |
| Kirsh, KL | 1 |
| Theobald, D | 1 |
| Donaghy, K | 1 |
| Holtsclaw, E | 1 |
| Cooper, M | 1 |
| Dugan, W | 1 |
| Ghelardini, C | 1 |
| Malmberg-Aiello, P | 1 |
| Giotti, A | 1 |
| Malcangio, M | 1 |
| Bartolini, A | 1 |
| Bardhan, KD | 1 |
| Thompson, M | 1 |
| Bose, K | 1 |
| Hinchliffe, RF | 1 |
| Crowe, J | 1 |
| Weir, DG | 1 |
| McCarthy, C | 1 |
| Walters, J | 1 |
| Thomson, TJ | 1 |
| Thompson, MH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients[NCT02939287] | Phase 3 | 429 participants (Actual) | Interventional | 2017-09-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for pirenzepine and Pain
| Article | Year |
|---|---|
Pirenzepine in duodenal ulcer. A six week, double-blind study.
Topics: Adult; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method | 1982 |
Pirenzepine and cimetidine in the treatment of peptic ulcer.
Topics: Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Female; Guanidines; Hum | 1982 |
Olanzapine in the management of cancer pain.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Middle Aged; N | 2002 |
Combined anti-muscarinic and H2 receptor blockade in the healing of refractory duodenal ulcer. A double blind study.
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; D | 1987 |
7 other studies available for pirenzepine and Pain
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Modulation of peripheral inflammatory pain thresholds by M(1) and nicotinic receptor antagonists.
Topics: Acetylcholine; Animals; Carrageenan; Dinoprostone; Hyperalgesia; Inflammation; Male; Mecamylamine; N | 2011 |
Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats.
Topics: Analgesics; Animals; Binding Sites; Diabetic Neuropathies; Guanosine 5'-O-(3-Thiotriphosphate); Inje | 2003 |
Report of three case studies with olanzapine for chronic pain.
Topics: Analgesics, Non-Narcotic; Benzodiazepines; Chronic Disease; Female; Humans; Middle Aged; Olanzapine; | 2003 |
Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesics; Animals; Atropine; | 2004 |
A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Benzodiazepines; Dyskinesia, Drug-Induced; | 2002 |
Investigation into atropine-induced antinociception.
Topics: Analgesics; Animals; Atropine; Dicyclomine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techn | 1990 |