Compounds > substance p, prolyl(2)-tryptophan(7,9)-
Page last updated: 2024-08-03 11:57:53
substance p, prolyl(2)-tryptophan(7,9)-
Description
substance P, prolyl(2)-tryptophan(7,9)-: substance P antagonist [MeSH]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 25078101 |
| MeSH ID | M0100459 |
Synonyms (12)
| Synonym |
|---|
| dt 79 |
| substance p, pro(2)-trp(7,9)- |
| 2-pro-7,9-trp-sp |
| l-methioninamide, l-arginyl-d-prolyl-l-lysyl-l-prolyl-l-glutaminyl-l-glutaminyl-d-tryptophyl-l-phenylalanyl-d-tryptophyl-l-leucyl- |
| 2-pro-7,9-trp-substance p |
| dt-79 |
| pttsp |
| substance p, 2-d-proline-7-d-tryptophan-9-d-tryptophan- |
| pt-sp |
| substance p, prolyl(2)-tryptophan(7,9)- |
| 80434-86-2 |
| dt79 |
Research
Studies (90)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 60 (66.67) | 18.7374 |
| 1990's | 28 (31.11) | 18.2507 |
| 2000's | 2 (2.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (1.05%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 94 (98.95%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| gamma-aminobutyric acid | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule | 1985 | 1985 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| ammonium hydroxide | | azane;
gas molecular entity;
mononuclear parent hydride | EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| choline | | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| formaldehyde | | aldehyde;
one-carbon compound | allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| histamine | | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter | 1983 | 1992 | 36.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| hydroquinone | | benzenediol;
hydroquinones | antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-amino-5-phosphonovalerate | | non-proteinogenic alpha-amino acid | NMDA receptor antagonist | 1990 | 1991 | 33.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| baclofen | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound | central nervous system depressant;
GABA agonist;
muscle relaxant | 1984 | 1986 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| verapamil | | aromatic ether;
nitrile;
polyether;
tertiary amino compound | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cimetidine | | aliphatic sulfide;
guanidines;
imidazoles;
nitrile | adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor | 1984 | 1986 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| clonidine | | clonidine;
imidazoline | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| diphenhydramine | | ether;
tertiary amino compound | anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| erythrosine | | | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| guanethidine | | azocanes;
guanidines | adrenergic antagonist;
antihypertensive agent;
sympatholytic agent | 1982 | 1986 | 39.5 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| haloperidol | | aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol | antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| hexamethonium | | quaternary ammonium salt | | 1985 | 1985 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| lidocaine | | benzenes;
monocarboxylic acid amide;
tertiary amino compound | anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic | 1987 | 1992 | 34.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| indomethacin | | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic | 1984 | 1997 | 33.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| isoproterenol | | catechols;
secondary alcohol;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ketanserin | | aromatic ketone;
organofluorine compound;
piperidines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| benoxinate | | amino acid ester;
benzoate ester;
substituted aniline;
tertiary amino compound | drug allergen;
local anaesthetic;
topical anaesthetic | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pentobarbital | | barbiturates | GABAA receptor agonist | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenoxybenzamine | | aromatic amine | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| procaine | | benzoate ester;
substituted aniline;
tertiary amino compound | central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug | 1984 | 1986 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| propranolol | | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic | 1983 | 1986 | 39.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| pyrilamine | | aromatic ether;
ethylenediamine derivative | H1-receptor antagonist | 1986 | 1991 | 36.3 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| tripelennamine | | aromatic amine | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| urethane | | carbamate ester | fungal metabolite;
mutagen | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| corticosterone | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phentolamine | | imidazoles;
phenols;
substituted aniline;
tertiary amino compound | alpha-adrenergic antagonist;
vasodilator agent | 1983 | 1990 | 37.5 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| carbachol | | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic | 1984 | 1984 | 40.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| pilocarpine | | pilocarpine | antiglaucoma drug | 1985 | 1987 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| physostigmine | | carbamate ester;
indole alkaloid | antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenylephrine | | phenols;
phenylethanolamines;
secondary amino compound | alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| methacholine chloride | | quaternary ammonium salt | | 1985 | 1992 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| gallamine triethiodide | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| arginine | | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyrrolidonecarboxylic acid | | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite | 1985 | 1990 | 36.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| yohimbine | | methyl 17-hydroxy-20xi-yohimban-16-carboxylate | alpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| hemicholinium 3 | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methysergide | | ergoline alkaloid | | 1987 | 1990 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| bicuculline | | benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines | agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin | 1984 | 1985 | 39.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| kainic acid | | dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid | antinematodal drug;
excitatory amino acid agonist | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Brilliant Blue | | organic molecular entity | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n-methylaspartate | | amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound | neurotransmitter agent | 1990 | 1991 | 33.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| metergoline | | carbamate ester;
ergoline alkaloid | dopamine agonist;
geroprotector;
serotonergic antagonist | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| glutamic acid | | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| substance p | | peptide | neurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent | 1981 | 2005 | 36.7 | high | 0 | 60 | 28 | 2 | 0 | 0 |
| mezlocillin | | | | 1984 | 1984 | 40.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| methacycline | | 1,2-diglyceride | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ubenimex | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| p-methoxy-n-methylphenethylamine | | aromatic ether;
secondary amino compound | metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| fpl 55712 | | aromatic ketone | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fk 888 | | peptide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| substance p (6-11) | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| substance p, methyl ester- | | | | 1984 | 1995 | 34.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| bradykinin, leu(8)-des-arg(9)- | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)fluorescein | | | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| glycerophosphoinositol 4,5-bisphosphate | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| substance p, sar(9)-met(o2)(11)- | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| atropine | | | | 1982 | 1992 | 38.8 | low | 0 | 10 | 1 | 0 | 0 | 0 |
| fibrin | | peptide | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| bradykinin | | oligopeptide | human blood serum metabolite;
vasodilator agent | 1983 | 1990 | 38.5 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| inositol 1,4,5-trisphosphate | | myo-inositol trisphosphate | mouse metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nitroarginine | | guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pentazocine | | benzazocine | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phosphoramidon | | deoxyaldohexose phosphate;
dipeptide | bacterial metabolite;
EC 3.4.24.11 (neprilysin) inhibitor;
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| enkephalin, leucine | | pentapeptide;
peptide zwitterion | analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite | 1982 | 1994 | 36.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| arginine vasopressin | | vasopressin | cardiovascular drug;
hematologic agent;
mitogen | 1993 | 1993 | 31.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 1983 | 1995 | 36.2 | low | 0 | 8 | 5 | 0 | 0 | 0 |
| thiopental | | barbiturates | anticonvulsant;
drug allergen;
environmental contaminant;
intravenous anaesthetic;
sedative;
xenobiotic | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| substance p | | pentapeptide | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alpha-chymotrypsin | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dinoprostone | | prostaglandins E | human metabolite;
mouse metabolite;
oxytocic | 1983 | 1997 | 35.3 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| dinoprost | | monocarboxylic acid;
prostaglandins Falpha | human metabolite;
mouse metabolite | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| alprostadil | | prostaglandins E | anticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| prostaglandin f1 | | prostaglandins Falpha | human metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-palmitoyl-2-oleoylglycero-3-phosphoglycerol | | phosphatidylglycerol | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nalorphine | | morphinane alkaloid | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| naloxone | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol | antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist | 1985 | 1991 | 37.0 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 1983 | 1990 | 37.8 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| neurokinin a | | | | 1986 | 1995 | 34.4 | low | 0 | 2 | 3 | 0 | 0 | 0 |
| neurokinin b | | polypeptide | | 1984 | 1995 | 35.6 | low | 0 | 4 | 3 | 0 | 0 | 0 |
| naltrexone | | cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound | antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| biphalin | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| guanabenz | | dichlorobenzene | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tetrodotoxin | | azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid | animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker | 1983 | 1985 | 39.7 | low | 0 | 6 | 0 | 0 | 0 | 0 |
| 1-palmitoyl-2-oleoylphosphatidylcholine | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sincalide | | oligopeptide | | 1983 | 1984 | 40.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| eledoisin | | peptide | | 1981 | 1984 | 41.0 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| substance p | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| physalaemin | | | | 1981 | 1984 | 40.6 | low | 0 | 5 | 0 | 0 | 0 | 0 |
| dynorphins | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| substance p (4-11), pro(4)-trp(7,9,10)- | | | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| vasoactive intestinal peptide (10-28) | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phosphatidylcholines | | 1,2-diacyl-sn-glycero-3-phosphocholine | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lhrh, pglu(1)-phe(2)-trp(3,6)- | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| substance p, arg(1)-pro(2)-trp(7,9)-leu(11)- | | | | 1988 | 2005 | 29.7 | medium | 0 | 1 | 1 | 1 | 0 | 0 |
| substance p, pro(2)-phe(7)-trp(9)- | | | | 1984 | 1988 | 39.0 | medium | 0 | 4 | 0 | 0 | 0 | 0 |
| substance p, arg(1)-pro(2)-trp(7),(9)-leunh(2)(11)- | | | | 1984 | 1992 | 36.8 | medium | 0 | 3 | 2 | 0 | 0 | 0 |
| piperidines | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| vasoactive intestinal peptide | | | | 1985 | 1993 | 35.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| d-ala(2),mephe(4),met(0)-ol-enkephalin | | | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye.Science (New York, N.Y.), , Nov-27, Volume: 214, Issue:4524, 1981
A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.British journal of pharmacology, , Volume: 99, Issue:3, 1990
A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye.Science (New York, N.Y.), , Nov-27, Volume: 214, Issue:4524, 1981
Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor.Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 342, Issue:6, 1990
Studies on effects of the substance P analogues [D-Pro2, D-Trp7,9]-substance P and [D-Arg1, D-Trp7,9, L-Leu11]-substance P not related to their antagonist action.Naunyn-Schmiedeberg's archives of pharmacology, , Volume: 333, Issue:3, 1986
Differentiation of multiple neurokinin receptors in the guinea pig ileum.Life sciences, , Nov-24, Volume: 39, Issue:21, 1986
A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.British journal of pharmacology, , Volume: 89, Issue:3, 1986
Effects of substance P on inositol triphosphate accumulation, on contractile responses and on arachidonic acid release and prostaglandin biosynthesis in rabbit iris sphincter muscle.Experimental eye research, , Volume: 43, Issue:2, 1986
On the nature of the contractile motor responses of the rat stomach elicited by serotonin or substance P in vitro.Journal of neural transmission, , Volume: 63, Issue:1, 1985
Pupillary supersensitivity to substance P following prolonged treatment with tetrodotoxin or substance P antagonists.European journal of pharmacology, , Feb-05, Volume: 108, Issue:3, 1985
Structure-activity relationship of C-terminal hexa- and heptapeptide substance P antagonists as studied in the guinea-pig ileum.European journal of pharmacology, , Oct-01, Volume: 105, Issue:1-2, 1984
Are the proposed substance P receptor sub-types, substance P receptors?Life sciences, , Aug-20, Volume: 35, Issue:8, 1984
Capsaicin and bradykinin-induced substance P-ergic responses in the iris sphincter muscle of the rabbit.The Journal of pharmacology and experimental therapeutics, , Volume: 230, Issue:2, 1984
A study of [D-Pro2, D-Phe7, D-Trp9]-substance P and [D-Trp7,9]-substance P as tachykinin partial agonists in the rat colon.British journal of pharmacology, , Volume: 82, Issue:2, 1984
Neuronally mediated non-cholinergic contraction of guinea-pig bronchial smooth muscle is inhibited by a substance P antagonist.Agents and actions, , Volume: 14, Issue:3-4, 1984
The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP.British journal of pharmacology, , Volume: 77, Issue:4, 1982
Evaluation of (D-Pro2, D-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system.Neuroscience letters, , Jun-30, Volume: 30, Issue:3, 1982
A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation.Nature, , Dec-03, Volume: 294, Issue:5840, 1981
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.Life sciences, , Volume: 54, Issue:14, 1994
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.Pain, , Volume: 44, Issue:2, 1991
Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons.Brain research, , Sep-03, Volume: 526, Issue:2, 1990
Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats.Neuroscience, , Volume: 39, Issue:3, 1990
Intradermal hypertonic saline-induced behavior as a nociceptive test in mice.Life sciences, , Jun-30, Volume: 38, Issue:26, 1986
Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration.Neuroscience letters, , Jun-12, Volume: 57, Issue:2, 1985
Characterization of the hyperalgesic effect induced by intrathecal injection of substance P.Neuropharmacology, , Volume: 24, Issue:5, 1985
Calcitonin gene-related peptide and substance P induce pronounced motor effects in the female rat urethra in vivo.Scandinavian journal of urology and nephrology, , Volume: 37, Issue:4, 2003
A substance P analogue reduces amino acid contents in the rat spinal cord.Pharmacology & toxicology, , Volume: 66, Issue:1, 1990
Intrathecal substance P analogue causes motor dysfunction in the rat.Neuropharmacology, , Volume: 24, Issue:8, 1985
A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye.Science (New York, N.Y.), , Nov-27, Volume: 214, Issue:4524, 1981
A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.British journal of pharmacology, , Volume: 99, Issue:3, 1990
A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye.Science (New York, N.Y.), , Nov-27, Volume: 214, Issue:4524, 1981
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.Life sciences, , Volume: 54, Issue:14, 1994
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.Pain, , Volume: 44, Issue:2, 1991
Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats.Neuroscience, , Volume: 39, Issue:3, 1990
Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons.Brain research, , Sep-03, Volume: 526, Issue:2, 1990
Intradermal hypertonic saline-induced behavior as a nociceptive test in mice.Life sciences, , Jun-30, Volume: 38, Issue:26, 1986
Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration.Neuroscience letters, , Jun-12, Volume: 57, Issue:2, 1985
Characterization of the hyperalgesic effect induced by intrathecal injection of substance P.Neuropharmacology, , Volume: 24, Issue:5, 1985
Calcitonin gene-related peptide and substance P induce pronounced motor effects in the female rat urethra in vivo.Scandinavian journal of urology and nephrology, , Volume: 37, Issue:4, 2003
A substance P analogue reduces amino acid contents in the rat spinal cord.Pharmacology & toxicology, , Volume: 66, Issue:1, 1990
Intrathecal substance P analogue causes motor dysfunction in the rat.Neuropharmacology, , Volume: 24, Issue:8, 1985
Safety/Toxicity (1)
Long-term Use (1)
Dosage (4)
| Article | Year |
|---|
A study of [D-Pro2, D-Phe7, D-Trp9]-substance P and [D-Trp7,9]-substance P as tachykinin partial agonists in the rat colon.
British journal of pharmacology, , Volume: 82, Issue:2 | 1984 |
Interaction of substance P antagonists with substance P receptors on dispersed pancreatic acini.
Biochimica et biophysica acta, , Jun-19, Volume: 804, Issue:2 | 1984 |
Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons.
Brain research, , Sep-03, Volume: 526, Issue:2 | 1990 |
Study on the dye leakage response of nasal mucosa following topical, capsaicin challenge in guinea pigs.
Acta oto-laryngologica, , Volume: 112, Issue:3 | 1992 |