alpha-chymotrypsin and Pain

Topics: Animals; Cholecystokinin; Chronic Disease; Chymotrypsin; Enzyme Therapy; Exocrine Pancreatic Insufficiency; Feedback; Female; Humans; Male; Pain; Pancreas; Pancreatitis; Rats; Trypsin

To evaluate changes on venous diameter and perimeter of lower limbs in chronic venous disorder (CVD) patients after different clinical treatments for four weeks.. Fifty-two female patients classified as C2,s or C2,3,s (CEAP classification) were allocated consecutively in three groups: Cirkan (40 mg of the root extract of Ruscus aculeatus + 100 mg of flavonoid hesperidine methylchalcone + 200 mg of vitamin C per pill); elastic compression stockings (ECS) and no treatment (NT). Diameters were determined by duplex ultrasound and perimeter with Leg-O-Meter.. After treatment, Cirkan significantly decreased popliteal vein and great saphenous vein (GSV) diameters bilaterally and ECS decreased popliteal vein diameter bilaterally and GSV and varices only on the left limb. Perimeters changed only with ECS. Clinical scores changed between Cirkan x NT and ECS x Cirkan. Disability score varied for ECS x NT and Cirkan x NT. chi2 test detected different distribution frequency for C3 and C2 classes according to treatment: ECS (both limbs) and Cirkan (only left limb). Varices and anatomical scores did not change.. ECS emerges as the most effective clinical treatment tested but improvements with Cirkan on vein diameter and CEAP class were also observed. Clinical scores improved due to pain relief and edema reduction (ECS). These findings point to a positive effect of Cirkan, suggesting that venotonic drugs should be taken into account in the treatment of CVD.

Topics: Adult; Anthropometry; Ascorbic Acid; Brazil; Cardiovascular Agents; Chi-Square Distribution; Chronic Disease; Chymotrypsin; Disability Evaluation; Drug Combinations; Female; Hesperidin; Humans; Lower Extremity; Middle Aged; Pain; Pain Measurement; Phytosterols; Popliteal Vein; Saphenous Vein; Stockings, Compression; Time Factors; Treatment Outcome; Trypsin; Ultrasonography, Doppler, Duplex; Vascular Diseases

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Episiotomy; Female; Hematoma; Humans; Inflammation; Pain; Placebos; Postoperative Complications; Pregnancy; Tablets, Enteric-Coated; Wound Healing

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Episiotomy; Female; Humans; Pain; Placebos; Postoperative Complications; Pregnancy

We report our initial clinical experience with local transrectal application of enzymatic treatment for chronic nonbacterial prostatitis and prostatodynia in 20 patients. Using a specially designed symptom score for evaluation of subjective treatment parameters, a statistically significant improvement of symptoms was found in the areas of pain, micturition, and recreational activities. No statistically significant differences were noted in laboratory values before and after treatment. Minimal local side effects were seen in only one patient. A favorable clinical response was noted in 75% of patients, whereas the remaining 25% showed only moderate improvement of symptoms. No patient experienced complete treatment failure.

Topics: Adjuvants, Immunologic; Administration, Rectal; Adult; Aged; Aged, 80 and over; Chronic Disease; Chymotrypsin; Drug Combinations; Humans; Male; Middle Aged; Pain; Pain Measurement; Pancreatic Extracts; Papain; Prostatic Diseases; Prostatitis; Retrospective Studies; Thymus Extracts; Treatment Outcome; Trypsin

Human cerebrospinal fluid (CSF) contains many uncharacterized endogenous opioids, in addition to the known enkephalins, endorphins, and dynorphins. These opioids may be separated by gel filtration chromatography and identified by radioreceptor assay for opioid activity. One region of the chromatographic elution profile, designated "Peak B" has previously been shown to be related to the pain status of chronic pain patients. We now report that human Peak B isolated from the CSF of pain-free elective surgery patients is present at a typical concentration equivalent in activity to 1.4 pmol of morphine sulfate per ml of CSF measured by radioreceptor assay. At a dose of 0.06 and 0.12 pmol morphine sulfate equivalents of CSF (MSE), injected into the cerebroventricular system of the mouse, Peak B produced an antinociceptive effect, the intensity and duration of which was dose-dependent and which was antagonized by naloxone. The mouse vas deferens (MVD) preparation was inhibited by Peak B in a manner that was sensitive to antagonism by naloxone only at low (less than 1.0 microM) but not at higher (greater than 6.0 microM) concentrations of the antagonist. Peak B activity in the MVD assay was unaffected by treatment with trypsin or alpha-chymotrypsin.

Topics: Animals; Chromatography, Gel; Chymotrypsin; Endorphins; Humans; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Pain; Radioligand Assay; Trypsin; Vas Deferens

Following a prolonged and unsuccessful treatment, 50 patients with severe compression-radical forms of lumbar osteochondritis received--under roentgenographic control--a course of epidural injections of drugs (trimecaine, chymotrypsin and lydasa). A considerable improvement was observed in 60% of the patients, which indicates that the method is effective.

Topics: Acetanilides; Adult; Chymotrypsin; Dexamethasone; Drug Combinations; Female; Humans; Lumbar Vertebrae; Male; Middle Aged; Nerve Compression Syndromes; Osteochondritis; Pain; Spinal Diseases; Spinal Nerve Roots; Trimecaine

The purposes of this study were to (a) evaluate the effect of pancreatic extract administered to patients with chronic pancreatitis and recurrent abdominal pain in a placebo-controlled, double-blind crossover study, (b) investigate the effects of acute intraduodenal pancreatic enzyme perfusion on pancreatic secretion, and (c) assess the effect of chronic, noninterrupted pancreatic extract administration on basal and stimulated pancreatic secretion. These studies demonstrated that pancreatic extract decreases abdominal pain and that intraduodenal perfusion with proteases but not with amylase or lipase suppresses pancreatic exocrine secretion in patients with chronic pancreatitis. Chronic administration of pancreatic extract to patients with chronic pancreatitis decreased both basal and stimulated pancreatic exocrine secretion.

Topics: Abdomen; Adult; Aged; Amylases; Chronic Disease; Chymotrypsin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Ovomucin; Pain; Pancreas; Pancreatic Extracts; Pancreatitis; Perfusion; Placebos; Trypsin

Pancreas divisum was demonstrated in 22 of 500 consecutive ERCP (4.4%). Among patients with otherwise normal ERCP, pancreas divisum was found in 12.8%. In contrast, only 1.8% of patients with other pathology in the ERCP exhibited pancreas divisum (p less than 0.001). In relation to the clinical indication, pancreas divisum was found in 13.3% of patients with suspected or proven pancreatitis, in 1.9% of patients with suspicion of biliary tract disease (p less than 0.001), in 1.9% of patients with suspicion of pancreatic cancer (p less than 0,05) and in 4.4% of patients with epigastric pain of undetermined origin (p greater than 0.05). In 14 patients pancreas divisum was the only pathological finding in a thorough clinical and gastrointestinal workup; 6 of the 14 patients had had typical episodes of pancreatitis, in 6 other patients there was clinical and biochemical evidence of pancreatic disease (mainly pain and hyperenzymemia), and the last 2 cases had chronic epigastric pain without biochemical abnormalities. In 2 patients of this series the pancreas divisum was misinterpreted morphologically (sonography, autopsy) as tumor of the head of the pancreas. Based upon our experience and the literature, the following practical conclusions can be drawn: 1. Pancreas divisum may cause typical episodes of acute (relapsing) pancreatitis. 2. In patients with chronic epigastric pain associated with hyperenzymemia but without typical acute pancreatitis, pancreas divisum may be the cause. 3. Morphologically pancreas divisum may mimic a pancreatic tumor (sonography, computer-tomography, autopsy).

Topics: Abdomen; Adult; Aged; Amylases; Cholangiopancreatography, Endoscopic Retrograde; Chymotrypsin; Feces; Female; Humans; Lipase; Male; Middle Aged; Pain; Pancreas; Pancreatic Diseases; Pancreatitis

Topics: Breast Diseases; Chymotrypsin; Female; Humans; Methandriol; Methyltestosterone; Pain; Parathyroid Hormone; Thiamine

Ten adolescent and young adults with cystic fibrosis (CF) have had well-documented recurrent attacks of acute pancreatitis. The diagnosis of CF in each patient was delayed because they did not have pancreatic insufficiency. The diagnosis of CF was documented by the typical pulmonary involvement and elevated sweat sodium and chloride levels in all cases and a positive family history in six of the ten patients. Two patients were diagnosed as having acute pancreatitis before the diagnosis of CF was made, thus indicating that acute pancreatitis may be the presenting complaint in the young adult with CF. The diagnosis of acute pancreatitis was based on the presence of severe abdominal pain, usually with vomiting, tenderness in the mid-epigastrium, elevated serum and urinary amylase and serum lipase. Attacks were precipitated by fatty meals, alcohol ingestion; postcholecystectomy and tetracycline administration. In some patients no precipitating event could be elicited. Intravenous secretin-pancreozymin stimulation tests revealed a diminished bicarbonate secretion with little effect on the secretion of the zymogen enzymes. A mild attack of pancreatitis occurred after secretin-pancreozymin stimulation. The endocrine pancreatic function tested in four patients was normal as revealed by the glucose tolerance tests and determinations of serum insulin, growth hormone and free fatty acid. Transduodenal pancreatograms were performed in three patients; one showed a normal pancreatic duct, one showed duct obstruction and in the third patient a beady type of narrowing was found. The selenomethionine Se 75 uptake of the pancreas was noted only in the head of the pancreas. This suggests that loss of function occurs initially to a greater extent in the tail and body of the pancreas. Three patients died and showed characteristic lesions of CF.

Topics: Acute Disease; Adolescent; Adult; Amylases; Chlorides; Cholecystokinin; Chymotrypsin; Cystic Fibrosis; Female; Glucose Tolerance Test; Humans; Intubation, Gastrointestinal; Lipase; Magnesium; Male; Methionine; Pain; Pancreas; Pancreatitis; Potassium; Recurrence; Secretin; Selenium; Sodium; Trypsin

Topics: Amylases; Chronic Disease; Chymotrypsin; Cytodiagnosis; Diet Therapy; Duodenum; Feces; Humans; Intestinal Secretions; Pain; Pancreatin; Pancreatitis; Radiography; Radionuclide Imaging; Tolbutamide

Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Biomedical Research; Chymotrypsin; Drug Therapy; Episiotomy; Female; Humans; Pain; Postoperative Complications; Pregnancy

Topics: Chymotrypsin; Edema; Episiotomy; Female; Hematologic Tests; Humans; Labor, Obstetric; Lacerations; Pain; Pregnancy; Sutures; Trypsin

Topics: Chymotrypsin; Dermatologic Agents; Edema; Episiotomy; Female; Humans; Pain; Peptide Hydrolases; Pregnancy

Topics: Chymotrypsin; Episiotomy; Female; Hematologic Tests; Pain; Pregnancy; Trypsin