pentylenetetrazole has been researched along with Pain in 29 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In PTZ seizure model Kyo and its analogues exerted strong inhibition on seizure intensity compared with control group." | 5.32 | Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. ( Bocheva, AI; Dzambazova-Maximova, EB, 2004) |
| " The initial anticonvulsant screening was performed in mice (ip) using the 'classical' maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests as well as in the six-Hertz (6Hz) model of pharmacoresistant limbic seizures." | 3.83 | New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones. ( Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ, 2016) |
| " The analgesic and anticonvulsant effects of piperine were studied in mice using acetic acid-induced writhing, tail flick assay, pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures models." | 3.79 | The analgesic and anticonvulsant effects of piperine in mice. ( Alhumayyd, MS; Bukhari, IA; Gilani, AH; Mahesar, AL; Pivac, N, 2013) |
| " A number of VPA analogues and their amide, N-methylamide and urea derivatives, were synthesized and evaluated in animal models of neuropathic pain and epilepsy." | 3.75 | Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. ( Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B, 2009) |
| " rupestris (100 mg/kg, intraperitoneally) in pentylenetetrazole-induced seizures on mice." | 3.74 | Neuropharmacological effects in mice of Lychnophora species (Vernonieae, Asteraceae) and anticonvulsant activity of 4,5-di-O-[E]-caffeoylquinic acid isolated from the stem of L. rupestris and L. staavioides. ( Lopes, JL; Lopes, NP; Mortari, MR; Santos, WF; Taleb-Contini, SH, 2008) |
| "001) delayed the onset of, and antagonized, pentylenetetrazole (PTZ)-induced seizures." | 3.73 | Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice. ( Ojewole, JA, 2005) |
| "The involvement of endogenous opioids and nitric oxide (NO) in the anticonvulsant effects of stress against pentylenetetrazole (PTZ)- or electroconvulsive shock-induced seizures was assessed in mice." | 3.71 | The involvement of endogenous opioids and nitricoxidergic pathway in the anticonvulsant effects of foot-shock stress in mice. ( Dehpour, AR; Homayoun, H; Khavandgar, S, 2002) |
| "0 mg/kg pentylenetetrazole, PTZ) would also reduce nociception; c) if exposure to the EPM would alter visceral pain, as measured by the abdominal contortion test." | 3.68 | Anxiety-induced antinociception in the mouse. ( Conceição, IM; Frussa-Filho, R; Maiolini Júnior, M; Mattia, N; Santos, BR; Smaili, S; Vital, MA, 1992) |
| "Finally, we showed that kainate induced seizures and glycemia were not modified by spadin treatments." | 1.38 | Spadin as a new antidepressant: absence of TREK-1-related side effects. ( Borsotto, M; Coppola, T; Gandin, C; Heurteaux, C; Labbal, F; Mazella, J; Moha Ou Maati, H; Veyssiere, J; Widmann, C, 2012) |
| " Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio." | 1.36 | Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010) |
| "Convulsions were followed by statistically significant increase in the tail-flick latencies (TFL), at least for 120 min of the postictal period." | 1.33 | Intrinsic neural circuits between dorsal midbrain neurons that control fear-induced responses and seizure activity and nuclei of the pain inhibitory system elaborating postictal antinociceptive processes: a functional neuroanatomical and neuropharmacologi ( Carvalho, AD; Coimbra, NC; Elias-Filho, DH; Ferreira, CM; Freitas, RL; Garcia-Cairasco, N; Ribeiro, SJ, 2005) |
| "Convulsions were followed by statistically significant increase in the tail-flick latencies (TFL), at least for 120 min of the post-ictal period." | 1.33 | Involvement of 5-HT(2) serotonergic receptors of the nucleus raphe magnus and nucleus reticularis gigantocellularis/paragigantocellularis complex neural networks in the antinociceptive phenomenon that follows the post-ictal immobility syndrome. ( Coimbra, NC; de Oliveira, R; de Oliveira, RC; Ferreira, CM, 2006) |
| "In PTZ seizure model Kyo and its analogues exerted strong inhibition on seizure intensity compared with control group." | 1.32 | Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. ( Bocheva, AI; Dzambazova-Maximova, EB, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.79) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Obniska, J | 3 |
| Góra, M | 1 |
| Rapacz, A | 3 |
| Sałat, K | 1 |
| Rybka, S | 1 |
| Abram, M | 2 |
| Jakubiec, M | 1 |
| Kamiński, K | 3 |
| Khan, H | 1 |
| Khan, MA | 1 |
| Hussain, S | 1 |
| Gaffar, R | 1 |
| Ashraf, N | 1 |
| Bukhari, IA | 1 |
| Pivac, N | 1 |
| Alhumayyd, MS | 1 |
| Mahesar, AL | 1 |
| Gilani, AH | 1 |
| Wujec, M | 1 |
| Kędzierska, E | 1 |
| Kuśmierz, E | 1 |
| Plech, T | 1 |
| Wróbel, A | 1 |
| Paneth, A | 1 |
| Orzelska, J | 1 |
| Fidecka, S | 1 |
| Paneth, P | 1 |
| Zagaja, M | 1 |
| Łuszczki, JJ | 1 |
| Andres-Mach, M | 1 |
| Koczurkiewicz, P | 1 |
| Pękala, E | 1 |
| Filipek, B | 1 |
| Kaufmann, D | 2 |
| Bialer, M | 2 |
| Shimshoni, JA | 1 |
| Devor, M | 1 |
| Yagen, B | 2 |
| Pessah, N | 1 |
| Hen, N | 1 |
| Wlodarczyk, B | 1 |
| Finnell, RH | 1 |
| Moha Ou Maati, H | 1 |
| Veyssiere, J | 1 |
| Labbal, F | 1 |
| Coppola, T | 1 |
| Gandin, C | 1 |
| Widmann, C | 1 |
| Mazella, J | 1 |
| Heurteaux, C | 1 |
| Borsotto, M | 1 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Bruni, F | 1 |
| Selleri, S | 1 |
| Martini, C | 1 |
| Daniele, S | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Costanzo, A | 1 |
| El-Azab, MF | 1 |
| Moustafa, YM | 1 |
| FROMMEL, E | 1 |
| FLEURY, C | 1 |
| LEDEBUR, IV | 1 |
| BEGUIN, M | 1 |
| FAMILY, S | 1 |
| Bocheva, AI | 1 |
| Dzambazova-Maximova, EB | 1 |
| Freitas, RL | 1 |
| Ferreira, CM | 2 |
| Ribeiro, SJ | 1 |
| Carvalho, AD | 1 |
| Elias-Filho, DH | 1 |
| Garcia-Cairasco, N | 1 |
| Coimbra, NC | 2 |
| Kenunen, OG | 2 |
| Prakh'e, IV | 2 |
| Ojewole, JA | 1 |
| Kozlovskii, VL | 1 |
| de Oliveira, RC | 1 |
| de Oliveira, R | 1 |
| Taleb-Contini, SH | 1 |
| Santos, WF | 1 |
| Mortari, MR | 1 |
| Lopes, NP | 1 |
| Lopes, JL | 1 |
| Li, YW | 1 |
| Zhu, XY | 1 |
| But, PP | 1 |
| Yeung, HW | 1 |
| Jenck, F | 1 |
| Wichmann, J | 1 |
| Dautzenberg, FM | 1 |
| Moreau, JL | 1 |
| Ouagazzal, AM | 1 |
| Martin, JR | 1 |
| Lundstrom, K | 1 |
| Cesura, AM | 1 |
| Poli, SM | 1 |
| Roever, S | 1 |
| Kolczewski, S | 1 |
| Adam, G | 1 |
| Kilpatrick, G | 1 |
| Mandal, SC | 1 |
| Dhara, AK | 1 |
| Maiti, BC | 1 |
| Homayoun, H | 1 |
| Khavandgar, S | 1 |
| Dehpour, AR | 1 |
| Bruins Slot, LA | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Ribet, JP | 1 |
| Colpaert, FC | 1 |
| Conceição, IM | 1 |
| Maiolini Júnior, M | 1 |
| Mattia, N | 1 |
| Vital, MA | 1 |
| Santos, BR | 1 |
| Smaili, S | 1 |
| Frussa-Filho, R | 1 |
| Yehuda, S | 1 |
| Carasso, RL | 1 |
| Mostofsky, DI | 1 |
| Antelman, SM | 1 |
| Knopf, S | 1 |
| Kocan, D | 1 |
| Edwards, DJ | 1 |
| Ritchie, JC | 1 |
| Nemeroff, CB | 1 |
| Beckett, AH | 1 |
| Hunter, WH | 1 |
| Kourounakis, P | 1 |
| Baldy-Moulinier, M | 1 |
| Ingvar, DH | 1 |
29 other studies available for pentylenetetrazole and Pain
| Article | Year |
|---|---|
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pain | 2021 |
In vivo antinociceptive and anticonvulsant activity of extracts of Heliotropium strigosum.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Heliotropium; Male; | 2016 |
The analgesic and anticonvulsant effects of piperine in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anticonvulsants; Benzodioxoles; Hot Temperature; Male; | 2013 |
Pharmacological and structure-activity relationship evaluation of 4-aryl-1-diphenylacetyl(thio)semicarbazides.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Male; Mice; Molecular Conformation; Molecular Doc | 2014 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2016 |
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Motor Ac | 2017 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rat | 2009 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo | 2010 |
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Topics: Animals; Antidepressive Agents; Biophysical Phenomena; Blood Glucose; Brain Infarction; CD8 Antigens | 2012 |
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.
Topics: Animals; Anti-Anxiety Agents; Cattle; Hyperalgesia; Male; Mice; Pain; Pentylenetetrazole; Radioligan | 2011 |
Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Synergi | 2012 |
THE PLACE OF ACETYLSALICYLIC ACID IN PSYCHOPHARMACOLOGY. AN EXPERIMENTAL STUDY.
Topics: Amphetamine; Amphetamines; Animals; Aspirin; Body Temperature Regulation; Chlordiazepoxide; Chlorpro | 1963 |
Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures.
Topics: Analgesics; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Endorphins; Male; Pain; P | 2004 |
Intrinsic neural circuits between dorsal midbrain neurons that control fear-induced responses and seizure activity and nuclei of the pain inhibitory system elaborating postictal antinociceptive processes: a functional neuroanatomical and neuropharmacologi
Topics: Adrenergic Antagonists; Animals; Biogenic Monoamines; Fear; Inferior Colliculi; Locus Coeruleus; Mal | 2005 |
[Is stress-induced analgesia a measure of stress severity?].
Topics: Animals; Cold Temperature; Immobilization; Male; Mice; Pain; Pentylenetetrazole; Severity of Illness | 2005 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male | 2005 |
Changes in anxiety levels are followed by changes in behavioral strategy in mice subjected to stress and in the extent of stress-induced analgesia.
Topics: Adaptation, Physiological; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convu | 2006 |
Involvement of 5-HT(2) serotonergic receptors of the nucleus raphe magnus and nucleus reticularis gigantocellularis/paragigantocellularis complex neural networks in the antinociceptive phenomenon that follows the post-ictal immobility syndrome.
Topics: Analgesia; Analysis of Variance; Animals; Behavior, Animal; Brain; Male; Medulla Oblongata; Models, | 2006 |
Neuropharmacological effects in mice of Lychnophora species (Vernonieae, Asteraceae) and anticonvulsant activity of 4,5-di-O-[E]-caffeoylquinic acid isolated from the stem of L. rupestris and L. staavioides.
Topics: Analgesics; Animals; Anticonvulsants; Asteraceae; Dose-Response Relationship, Drug; Male; Mice; Mono | 2008 |
Ethnopharmacology of bear gall bladder: I.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Bile; Bile Ac | 1995 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; | 2000 |
Studies on psychopharmacological activity of Andrographis paniculata extract.
Topics: Acetic Acid; Animals; Behavior, Animal; Magnoliopsida; Mice; Pain; Pain Measurement; Pentylenetetraz | 2001 |
The involvement of endogenous opioids and nitricoxidergic pathway in the anticonvulsant effects of foot-shock stress in mice.
Topics: Animals; Convulsants; Differential Threshold; Disease Susceptibility; Electroshock; Endorphins; Foot | 2002 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
Anxiety-induced antinociception in the mouse.
Topics: Analgesia; Animals; Anxiety; Male; Mice; Pain; Pain Measurement; Pentylenetetrazole; Random Allocati | 1992 |
The effect of pain on pentylenetetrazol induced seizures.
Topics: Animals; Formaldehyde; Male; Pain; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1991 |
One stressful event blocks multiple actions of diazepam for up to at least a month.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebral Cortex; Diazepam; Dopamine; Male; Pain; Pentylenet | 1988 |
Synthesis and pharmacological action of some N-alkyl morpholines and their salts.
Topics: Acetylcholine; Animals; Female; Magnetic Resonance Spectroscopy; Mice; Morpholines; Nicotine; Pain; | 1968 |
EEG frequency content related to regional blood flow of cerebral cortex in cat.
Topics: Animals; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Fentanyl; Krypt | 1968 |