A 4-hydroxy-2-oxoglutarate aldolase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XE5]
EC 4.1.3.16;
Dihydrodipicolinate synthase-like;
DHDPS-like protein;
Probable 2-keto-4-hydroxyglutarate aldolase;
Probable KHG-aldolase;
Protein 569272
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| chelidamic acid | Homo sapiens (human) | Ki | 170.0000 | 1 | 1 |
| dipicolinic acid | Homo sapiens (human) | Ki | 11,000.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| 4-hydroxy-2-oxoglutarate aldolase activity | molecular function | Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. [EC:4.1.3.16] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| (4S)-4-hydroxy-2-oxoglutarate aldolase activity | molecular function | Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418] |
| N-acetylneuraminate lyase activity | molecular function | Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. [EC:4.1.3.3, RHEA:23296] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| glyoxylate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH. [ISBN:0198506732] |
| 4-hydroxyproline catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. [GOC:ai] |
| oxalate metabolic process | biological process | The chemical reactions and pathways involving oxalate, the organic acid ethanedioate. [GOC:mlg] |
| pyruvate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. [GOC:go_curators] |
| glyoxylate metabolic process | biological process | The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. [ISBN:0198506732] |
| N-acetylneuraminate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732] |