Page last updated: 2024-11-04

sulpiride and Pain

sulpiride has been researched along with Pain in 23 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)."5.28L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. ( Paalzow, GH, 1992)
"The pathogenesis of chronic migraine remains unresolved."1.72Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine. ( Chen, L; Lei, M; Qin, G; Wen, Q; Zhang, D; Zhang, W; Zhou, J, 2022)
" Apomorphine induced a biphasic dose-response relationship, low doses producing hyperalgesia and high doses inducing antinociception."1.33Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. ( Constandil, L; Eschalier, A; Hernandez, A; Laurido, C; Pelissier, T, 2006)
"Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)."1.28L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. ( Paalzow, GH, 1992)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's5 (21.74)18.2507
2000's2 (8.70)29.6817
2010's5 (21.74)24.3611
2020's6 (26.09)2.80

Authors

AuthorsStudies
Merdasi, PG1
Dezfouli, RA2
Mazaheri, S2
Haghparast, A8
Zhang, W1
Lei, M1
Wen, Q1
Zhang, D1
Qin, G1
Zhou, J1
Chen, L1
Abdi Dezfouli, R1
Ghanbari Merdasi, P1
Rashvand, M2
Mousavi, Z2
Faramarzi, G2
Charmchi, E1
Salehi, S1
Zendehdel, M2
Torkamand, F1
Aghakhani-Lobnani, AM1
Khaleghzadeh-Ahangar, H1
Rahban, M1
Siahposht-Khachaki, A1
Pourreza, P1
Ezzatpanah, S1
Becker, S1
Ceko, M1
Louis-Foster, M1
Elfassy, NM1
Leyton, M1
Shir, Y1
Schweinhardt, P1
Lapirot, O1
Melin, C1
Modolo, A1
Nicolas, C1
Messaoudi, Y1
Monconduit, L1
Artola, A1
Luccarini, P1
Dallel, R1
Ghalandari-Shamami, M1
Hassanpour-Ezatti, M1
Tamae, A1
Nakatsuka, T1
Koga, K1
Kato, G1
Furue, H1
Katafuchi, T1
Yoshimura, M1
Pelissier, T1
Laurido, C1
Hernandez, A1
Constandil, L1
Eschalier, A1
Gonzalez, JP2
Sewell, RD2
Spencer, PS1
Omiya, Y1
Goto, K1
Suzuki, Y1
Ishige, A1
Komatsu, Y1
Farzin, D1
Carta, G1
Gessa, GL1
Nava, F1
Mazeman, E1
Paalzow, GH1
Zhu, XZ1
Ji, XQ1
Wu, SX1
Zou, G1
Lubischer, JL1
See, RE1
Levin, ED1
Liebeskind, JC1
Pradel, E1
Rodier, B1
Mot, JC1
Catalan, F1
Barasi, S1
Ben-Sreti, MM1
Clatworthy, AL1
Duggal, KN1
Robertson, J1
Rooney, KF1

Other Studies

23 other studies available for sulpiride and Pain

ArticleYear
Blocking the dopaminergic receptors in the hippocampal dentate gyrus reduced the stress-induced analgesia in persistent inflammatory pain in the rat.
    Physiology & behavior, 2022, 09-01, Volume: 253

    Topics: Analgesia; Animals; Benzazepines; Dentate Gyrus; Hippocampus; Male; Pain; Rats; Rats, Wistar; Recept

2022
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
    The journal of headache and pain, 2022, Aug-10, Volume: 23, Issue:1

    Topics: Animals; Calcium; Central Nervous System Sensitization; Male; Migraine Disorders; Pain; Phosphatidyl

2022
The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain.
    Behavioural pharmacology, 2022, 10-01, Volume: 33, Issue:7

    Topics: Analgesia; Animals; Benzazepines; Dimethyl Sulfoxide; Disease Models, Animal; Dopamine Antagonists;

2022
Restraint stress induced the antinociceptive responses via the dopamine receptors within the hippocampal CA1 area in animal model of persistent inflammatory pain.
    Behavioural brain research, 2023, 04-12, Volume: 443

    Topics: Analgesics; Animals; Benzazepines; Formaldehyde; Hippocampus; Male; Models, Animal; Pain; Rats; Rats

2023
Intra-accumbal dopaminergic system modulates the restraint stress-induced antinociceptive behaviours in persistent inflammatory pain.
    European journal of pain (London, England), 2021, Volume: 25, Issue:4

    Topics: Analgesics; Animals; Male; Nucleus Accumbens; Pain; Rats; Rats, Wistar; Receptors, Dopamine D2; Sulp

2021
The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats.
    Behavioural brain research, 2021, 08-27, Volume: 412

    Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzazepines; Carbachol; Dentate Gyrus; Dopamine Anta

2021
Nucleus accumbens dopamine receptors mediate hypothalamus-induced antinociception in the rat formalin test.
    European journal of pain (London, England), 2017, Volume: 21, Issue:7

    Topics: Analgesia; Animals; Benzazepines; Carbachol; Hypothalamus; Male; Nucleus Accumbens; Pain; Pain Measu

2017
Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Adolescent; Adult; Affect; Anxiety; Dopamine; Dopamine D2 Receptor Antagonists; Female; Healthy Volu

2013
D1- and D2-like dopamine receptors within the nucleus accumbens contribute to stress-induced analgesia in formalin-related pain behaviours in rats.
    European journal of pain (London, England), 2016, Volume: 20, Issue:9

    Topics: Analgesia; Animals; Benzazepines; Dopamine; Dopamine Antagonists; Formaldehyde; Male; Nucleus Accumb

2016
Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Capsaicin; Dopamine; Dopamine A

2011
Blockade of D1/D2 dopamine receptors within the nucleus accumbens attenuated the antinociceptive effect of cannabinoid receptor agonist in the basolateral amygdala.
    Brain research, 2012, Aug-30, Volume: 1471

    Topics: Amygdala; Analysis of Variance; Animals; Benzazepines; Benzoxazines; Cannabinoid Receptor Agonists;

2012
Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-like receptors.
    The Journal of physiology, 2005, Oct-01, Volume: 568, Issue:Pt 1

    Topics: Action Potentials; Analgesics; Animals; Barium; Cesium; Dopamine; Dopamine Agonists; Dopamine Antago

2005
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Analgesics; Animals; Apomorphine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine D2

2006
Evidence for central selective dopamine receptor stimulation in the mediation of nomifensine-induced hyperalgesia and the effects of opiate antagonists.
    Neuropharmacology, 1981, Volume: 20, Issue:11

    Topics: Animals; Brain; Bromocriptine; Domperidone; Flupenthixol; Hot Temperature; Isoquinolines; Male; Mice

1981
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administra

1999
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice.
    European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1

    Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Dextromethorphan; Domperidone; Dopamine Agonis

1999
Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats.
    European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3

    Topics: Analgesics, Non-Narcotic; Animals; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Dopamine

1999
[Dogmatil in psychosomatic urologic diseases].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1975, Volume: 20, Issue:1

    Topics: Adult; Female; Humans; Male; Middle Aged; Pain; Psychophysiologic Disorders; Sexual Dysfunction, Phy

1975
L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2

    Topics: Analgesics; Animals; Benzazepines; Catecholamines; Drug Interactions; Electric Stimulation; Hyperalg

1992
Sulpiride attenuates ranatensin-M-induced antinociception.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991, Volume: 12, Issue:4

    Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Benzazepines; Dose-Response Relationship, Drug;

1991
The effects of D1 and D2 receptor antagonists on pain sensitivity and morphine analgesia in the rat.
    Proceedings of the Western Pharmacology Society, 1987, Volume: 30

    Topics: Animals; Benzazepines; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpir

1987
[New diagnostic and therapeutic directions in so-called essential anorectal pain].
    Annales de gastroenterologie et d'hepatologie, 1987, Volume: 23, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Anus Diseases; Female; Humans; Male;

1987
Dopamine receptor-mediated spinal antinociception in the normal and haloperidol pretreated rat: effects of sulpiride and SCH 23390.
    British journal of pharmacology, 1987, Volume: 90, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Benz

1987