sulpiride has been researched along with Pain in 23 studies
Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)." | 5.28 | L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. ( Paalzow, GH, 1992) |
| "The pathogenesis of chronic migraine remains unresolved." | 1.72 | Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine. ( Chen, L; Lei, M; Qin, G; Wen, Q; Zhang, D; Zhang, W; Zhou, J, 2022) |
| " Apomorphine induced a biphasic dose-response relationship, low doses producing hyperalgesia and high doses inducing antinociception." | 1.33 | Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. ( Constandil, L; Eschalier, A; Hernandez, A; Laurido, C; Pelissier, T, 2006) |
| "Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)." | 1.28 | L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. ( Paalzow, GH, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
| Authors | Studies |
|---|---|
| Merdasi, PG | 1 |
| Dezfouli, RA | 2 |
| Mazaheri, S | 2 |
| Haghparast, A | 8 |
| Zhang, W | 1 |
| Lei, M | 1 |
| Wen, Q | 1 |
| Zhang, D | 1 |
| Qin, G | 1 |
| Zhou, J | 1 |
| Chen, L | 1 |
| Abdi Dezfouli, R | 1 |
| Ghanbari Merdasi, P | 1 |
| Rashvand, M | 2 |
| Mousavi, Z | 2 |
| Faramarzi, G | 2 |
| Charmchi, E | 1 |
| Salehi, S | 1 |
| Zendehdel, M | 2 |
| Torkamand, F | 1 |
| Aghakhani-Lobnani, AM | 1 |
| Khaleghzadeh-Ahangar, H | 1 |
| Rahban, M | 1 |
| Siahposht-Khachaki, A | 1 |
| Pourreza, P | 1 |
| Ezzatpanah, S | 1 |
| Becker, S | 1 |
| Ceko, M | 1 |
| Louis-Foster, M | 1 |
| Elfassy, NM | 1 |
| Leyton, M | 1 |
| Shir, Y | 1 |
| Schweinhardt, P | 1 |
| Lapirot, O | 1 |
| Melin, C | 1 |
| Modolo, A | 1 |
| Nicolas, C | 1 |
| Messaoudi, Y | 1 |
| Monconduit, L | 1 |
| Artola, A | 1 |
| Luccarini, P | 1 |
| Dallel, R | 1 |
| Ghalandari-Shamami, M | 1 |
| Hassanpour-Ezatti, M | 1 |
| Tamae, A | 1 |
| Nakatsuka, T | 1 |
| Koga, K | 1 |
| Kato, G | 1 |
| Furue, H | 1 |
| Katafuchi, T | 1 |
| Yoshimura, M | 1 |
| Pelissier, T | 1 |
| Laurido, C | 1 |
| Hernandez, A | 1 |
| Constandil, L | 1 |
| Eschalier, A | 1 |
| Gonzalez, JP | 2 |
| Sewell, RD | 2 |
| Spencer, PS | 1 |
| Omiya, Y | 1 |
| Goto, K | 1 |
| Suzuki, Y | 1 |
| Ishige, A | 1 |
| Komatsu, Y | 1 |
| Farzin, D | 1 |
| Carta, G | 1 |
| Gessa, GL | 1 |
| Nava, F | 1 |
| Mazeman, E | 1 |
| Paalzow, GH | 1 |
| Zhu, XZ | 1 |
| Ji, XQ | 1 |
| Wu, SX | 1 |
| Zou, G | 1 |
| Lubischer, JL | 1 |
| See, RE | 1 |
| Levin, ED | 1 |
| Liebeskind, JC | 1 |
| Pradel, E | 1 |
| Rodier, B | 1 |
| Mot, JC | 1 |
| Catalan, F | 1 |
| Barasi, S | 1 |
| Ben-Sreti, MM | 1 |
| Clatworthy, AL | 1 |
| Duggal, KN | 1 |
| Robertson, J | 1 |
| Rooney, KF | 1 |
23 other studies available for sulpiride and Pain
| Article | Year |
|---|---|
Blocking the dopaminergic receptors in the hippocampal dentate gyrus reduced the stress-induced analgesia in persistent inflammatory pain in the rat.
Topics: Analgesia; Animals; Benzazepines; Dentate Gyrus; Hippocampus; Male; Pain; Rats; Rats, Wistar; Recept | 2022 |
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.
Topics: Animals; Calcium; Central Nervous System Sensitization; Male; Migraine Disorders; Pain; Phosphatidyl | 2022 |
The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain.
Topics: Analgesia; Animals; Benzazepines; Dimethyl Sulfoxide; Disease Models, Animal; Dopamine Antagonists; | 2022 |
Restraint stress induced the antinociceptive responses via the dopamine receptors within the hippocampal CA1 area in animal model of persistent inflammatory pain.
Topics: Analgesics; Animals; Benzazepines; Formaldehyde; Hippocampus; Male; Models, Animal; Pain; Rats; Rats | 2023 |
Intra-accumbal dopaminergic system modulates the restraint stress-induced antinociceptive behaviours in persistent inflammatory pain.
Topics: Analgesics; Animals; Male; Nucleus Accumbens; Pain; Rats; Rats, Wistar; Receptors, Dopamine D2; Sulp | 2021 |
The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzazepines; Carbachol; Dentate Gyrus; Dopamine Anta | 2021 |
Nucleus accumbens dopamine receptors mediate hypothalamus-induced antinociception in the rat formalin test.
Topics: Analgesia; Animals; Benzazepines; Carbachol; Hypothalamus; Male; Nucleus Accumbens; Pain; Pain Measu | 2017 |
Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers.
Topics: Adolescent; Adult; Affect; Anxiety; Dopamine; Dopamine D2 Receptor Antagonists; Female; Healthy Volu | 2013 |
D1- and D2-like dopamine receptors within the nucleus accumbens contribute to stress-induced analgesia in formalin-related pain behaviours in rats.
Topics: Analgesia; Animals; Benzazepines; Dopamine; Dopamine Antagonists; Formaldehyde; Male; Nucleus Accumb | 2016 |
Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Capsaicin; Dopamine; Dopamine A | 2011 |
Blockade of D1/D2 dopamine receptors within the nucleus accumbens attenuated the antinociceptive effect of cannabinoid receptor agonist in the basolateral amygdala.
Topics: Amygdala; Analysis of Variance; Animals; Benzazepines; Benzoxazines; Cannabinoid Receptor Agonists; | 2012 |
Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-like receptors.
Topics: Action Potentials; Analgesics; Animals; Barium; Cesium; Dopamine; Dopamine Agonists; Dopamine Antago | 2005 |
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists.
Topics: Analgesics; Animals; Apomorphine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 | 2006 |
Evidence for central selective dopamine receptor stimulation in the mediation of nomifensine-induced hyperalgesia and the effects of opiate antagonists.
Topics: Animals; Brain; Bromocriptine; Domperidone; Flupenthixol; Hot Temperature; Isoquinolines; Male; Mice | 1981 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administra | 1999 |
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Dextromethorphan; Domperidone; Dopamine Agonis | 1999 |
Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Dopamine | 1999 |
[Dogmatil in psychosomatic urologic diseases].
Topics: Adult; Female; Humans; Male; Middle Aged; Pain; Psychophysiologic Disorders; Sexual Dysfunction, Phy | 1975 |
L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.
Topics: Analgesics; Animals; Benzazepines; Catecholamines; Drug Interactions; Electric Stimulation; Hyperalg | 1992 |
Sulpiride attenuates ranatensin-M-induced antinociception.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Benzazepines; Dose-Response Relationship, Drug; | 1991 |
The effects of D1 and D2 receptor antagonists on pain sensitivity and morphine analgesia in the rat.
Topics: Animals; Benzazepines; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpir | 1987 |
[New diagnostic and therapeutic directions in so-called essential anorectal pain].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Anus Diseases; Female; Humans; Male; | 1987 |
Dopamine receptor-mediated spinal antinociception in the normal and haloperidol pretreated rat: effects of sulpiride and SCH 23390.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Benz | 1987 |