prazosin has been researched along with Pain in 40 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 7.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission." | 7.72 | Inhibitory actions of endothelin-1 on pain processing. ( Fukuda, Y; Hasue, F; Kuwaki, T; Shimoyama, M; Yamada, H, 2004) |
| "The purpose of this trial was to study the use of terazosin in nonbacterial prostatitis/prostatodynia, and to evaluate a new symptom score sheet for this disease." | 5.07 | Use of terazosin in prostatodynia and validation of a symptom score questionnaire. ( Moon, TD; Neal, DE, 1994) |
| "The probable mechanisms of action of kolaviron were assessed by using naloxone, prazosin, and atropine to investigate the involvement of adrenergic, opioidergic, and cholinergic systems, respectively, using tail flick, the acetic acid-induced writhing, formalin-induced paw licking, and carrageenan-induced paw edema models." | 3.83 | Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action. ( Onasanwo, SA; Rotu, RA, 2016) |
| "How can we treat patients with reduced morphine doses without loosing the pain killing effect or morphine antinociceptive effects (MAE)? To address this question, we hypothesized that serotonin (5-HT2) receptor antagonism could enhance MAE mediated by kappa-opioid receptors." | 3.77 | Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation. ( Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P, 2011) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 3.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission." | 3.72 | Inhibitory actions of endothelin-1 on pain processing. ( Fukuda, Y; Hasue, F; Kuwaki, T; Shimoyama, M; Yamada, H, 2004) |
| "To investigate whether alpha1-adrenoceptors are involved in pain behaviors in streptozotocin (STZ)-induced diabetic rats, we measured the effects of phenylephrine or prazosin on allodynia in the diabetic rats." | 3.70 | Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia. ( Hur, GM; Jeon, BH; Kim, KJ; Lee, YH; Park, SJ; Ryu, TG; Yang, EJ, 2000) |
| " In addition, we also investigate the action of both HEs against capsaicin-mediated pain." | 3.69 | Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus. ( Calixto, JB; Filho, VC; Santos, AR; Yunes, RA, 1995) |
| " The number of colic episodes, lower urinary tract symptoms, analgesic dosage and days for spontaneous passage of the stones through the ureter were recorded by diary." | 2.74 | Adjunctive medical therapy with an alpha-1A-specific blocker after shock wave lithotripsy of lower ureteral stones. ( Chang, CH; Huang, SW; Wang, CJ, 2009) |
| "Amitriptyline (10 mg/kg) has analgesic effect as expected." | 1.33 | [Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline]. ( Büyükşekerci, M; Gültekin, H, 2005) |
| "Morphine tolerance was induced using a 3-day cumulative twice-daily dosing regimen with s." | 1.32 | Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice. ( Lähdesmäki, J; Ozdoğan, UK; Scheinin, M, 2003) |
| "Moxonidine is a mixed I(1) imidazoline/alpha(2)moxonidine=morphine." | 1.31 | Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats. ( Lutz, EA; Shannon, HE, 2000) |
| "Caffeine did not produce an anti-inflammatory effect as determined by hindpaw plethysmometry, suggesting that antinociception was not secondary to an anti-inflammatory action." | 1.29 | Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. ( Doak, GJ; Reid, AR; Sawynok, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (15.00) | 18.7374 |
| 1990's | 12 (30.00) | 18.2507 |
| 2000's | 18 (45.00) | 29.6817 |
| 2010's | 4 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hlasta, DJ | 1 |
| Luttinger, D | 1 |
| Perrone, MH | 1 |
| Silbernagel, MJ | 1 |
| Ward, SJ | 1 |
| Haubrich, DR | 1 |
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Rodrigo, C | 1 |
| Gnanathasan, A | 1 |
| Onasanwo, SA | 1 |
| Rotu, RA | 1 |
| Wang, CJ | 1 |
| Huang, SW | 1 |
| Chang, CH | 1 |
| Nalepa, I | 2 |
| Vetulani, J | 2 |
| Borghi, V | 2 |
| Kowalska, M | 2 |
| Przewłocka, B | 2 |
| Roman, A | 1 |
| Pavone, F | 2 |
| Peiró, AM | 1 |
| Climent, L | 1 |
| Zapater, P | 1 |
| Horga, A | 1 |
| Horga, JF | 1 |
| Wang, J | 1 |
| Li, J | 1 |
| Lu, R | 1 |
| Wang, JM | 1 |
| Ozdoğan, UK | 1 |
| Lähdesmäki, J | 1 |
| Scheinin, M | 1 |
| Zarrindast, MR | 3 |
| Vousooghi, N | 1 |
| Sahebgharani, M | 3 |
| Büyükşekerci, M | 1 |
| Gültekin, H | 1 |
| Hasue, F | 1 |
| Kuwaki, T | 1 |
| Yamada, H | 1 |
| Fukuda, Y | 1 |
| Shimoyama, M | 1 |
| Jürgensen, S | 1 |
| Dalbó, S | 1 |
| Angers, P | 1 |
| Santos, AR | 2 |
| Ribeiro-do-Valle, RM | 1 |
| Akada, Y | 1 |
| Mori, R | 1 |
| Kato, Y | 1 |
| Yamasaki, F | 1 |
| Mochizuki, H | 1 |
| Kim, SK | 1 |
| Min, BI | 1 |
| Kim, JH | 1 |
| Hwang, BG | 1 |
| Yoo, GY | 1 |
| Park, DS | 1 |
| Na, HS | 1 |
| Hossein-Abad, AA | 1 |
| Houfflin Debarge, V | 1 |
| Sicot, B | 1 |
| Jaillard, S | 1 |
| Gueorgiva, I | 1 |
| Delelis, A | 1 |
| Deruelle, P | 1 |
| Ducloy, AS | 1 |
| Storme, L | 1 |
| Miranda, HF | 1 |
| Prieto, JC | 1 |
| Puig, MM | 1 |
| Pinardi, G | 1 |
| Kuraishi, Y | 1 |
| Hirota, N | 1 |
| Sugimoto, M | 1 |
| Satoh, M | 1 |
| Takagi, H | 1 |
| Marwaha, J | 1 |
| Sagen, J | 1 |
| Proudfit, HK | 2 |
| Neal, DE | 1 |
| Moon, TD | 1 |
| Sawynok, J | 2 |
| Reid, AR | 1 |
| Doak, GJ | 1 |
| Kanui, TI | 1 |
| Tjølsen, A | 1 |
| Lund, A | 1 |
| Mjellem-Joly, N | 1 |
| Hole, K | 1 |
| Rochford, J | 1 |
| Dawes, P | 1 |
| Stewart, J | 1 |
| Filho, VC | 1 |
| Yunes, RA | 1 |
| Calixto, JB | 1 |
| Fang, F | 1 |
| Shannon, HE | 1 |
| Lutz, EA | 1 |
| Turgut, M | 1 |
| Bölükbaşi, O | 1 |
| Akyol, A | 1 |
| Lee, YH | 1 |
| Ryu, TG | 1 |
| Park, SJ | 1 |
| Yang, EJ | 1 |
| Jeon, BH | 1 |
| Hur, GM | 1 |
| Kim, KJ | 1 |
| Bardin, L | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Colpaert, FC | 1 |
| Peng, YI | 1 |
| Liu, HJ | 1 |
| Guo, L | 1 |
| Fu, TC | 1 |
| Bojö, L | 1 |
| Cassuto, J | 1 |
| Nellgård, P | 1 |
| Reid, A | 1 |
| Foo, H | 1 |
| Westbrook, RF | 1 |
| Danzebrink, RM | 1 |
| Gebhart, GF | 2 |
| Zaĭtsev, AA | 1 |
| Butkhuzi, SM | 1 |
| Kolchin, VV | 1 |
| Moroz, BT | 1 |
| Sakvarelidze, ZA | 1 |
| Janss, AJ | 1 |
1 review available for prazosin and Pain
| Article | Year |
|---|---|
Management of scorpion envenoming: a systematic review and meta-analysis of controlled clinical trials.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antivenins; Controlled Clinical Trials as Topic; D | 2017 |
3 trials available for prazosin and Pain
| Article | Year |
|---|---|
Adjunctive medical therapy with an alpha-1A-specific blocker after shock wave lithotripsy of lower ureteral stones.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Bu | 2009 |
[Treatment of external RF hyperthermia combining with alpha 1-adrenergic receptor blocker for patients with prostatodynia and chronic non-bacterial prostatitis].
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Chronic Disease; Combi | 2002 |
Use of terazosin in prostatodynia and validation of a symptom score questionnaire.
Topics: Adrenergic alpha-Antagonists; Adult; Humans; Logistic Models; Male; Middle Aged; Pain; Pain Measurem | 1994 |
36 other studies available for prazosin and Pain
| Article | Year |
|---|---|
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Imidazoles; Indo | 1987 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Antinociceptive and anti-inflammatory potentials of kolaviron: mechanisms of action.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Atropine; Carrageenan; Edema; Female; Fl | 2016 |
Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analgesics; Animals; A | 2010 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug | 2011 |
Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Behavior, Anim | 2003 |
Imipramine-induced antinociception in the formalin test. Receptor mechanisms involved and effect of swim stress.
Topics: Animals; Dose-Response Relationship, Drug; Imipramine; Injections, Intraventricular; Male; Mice; Mic | 2003 |
Formalin hindpaw injection induces changes in the [3H]prazosin binding to alpha1-adrenoceptors in specific regions of the mouse brain and spinal cord.
Topics: Amygdala; Animals; Autoradiography; Central Nervous System; Hindlimb; Male; Mice; Mice, Inbred Strai | 2005 |
[Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline].
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Animals; Dose-Response Relati | 2005 |
Inhibitory actions of endothelin-1 on pain processing.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Ani | 2004 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose- | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
On the mechanism of carbamazepine-induced antinociception in the formalin test.
Topics: Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Ani | 2006 |
The mechanisms of pain-induced pulmonary vasoconstriction: an experimental study in fetal lambs.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Fetal | 2007 |
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; An | 2008 |
Effects of morphine on noxious stimuli-induced release of substance P from rabbit dorsal horn in vivo.
Topics: Animals; Male; Methysergide; Morphine; Naloxone; Pain; Prazosin; Rabbits; Spinal Cord; Substance P | 1983 |
Supersensitivity of analgesic responses to alpha 2-adrenergic agonists in genetically hypertensive rats.
Topics: Animals; Clonidine; Hypertension; Male; Naphazoline; Pain; Prazosin; Rats; Rats, Inbred Strains; Rec | 1984 |
Effect of intrathecally administered noradrenergic antagonists on nociception in the rat.
Topics: Animals; Brain Mapping; Brain Stem; Dioxanes; Efferent Pathways; Injections, Spinal; Male; Norepinep | 1984 |
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Tempera | 1995 |
Antinociceptive effects of intrathecal administration of alpha-adrenoceptor antagonists and clonidine in the formalin test in the mouse.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Body Temperature; Clonidine; Formaldehyde; Inject | 1993 |
Naloxone potentiation of novelty-induced hypoalgesia: characterization of the alpha-noradrenergic receptor subtype.
Topics: Animals; Clonidine; Drug Synergism; Habituation, Psychophysiologic; Male; Naloxone; Pain; Phentolami | 1993 |
Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Arginine; Capsaicin; C | 1995 |
Antinociception produced by microinjection of morphine in the rat periaqueductal gray is enhanced in the foot, but not the tail, by intrathecal injection of alpha1-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Behavior, Animal; Dioxanes; Female; Foot; | 1998 |
Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2000 |
Chemical sympathectomy in the relief of persistent sympathetic pain after carpal tunnel release. A case report.
Topics: Adrenergic alpha-Antagonists; Adrenergic Fibers; Carpal Tunnel Syndrome; Female; Humans; Middle Aged | 1999 |
Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia.
Topics: Adrenergic alpha-Antagonists; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Gangl | 2000 |
In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Behavior, Animal; Dose-Response Relation | 2001 |
Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; | 2002 |
Mechanisms of adrenaline-induced antinociception in mice.
Topics: Analgesics; Animals; Epinephrine; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; | 1992 |
Pain-induced inhibition of gastric motility is mediated by adrenergic and vagal non-adrenergic reflexes in the rat.
Topics: Anesthesia; Animals; Autonomic Nervous System; Gastrointestinal Motility; Male; Muscle Relaxation; N | 1992 |
Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Oxidopamine; Pain; | 1991 |
Naloxone-induced hypoalgesia: effects of noradrenergic antagonists and agonist.
Topics: Animals; Clonidine; Hot Temperature; Male; Naloxone; Norepinephrine; Pain; Prazosin; Propranolol; Ra | 1991 |
Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxane | 1990 |
[Effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord].
Topics: Animals; Cats; Clonidine; Mesencephalon; Naloxone; Neurons; Nociceptors; Pain; Prazosin; Spinal Cord | 1989 |
Spinal monoaminergic receptors mediate the antinociception produced by glutamate in the medullary lateral reticular nucleus.
Topics: Animals; Electric Stimulation; Glutamates; Glutamic Acid; Hot Temperature; Male; Methysergide; Micro | 1987 |