Page last updated: 2024-12-11
3,4',5-trimethoxystilbene
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
3,4',5-trimethoxystilbene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5388063 |
| CHEMBL ID | 296411 |
| SCHEMBL ID | 918740 |
| SCHEMBL ID | 918739 |
| MeSH ID | M0481707 |
Synonyms (47)
| Synonym |
|---|
| AC-7024 |
| LS-14572 |
| 5-[2-(4-methoxyphenyl)ethenyl]-1,3-dimethoxy benzene |
| nsc631363 |
| nsc-631363 |
| 3,5,4'-trimethoxystilbene |
| 3,4',5-trimethoxystilbene |
| trans-stilbene derivative, 4a |
| 3,4',5-trimethoxy-trans-stilbene |
| bdbm23928 |
| 1,3-dimethoxy-5-[(e)-2-(4-methoxyphenyl)ethenyl]benzene |
| chembl296411 , |
| (e)-3,5,40-trimethoxystilbene |
| 8e-3,4',5-trimethoxystilbene |
| trans-3,4',5-trimethoxystilbene |
| trismethoxyresveratrol |
| (e)-3,5,4'-trimethoxystilbene |
| tri-o-methylresveratrol |
| 1,3-dimethoxy-5-[(1e)-2-(4-methoxyphenyl)ethenyl]benzene |
| 22255-22-7 |
| T1829 |
| trans-1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethylene |
| (e)-1,3-dimethoxy-5-(4-methoxystyryl)benzene , |
| A816066 |
| 63844-75-7 |
| S3888 |
| AKOS015915036 |
| trimethoxystilbene |
| 1,3-dimethoxy-5-[(e)-2-(4-methoxyphenyl)vinyl]benzene |
| trans-trimethoxyresveratrol |
| SCHEMBL918740 |
| SCHEMBL918739 |
| e-resveratrol trimethyl ether |
| benzene,1,3-dimethoxy-5-[(1e)-2-(4-methoxyphenyl)ethenyl]- |
| HY-N1408 |
| mr-3 |
| CS-5797 |
| J-014611 |
| trans-3,5,4'-trimethoxystilbene |
| 3,4`,5-trimethoxy-trans-stilbene |
| AS-19232 |
| AMY5759 |
| CCG-267163 |
| benzene, 1,3-dimethoxy-5-[(e)-2-(4-methoxyphenyl)ethenyl]- |
| Z2216901131 |
| DTXSID701034889 |
| 1,3-dimethoxy-5-(4-methoxystyryl)benzene |
Research Excerpts
Pharmacokinetics
| Excerpt | Reference | Relevance |
|---|---|---|
| " This HPLC method was successfully applied to assess the pharmacokinetic profile of Z-TMS in Sprague-Dawley rats using hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) as a dosing vehicle." | ( Determination of Z-3,5,4'-trimethoxystilbene in rat plasma by a simple HPLC method: application in a pre-clinical pharmacokinetic study. Choo, QY; Go, ML; Ho, PC; Lin, HS; Zhang, W, 2010) | 0.36 |
| " To evaluate its suitability as a drug candidate, a pharmacokinetic study was carried out in Sprague-Dawley rats with the emphasis to identify the impact of aqueous solubility, dose escalation, food, and repeated dosing on its oral bioavailability." | ( Preclinical pharmacokinetic evaluation of resveratrol trimethyl ether in sprague-dawley rats: the impacts of aqueous solubility, dose escalation, food and repeated dosing on oral bioavailability. Ho, PC; Lin, HS, 2011) | 0.37 |
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " These results serve to highlight the contrasting effects on different activities brought about by methoxylation, which is widely employed as a structural modification approach to improve potency and bioavailability of resveratrol." | ( Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. Go, ML; Zhang, W, 2011) | 0.37 |
| " The absolute bioavailability of TMS was 45." | ( [Trimethoxystilbene and its effects on the proliferation and apoptosis of PASMCs]. Gao, G; Gao, J; Hu, J; Jiang, X; Wang, X; Xiang, D; Xie, L, 2012) | 0.38 |
| " The bioavailability of TMS was to 45%." | ( [Trimethoxystilbene and its effects on the proliferation and apoptosis of PASMCs]. Gao, G; Gao, J; Hu, J; Jiang, X; Wang, X; Xiang, D; Xie, L, 2012) | 0.38 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " This HPLC method was successfully applied to assess the pharmacokinetic profile of Z-TMS in Sprague-Dawley rats using hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) as a dosing vehicle." | ( Determination of Z-3,5,4'-trimethoxystilbene in rat plasma by a simple HPLC method: application in a pre-clinical pharmacokinetic study. Choo, QY; Go, ML; Ho, PC; Lin, HS; Zhang, W, 2010) | 0.36 |
| " To evaluate its suitability as a drug candidate, a pharmacokinetic study was carried out in Sprague-Dawley rats with the emphasis to identify the impact of aqueous solubility, dose escalation, food, and repeated dosing on its oral bioavailability." | ( Preclinical pharmacokinetic evaluation of resveratrol trimethyl ether in sprague-dawley rats: the impacts of aqueous solubility, dose escalation, food and repeated dosing on oral bioavailability. Ho, PC; Lin, HS, 2011) | 0.37 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (17)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aryl hydrocarbon receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.0921 | 0.0077 | 0.2332 | 0.7850 | AID1798379; AID239550 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0001 | 0.7128 | 10.0000 | AID264592 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.1766 | 0.0000 | 0.4229 | 7.9070 | AID1798379; AID239674 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 (µMol) | 0.8300 | 0.0079 | 1.2478 | 9.9000 | AID54202 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 (µMol) | 6.2000 | 0.0001 | 1.7740 | 10.0000 | AID54221 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 (µMol) | 1.2280 | 0.0003 | 2.1774 | 10.0000 | AID1278605 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 (µMol) | 8.0000 | 0.0002 | 2.3185 | 10.0000 | AID264590 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 (µMol) | 2.1900 | 0.0001 | 1.6847 | 9.3200 | AID1570236; AID1570237 |
| Breakpoint cluster region protein | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0003 | 0.6200 | 10.0000 | AID264592 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 (µMol) | 14.6000 | 0.0027 | 1.6287 | 9.9000 | AID770333 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 (µMol) | 1.6670 | 0.0001 | 0.9950 | 10.0000 | AID1278606 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 (µMol) | 0.7900 | 0.0013 | 0.8696 | 9.9000 | AID54233 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 3.0000 | 0.4500 | 3.4243 | 7.5000 | AID1272522 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0002 | 0.6060 | 10.0000 | AID1272526 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Activation Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Protein kinase C alpha type | Homo sapiens (human) | EC50 (µMol) | 1,560.0000 | 0.0095 | 0.3307 | 0.9100 | AID614623 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 1.7000 | 0.0600 | 2.2223 | 8.4000 | AID1272523 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Other Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (429)
Molecular Functions (126)
Ceullar Components (59)
Bioassays (153)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1272525 | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID103367 | Cytotoxicity against human MCF-7 breast cancer cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
| AID1314124 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 1000 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID200787 | In vitro growth inhibition of central nervous system SF-268 cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1884067 | Antibacterial activity against Clostridium perfringens CECT376 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID738178 | Inhibition of FoxO signaling pathway in human HeLa cells assessed as inhibition of luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID568517 | Selectivity ratio of IC50 for human IMR90 cells to IC50 for human MCF7 cells | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID264589 | Proapoptotic activity against human HL60 cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID1467690 | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay relative to AITC | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID1278604 | Antiinflammatory activity in BALB/c mouse paw edema model assessed as decrease in myeloperoxidase activity in paw exudates at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 4 hrs by microplate reader analysis relative to c | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1278616 | Antioxidant activity in human HepG2 cells assessed as reduction of H2O2-induced ROS level at 10 uM pretreated for 20 hrs followed by H2O2 stimulation for 30 mins by DCF-DA-based fluorescence analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID255902 | Inhibitory concentration required for antiproliferative activity against human MDA-MB-231 cells | 2005 | Journal of medicinal chemistry, Nov-03, Volume: 48, Issue:22 | Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells. |
| AID738209 | Cytotoxicity against human SK-MEL cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID221812 | Cytotoxicity against human HT-29 colon cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
| AID1884062 | Antibacterial activity against Staphylococcus aureus LMG 15975 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID510865 | Antitumor activity against human HT-29 cells xenografted in SCID mouse assessed as reduction tumor weight at 10 mg/kg, ip qd for 3 weeks (Rvb = 0.72 +/- 0.1 g) | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID634525 | Antioxidant activity in ethyl alcohol assessed as trolox equivalents of ABTS radical scavenging activity after 6 mins by TEAC assay | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID1884065 | Antibacterial activity against Clostridium difficile CECT531 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1314125 | Toxicity in rat thymocytes assessed as increase in cell death at 1 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID150946 | In vitro inhibition of P388 (murine leukemia) cell proliferation. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID510864 | Antitumor activity against human HT-29 cells xenografted in SCID mouse assessed as reduction tumor volume at 10 mg/kg, ip qd for 3 weeks (Rvb = 1087 +/- 138.9 mm'3) | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID738179 | Inhibition of Notch signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1272526 | Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1314126 | Toxicity in rat thymocytes assessed as increase in cell death at 10 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID475504 | Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17 | A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. |
| AID614619 | Binding affinity to recombinant C1B domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID738192 | Inhibition of AP1 signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1884053 | Antibacterial activity against Bacillus cereus ATCC 14579 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID264591 | Proapoptotic activity against MDR human HL60R cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID416968 | Inhibition of hydrogen peroxide-induced DNA damage in human PBL cells at 12.5 uM by Comet assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID416978 | Induction of apoptosis in human HL60 cells assessed as cell accumulation at sub-G1 phase at 50 uM after 48 hrs by propidium iodide staining based flow cytometry | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID265509 | Induction of partial block of S phase in HL60 cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. |
| AID252353 | Tested for cytotoxicity towards T47D cell line (human breast cancer) | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID1884057 | Antibacterial activity against Enterococcus faecalis V583 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID264592 | Antiproliferative activity against human K562 cell line expressing Bcr-Abl | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID634526 | Antioxidant activity in 0.05 M phosphate buffered saline assessed as trolox equivalents of ABTS radical scavenging activity after 6 mins by TEAC assay | 2011 | Bioorganic & medicinal chemistry, Dec-15, Volume: 19, Issue:24 | Synthesis and study of new paramagnetic resveratrol analogues. |
| AID738210 | Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID252354 | Tested for cytotoxicity towards A549 cell line (human lung carcinoma) | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID568514 | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID471949 | Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID264593 | Proapoptotic activity against human K562 cell line expressing Bcr-Abl | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID510861 | Up-regulation of p27 expression level in human HT-29 cells by Western blotting | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID265507 | Antiproliferative activity against human HL60 cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. |
| AID40024 | In vitro growth inhibition of BXPC-3 (human pancreatic adenocarcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID252355 | Tested for cytotoxicity towards MCF-7 cell line (human breast cancer) | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID1884056 | Antibacterial activity against Enterococcus faecalis LMG 16216 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID54233 | Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1 | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
| AID1467689 | Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx at 30 uM preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay relative to resveratrol | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. |
| AID54204 | Selectivity ratio for Cytochrome P450 1B1 compared to Cytochrome P450 1A1 | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
| AID1278613 | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by plethysmometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID294470 | Cytotoxicity against mouse Hepa 1c1c7 cells assessed as cell viability at 1 uM after 24 hrs by MTT assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID1570236 | Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition by HPLC analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID416964 | Antioxidant effect assessed as inhibition of AAPH-induced oxidative pBR322 plasmid DNA strand breakage at 10 uM by gel electrophoresis | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID510862 | Up-regulation of p27 expression level in human HT-29 cells by immunohistochemistry analysis | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID57707 | In vitro growth inhibition of DU-145 (human prostate carcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1278611 | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume at 10 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by plethysmometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID54225 | Selectivity ratio for Cytochrome P450 1B1 compared to Cytochrome P450 1A2 | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
| AID490273 | Cell cycle arrest in human SW480 cells assessed as tetraploid cells generation at 30 uM after 48 hrs by flow cytometry | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs. |
| AID738207 | Cytotoxicity against pig LLC-PK1 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID475505 | Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins | 2009 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17 | A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. |
| AID490271 | Cell cycle arrest in human SW480 cells assessed as disturbance of diploid cells at 30 uM after 48 hrs by flow cytometry | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs. |
| AID738206 | Cytotoxicity against african green monkey Vero cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1272523 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID1314121 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 1 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID738213 | Cytotoxicity against human HL60 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID471946 | Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID1571122 | Inhibition of self-induced aggregation of amyloid beta (1 to 42) (unknown origin) after 48 hrs by thioflavin T-based fluorescence method | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1571124 | Antioxidant activity assessed as trolox equivalents of AAPH radical scavenging activity at 20 uL preincubated for 10 mins followed by AAPH addition measured every min for 120 mins by ORAC-FL assay | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID471944 | Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID490192 | Antiproliferative activity against human SW480 cells assessed as cell viability using propidium iodide staining after 48 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs. |
| AID400585 | Antimicrobial activity against Staphylococcus aureus after 18 hrs by serial twofold dilution test | 2004 | Journal of natural products, Mar, Volume: 67, Issue:3 | Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria. |
| AID1571121 | Inhibition of self-induced aggregation of amyloid beta (1 to 42) (unknown origin) at 20 uM after 48 hrs by thioflavin T-based fluorescence method relative to control | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11 | Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1884058 | Antibacterial activity against Enterococcus faecalis LMG 11423 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID510869 | Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID614623 | Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1884054 | Antibacterial activity against Bacillus cereus ATCC 10987 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1278609 | Antiinflammatory activity in carrageenan-induced BALB/c mouse peritonitis model assessed as decrease in number of leukocytes in peritoneal exudates administered via oral gavage 30 mins prior to carrageenan challenge measured after 4 hrs | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID568516 | Cytotoxicity against human IMR90 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID264590 | Antiproliferative activity against MDR human HL60R cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID265508 | Apoptosis inducing activity in human HL60 cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. |
| AID1278607 | Selectivity index ratio of IC50 for ovine COX-1 to IC50 for human recombinant COX-2 | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID1884060 | Antibacterial activity against Staphylococcus aureus LMG 8224 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID416969 | Prooxidant activity assessed as induction calf thymus DNA damage in presence of 250 uM Cu(II) by ethidium bromide binding based fluorimetric assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID738182 | Inhibition of Ets signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1884055 | Antibacterial activity against Enterococcus faecalis LMG 08222 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1278610 | Antiinflammatory activity in carrageenan-induced BALB/c mouse peritonitis model assessed as decrease in nitric oxide level in peritoneal exudates at 10 to 20 mg/kg administered via oral gavage 30 mins prior to carrageenan challenge measured after 4 hrs by | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID132501 | Inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal macrophages | 2000 | Bioorganic & medicinal chemistry letters, Feb-21, Volume: 10, Issue:4 | Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages. |
| AID221950 | Cytotoxicity against human MLM melanoma cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
| AID568515 | Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID1081919 | Octanol-water partition coefficient, log P of the compound by HPLC analysis | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID1272524 | Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level relative to allyl isothiocyanate | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID510867 | Reduction of proliferating cell nuclear antigen level in human HT-29 cells by Western blotting | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1272522 | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | TRPA1 channels as targets for resveratrol and related stilbenoids. |
| AID614624 | Cytotoxicity against HEK293 cells assessed as increase in cell viability at 100 uM after 48 hrs by MTT assay relative to resveratrol | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID738189 | Inhibition of NFkappaB signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID287091 | Cytotoxicity against human KB cells after 48 hrs | 2007 | European journal of medicinal chemistry, Feb, Volume: 42, Issue:2 | Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. |
| AID568518 | Selectivity ratio of IC50 for human IMR90 cells to IC50 for human HCT116 cells | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID510866 | Toxicity in SCID mouse assessed as effect on body weight at 10 mg/kg, ip qd for 3 weeks (Rvb = 20.4 +/- 0.4 g) | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1314128 | Toxicity in rat thymocytes assessed as increase in cell death at 1000 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1278606 | Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition incubated for 2 mins by ELISA | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID294475 | Induction of quinone reductase activity in mouse Hepa 1c1c7 cells at 1 uM after 24 hrs relative to control | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
| AID221796 | Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
| AID738196 | Inhibition of Stat3 signaling pathway in human HeLa cells assessed as inhibition of IL-6 induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID416965 | Inhibition of hydrogen peroxide-induced cell death of BALB/c mouse thymocytes preincubated for 30 mins before hydrogen peroxide challenge measured after 24 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID1183073 | Antifungal activity against Candida albicans SC5314 ATCC MYA-2876 assessed as growth inhibition at 300 ug/ml after 48 hrs by broth microdilution method | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7 | Antifungal activity of resveratrol derivatives against Candida species. |
| AID1278605 | Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition incubated for 2 mins by ELISA | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID510859 | Induction of apoptosis in human HT-29 cells assessed as PARP cleavage | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1884066 | Antibacterial activity against Clostridium-ihumii AP5 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID54221 | Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1A2 | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
| AID738211 | Cytotoxicity against human BT549 cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID510868 | Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID221962 | Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
| AID614622 | Inhibition of membrane translocation of PKCalpha expressed in HEK293 cells assessed as increase of protein found in membrane fraction at 100 uM after 2 hrs by Western blotting relative to resveratrol | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1081915 | Antifungal activity against Phomopsis obscurans assessed as growth inhibition at 30 uM after 144 hr by NCCLS M27-A broth microdilution method | 2011 | Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5 | Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids. |
| AID490272 | Cell cycle arrest in human SW480 cells assessed as polyploid cells generation at 30 uM after 48 hrs by flow cytometry | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs. |
| AID510863 | Drug level in SCID mouse serum at 10 mg/kg, ip by GC-MS analysis | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID416974 | Induction of DNA fragmentation in human HL60 cells at 50 uM after 48 hrs by ethidium bromide based gel electrophoresis | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID146551 | In vitro growth inhibition of NCI-H460 (human non-small cell lung carcinoma) cell line. | 2002 | Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12 | Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. |
| AID1884061 | Antibacterial activity against Staphylococcus aureus LMG 10147 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1278617 | Cytotoxicity against human HepG2 cells at 2.5 to 10 uM by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID738185 | Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1314127 | Toxicity in rat thymocytes assessed as increase in cell death at 100 uM measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1884069 | Antimicrobial activity against Escherichia coli LMG 8224 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID228455 | Inhibition of tubulin polymerization | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
| AID510860 | Reduction of proliferating cell nuclear antigen level in human HT-29 cells by immunohistochemistry analysis | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID1884059 | Antibacterial activity against Enterococcus faecalis LMG 16003 incubated for 20 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID54202 | Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes epressing human cytochrome P450 1A1 | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
| AID264595 | Cell cycle arrest in human HL60 cells by accumulation at G2/M phase at 10 uM | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID265510 | Induction of apoptotic sub-G0/G1 phase in HL60 cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12 | Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. |
| AID1314122 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 10 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID471947 | Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. |
| AID568508 | Cytotoxicity against mouse Hepa-1c1c7 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID1570233 | Cytoprotective activity against hypoxia-induced toxicity rat H9c2 cells assessed as increase in cell viability at 80 nM preincubated for 18 hrs followed by incubated in hypoxia for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID568507 | Induction of NQO1 activity in mouse Hepa1c1c7 cells assessed as concentration required to twofold increase of NQO1 activity at IC50 concentration relative to control | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
| AID1884064 | Antibacterial activity against Clostridium botulinum CECT551 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID1570237 | Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measured after 10 mins by HPLC analysis | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. |
| AID738188 | Inhibition of E2F signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1314123 | Radioprotective activity in rat thymocytes assessed as radio-modification factor pretreated at 100 uM followed by 2 Gy X-ray irradiation measured after 4 hrs by flow cytometric analysis relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | A facile and rapid access to resveratrol derivatives and their radioprotective activity. |
| AID1884063 | Antibacterial activity against Clostridium beijerinckii B504 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID239674 | Binding affinity for estrogen receptor (ER) alpha of MCF-7 cell cytosol incubated with 2 nM [3H]estradiol; Agonist | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID370921 | Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. |
| AID239550 | Binding affinity for aryl hydrocarbon receptor (AhR) of rabbit liver cytosol incubated with 0.2 nM [3H]-TCDD; Antagonist | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| AID614620 | Inhibition of TPA-induced membrane translocation of PKCalpha expressed in HEK293 cells assessed as protein found in membrane fraction at 100 uM after 2 hrs by Western blotting relative to TPA | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Chemical modifications of resveratrol for improved protein kinase C alpha activity. |
| AID1884068 | Antibacterial activity against Clostridium tetani CECT 4629 incubated for 24 hrs by CLSI based broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens. |
| AID770333 | Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) using N-methyldihydronicotinamide as co-substrate | 2013 | Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. |
| AID264588 | Antiproliferative activity against human HL60 cell line | 2006 | Journal of medicinal chemistry, May-18, Volume: 49, Issue:10 | Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. |
| AID510858 | Induction of apoptosis in human HT-29 cells assessed as caspase3 activity | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer. |
| AID416966 | Inhibition of hydrogen peroxide-induced DNA fragmentation in BALB/c mouse thymocytes at 100 uM preincubated for 30 mins before hydrogen peroxide challenge measured after 6 hrs | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7 | Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. |
| AID738212 | Cytotoxicity against human KB cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID738173 | Inhibition of Hedgehog signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase at 100 uM treated 30 mins before induction | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1278612 | Antiinflammatory activity in carrageenan-induced BALB/c mouse paw edema model assessed as decrease in paw volume administered orally 30 mins prior to carrageenan challenge measured after 1 to 6 hrs by plethysmometric analysis | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5 | Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog. |
| AID738208 | Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 48 hrs by XTT assay | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID1798379 | In Vitro Binding Assay from Article 10.1021/jm0498194: \\Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.\\ | 2005 | Journal of medicinal chemistry, Jan-13, Volume: 48, Issue:1 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (65)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.54) | 18.2507 |
| 2000's | 23 (35.38) | 29.6817 |
| 2010's | 36 (55.38) | 24.3611 |
| 2020's | 5 (7.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.51
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.51) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (3.03%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 64 (96.97%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||