Page last updated: 2024-12-07

septacidin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

septacidin: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	96278
MeSH ID	M0064812

Synonyms (10)

Synonym
septacidin
l-glycero-beta-l-gluco-heptopyranosylamine, 4-deoxy-4-((((14-methyl-1-oxopentadecyl)amino)acetyl)amino)-n-1h-purin-6-yl-
lia-0101
2'-epi-septacidin
nsc 65104
lia-0101 b
62362-59-8
n-[2-[[(2r,3r,4r,5s,6s)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxy-6-(7h-purin-6-ylamino)oxan-3-yl]amino]-2-oxoethyl]-14-methylpentadecanamide
n-(2-(((2r,3r,4r,5s,6s)-6-((9h-purin-6-yl)amino)-2-((s)-1,2-dihydroxyethyl)-4,5-dihydroxytetrahydro-2h-pyran-3-yl)amino)-2-oxoethyl)-14-methylpentadecanamide
AKOS040747474

Research Excerpts

Overview

Septacidin is an adenine nucleoside antibiotic with antifungal and antitumor activities.

Excerpt	Reference	Relevance
"Septacidin is an adenine nucleoside antibiotic with antifungal and antitumor activities. "	( Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597. Cao, Z; Chen, M; Chen, Y; Guo, Z; Tang, W; Wang, M, 2022)	2.49

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (14.29)	18.7374
1990's	6 (28.57)	18.2507
2000's	7 (33.33)	29.6817
2010's	2 (9.52)	24.3611
2020's	3 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	26.39 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	4.80 (4.65)
Search Engine Demand Index	29.35 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (26.39)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (9.52%)	6.00%
Case Studies	1 (4.76%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	2.25	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
glycine [no description available]	2.1	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
inositol Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.	2.41	2	cyclitol; hexol
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	1.98	1	mitomycin	alkylating agent; antineoplastic agent
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	3.08	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.41	2	metal allergen; nickel group element atom; platinum group metal atom
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2.6	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
sedoheptulose 7-phosphate sedoheptulose 7-phosphate : A ketoheptose phosphate consisting of sedoheptulose having a phosphate group at the 7-position. It is an intermediate metabolite in the pentose phosphate pathway.	2.17	1	ketoheptose phosphate; sedoheptulose derivative	Escherichia coli metabolite; human metabolite; mouse metabolite
oxanosine oxanosine: from Streptomyces capreolus MG265-CF3; has weak anti-bacterial action; structure in first source	3.08	1
glycosides [no description available]	2.01	1
sesquiterpenes [no description available]	3.08	1
ascofuranone ascofuranone: structure. ascofuranone : A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis.	3.08	1	dihydroxybenzaldehyde; meroterpenoid; monochlorobenzenes; olefinic compound; resorcinols; sesquiterpenoid; tetrahydrofuranone	angiogenesis inhibitor; antilipemic drug; antineoplastic agent; antiprotozoal drug; fungal metabolite
krn 5500 KRN 5500: a derivative of spicamycin with a wide range of antitumor activity against human cancer cell lines; structure given in first source	3.52	2
lactacystin [no description available]	3.08	1	lactam; S-substituted L-cysteine
staurosporine staurosporinium : Conjugate acid of staurosporine.	3.08	1	ammonium ion derivative
hygromycin b [no description available]	7.17	1

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.01	1
Peripheral Nerve Diseases [description not available]	2.01	1
Peripheral Nervous System Diseases Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.	2.01	1
Ache [description not available]	2.02	1
Polyneuropathy, Acquired [description not available]	2.02	1
Cold Fingers, Hereditary [description not available]	2.02	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.02	1
Polyneuropathies Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.	2.02	1
Raynaud Disease An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.	2.02	1
Acute Myelogenous Leukemia [description not available]	1.96	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	1.96	1
Cancer of Stomach [description not available]	2.39	2
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.39	2
Cancer of Colon [description not available]	1.98	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.39	2
Colonic Neoplasms Tumors or cancer of the COLON.	1.98	1
Experimental Neoplasms [description not available]	1.98	1
Experimental Leukemia [description not available]	3.28	2
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.9	1
Breast Cancer [description not available]	1.98	1
Cancer of Lung [description not available]	1.98	1
Breast Neoplasms Tumors or cancer of the human BREAST.	1.98	1
Lung Neoplasms Tumors or cancer of the LUNG.	1.98	1
Leukemia L 1210 [description not available]	1.95	1
Leukemia, Lymphocytic [description not available]	1.95	1
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	1.95	1

chemdatabank.com