Compounds > ezogabine
Page last updated: 2024-09-03

ezogabine and Pain

ezogabine has been researched along with Pain in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's6 (46.15)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Dalby-Brown, W; Munro, G1
Gao, J; Guo, Y; Hu, X; Huang, H; Jin, Z; Li, Z; Liu, Z; Wang, K; Wang, Y; Zhang, L; Zhong, Y; Zong, X1
Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X1
Hayashi, H; Iwata, M; Matsumoto, T; Tsuchimori, N1
Cai, J; Fang, D; Li, S; Liu, XD; Ren, J; Xing, GG1
Chen, B; Chen, J; Li, H; Sun, R; Wang, F; Wang, X; Zhang, Y1
Lopez-Garcia, JA; Rivera-Arconada, I; Vicente-Baz, J1
Gamper, N; Huang, D; Linley, JE; Pettinger, L1
Cai, J; Fang, D; Han, JS; Liu, M; Wan, Y; Xing, GG; Zheng, Q1
Al-Qatari, M; Brown, DA; Brown, TA; Burbidge, SA; Dickenson, AH; Main, M; Marsh, SJ; Matthews, EA; Mistry, M; Passmore, GM; Selyanko, AA1
Dworetzky, SI; Wua, YJ1
Blackburn-Munro, G; Blackburn-Munro, RE; Dalby-Brown, W; Mikkelsen, JD; Mirza, NR1
Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N1

Reviews

3 review(s) available for ezogabine and Pain

ArticleYear
Kv7 (KCNQ) channel modulators and neuropathic pain.
    Journal of medicinal chemistry, 2007, May-31, Volume: 50, Issue:11

    Topics: Analgesics; Animals; Humans; Ion Channel Gating; KCNQ Potassium Channels; Pain; Peripheral Nervous System Diseases; Signal Transduction

2007
Recent developments on KCNQ potassium channel openers.
    Current medicinal chemistry, 2005, Volume: 12, Issue:4

    Topics: Acrylamides; Aminopyridines; Benzamides; Carbamates; Epilepsy; Humans; Indoles; Ion Channel Gating; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Migraine Disorders; Oxindoles; Pain; Phenylenediamines; Potassium Channels, Voltage-Gated

2005
Retigabine: chemical synthesis to clinical application.
    CNS drug reviews, 2005,Spring, Volume: 11, Issue:1

    Topics: Animals; Anticonvulsants; Anxiety; Carbamates; Dose-Response Relationship, Drug; Epilepsy; Humans; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Neurons; Pain; Phenylenediamines; Potassium Channels, Voltage-Gated; Time Factors

2005

Other Studies

10 other study(ies) available for ezogabine and Pain

ArticleYear
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neoplasm Proteins; Pain

2022
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
    Pharmacology, 2020, Volume: 105, Issue:7-8

    Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Carbamates; Disease Models, Animal; Hyperalgesia; KCNQ Potassium Channels; Male; Pain; Phenylenediamines; Rats; Rats, Sprague-Dawley; Uric Acid

2020
Activation of peripheral KCNQ channels attenuates inflammatory pain.
    Molecular pain, 2014, Feb-21, Volume: 10

    Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Formaldehyde; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; KCNQ Potassium Channels; Motor Skills Disorders; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats

2014
Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain.
    Oncology reports, 2015, Volume: 33, Issue:3

    Topics: Acetylcholine; Animals; Anthracenes; Bone Neoplasms; Carbamates; Disease Models, Animal; Female; Hyperalgesia; KCNQ Potassium Channels; Membrane Transport Modulators; Neoplasm Transplantation; Pain; Phenylenediamines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord

2015
Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain.
    Pharmacology, 2015, Volume: 95, Issue:5-6

    Topics: Analgesics; Animals; Arthritis, Experimental; Behavior, Animal; Carbamates; Disease Models, Animal; Iodoacetates; Knee Joint; Male; Membrane Transport Modulators; Osteoarthritis; Pain; Phenylenediamines; Rats, Sprague-Dawley; Treatment Outcome

2015
Targeting Kv7 channels in pain pathways.
    Oncotarget, 2017, Feb-21, Volume: 8, Issue:8

    Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channels; Long QT Syndrome; Mutation; Neurons; Pain; Pain Management; Phenylenediamines; Protein Conformation

2017
M channel enhancers and physiological M channel block.
    The Journal of physiology, 2012, Feb-15, Volume: 590, Issue:4

    Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Hydrogen Peroxide; Inflammation; KCNQ Potassium Channels; Organometallic Compounds; Pain; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyridines; Rats; Rats, Wistar; Sensory Receptor Cells; Type C Phospholipases

2012
Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.
    Pain, 2013, Volume: 154, Issue:3

    Topics: Animals; Anthracenes; Bone Neoplasms; Carbamates; Carcinoma; Down-Regulation; Female; Ganglia, Spinal; Hot Temperature; Hyperalgesia; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mammary Neoplasms, Experimental; Neoplasm Transplantation; Nociception; Pain; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Stress, Mechanical; Synaptic Transmission; Tibia

2013
KCNQ/M currents in sensory neurons: significance for pain therapy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Aug-06, Volume: 23, Issue:18

    Topics: Animals; Anthracenes; Anura; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Indoles; Male; Neurons, Afferent; Oocytes; Pain; Pain Management; Pain Measurement; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transfection

2003
Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice.
    Neuroscience letters, 2007, Feb-14, Volume: 413, Issue:2

    Topics: Animals; Anticonvulsants; Capsaicin; Carbamates; Colon; KCNQ2 Potassium Channel; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Reaction Time; Sensory Receptor Cells; Visceral Afferents

2007