a-317567 has been researched along with Pain* in 1 studies
1 other study(ies) available for a-317567 and Pain
| Article | Year |
|---|---|
Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.
The synthesis, structure-activity relationship (SAR), and pharmacological evaluation of analogs of the acid-sensing ion channel (ASIC) inhibitor A-317567 are reported. It was found that the compound with an acetylenic linkage was the most potent ASIC-3 channel blocker. This compound reversed mechanical hypersensitivity in the rat iodoacetate model of osteoarthritis pain, although sedation was noted. Sedation was also observed in ASIC-3 knockout mice, questioning whether sedation and antinociception are mediated via a non-ASIC-3 specific mechanism. Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Analgesics; Animals; Behavior, Animal; Electrophysiological Phenomena; Freund's Adjuvant; Iodoacetates; Isoquinolines; Male; Mice; Naphthalenes; Neurons; Osteoarthritis; Pain; Pain Measurement; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2010 |