domperidone has been researched along with Pain in 11 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe the health-related quality of life (HRQOL) of patients with insulin-treated diabetes and symptoms of diabetic gastroparesis and to assess the impact of domperidone on HRQOL in these patients." | 9.08 | Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis. ( Farup, CE; Helbers, L; Leidy, NK; Murray, M; Quigley, EM; Williams, GR, 1998) |
| "To describe the health-related quality of life (HRQOL) of patients with insulin-treated diabetes and symptoms of diabetic gastroparesis and to assess the impact of domperidone on HRQOL in these patients." | 5.08 | Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis. ( Farup, CE; Helbers, L; Leidy, NK; Murray, M; Quigley, EM; Williams, GR, 1998) |
| "Domperidone was taken at a dosage of 10 mg tablets 4-times daily." | 2.65 | Use of the peripheral dopamine antagonist, domperidone, in the management of gastro-intestinal symptoms in patients with irritable bowel syndrome. ( Milo, R, 1980) |
| " Apomorphine induced a biphasic dose-response relationship, low doses producing hyperalgesia and high doses inducing antinociception." | 1.33 | Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. ( Constandil, L; Eschalier, A; Hernandez, A; Laurido, C; Pelissier, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Li, T | 1 |
| Wang, L | 1 |
| Zhang, L | 2 |
| Li, B | 1 |
| Wang, D | 1 |
| Wang, T | 1 |
| Fu, F | 1 |
| Tsukuura, H | 1 |
| Ando, Y | 1 |
| Gyawali, B | 1 |
| Matsumoto, M | 1 |
| Sugishita, M | 1 |
| Honda, K | 1 |
| Urakawa, H | 1 |
| Maeda, O | 1 |
| Hasegawa, Y | 1 |
| Sivasanker, M | 1 |
| Reddy, PM | 1 |
| Shashindran, CH | 1 |
| Ramaswamy, S | 1 |
| Pelissier, T | 1 |
| Laurido, C | 1 |
| Hernandez, A | 1 |
| Constandil, L | 1 |
| Eschalier, A | 1 |
| Gonzalez, JP | 1 |
| Sewell, RD | 1 |
| Spencer, PS | 1 |
| Milo, R | 1 |
| Nagler, J | 1 |
| Miskovitz, P | 1 |
| Farup, CE | 1 |
| Leidy, NK | 1 |
| Murray, M | 1 |
| Williams, GR | 1 |
| Helbers, L | 1 |
| Quigley, EM | 1 |
| Farzin, D | 1 |
| Bradette, M | 1 |
| Pare, P | 1 |
| Douville, P | 1 |
| Morin, A | 1 |
| Angelini, G | 1 |
| Castagnini, A | 1 |
| Rizzoli, R | 1 |
| Pasini, AF | 1 |
| Lavarini, E | 1 |
| Brocco, G | 1 |
| Scuro, LA | 1 |
5 trials available for domperidone and Pain
| Article | Year |
|---|---|
Use of the peripheral dopamine antagonist, domperidone, in the management of gastro-intestinal symptoms in patients with irritable bowel syndrome.
Topics: Abdomen; Adult; Aged; Benzimidazoles; Clinical Trials as Topic; Colonic Diseases, Functional; Defeca | 1980 |
Clinical evaluation of domperidone in the treatment of chronic postprandial idiopathic upper gastrointestinal distress.
Topics: Chronic Disease; Clinical Trials as Topic; Domperidone; Double-Blind Method; Eating; Erythema; Gastr | 1981 |
Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis.
Topics: Adult; Aged; Antiemetics; Diabetes Complications; Diabetes Mellitus; Domperidone; Double-Blind Metho | 1998 |
Visceral perception in health and functional dyspepsia. Crossover study of gastric distension with placebo and domperidone.
Topics: Adult; Domperidone; Double-Blind Method; Dyspepsia; Female; Humans; Pain; Pressure; Reference Values | 1991 |
Treatment of reflux gastritis: double blind comparison between clebopride and domperidone. A preliminary report.
Topics: Adolescent; Adult; Aged; Antiemetics; Benzamides; Bile Acids and Salts; Domperidone; Double-Blind Me | 1990 |
6 other studies available for domperidone and Pain
| Article | Year |
|---|---|
Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system.
Topics: Analgesics; Animals; Carrageenan; Corpus Striatum; Disease Models, Animal; Domperidone; Dopamine; Do | 2021 |
Prophylactic Use of Antiemetics for Prevention of Opioid-Induced Nausea and Vomiting: A Questionnaire Survey among Japanese Physicians.
Topics: Analgesics, Opioid; Antiemetics; Benzodiazepines; Chemoprevention; Domperidone; Health Care Surveys; | 2015 |
Formalin assay parameters differ in confirming the antinociceptive mechanism of domperidone in mice.
Topics: Analgesics; Animals; Disinfectants; Domperidone; Dopamine Antagonists; Drug Combinations; Formaldehy | 2004 |
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists.
Topics: Analgesics; Animals; Apomorphine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 | 2006 |
Evidence for central selective dopamine receptor stimulation in the mediation of nomifensine-induced hyperalgesia and the effects of opiate antagonists.
Topics: Animals; Brain; Bromocriptine; Domperidone; Flupenthixol; Hot Temperature; Isoquinolines; Male; Mice | 1981 |
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Dextromethorphan; Domperidone; Dopamine Agonis | 1999 |