| Assay ID | Title | Year | Journal | Article |
|---|
| AID296822 | Volume of distribution at steady state in Wistar rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID662958 | Ratio of drug level in brain to plasma in rat by microdialysis assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID296823 | Total clearance in Wistar rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID646623 | Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay relative to Win55,212-2 | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. |
| AID1362836 | Displacement of [3H]SR141716A from membrane bound human CB1 receptor after 1 hr by beta scintillation counting method | | | |
| AID296815 | Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as reversal of forskolin-evoked cAMP accumulation relative to CP-55940 | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296821 | Half life in Wistar rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296824 | AUC (0 to infinity) in Wistar rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID646624 | Binding affinity to human CB2 receptor | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. |
| AID662934 | Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as [35S]GTPgamma binding relative to WIN55212-2 | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID296832 | Inhibition of CYP2C8 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296827 | AUC (0 to infinity) in Wistar rat at 3.4 mg/kg, po | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296819 | Antihyperalgesic activity in rat assessed as reversal of hyperalgesia at 3 mg/kg, po after 1 hr | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296835 | Inhibition of CYP2D6 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID1362837 | Displacement of [3H]CP55940 from membrane bound human CB2 receptor at 100 uM after 1 hr by beta scintillation counting method relative to control | | | |
| AID1362834 | Displacement of [3H]SR141716A from membrane bound human CB1 receptor at 100 uM after 1 hr by beta scintillation counting method relative to control | | | |
| AID296829 | Intrinsic clearance in rat liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296820 | Antihyperalgesic activity in rat assessed as reversal of hyperalgesia | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296838 | Plasma protein binding | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296840 | Cmax in Wistar rat at 3 mg/kg, po after 1 hr | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296831 | Inhibition of CYP1A2 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296818 | Inhibition of rat CB1 receptor | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID646683 | Ratio of drug uptake in brain to plasma of Sprague-Dawley rat at 1 mg/kg, sc | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. |
| AID646622 | Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. |
| AID296828 | Bioavailability in Wistar rat at 3.4 mg/kg, po | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296813 | Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cells | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296816 | Agonist activity at human CB2 receptor expressed in CHOK1 cells assessed as reversal of forskolin-evoked cAMP accumulation | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296812 | Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cells | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296825 | Tmax in Wistar rat at 3.4 mg/kg, po | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID1362839 | Displacement of [3H]CP55940 from membrane bound human CB2 receptor after 1 hr by beta scintillation counting method | | | |
| AID646621 | Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. |
| AID296834 | Inhibition of CYP2C19 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296814 | Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as reversal of forskolin-evoked cAMP accumulation | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID662937 | Thermodynamic solubility of the compound at pH 7.4 | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID662938 | Apparent permeability from apical to basal side of human Caco2 cells at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID296841 | Drug level in brain in Wistar rat after 4 hrs | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296817 | Agonist activity at human CB2 receptor expressed in CHOK1 cells assessed as reversal of forskolin-evoked cAMP accumulation relative to CP-55940 | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID662936 | Inhibition of human ERG | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID296836 | Inhibition of CYP2E1 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID1362842 | Selectivity ratio of compound effect for displacement of [3H]CP55940 from membrane bound human CB2 receptor at 10 uM to compound effect for displacement of [3H]SR141716A from membrane bound human CB1 receptor at 10 uM | | | |
| AID662931 | Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID1362840 | Selectivity ratio of IC50 for displacement of [3H]SR141716A from membrane bound human CB1 receptor to IC50 for displacement of [3H]CP55940 from membrane bound human CB2 receptor | | | |
| AID296830 | Intrinsic clearance in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296839 | Partition coefficient, log P of the compound | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID662932 | Binding affinity to human CB2 receptor | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID296833 | Inhibition of CYP2C9 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID296837 | Inhibition of CYP3A4 in human liver microsomes | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID1362835 | Displacement of [3H]SR141716A from membrane bound human CB1 receptor at 10 uM after 1 hr by beta scintillation counting method relative to control | | | |
| AID662935 | Intrinsic clearance in human liver microsomes at 1 uM in presence of NADPH | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID296826 | Cmax in Wistar rat at 3.4 mg/kg, po | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| AID662933 | Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as [35S]GTPgamma binding | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. |
| AID1362838 | Displacement of [3H]CP55940 from membrane bound human CB2 receptor at 10 uM after 1 hr by beta scintillation counting method relative to control | | | |
| AID646627 | Aqueous solubility of the compound at pH 7.4 | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| γ-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. |
| AID493017 | Wombat Data for BeliefDocking | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |