cilnidipine and Pain
cilnidipine has been researched along with Pain* in 1 studies
Other Studies
1 other study(ies) available for cilnidipine and Pain
| Article | Year |
|---|---|
Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity. In order to find specific N-type calcium channel blockers with the least effects on cardiovascular system, we performed structure-activity relationship study on APJ2708, which is a derivative of cilnidipine, and found a promising N-type calcium channel blocker 21b possessing analgesic effect in vivo with a 1600-fold lower activity against L-type calcium channels than that of cilnidipine. Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Formaldehyde; Molecular Structure; Pain; Pain Measurement; Rats; Structure-Activity Relationship | 2006 |