Page last updated: 2024-12-08

salvigenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

salvigenin: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

salvigenin : A trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4', 6, and 7 are replaced by methoxy groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID161271
CHEMBL ID376644
CHEBI ID192703
SCHEMBL ID1427018
MeSH IDM0062286

Synonyms (32)

Synonym
5-hydroxy-6,7,4'-trimethoxyflavone
salvigenin
CHEMBL376644
LMPK12111166
psathyrotin
5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4h-chromen-4-one
7-o-methylpectolinarigenin
CHEBI:192703
5-hydroxy-4',6,7-trimethoxyflavone
5-hydroxy-6,7,4'-trimethoxy-flavone
5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one
19103-54-9
5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
v522ycm28a ,
4h-1-benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-
unii-v522ycm28a
bdbm50092613
SCHEMBL1427018
4h-1-bbenzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-
flavone, 5-hydroxy-4',6,7-trimethoxy-
QCDYOIZVELGOLZ-UHFFFAOYSA-N
DTXSID90172629 ,
J-012342
salvesigenine
AKOS032948589
HY-N1318
Q63398893
FT-0775503
CS-0016722
MS-24914
dtxcid0095120
B0005-172412

Research Excerpts

Overview

Salvigenin is a Trimethoxylated Flavone enriched in Scutellariae Barbatae Herba and Scutelliariae Radix. It is demonstrated to have anti-tumor properties in colon cancer.

ExcerptReferenceRelevance
"Salvigenin is a Trimethoxylated Flavone enriched in Scutellariae Barbatae Herba and Scutellariae Radix and is demonstrated to have anti-tumor properties in colon cancer. "( Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway.
Chen, H; Chen, J; Chen, Y; Li, A; Liu, J; Ma, L; Shao, H; Tang, Y, 2023
)
3.8
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (8)

RoleDescription
autophagy inducerAny compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
apoptosis inhibitorAny substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
antilipemic drugA substance used to treat hyperlipidemia (an excess of lipids in the blood).
immunomodulatorBiologically active substance whose activity affects or plays a role in the functioning of the immune system.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
neuroprotective agentAny compound that can be used for the treatment of neurodegenerative disorders.
hypoglycemic agentA drug which lowers the blood glucose level.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
trimethoxyflavoneA methoxyflavone that is flavone substituted by three methoxy groups.
monohydroxyflavoneA hydroxyflavone carrying a single hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
nevadensin biosynthesis012
salvigenin biosynthesis713
nevadensin biosynthesis013

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)IC50 (µMol)0.47330.00010.32759.5480AID1756088; AID1756090; AID1756091
Delta-type opioid receptorHomo sapiens (human)Ki26.00000.00000.59789.9300AID1230327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (44)

Processvia Protein(s)Taxonomy
hemopoiesisReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
leukocyte homeostasisReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
myeloid progenitor cell differentiationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
pro-B cell differentiationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathwayReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
positive regulation of cell population proliferationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
response to organonitrogen compoundReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
peptidyl-tyrosine phosphorylationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
cytokine-mediated signaling pathwayReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
B cell differentiationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
animal organ regenerationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
common myeloid progenitor cell proliferationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
vascular endothelial growth factor signaling pathwayReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT proteinReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
regulation of apoptotic processReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
positive regulation of MAP kinase activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
positive regulation of MAPK cascadeReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
lymphocyte proliferationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
protein autophosphorylationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
cellular response to cytokine stimulusReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
cellular response to glucocorticoid stimulusReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
dendritic cell differentiationReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
positive regulation of kinase activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
multicellular organism developmentReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
immune responseDelta-type opioid receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayDelta-type opioid receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerDelta-type opioid receptorHomo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayDelta-type opioid receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayDelta-type opioid receptorHomo sapiens (human)
adult locomotory behaviorDelta-type opioid receptorHomo sapiens (human)
negative regulation of gene expressionDelta-type opioid receptorHomo sapiens (human)
negative regulation of protein-containing complex assemblyDelta-type opioid receptorHomo sapiens (human)
positive regulation of CREB transcription factor activityDelta-type opioid receptorHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationDelta-type opioid receptorHomo sapiens (human)
response to nicotineDelta-type opioid receptorHomo sapiens (human)
G protein-coupled opioid receptor signaling pathwayDelta-type opioid receptorHomo sapiens (human)
eating behaviorDelta-type opioid receptorHomo sapiens (human)
regulation of mitochondrial membrane potentialDelta-type opioid receptorHomo sapiens (human)
regulation of calcium ion transportDelta-type opioid receptorHomo sapiens (human)
cellular response to growth factor stimulusDelta-type opioid receptorHomo sapiens (human)
cellular response to hypoxiaDelta-type opioid receptorHomo sapiens (human)
cellular response to toxic substanceDelta-type opioid receptorHomo sapiens (human)
neuropeptide signaling pathwayDelta-type opioid receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (14)

Processvia Protein(s)Taxonomy
protein tyrosine kinase activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
cytokine receptor activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
vascular endothelial growth factor receptor activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
protein bindingReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
ATP bindingReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
nuclear glucocorticoid receptor bindingReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
protein-containing complex bindingReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
phosphatidylinositol 3-kinase activator activityReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
growth factor bindingReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
G protein-coupled opioid receptor activityDelta-type opioid receptorHomo sapiens (human)
protein bindingDelta-type opioid receptorHomo sapiens (human)
receptor serine/threonine kinase bindingDelta-type opioid receptorHomo sapiens (human)
G protein-coupled enkephalin receptor activityDelta-type opioid receptorHomo sapiens (human)
neuropeptide bindingDelta-type opioid receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Processvia Protein(s)Taxonomy
endoplasmic reticulumReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
endoplasmic reticulum lumenReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
plasma membraneReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
endosome membraneReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
receptor complexReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
plasma membraneReceptor-type tyrosine-protein kinase FLT3Homo sapiens (human)
plasma membraneDelta-type opioid receptorHomo sapiens (human)
synaptic vesicle membraneDelta-type opioid receptorHomo sapiens (human)
dendrite membraneDelta-type opioid receptorHomo sapiens (human)
presynaptic membraneDelta-type opioid receptorHomo sapiens (human)
axon terminusDelta-type opioid receptorHomo sapiens (human)
spine apparatusDelta-type opioid receptorHomo sapiens (human)
postsynaptic density membraneDelta-type opioid receptorHomo sapiens (human)
neuronal dense core vesicleDelta-type opioid receptorHomo sapiens (human)
plasma membraneDelta-type opioid receptorHomo sapiens (human)
neuron projectionDelta-type opioid receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (64)

Assay IDTitleYearJournalArticle
AID1756116Cell cycle arrest in human MV4-11 cells assessed as accumulation at S phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 17.51 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756092Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756109Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G2/M phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 20.36 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1265076Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of prothrombin time at 100 uM after 3 mins (Rvb = 4.99 +/- 0.18 seconds)2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1070435Activation of Nrf2 (unknown origin) expressed in CHO-ARE luc cells at 10 to 30 uM after 18 hrs by luciferase reporter gene assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata.
AID1265075Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of thrombin time at 100 uM after 3 mins (Rvb = 20.25 +/- 1.02 seconds)2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1230327Displacement of [3H]DPDPE from delta opioid receptor (unknown origin) transfected into HEK293 cells by microplate scintillation counting2015Journal of natural products, Jun-26, Volume: 78, Issue:6
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
AID1756108Cell cycle arrest in human MOLM-13 cells assessed as accumulation at S phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 11.14 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1230329Displacement of [3H]-CP55940 from human CB2 receptor transfected into HEK293 cells at 10 uM by microplate scintillation counting2015Journal of natural products, Jun-26, Volume: 78, Issue:6
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
AID1756119Cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 50.06 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756091Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756090Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in Sf9 insect cells incubated for 1 hr by LanthaScreen assay2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756111Cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 50.06 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1265084N-octanol/0.15 M NaCl partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1230328Displacement of [3H]-CP55940 from human CB1 receptor transfected into HEK293 cells at 10 uM by microplate scintillation counting2015Journal of natural products, Jun-26, Volume: 78, Issue:6
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
AID280040Cytotoxicity against human HUVEC cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
AID1756121Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2/M phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 26.26 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID280039Cytotoxicity against human TERT-RPE1 cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
AID1265083N-octanol/0.1 M HCl partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1756123Cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 50.06 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756093Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1265081Antioxidant activity in rat PC12 cells assessed as inhibition of H2O2-induced cytotoxicity at 25 uM after 4 hrs by MTT assay2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1756128Cell cycle arrest in human MV4-11 cells assessed as increase in accumulation at sub-G1 phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756125Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2/M phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 26.26 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756089Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system at 10 uM using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay relative to control2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756127Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G0/G1 phase at 0.3 to 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756112Cell cycle arrest in human MV4-11 cells assessed as accumulation at S phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 17.51 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1265085N-octanol/0.15 M NaHCO3 partition coefficient, log P of the compound after 5 hrs by spectrophotometric analysis2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1265079Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1265082Aqueous solubility of the compound in water after 1 hr by UV-vis spectrophotometer analysis2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1756122Cell cycle arrest in human MV4-11 cells assessed as accumulation at sub-G1 phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 7.43 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756115Cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 50.06 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1230324Displacement of [3H]DPDPE from delta opioid receptor (unknown origin) transfected into HEK293 cells at 10 uM by microplate scintillation counting2015Journal of natural products, Jun-26, Volume: 78, Issue:6
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
AID1230325Displacement of [3H]U69593 from kappa opioid receptor (unknown origin) transfected into HEK293 cells at 10 uM by microplate scintillation counting2015Journal of natural products, Jun-26, Volume: 78, Issue:6
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
AID1756100Cell cycle arrest in human MOLM-13 cells assessed as accumulation at S phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 11.14 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756088Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1265080Antioxidant activity in rat PC12 cells assessed as inhibition of H2O2-induced cytotoxicity at 50 uM after 4 hrs by MTT assay2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1756113Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2/M phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 26.26 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756117Cell cycle arrest in human MV4-11 cells assessed as accumulation at G2/M phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 26.26 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756118Cell cycle arrest in human MV4-11 cells assessed as accumulation at sub-G1 phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 7.43 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756124Cell cycle arrest in human MV4-11 cells assessed as accumulation at S phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 17.51 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID280038Cytotoxicity against human LNCaP cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
AID1756101Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G2/M phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 20.36 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756104Cell cycle arrest in human MOLM-13 cells assessed as accumulation at S phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 11.14 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID280036Cytotoxicity against human Lu1 cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
AID280037Cytotoxicity against human Col2 cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
AID1756102Cell cycle arrest in human MOLM-13 cells assessed as accumulation at sub-G1 phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 13.76 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756103Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G0/G1 phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 53.92 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756120Cell cycle arrest in human MV4-11 cells assessed as accumulation at S phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 17.51 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1265078Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of fibrinogen at 100 uM after 3 mins (Rvb = 7.02+/- 0.16 g/L)2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1756099Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G0/G1 phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 53.92 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1230330Agonist activity at human delta opioid receptor transfected into HEK293 cells assessed as effect on [35S]-GTPgammaS binding at 300 uM2015Journal of natural products, Jun-26, Volume: 78, Issue:6
Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
AID1756096Cell cycle arrest in human MOLM-13 cells assessed as accumulation at S phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 11.14 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756114Cell cycle arrest in human MV4-11 cells assessed as accumulation at sub-G1 phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 7.43 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756097Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G2/M phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 20.36 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756105Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G2/M phase at 10 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 20.36 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID280035Cytotoxicity against human MCF7 cells2007Journal of natural products, Mar, Volume: 70, Issue:3
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.
AID1265077Antithrombotic activity in New Zealand white rabbit platelet-poor plasma assessed as increase of activated partial thromboplastin time at 100 uM after 3 mins (Rvb = 30.58 +/- 1.55 seconds)2015European journal of medicinal chemistry, Dec-01, Volume: 106Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo.
AID1756110Cell cycle arrest in human MV4-11 cells assessed as accumulation at sub-G1 phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 7.43 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756095Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G0/G1 phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 53.92 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756098Cell cycle arrest in human MOLM-13 cells assessed as accumulation at sub-G1 phase at 3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 13.76 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756107Cell cycle arrest in human MOLM-13 cells assessed as accumulation at G0/G1 phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 53.92 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756094Cell cycle arrest in human MOLM-13 cells assessed as accumulation at sub-G1 phase at 0.3 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 13.76 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
AID1756106Cell cycle arrest in human MOLM-13 cells assessed as accumulation at sub-G1 phase at 30 uM measured after 72 hrs by propidium iodide/RNaseA staining based flow cytometry analysis (Rvb = 13.76 %)2021Journal of natural products, 01-22, Volume: 84, Issue:1
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (12.50)29.6817
2010's18 (75.00)24.3611
2020's3 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.47 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]