Page last updated: 2024-10-15

acetylcarnitine and Pain

acetylcarnitine has been researched along with Pain in 24 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Thioctic acid 600 mg/day appears to be at least as effective as ALC in the treatment of sciatic pain caused by a herniated disc and may be associated with an improvement in symptom scores and reduced need for analgesia."9.13Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008)
"Prophylactic treatment with acetyl-L-carnitine (ALCAR) prevents the neuropathic pain syndrome that is evoked by the chemotherapeutic agent, paclitaxel."7.74Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. ( Bennett, GJ; Flatters, SJ; Jin, HW; Mulhern, HL; Xiao, WH, 2008)
"This study examines the potential efficacy of acetyl-L-carnitine (ALC) to prevent and treat paclitaxel-induced pain."7.73Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. ( Bennett, GJ; Flatters, SJ; Xiao, WH, 2006)
"Although sciatic pain is typically self-limiting, pharmacological analgesic therapy forms the mainstay of treatment."6.73Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008)
"Sciatica is a painful condition characterized by radiating leg pain that most commonly originates from a herniated disc in the lumbar or sacral spine."6.73Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008)
" Evidence from animal models of chemotherapy-induced painful peripheral neuropathy produced by the taxane agent, paclitaxel, and the platinum-complex agent, oxaliplatin, indicate that they produce neuropathy via a common mechanism-a toxic effect on the mitochondria in primary afferent sensory neurons."5.38Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. ( Bennett, GJ; Xiao, WH; Zheng, H, 2012)
"Thioctic acid 600 mg/day appears to be at least as effective as ALC in the treatment of sciatic pain caused by a herniated disc and may be associated with an improvement in symptom scores and reduced need for analgesia."5.13Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008)
"Prophylactic treatment with acetyl-L-carnitine (ALCAR) prevents the neuropathic pain syndrome that is evoked by the chemotherapeutic agent, paclitaxel."3.74Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. ( Bennett, GJ; Flatters, SJ; Jin, HW; Mulhern, HL; Xiao, WH, 2008)
"This study examines the potential efficacy of acetyl-L-carnitine (ALC) to prevent and treat paclitaxel-induced pain."3.73Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. ( Bennett, GJ; Flatters, SJ; Xiao, WH, 2006)
"Although sciatic pain is typically self-limiting, pharmacological analgesic therapy forms the mainstay of treatment."2.73Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008)
"Sciatica is a painful condition characterized by radiating leg pain that most commonly originates from a herniated disc in the lumbar or sacral spine."2.73Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008)
"Treatment of peripheral neuropathies is targeted to its symptomatic and aetiological features."2.44Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies. ( Capiluppi, E; Mailland, E; Mariani, C; Nascimbene, C; Osio, M; Vanotti, A, 2007)
"Peripheral neuropathies are extremely heterogeneous nosological entities."2.44Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies. ( Capiluppi, E; Mailland, E; Mariani, C; Nascimbene, C; Osio, M; Vanotti, A, 2007)
"Pancreatitis was induced with 6 hly intraperitoneal (i."1.62Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain's pain circuitry. ( High, AE; McIlwrath, SL; Saito, H; Starr, ME; Westlund, KN, 2021)
"Pain was measured in animals submitted to MIA model by paw pressure and compression behavioral tests in the presence or absence of ALC."1.40Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis. ( Aglianò, M; Bianchi, E; Di Cesare Mannelli, L; Ghelardini, C; Lorenzoni, P; Menicacci, C, 2014)
" Evidence from animal models of chemotherapy-induced painful peripheral neuropathy produced by the taxane agent, paclitaxel, and the platinum-complex agent, oxaliplatin, indicate that they produce neuropathy via a common mechanism-a toxic effect on the mitochondria in primary afferent sensory neurons."1.38Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. ( Bennett, GJ; Xiao, WH; Zheng, H, 2012)
"ALCAR completely prevented mechanical hyperalgesia and provoked in the nerve a c-Jun increment only."1.36The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain. ( Bartolini, A; Di Cesare Mannelli, L; Ghelardini, C; Pacini, A; Toscano, A, 2010)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (8.33)18.2507
2000's9 (37.50)29.6817
2010's8 (33.33)24.3611
2020's5 (20.83)2.80

Authors

AuthorsStudies
D'Orio, M1
De Vitis, R1
Taccardo, G1
Rocchi, L1
Ferrari, F1
Perna, A1
Passiatore, M1
Salaffi, F1
Farah, S1
Sarzi-Puttini, P1
Di Carlo, M1
Lowry, E1
Marley, J1
McVeigh, JG1
McSorley, E1
Allsopp, P1
Kerr, D1
Ardizzone, A1
Fusco, R1
Casili, G1
Lanza, M1
Impellizzeri, D1
Esposito, E1
Cuzzocrea, S1
McIlwrath, SL1
Starr, ME1
High, AE1
Saito, H1
Westlund, KN1
Sergi, G1
Pizzato, S1
Piovesan, F1
Trevisan, C1
Veronese, N1
Manzato, E1
Cruccu, G1
Di Stefano, G1
Fattapposta, F1
Jann, S1
Padua, L1
Schenone, A1
Truini, A1
Bianchi, E1
Di Cesare Mannelli, L3
Menicacci, C1
Lorenzoni, P1
Aglianò, M1
Ghelardini, C3
Traina, G1
Memeo, A1
Loiero, M1
Toscano, A1
Pacini, A1
Bartolini, A2
Chiechio, S3
Copani, A3
Zammataro, M1
Battaglia, G1
Gereau, RW2
Nicoletti, F3
Vivoli, E1
Salvicchi, A1
Koverech, A1
Nicolai, R2
Benatti, P1
Zheng, H1
Xiao, WH3
Bennett, GJ3
Melchiorri, D1
Canudas, AM1
Storto, M1
Calvani, M2
Sima, AA1
Mehra, M1
Amato, A1
Flatters, SJ2
Osio, M3
Muscia, F1
Zampini, L1
Nascimbene, C2
Mailland, E2
Cargnel, A1
Mariani, C2
Youle, M1
Vanotti, A1
Capiluppi, E1
Jin, HW1
Mulhern, HL1
Onofrj, M1
Fulgente, T1
Melchionda, D1
Marchionni, A1
Tomasello, F1
Salpietro, FM1
Alafaci, C1
De Sanctis, E1
Pennisi, G1
Bella, R1
Scarpini, E1
Sacilotto, G1
Baron, P1
Cusini, M1
Scarlato, G1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Microbiome Correlates of Dietary Interventions in Patients With Fibromyalgia and Their Association With Symptom Modification[NCT05329571]50 participants (Anticipated)Interventional2021-03-12Active, not recruiting
Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial.[NCT02141035]Phase 2/Phase 320 participants (Actual)Interventional2015-09-30Completed
An Open-Label, Dose-Escalation Pilot Study of Acetyl-L-Carnitine for the Treatment of Dideoxynucleoside-Associated Distal Symmetric Peripheral Neuropathy[NCT00050271]27 participants (Actual)InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for acetylcarnitine and Pain

ArticleYear
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.
    Nutrients, 2020, Aug-31, Volume: 12, Issue:9

    Topics: Acetylcarnitine; Ascorbic Acid; Chlorella; Diet, Vegan; Dietary Supplements; Fermented Foods; Fibrom

2020
Effects of acetyl-L-carnitine in diabetic neuropathy and other geriatric disorders.
    Aging clinical and experimental research, 2018, Volume: 30, Issue:2

    Topics: Acetylcarnitine; Aged; Alzheimer Disease; Analgesics; Diabetic Neuropathies; Humans; Mitochondria; P

2018
The neurobiology of acetyl-L-carnitine.
    Frontiers in bioscience (Landmark edition), 2016, 06-01, Volume: 21, Issue:7

    Topics: Acetylcarnitine; Aging; Animals; Apoptosis; Brain; Dietary Supplements; Energy Metabolism; Epigenesi

2016
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.
    Journal of endocrinological investigation, 2004, Volume: 27, Issue:6 Suppl

    Topics: Acetylcarnitine; Analgesics; Animals; Humans; Nootropic Agents; Pain; Peripheral Nervous System Dise

2004
Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies.
    CNS drugs, 2007, Volume: 21 Suppl 1

    Topics: Acetylcarnitine; Analgesics, Opioid; Animals; Anticonvulsants; Antidepressive Agents; Antineoplastic

2007
Acetyl-L-carnitine in neuropathic pain: experimental data.
    CNS drugs, 2007, Volume: 21 Suppl 1

    Topics: Acetylcarnitine; Analgesia; Animals; Humans; Nootropic Agents; Pain; Peripheral Nervous System Disea

2007

Trials

8 trials available for acetylcarnitine and Pain

ArticleYear
Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective stu
    Acta bio-medica : Atenei Parmensis, 2023, 06-23, Volume: 94, Issue:S2

    Topics: Acetylcarnitine; Carpal Tunnel Syndrome; COVID-19; Curcumin; Humans; Pain; Pandemics; Phosphatidylse

2023
Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled study.
    Clinical and experimental rheumatology, 2023, Volume: 41, Issue:6

    Topics: Acetylcarnitine; Analgesics; Duloxetine Hydrochloride; Fibromyalgia; Humans; Pain; Pregabalin; Treat

2023
Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study.
    Clinical drug investigation, 2008, Volume: 28, Issue:8

    Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Analgesics; Antioxidants; Double-Blind Method; Elec

2008
Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.
    Diabetes care, 2005, Volume: 28, Issue:1

    Topics: Acetylcarnitine; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Human

2005
Acetyl-l-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: an open label study.
    Journal of the peripheral nervous system : JPNS, 2006, Volume: 11, Issue:1

    Topics: Acetylcarnitine; Adult; Aged; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Middle

2006
A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection.
    HIV medicine, 2007, Volume: 8, Issue:4

    Topics: Acetylcarnitine; Administration, Oral; Adult; Anti-HIV Agents; Double-Blind Method; Female; HIV Infe

2007
L-acetylcarnitine as a new therapeutic approach for peripheral neuropathies with pain.
    International journal of clinical pharmacology research, 1995, Volume: 15, Issue:1

    Topics: Acetylcarnitine; Adolescent; Adult; Aged; Double-Blind Method; Humans; Injections, Intramuscular; Mi

1995
Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients.
    Journal of the peripheral nervous system : JPNS, 1997, Volume: 2, Issue:3

    Topics: Acetylcarnitine; Adult; Female; HIV Seropositivity; Humans; Male; Middle Aged; Nootropic Agents; Pai

1997

Other Studies

10 other studies available for acetylcarnitine and Pain

ArticleYear
Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain.
    International journal of molecular sciences, 2021, Feb-17, Volume: 22, Issue:4

    Topics: Acetylcarnitine; Amides; Animals; Carrageenan; Cell Count; Cyclooxygenase 2; Disease Models, Animal;

2021
Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain's pain circuitry.
    World journal of gastroenterology, 2021, Mar-07, Volume: 27, Issue:9

    Topics: Acetylcarnitine; Acute Disease; Animals; Brain; Ceruletide; Disease Models, Animal; Male; Mice; Mice

2021
L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain.
    CNS drugs, 2017, Volume: 31, Issue:12

    Topics: Acetylcarnitine; Adult; Analgesics; Carpal Tunnel Syndrome; Female; Humans; Male; Median Nerve; Midd

2017
Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis.
    Life sciences, 2014, Jun-13, Volume: 106, Issue:1-2

    Topics: Acetylcarnitine; Animals; Chondrocytes; Disease Models, Animal; Male; Osteoarthritis, Knee; Pain; Pa

2014
The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain.
    Neuroscience, 2010, Feb-17, Volume: 165, Issue:4

    Topics: Acetylcarnitine; Animals; Disease Models, Animal; Enzyme Activation; Functional Laterality; Hyperalg

2010
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain.
    Trends in pharmacological sciences, 2010, Volume: 31, Issue:4

    Topics: Acetylcarnitine; Animals; Chronic Disease; Epigenesis, Genetic; Humans; Pain; Pain Management; Recep

2010
Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy.
    Neuroscience, 2010, Jun-02, Volume: 167, Issue:4

    Topics: Acetylcarnitine; Analgesics; Animals; Constriction, Pathologic; Ganglia, Spinal; Male; Nerve Growth

2010
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
    Experimental neurology, 2012, Volume: 238, Issue:2

    Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; An

2012
Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy.
    Neuroscience letters, 2006, Apr-24, Volume: 397, Issue:3

    Topics: Acetylcarnitine; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Male; Paclitaxel;

2006
Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells.
    Experimental neurology, 2008, Volume: 210, Issue:1

    Topics: Acetylcarnitine; Animals; Axons; Behavior, Animal; Disease Models, Animal; Drug Interactions; Langer

2008