Page last updated: 2024-11-02

phenoxybenzamine and Pain

phenoxybenzamine has been researched along with Pain in 23 studies

Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons."1.36Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. ( Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW, 2010)
"Morphine was administered subcutaneously (2."1.26The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique. ( Azami, J; Llewelyn, MB; Roberts, MHT, 1982)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199013 (56.52)18.7374
1990's2 (8.70)18.2507
2000's4 (17.39)29.6817
2010's4 (17.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Toda, H1
Maruyama, H1
Budgell, B1
Kurosawa, M1
Silveira, JW1
Dias, QM2
Del Bel, EA1
Prado, WA4
Cadirci, E1
Suleyman, H1
Hacimuftuoglu, A1
Halici, Z1
Akcay, F1
Chang, M1
Smith, S1
Thorpe, A1
Barratt, MJ1
Karim, F1
Petronilho, A1
Reis, GM1
Fais, RS1
Tanimoto, T1
Takeda, M1
Matsumoto, S1
Jain, S1
Sharma, R2
Snow, AE1
Tucker, SM1
Dewey, WL1
Llewelyn, MB2
Azami, J2
Roberts, MH1
Roberts, MHT1
Gintautas, J1
Kraynack, B1
Hughston, T1
Thomas, E1
Racz, G1
Franco, AC1
Guimarães, AP1
Guimarães, FS1
Manchanda, SK1
Nayar, U1
Zheng, P1
Yang, YR1
Archer, CB2
Whittaker, S1
Greaves, MW2
Yu, GD1
Chen, JS1
Yin, WP1
Yin, QZ1
Saarnivaara, L1
Vorherr, H1
Meyer, W2
Fewings, JD1
Rand, MJ1
Scroop, GC1
Whelan, RF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin[NCT00971620]Phase 218 participants (Actual)Interventional2008-11-17Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Post-Ice Provocation Visual Analog Score (VAS) Between Week 12 and Week 24

The VAS is a commonly used validated tool for assessment of pain. The 10-cm VAS was used to assess current patient pain/discomfort before and after application of ice to study lesions. A clinically meaningful change in chronic pain intensity using the VAS has been determined as a reduction of 2 points or 30%. Scale is 0-10. 10 denotes worse pain than 0. (NCT00971620)
Timeframe: Between week 12 and 24

InterventionScore (Median)
BTX-A4.10
Placebo/Saline-0.30

Change in Worst Lesional Pain in the Past Week Based on Brief Pain Inventory

Change in worst lesional pain in the past week based on Brief Pain Inventory (BPI) from Week 0 to Week 4 in treated patients versus controls. The BPI uses an arbitrary units on a 0-10 scale. For the purposes of the statistical calculation, a difference of 1 standard deviation between groups at baseline vs. week 4 was considered significant. Any BPI value above zero (no pain) is abnormal. The mean change indicates mean change in pain score. (NCT00971620)
Timeframe: Between week 0 and week 4

Interventionunits on a scale (Mean)
BTX-A-2.50
Placebo/Saline-1.26

Comparison of Change in Skin Related Quality of Life by Total Dermatology Life Quality Index (DLQI) at Week 0 vs. Week 4

The DLQI is a 10-question quality of life survey which has been extensively validated and frequently used in dermatologic disorders such as atopic dermatitis, acne, and psoriasis. Score is 0-30 based on 10 questions. The higher the score, the more quality of life is impaired. (NCT00971620)
Timeframe: Week 0 vs. week 4

InterventionUnits on a scale (Median)
BTX-A-4.00
Placebo/Saline0.00

Immunohistochemical Staining of Cutaneous Leiomyomas for Acetylcholinesterase (AchE) Before (i.e.,Week 0) and 12 Weeks After Botulinum Toxin Administration

AchE staining was scored as 0 (none), 1 (rare), 2 (scattered), or 3 (focal or greater). (NCT00971620)
Timeframe: Week 0 vs. week 12

InterventionScore (Median)
BTX-A1.00
Placebo/Saline0.00

Immunohistochemical Staining of Cutaneous Leiomyomas for C-fos Before (i.e., Week 0) and 12 Weeks After Botulinum Toxin Administration

c-fos, a marker of neuronal activation after pain stimulation, was scored as 0 (none), 1 (scattered), 2 (<66% of tumor cells), or 3 (≥66% of tumor cells). (NCT00971620)
Timeframe: Week 0 vs. week 12

InterventionScore (Median)
BTX-A-1.00
Placebo/Saline0.00

Median Change in Average Pain Between Two Arms

Change in average pain was assessed by the Brief Pain Inventory (BPI). The BPI is a validated pain assessment tool that assesses severity of pain, location of pain, impact of pain on daily functions, pain medications, and amount of pain relief in the past 24 hours or past week (e.g. scale of 0-10 (worst pain)). (NCT00971620)
Timeframe: Between weeks 0 and week 4

InterventionScore (Median)
BTX-A0.00
Placebo/Saline0.00

Number of Participants With Adverse Events

Here is the number of participants with adverse events. For a detailed list of adverse events, see the adverse event module. (NCT00971620)
Timeframe: 37 months

Interventionparticipants (Number)
BTX-A4
Placebo/Saline5

Specific Skin Pain-Related Question on the Dermatology Life Quality Index

"The DLQI is a 10-question quality of life survey which has been extensively validated and frequently used in dermatologic disorders such as atopic dermatitis, acne, and psoriasis. Participants response to the question Over the last week, how itchy, sore, painful or stinging has your skin been? was assessed by the Dermatology Life Quality Index. This outcome refers to a single specific question on the DLQI, so the range for this outcome is 0-3. Lower values in the DLQI indicate less impairment (or greater improvement) in life quality from the skin disease." (NCT00971620)
Timeframe: Week 0 vs. week 4

InterventionUnits on a scale (Median)
BTX-A-1.00
Placebo/Saline0.00

Visual Analog Scale (VAS) of Patient Perceived Pain at Leiomyoma Site Prior to Ice Provocation at Week 0 vs. Week 4

The VAS is a commonly used validated tool for assessment of pain. For this measure, a 10-cm VAS was used to assess current patient pain/discomfort before application of ice to study lesions at week 0 and week 4. A clinically meaningful change in chronic pain intensity using the VAS has been determined as a reduction of 2 points or 30%. Range is 0-10; 0 is no pain and 10 is worst possible pain. (NCT00971620)
Timeframe: Week 0 vs. week 4

InterventionScore (Median)
BTX-A0.00
Placebo/Saline0.40

Worst Pain Severity

Pain severity was assessed by the Brief Pain Inventory (BPI). The BPI is a validated pain assessment tool that assesses severity of pain, location of pain, impact of pain on daily functions, pain medications, and amount of pain relief in the past 24 hours or past week (e.g. scale of 0-10 (worst pain)). This outcome was based on a single 0-10 question on the BPI. (NCT00971620)
Timeframe: Week 0 vs. week 4

InterventionScore (Median)
BTX-A-2.25
Placebo/Saline-0.75

Percentage of Patients With a Change in Average Pain Score

Average pain was determined from a 0-10 scale question on the Brief Pain Inventory (BPI). 10 denotes worse pain. (NCT00971620)
Timeframe: Week 0 score vs. week 4 score

,
Interventionpercentage of patients (Number)
>50% pain reduction≤50% pain reductionNo change in painIncreased painMissing
BTX-A440222211
Placebo/Saline2211332211

Percentage of Patients With a Change in Post-Ice Visual Analog Score (VAS) Between Week 0 and Week 4

The VAS is a commonly used validated tool for assessment of pain. The 10-cm VAS was used to assess current patient pain/discomfort before and after application of ice to study lesions. A clinically meaningful change in chronic pain intensity using the VAS has been determined as a reduction of 2 points or 30%. Scale is 0-10. 10 = worse pain. (NCT00971620)
Timeframe: Week 0 vs. week 4

,
Interventionpercentage of patients (Number)
>50% pain reduction≤50% pain reductionNo change in painIncreased painMissing
BTX-A33440220
Placebo/Saline33440220

Percentage of Patients With a Change in Pre-Ice Visual Analog Score (VAS) Between Week 0 and Week 4

The VAS is a commonly used validated tool for assessment of pain. The 10-cm VAS was used to assess current patient pain/discomfort before and after application of ice to study lesions. A clinically meaningful change in chronic pain intensity using the VAS has been determined as a reduction of 2 points or 30%. Scale of 0-10. 10 = worse pain. (NCT00971620)
Timeframe: Week 0 vs. week 4

,
Interventionpercentage of patients (Number)
>50% pain reduction≤50% pain reductionNo change in painIncreased painMissing
BTX-A223301133
Placebo/Saline110115522

Reviews

2 reviews available for phenoxybenzamine and Pain

ArticleYear
[Cliniccal aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
    Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5

    Topics: Adult; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; Escherichia

1966
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
    Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5

    Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins;

1966

Other Studies

21 other studies available for phenoxybenzamine and Pain

ArticleYear
Responses of dorsal spinal cord blood flow to noxious mechanical stimulation of the skin in anesthetized rats.
    The journal of physiological sciences : JPS, 2008, Volume: 58, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia, General; Animals; Blood Pressur

2008
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
    Molecular pain, 2010, Mar-23, Volume: 6

    Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Me

2010
Indirect role of beta2-adrenergic receptors in the mechanism of analgesic action of nonsteroidal antiinflammatory drugs.
    Critical care medicine, 2010, Volume: 38, Issue:9

    Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analgesics; Animals; Anti-

2010
Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping.
    Molecular pain, 2010, Sep-16, Volume: 6

    Topics: Administration, Oral; Algorithms; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Fre

2010
Antinociceptive effect of stimulating the zona incerta with glutamate in rats.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3

    Topics: Analgesics; Animals; Atropine; Glutamic Acid; Haloperidol; Male; Mecamylamine; Methysergide; Microin

2012
Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the rat.
    Experimental brain research, 2002, Volume: 145, Issue:4

    Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Dental Pulp; Dose-Response Relationship, D

2002
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:11

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio

2002
The role of neurotransmitters in stress-induced antinociception (SIA).
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:1

    Topics: Animals; Apomorphine; Clonidine; Dopamine; Haloperidol; Kinetics; Male; Neurotransmitter Agents; Nor

1982
The effect of modification of 5-hydroxytryptamine function in nucleus raphe magnus on nociceptive threshold.
    Brain research, 1984, Jul-23, Volume: 306, Issue:1-2

    Topics: Animals; Brain Stem; Cinanserin; Hot Temperature; Male; Morphine; Pain; Phenoxybenzamine; Raphe Nucl

1984
The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique.
    Pain, 1982, Volume: 12, Issue:3

    Topics: Analgesia; Animals; Cinanserin; Male; Microinjections; Morphine; Naloxone; Nociceptors; Pain; Phenox

1982
Activation of coerulospinal systems by nociceptive stimulus.
    Proceedings of the Western Pharmacology Society, 1981, Volume: 24

    Topics: Animals; Cats; Electric Stimulation; Female; Hindlimb; Locus Coeruleus; Male; Methysergide; Pain; Ph

1981
Antinociceptive effects of stimulation of discrete sites in the rat hypothalamus: evidence for the participation of the lateral hypothalamus area in descending pain suppression mechanisms.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1996, Volume: 29, Issue:11

    Topics: Adrenergic alpha-Antagonists; Analgesia; Analgesics, Opioid; Animals; Atropine; Dopamine Antagonists

1996
Modulation of carbachol-induced antinociception from the rat periaqueductal gray.
    Brain research bulletin, 2000, Volume: 51, Issue:6

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Anxiety; Bethanechol; Carbachol; Cholinergic Agon

2000
Role of opioid receptors in self-aggression in rats.
    Indian journal of physiology and pharmacology, 1991, Volume: 35, Issue:3

    Topics: Aggression; Amphetamine; Animals; Behavior, Animal; Male; Naloxone; Norepinephrine; Pain; Phenoxyben

1991
[Site of analgesic action of aconitine and the relation between its action and the central noradrenergic system].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:6

    Topics: Aconitine; Aconitum; Analgesics; Animals; Female; Injections, Intraventricular; Injections, Spinal;

1988
Pharmacological modulation of cold-induced pain in cutaneous leiomyomata.
    The British journal of dermatology, 1988, Volume: 118, Issue:2

    Topics: Adult; Cold Temperature; Female; Humans; Leiomyoma; Male; Middle Aged; Pain; Phenoxybenzamine; Scopo

1988
Assessment of treatment for painful cutaneous leiomyomas.
    Journal of the American Academy of Dermatology, 1987, Volume: 17, Issue:1

    Topics: Adult; Humans; Leiomyoma; Male; Nifedipine; Pain; Pain Measurement; Phenoxybenzamine; Skin Neoplasms

1987
[Effect of locus coeruleus stimulation on unit discharge of the hypothalamic arcuate nucleus in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:2

    Topics: Animals; Arcuate Nucleus of Hypothalamus; Clonidine; Electric Stimulation; Electrophysiology; Hypoth

1985
Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
    Annales medicinae experimentalis et biologiae Fenniae, 1969, Volume: 47, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A

1969
Catecholamine antagonism to oxytocin-induced milk-ejection.
    Acta endocrinologica. Supplementum, 1971, Volume: 154

    Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Pressure; Catecholamines; Epinephrine; F

1971
The action of nicotine on the blood vessels of the hand and forearm in man.
    British journal of pharmacology and chemotherapy, 1966, Volume: 26, Issue:3

    Topics: Anesthesia, Conduction; Arm; Blood Flow Velocity; Blood Vessels; Denervation; Hand; Hexamethonium Co

1966