cyproheptadine has been researched along with Pain in 19 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 7.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "The effects of aspirin or 5-hydroxytryptamine (5-HT)-related drugs on the dental pain induced by electrical stimulation of tooth pulp afferent fibers were assessed in conscious monkeys." | 7.67 | Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey. ( Lin, MT; Shyu, KW; Wu, TC, 1984) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 3.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "Cyproheptadine-HCl raised the pain thresholds during hot plat test and writhing test in mice and tail flick test in rats, strengthened the hypnotic action by subthreshold dosage of sodium pentobarbital and chloral hydrate." | 3.68 | [Analgesic and antipyretic effects of cyproheptadine]. ( Cui, J; Fan, CK; Tan, JQ; Xu, B, 1990) |
| "The effects of aspirin or 5-hydroxytryptamine (5-HT)-related drugs on the dental pain induced by electrical stimulation of tooth pulp afferent fibers were assessed in conscious monkeys." | 3.67 | Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey. ( Lin, MT; Shyu, KW; Wu, TC, 1984) |
| " In this study, we investigated the antinociceptive action of neurotropin in relation to the serotonergic system, a pain inhibitory system, and substance P, a pain transmitter; we also attempted to determine whether it acts at the spinal or supraspinal level in mice." | 3.67 | Analgesic mechanism of neurotropin: relation to the serotonergic system and influence of spinal cord transection. ( Hata, T; Itoh, E, 1989) |
| "The edema was inhibited by previous treatment with promethazine (5 or 10mg/kg) or cyproheptadine (5 or 10mg/kg), but not by indomethacin (2 or 4mg/kg), dexamethasone (1 or 4mg/kg) or cromolyn (40 or 80mg/kg)." | 1.33 | Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. ( Bertollo, CM; Coelho, MM; Costa, KA; Glória, MB; Moraes-Santos, T; Nascimento, EB; Oliveira, AC; Rocha, LT; Souza, AL, 2005) |
| "The ability of allergens to induce hyperalgesia in immunoglobulin E (IgE)-sensitized rats was investigated." | 1.32 | Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. ( Calixto, JB; Cordeiro, RS; e Silva, PM; Lavich, TR; Martins, MA, 2003) |
| "pretreatment with phentolamine and cyproheptadine caused a reduction of Fos-like immunoreactive neurons of only 4% on the intact side, namely, the differences in the number of Fos-like immunoreactive neurons on two sides of the lumbar spinal cord owing to the unilateral dorsolateral funiculus lesion were nearly abolished by i." | 1.30 | Effects of intrathecal monoamine antagonists on the nociceptive c-Fos expression in a lesioned rat spinal cord. ( Dafny, N; Liu, RJ; Nie, H; Qiao, JT; Wang, R; Zhang, RX, 1997) |
| "pretreatment with cyproheptadine or thioperamide dose-dependently attenuated the inhibition of the tail-flick response induced by i." | 1.30 | Effects of histamine receptor antagonists injected intrathecally on antinociception induced by opioids administered intracerebroventricularly in the mouse. ( Chung, KM; Huh, SO; Kim, YH; Song, DK; Suh, HW, 1999) |
| "pretreatment with cyproheptadine attenuated the inhibition of the tail-flick response induced by i." | 1.29 | Effects of intrathecally injected histamine receptor antagonists on the antinociception induced by morphine, beta-endorphin, and U50, 488H administered intrathecally in the mouse. ( Choi, YS; Kim, YH; Song, DK; Suh, HW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kilic, FS | 1 |
| Dogan, AE | 1 |
| Baydemir, C | 1 |
| Erol, K | 1 |
| Qiu, F | 1 |
| Qiu, CY | 1 |
| Liu, YQ | 1 |
| Wu, D | 1 |
| Li, JD | 1 |
| Hu, WP | 1 |
| Lavich, TR | 1 |
| Cordeiro, RS | 1 |
| Calixto, JB | 1 |
| e Silva, PM | 1 |
| Martins, MA | 1 |
| Choi, SS | 1 |
| Han, KJ | 1 |
| Lee, JK | 1 |
| Lee, HK | 1 |
| Han, EJ | 1 |
| Kim, DH | 1 |
| Suh, HW | 3 |
| KAHIL, ME | 1 |
| BROWN, H | 1 |
| FRED, HL | 1 |
| Nascimento, EB | 1 |
| Costa, KA | 1 |
| Bertollo, CM | 1 |
| Oliveira, AC | 1 |
| Rocha, LT | 1 |
| Souza, AL | 1 |
| Glória, MB | 1 |
| Moraes-Santos, T | 1 |
| Coelho, MM | 1 |
| Yamamoto, T | 1 |
| Niwa, S | 1 |
| Iwayama, S | 1 |
| Koganei, H | 1 |
| Fujita, S | 1 |
| Takeda, T | 1 |
| Kito, M | 1 |
| Ono, Y | 1 |
| Saitou, Y | 1 |
| Takahara, A | 1 |
| Iwata, S | 1 |
| Yamamoto, H | 1 |
| Shoji, M | 1 |
| Shyu, KW | 1 |
| Lin, MT | 1 |
| Wu, TC | 1 |
| Ramabadran, K | 1 |
| Jacob, JJ | 1 |
| Song, DK | 2 |
| Choi, YS | 1 |
| Kim, YH | 2 |
| Liu, RJ | 2 |
| Wang, R | 1 |
| Nie, H | 1 |
| Zhang, RX | 2 |
| Qiao, JT | 2 |
| Dafny, N | 2 |
| Chung, KM | 1 |
| Huh, SO | 1 |
| Wu, Q | 1 |
| Li, XC | 1 |
| Ruan, HZ | 1 |
| Li, HD | 1 |
| Lundberg, PO | 1 |
| Neuman, RS | 1 |
| Zebrowska, G | 1 |
| Tan, JQ | 1 |
| Fan, CK | 1 |
| Cui, J | 1 |
| Xu, B | 1 |
| Bero, LA | 1 |
| Kuhn, CM | 1 |
| Itoh, E | 1 |
| Hata, T | 1 |
19 other studies available for cyproheptadine and Pain
| Article | Year |
|---|---|
The acute effects of mirtazapine on pain related behavior in healthy animals.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe | 2011 |
Potentiation of acid-sensing ion channel activity by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channels; Animals; Cyproheptadine; Dose-Response Relationship, Drug; E | 2012 |
Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.
Topics: Allergens; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cyproheptadine; Dinitrophenols; Dos | 2003 |
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzopyrans; Butyrates; Cyp | 2003 |
THE CARCINOID CRISIS.
Topics: Cyproheptadine; Drug Therapy; Humans; Hyperesthesia; Hypotension; Malignant Carcinoid Syndrome; Meth | 1964 |
Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyproheptadine; Dipyrone; Edema; Indomethacin; Inje | 2005 |
Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity.
Topics: Administration, Oral; Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, N-Type; | 2006 |
Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey.
Topics: 5,7-Dihydroxytryptamine; Animals; Aspirin; Cyproheptadine; Dental Pulp; Fenclonine; Macaca; Male; Pa | 1984 |
Effects of various serotoninergic agonists and an antagonist on a nociceptive reaction in mice.
Topics: 5-Hydroxytryptophan; Animals; Cyproheptadine; Enkephalins; Male; Mice; Mice, Inbred Strains; Nocicep | 1982 |
Effects of intrathecally injected histamine receptor antagonists on the antinociception induced by morphine, beta-endorphin, and U50, 488H administered intrathecally in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1996 |
Effects of intrathecal monoamine antagonists on the nociceptive c-Fos expression in a lesioned rat spinal cord.
Topics: Adrenergic alpha-Antagonists; Animals; Cyproheptadine; Drug Interactions; Female; Immunohistochemist | 1997 |
Interrelations of opioids with monoamines in descending inhibition of nociceptive transmission at the spinal level: an immunocytochemical study.
Topics: Adrenergic alpha-Antagonists; Animals; Biogenic Monoamines; Cyproheptadine; Immunohistochemistry; In | 1999 |
Effects of histamine receptor antagonists injected intrathecally on antinociception induced by opioids administered intracerebroventricularly in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1999 |
[Effect of ACTH on the expression of somatostatin and c-fos in the spinal cord and formalin evoked pain response].
Topics: Adrenocorticotropic Hormone; Animals; Cyproheptadine; Female; Formaldehyde; Immunohistochemistry; Ma | 1999 |
Abdominal migraine--diagnosis and therapy.
Topics: Abdomen; Adult; Aged; Cyproheptadine; Female; Humans; Lynestrenol; Male; Middle Aged; Migraine Disor | 1975 |
Serotonin (5-HT2) receptor mediated enhancement of cortical unit activity.
Topics: Animals; Cerebral Cortex; Cinanserin; Cyproheptadine; Iontophoresis; Ketanserin; Male; Microelectrod | 1992 |
[Analgesic and antipyretic effects of cyproheptadine].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyproheptadine; Female; Fever; Hypnotics and Sedat | 1990 |
Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Cyproheptadine; Hydroxyindoleacetic Acid; | 1987 |
Analgesic mechanism of neurotropin: relation to the serotonergic system and influence of spinal cord transection.
Topics: Analgesics; Animals; Behavior, Animal; Cisterna Magna; Cyproheptadine; Decerebrate State; Fenclonine | 1989 |