Receptor activity-modifying protein 1

A receptor activity-modifying protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60894]

Synonyms

Calcitonin-receptor-like receptor activity-modifying protein 1;
CRLR activity-modifying protein 1

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
telcagepant	Homo sapiens (human)	Ki	0.0008	1	1
mk 3207	Homo sapiens (human)	Ki	0.0000	1	1
mk-8825	Homo sapiens (human)	Ki	0.0003	2	2
atogepant	Homo sapiens (human)	Ki	0.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
calcitonin gene-related peptide receptor activity	molecular function	Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. [GOC:mah, PMID:12037140]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
amylin receptor activity	molecular function	Combining with amylin to initiate a change in cell activity. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
calcitonin gene-related peptide binding	molecular function	Binding to calcitonin gene-related peptide (CGRP). [GOC:bhm, PMID:10882736]
coreceptor activity	molecular function	Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]
CGRP receptor complex	cellular component	A transmembrane, G protein-coupled signaling receptor complex recognized by calcitonin gene-related peptides (CGRP). [GOC:bhm, PMID:20826335]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
intracellular protein transport	biological process	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
regulation of G protein-coupled receptor signaling pathway	biological process	Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. [GOC:go_curators]
protein transport	biological process	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
receptor internalization	biological process	A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]
positive regulation of protein glycosylation	biological process	Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:dms, GOC:dph, GOC:pr]
protein localization to plasma membrane	biological process	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]
amylin receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416]
calcitonin gene-related peptide receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers. [GOC:bhm, PMID:10882736]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
cellular response to hormone stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah]