Page last updated: 2024-10-20

uric acid and Pain

uric acid has been researched along with Pain in 138 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Although previous findings indicated that allopurinol could present intrinsic analgesic effects in both animals and humans, this study showed no benefit of the use of oral allopurinol as an adjuvant strategy during 30 days in women displaying fibromyalgia."9.51Allopurinol for fibromyalgia pain in adults: A randomized controlled trial. ( Andrade, CF; Botelho, LM; de Oliveira, ED; Dos Santos, LMM; Fagundes, AC; Ferrari, SG; Lara, DR; Schmidt, AP; Schmidt, SRG; Souza, DO, 2022)
"A dosage of 300 mg/d of allopurinol was not effective in reducing pain or improving activities of daily living in chronic pancreatitis."9.08Does allopurinol reduce pain of chronic pancreatitis? ( Banks, PA; Ferrante, M; Hughes, M; Noordhoek, EC; Ramagopal, V; Slivka, A, 1997)
"In a double-blind multiclinic trial, a new nonsteroidal anti-inflammatory agent (ibuprofen) was compared with an established therapeutic agent (phenylbutazone-alka) for the treatment of osteoarthritis."9.04Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial. ( Donovan, JF; Hearron, MS; Levi, L; Moxley, TE; Royer, GL, 1975)
"Eucalyptol alleviates MSU-induced pain and inflammation via mechanisms possibly involving anti-oxidative effect."7.96Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. ( Li, X; Li, Y; Liu, B; Tai, Y; Wang, C; Wang, P; Yin, C; Zheng, X, 2020)
"Retigabine and flupirtine showed antinociceptive effects for MSU-induced gout pain at different times during pain development."7.96Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020)
"Procyanidins significantly attenuated gout pain and suppressed ankle swelling."7.85Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. ( Fan, YX; Gui, X; Han, Y; Hu, L; Jiang, CY; Liu, BQ; Liu, HJ; Liu, WT; Pan, XX; Tang, YL, 2017)
"The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception (levels I, II, and III) using the "Pain-induced functional impairment model in the rat"."7.74The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. ( Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Godínez-Chaparro, B; Guevara-López, U; Huerta-Cruz, JC; López-Muñoz, FJ, 2008)
"The potential antinociceptive effects of the S(+)- and R(-)-enantiomers of flurbiprofen (SFB and RFB, respectively) were investigated when given intravenously to rats using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."7.70Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain. ( Cabré, F; Díaz, MI; Domínguez, AM; García, ML; Hernández, GP; López-Muñoz, FJ; Mauleón, D; Ventura, R, 2000)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."7.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat."7.68Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993)
"Suprofen, a nonsteroidal anti-inflammatory drug, has been associated with the onset of acute flank pain, hematuria, and transient renal dysfunction after the ingestion of one or two doses, particularly in young males."7.67Suprofen-induced uricosuria. A potential mechanism for acute nephropathy and flank pain. ( Abraham, PA; Halstenson, CE; Keane, WF; Matzke, GR; Opsahl, JA, 1988)
"Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib."6.70Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002)
" Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months."6.64Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974)
"Dimethyl fumarate (DMF) has shown anti-inflammatory and antioxidant activities."5.91Dimethyl fumarate attenuates MSU-induced gouty arthritis by inhibiting NLRP3 inflammasome activation and oxidative stress. ( Cao, Y; Hu, Y; Jin, XF; Liu, Y; Zou, JM, 2023)
"Although previous findings indicated that allopurinol could present intrinsic analgesic effects in both animals and humans, this study showed no benefit of the use of oral allopurinol as an adjuvant strategy during 30 days in women displaying fibromyalgia."5.51Allopurinol for fibromyalgia pain in adults: A randomized controlled trial. ( Andrade, CF; Botelho, LM; de Oliveira, ED; Dos Santos, LMM; Fagundes, AC; Ferrari, SG; Lara, DR; Schmidt, AP; Schmidt, SRG; Souza, DO, 2022)
" The assessed outcomes were total effective rate, uric acid level, pain score, and inflammatory factor levels such as erythrocyte sedimentation rate and C-reactive protein."5.41Herbal medicine for external use in acute gouty arthritis: A PRISMA-compliant systematic review and meta-analysis. ( Choi, SH; Hwang, J; Song, HS, 2023)
"The optimum doses of carprofen, flunixin, ketoprofen and sodium salicylate for the treatment of inflammatory pain were determined in domestic fowl using the microcrystalline sodium urate model of articular pain."5.11Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl. ( Gentle, MJ; Hocking, PM; Robertson, GW, 2005)
"A dosage of 300 mg/d of allopurinol was not effective in reducing pain or improving activities of daily living in chronic pancreatitis."5.08Does allopurinol reduce pain of chronic pancreatitis? ( Banks, PA; Ferrante, M; Hughes, M; Noordhoek, EC; Ramagopal, V; Slivka, A, 1997)
"In a double-blind multiclinic trial, a new nonsteroidal anti-inflammatory agent (ibuprofen) was compared with an established therapeutic agent (phenylbutazone-alka) for the treatment of osteoarthritis."5.04Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial. ( Donovan, JF; Hearron, MS; Levi, L; Moxley, TE; Royer, GL, 1975)
"Along with uric acid, which is the primary driving factor of gout, downstream inflammatory mediators have been shown to be involved in the pathogenesis of gouty arthritis flares."4.12Plasma adsorption in refractory chronic gouty arthritis flare: A case report. ( Cui, TJ; Lei, Y; Tang, C; Wang, XH; Zhang, XM; Zheng, ZH, 2022)
"Eucalyptol alleviates MSU-induced pain and inflammation via mechanisms possibly involving anti-oxidative effect."3.96Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. ( Li, X; Li, Y; Liu, B; Tai, Y; Wang, C; Wang, P; Yin, C; Zheng, X, 2020)
"Retigabine and flupirtine showed antinociceptive effects for MSU-induced gout pain at different times during pain development."3.96Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020)
"Procyanidins significantly attenuated gout pain and suppressed ankle swelling."3.85Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. ( Fan, YX; Gui, X; Han, Y; Hu, L; Jiang, CY; Liu, BQ; Liu, HJ; Liu, WT; Pan, XX; Tang, YL, 2017)
" Further, an acetic acid-induced writhing test and tail immersion test were employed to screen for analgesic effects, yeast-induced pyrexia was used to test for antipyretic effects, and gastric ulceration was used to evaluate ulcerogenic effects."3.79Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats. ( Pragasam, SJ; Rasool, M, 2013)
"Diazepam-reduced experimental anxiety was paralleled by antinociceptive effects."3.76Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2010)
"The aim of this study is to evaluate connection of plasma level of beta2-microglobulin, C-reactive protein and uric acid as well as sonographic parameters like thickness of synovial membrane, thickness of femoral condylar cartilage and presence of joint effusion and Baker's cysts with bilateral knee pain in dialyzed patients, comparing them with parameters in asymptomatic dialyzed patients."3.74Laboratory and sonographic findings in dialyzed patients with bilateral chronic knee pain versus dialyzed asymptomatic patients. ( Barisić, I; Bekavac, J; Janković, S; Ljutić, D; Vlak, T, 2007)
"The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception (levels I, II, and III) using the "Pain-induced functional impairment model in the rat"."3.74The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. ( Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Godínez-Chaparro, B; Guevara-López, U; Huerta-Cruz, JC; López-Muñoz, FJ, 2008)
" The role of factors with anxiogenic properties produced during inflammation, which may modify diazepam and buspirone effects, is discussed."3.73Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005)
"The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout."3.72Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. ( Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R, 2004)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."3.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"The potential antinociceptive effects of the S(+)- and R(-)-enantiomers of flurbiprofen (SFB and RFB, respectively) were investigated when given intravenously to rats using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."3.70Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain. ( Cabré, F; Díaz, MI; Domínguez, AM; García, ML; Hernández, GP; López-Muñoz, FJ; Mauleón, D; Ventura, R, 2000)
"The presence of nausea and vomiting, epigastric pain, or both in association with admission laboratory values that are in excess of the cutoffs for lactate dehydrogenase, aspartate aminotransferase, and uric acid concentrations or for all 6 tests is predictive of high risk of morbidity for the patient with severe preeclampsia."3.70Early risk assessment of severe preeclampsia: admission battery of symptoms and laboratory tests to predict likelihood of subsequent significant maternal morbidity. ( Blake, PG; Magann, EF; Martin, JN; May, WL; Rinehart, BK; Terrone, DA, 1999)
"The analgesic activities of paracetamol (100, 178, 316 and 562 mg kg-1), caffeine (10, 18, 32 and 56 mg kg-1) and combinations of these doses were tested on a pain-induced functional impairment model in the rat."3.68Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. ( Castañeda-Hernández, G; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ; Salazar, LA; Villarreal, JE, 1993)
"In previous studies we reported that the rat spinal cord contains relatively high levels of uric acid and that the levels in a rat model of bilateral chronic pain, experimental adjuvant arthritis."3.67Effect of deafferentation on the levels of uric acid in the spinal cord of the rat. ( Basbaum, AI; Godefroy, F; Weil-Fugazza, J, 1989)
"Suprofen, a nonsteroidal anti-inflammatory drug, has been associated with the onset of acute flank pain, hematuria, and transient renal dysfunction after the ingestion of one or two doses, particularly in young males."3.67Suprofen-induced uricosuria. A potential mechanism for acute nephropathy and flank pain. ( Abraham, PA; Halstenson, CE; Keane, WF; Matzke, GR; Opsahl, JA, 1988)
" Surface electromyograms were used to evaluate the muscle spasm theory; the possibility of actual muscle cell damage was monitored by the presence of myoglobinuria, while the ratio of hydroxyproline/creatinine (OHP/Cr) in 24 hr urine collection was used as a marker for connective tissue involvement."3.65Factors in delayed muscle soreness. ( Abraham, WM, 1977)
"Gout is triggered by high urate levels and causes inflammation, pain, and an impaired quality of life."3.30Immersion in Water Between 20-30 ( Chou, KR; Karwur, FF; Kurniasari, MD; Miao, NF; Rayanti, RE; Shen, CJ; Shih, YW; Tsai, HT; Yuliana, S, 2023)
"The primary outcomes will be joint pain measured by VAS score, and joint swelling measured using width and thickness of affected joints and VAS score."3.11Efficacy and safety of Tibetan medicine Qingpeng ointment for acute gouty arthritis: protocol for a multi-center, randomized, double-blind, placebo-controlled trial. ( Dong, X; Huang, JY; Li, XP; Liu, JP; Liu, Y; Shang, YX; Wang, XC; Wei, SF; Xie, ZM, 2022)
" To investigate the potency of MSU crystals as a cancer vaccine carrier in vivo, this preclinical study examined whether intradermal injection of MSU crystals was safe for healthy adults."2.76Safety of intradermal injection of monosodium urate crystals as a vaccine carrier in volunteers. ( Inai, K; Sakamaki, I; Tsutani, H, 2011)
" The treatment group was treated by jiawei simiaosan and combined with the external application of Sihuangshuimi."2.73[A clinical research of Jiawei simiaosan oral administration combined with the external application of Sihuangshuimi in the treatment of acute gouty arthritis]. ( Chen, SQ; Chen, ZX; Sun, BG; Ye, XY; Yin, LR; Zhou, HM, 2007)
"To study the therapeutic effect of treatment of acute gouty arthritis (AGA) respectively by electroacupuncture (EA) with different frequency and oral intake of Western medicine."2.72Comparative study on treatment of acute gouty arthritis by electroacupuncture with different frequency. ( Zhang, HX; Zhang, TF; Zou, R, 2006)
"Carprofen was also somewhat effective in attenuating the severity of urate-induced synovitis but to a lesser degree than the medium dose of deracoxib."2.70Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. ( Buonomo, FC; Millis, DL; Moyers, T; Weigel, JP, 2002)
" It is concluded that the arthralgia was often self-limiting, that aspirin had a small beneficial effect, that allopurinol, in the dosage studied, may have had a slightly deleterious effect, but that it would be worth studying larger dosages of allopurinol because the dosage studied did not affect the serum uric acid concentration."2.65Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration. ( Allan, WG; Fox, W; Girling, DJ; Horsfall, PA; Nunn, AJ; Plummer, J, 1979)
" Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months."2.64Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974)
"The pharmacological treatment of pain in CIA is strictly associated with the treatment of acute phases and flares of the disease, during which crystals trigger the inflammatory response."2.52Molecular mechanisms of pain in crystal-induced arthritis. ( Frallonardo, P; Galozzi, P; Lorenzin, M; Oliviero, F; Ortolan, A; Punzi, L; Ramonda, R; Scanu, A, 2015)
"Gout is the most common cause of inflammatory arthritis among men and postmenopausal women."2.46Gout: epitome of painful arthritis. ( VanItallie, TB, 2010)
"We describe here a new type of acute renal failure with severe loin pain which develops after anaerobic exercise (ALPE), for example, 200-meter track racing."2.41Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise in patients with or without renal hypouricemia. ( Ishikawa, I, 2002)
"Gouty arthritis is characterized by painful inflammation due to the deposition of monosodium urate crystals in joint tissues."1.91Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model. ( Bertolini, GRF; Costa, RM; Hoss, IM; Leal, TSDS; Pradal, LA; Ribeiro, LFC, 2023)
"Dimethyl fumarate (DMF) has shown anti-inflammatory and antioxidant activities."1.91Dimethyl fumarate attenuates MSU-induced gouty arthritis by inhibiting NLRP3 inflammasome activation and oxidative stress. ( Cao, Y; Hu, Y; Jin, XF; Liu, Y; Zou, JM, 2023)
"Mechanical hyperalgesia was conducted using the electronic von Frey."1.72Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice. ( Li, G; Xu, X; Yuan, Z; Zhang, G; Zhang, S, 2022)
"RvD1 inhibited MSU-induced mechanical hyperalgesia in a dose- and time-dependent manner by reducing leukocyte recruitment and IL-1β production in the knee joint."1.72RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice. ( Amaral, FA; Andrade, KC; Artero, NA; Badaro-Garcia, S; Bertozzi, MM; Borghi, SM; Casagrande, R; Fattori, V; Ferraz, CR; Manchope, MF; Rasquel-Oliveira, F; Rogers, MS; Saraiva-Santos, T; Staurengo-Ferrari, L; Teixeira, MM; Verri, WA; Zaninelli, TH, 2022)
"Pain was determined using the electronic von Frey and static weight bearing."1.56IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis. ( Alves-Filho, JC; Amaral, FA; Casagrande, R; Cunha, FQ; Cunha, TM; Fattori, V; Louzada-Junior, P; Oliveira, RD; Staurengo-Ferrari, L; Teixeira, MM; Verri, WA; Zaninelli, TH, 2020)
"The swelling degree reached its maximum at 10 h and the minimum pain threshold was maintained between 8 and 48 h after MSU treatment in mice."1.56Characteristics of voltage-gated potassium currents in monosodium urate induced gouty arthritis in mice. ( Hong, J; Qiu, J; Wang, X; Zhang, G, 2020)
"Gout is the most common inflammatory arthritis in adults in the Western world."1.43Gout: will the "King of Diseases" be the first rheumatic disease to be cured? ( Singh, JA, 2016)
"Pain was measured before and during the TDP using the Premature Infant Pain Profile (PIPP)."1.38Procedural pain and oxidative stress in premature neonates. ( Angeles, DM; Angeles, KR; Ashwal, S; Asmerom, Y; Bahjri, K; Boskovic, DS; Deming, D; Fayard, E; Hougland, K; Phillips, R; Plank, MS; Slater, L, 2012)
"Gout is a common rheumatologic condition of recurrent polyarticular involvement."1.37Unknown: Multiple painful nodules - what is the diagnosis? Chronic tophaceous gout. ( Avhad, G; Dandale, A; Dhurat, R; Ghate, S, 2011)
"Urolithiasis is one of the commonest problems in pediatric nephrology."1.36Clinical manifestations and etiology of renal stones in children less than 14 years age. ( Heidari, A; Sepahi, MA; Shajari, A, 2010)
"Allopurinol is an old and extensively used compound and seems to be well tolerated with no obvious central nervous system toxic effects at high doses."1.35Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. ( Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO, 2009)
"Flank pain was the most common manifestation."1.31Urolithiasis in childhood. ( Gündüz, Z; Kabaklioğlu, M; Küçükaydin, M; Okur, H; Ozokutan, BH; Turan, C, 2000)
"Bone pain (82%), headache (70%), fatigue (20%), and nausea (10%) were reported."1.29Clinical toxicity and laboratory effects of granulocyte-colony-stimulating factor (filgrastim) mobilization and blood stem cell apheresis from normal donors, and analysis of charges for the procedures. ( Anderlini, P; Champlin, R; Chan, KW; Körbling, M; Lichtiger, B; Miller, P; Norfleet, F; Przepiorka, D; Seong, D; Sundberg, J, 1996)
"It is shown that in osteoarthrosis the clinical characteristics vary from one joint group to another."1.26Heberden Oration 1981: epidemiology and the arthritides. ( Acheson, RM, 1982)
"A review of 869 cases of multiple myeloma seen at the Mayo Clinic from 1960 through 1971 revealed that 98% of patients were 40 years of age or older and that 61% of them were males."1.25Multiple myeloma: review of 869 cases. ( Kyle, RA, 1975)

Research

Studies (138)

TimeframeStudies, this research(%)All Research%
pre-199040 (28.99)18.7374
1990's18 (13.04)18.2507
2000's26 (18.84)29.6817
2010's33 (23.91)24.3611
2020's21 (15.22)2.80

Authors

AuthorsStudies
Goo, B1
Lee, J1
Park, C1
Yune, T1
Park, Y1
Hannarici, Z1
Yılmaz, A1
Buyukbayram, ME1
Turhan, A1
Tekin, SB1
Bilici, M1
Keenan, RT1
Yeo, AE1
Lipsky, PE1
Xu, X1
Yuan, Z1
Zhang, S1
Li, G1
Zhang, G2
Shang, YX1
Dong, X1
Xie, ZM1
Li, XP1
Wang, XC1
Huang, JY1
Wei, SF1
Liu, Y2
Liu, JP1
Zaninelli, TH3
Fattori, V3
Saraiva-Santos, T1
Badaro-Garcia, S2
Staurengo-Ferrari, L3
Andrade, KC2
Artero, NA1
Ferraz, CR1
Bertozzi, MM1
Rasquel-Oliveira, F1
Manchope, MF1
Amaral, FA2
Teixeira, MM2
Borghi, SM2
Rogers, MS1
Casagrande, R3
Verri, WA3
Topless, R1
Noorbaloochi, S1
Merriman, TR1
Singh, JA3
Kurniasari, MD1
Karwur, FF1
Rayanti, RE1
Shih, YW1
Yuliana, S1
Miao, NF1
Chou, KR1
Shen, CJ1
Tsai, HT1
Lei, Y2
Cui, TJ2
Wang, XH2
Zhang, XM2
Tang, C2
Zheng, ZH2
Cao, Y1
Hu, Y1
Jin, XF1
Zou, JM1
Lee, YH1
Song, GG1
Choi, SH1
Song, HS1
Hwang, J1
Hoss, IM1
Pradal, LA1
Leal, TSDS1
Bertolini, GRF1
Costa, RM1
Ribeiro, LFC1
Yin, C2
Liu, B4
Wang, P2
Li, X2
Li, Y2
Zheng, X2
Tai, Y2
Wang, C1
Zhang, F1
Liu, S1
Jin, L1
Tang, L1
Zhao, X1
Yang, T1
Wang, Y2
Huo, B1
Liu, R1
Li, H1
Hong, J1
Qiu, J1
Wang, X1
Oliveira, RD1
Louzada-Junior, P1
Cunha, TM2
Alves-Filho, JC2
Cunha, FQ2
Wang, J1
Chen, R1
Shou, Q1
Shao, X1
Liang, Y1
Zhou, H1
Mi, W1
Fang, J1
López-Reyes, A1
Medina-Luna, D1
Santamaría-Olmedo, M1
Martínez-Flores, K1
Zamudio-Cuevas, Y1
Fernández-Torres, J1
Martínez-Nava, GA1
Olivos-Meza, A1
Camacho-Rea, C1
Fernández-Moreno, M1
Blanco, FJ1
Pineda, C1
Feng, J1
Set Byeol, K1
Hee Jung, L1
Su Min, S1
Soon Sung, L1
Hong Won, S1
Fagundes, AC1
de Oliveira, ED1
Ferrari, SG1
Dos Santos, LMM1
Botelho, LM1
Schmidt, SRG1
Andrade, CF1
Lara, DR2
Souza, DO2
Schmidt, AP2
Liu, HJ1
Pan, XX1
Liu, BQ1
Gui, X1
Hu, L1
Jiang, CY1
Han, Y1
Fan, YX1
Tang, YL1
Liu, WT1
Zuo, J1
He, H1
Zuo, Z1
Bou-Chacra, N1
Löbenberg, R1
Nakano, Y1
Otsuka, F1
Ruiz-Miyazawa, KW1
Pinho-Ribeiro, FA1
Clemente-Napimoga, JT1
Fraceto, LF1
Napimoga, MH1
Alammari, YM1
Gheta, D1
Flood, RM1
Boran, G1
Kane, DJ1
Mullan, RH1
Nery, RA1
Skare, TL1
Pragasam, SJ1
Rasool, M1
Kodithuwakku, ND1
Pan, M1
Zhu, YL1
Zhang, YY1
Feng, YD1
Fang, WR1
Li, YM1
Shi, L1
Xu, L1
Yang, Y1
Song, H1
Pan, H1
Yin, L1
Liu, LM1
Cheng, SF1
Shieh, PC1
Lee, JC1
Chen, JJ1
Ho, CT1
Kuo, SC1
Kuo, DH1
Huang, LJ1
Way, TD1
Silva, CR1
Oliveira, SM1
Hoffmeister, C2
Funck, V1
Guerra, GP1
Trevisan, G2
Tonello, R1
Rossato, MF2
Pesquero, JB1
Bader, M1
Oliveira, MS1
McDougall, JJ1
Ferreira, J2
Moilanen, LJ1
Hämäläinen, M1
Lehtimäki, L1
Nieminen, RM1
Moilanen, E1
Ramonda, R1
Oliviero, F1
Galozzi, P1
Frallonardo, P1
Lorenzin, M1
Ortolan, A1
Scanu, A1
Punzi, L1
Jaramillo-Morales, OA1
Espinosa-Juárez, JV1
Corona-Ramos, JN1
López-Muñoz, FJ15
Hassan, EA1
Lambrechts, NE1
Weng, HY1
Snyder, PW1
Breur, GJ1
Godínez-Chaparro, B1
Huerta-Cruz, JC1
Guevara-López, U2
Domínguez-Ramírez, AM1
Cortés-Arroyo, AR1
Kaneko, K1
Taniguchi, N1
Tanabe, Y1
Nakano, T1
Hasui, M1
Nozu, K1
Carroll, GL2
Narbe, R2
Peterson, K2
Kerwin, SC2
Taylor, L2
DeBoer, M1
Lundberg, GD1
Böhmer, AE1
Antunes, C1
Schallenberger, C1
Porciúncula, LO1
Elisabetsky, E1
Martínez, AL1
González-Trujano, ME2
Pellicer, F1
Navarrete, A1
Kimura, T1
Iio, K1
Imai, E1
Rakugi, H1
Isaka, Y1
Hayashi, T1
Sepahi, MA1
Heidari, A1
Shajari, A1
Yang, X1
Li, J1
Ye, C1
Song, X1
Peláez-Ballestas, I1
Hernández Cuevas, C1
Burgos-Vargas, R1
Hernández Roque, L1
Terán, L1
Espinoza, J1
Esquivel-Valerio, JA1
Goycochea-Robles, MV1
Aceves, FJ1
Bernard, AG1
Ventura, L1
Shumsky, C1
Hernández Garduño, A1
Vázquez-Mellado, J1
Jiménez-Velázquez, G1
Fernández-Guasti, A3
Feldsein, JD1
Wilke, VL1
Evans, RB1
Conzemius, MG1
VanItallie, TB1
Tausche, AK1
Panzner, I1
Aust, D1
Wunderlich, C1
Kuritzky, L1
Panchal, R1
Plank, MS2
Boskovic, DS2
Tagge, E1
Chrisler, J1
Slater, L2
Angeles, KR2
Angeles, DM2
de Oliveira, SM1
Gomez, MV1
Hartsfield, SM1
Sakamaki, I1
Inai, K1
Tsutani, H1
Avhad, G1
Dandale, A1
Ghate, S1
Dhurat, R1
Asmerom, Y1
Bahjri, K1
Phillips, R1
Deming, D1
Ashwal, S1
Hougland, K1
Fayard, E1
Strand, V1
Khanna, D1
Forsythe, A1
Edwards, NL1
Swięchowicz, S1
Ostałowska, A1
Kasperczyk, A1
Nowak, D1
Birkner, E1
Kasperczyk, S1
Ishikawa, I1
Millis, DL1
Weigel, JP1
Moyers, T1
Buonomo, FC1
Ortega, LF1
Herrera, JE2
Salazar, LA4
Tinajero, J2
Déciga-Campos, M2
Ventura-Martínez, R1
Díaz-Reval, MI1
Hocking, PM2
Robertson, GW1
Gentle, MJ4
Reyes, R1
Martínez-Mota, L1
Zou, R1
Zhang, HX1
Zhang, TF1
Sugimoto, T1
Ide, R1
Uzu, T1
Kashiwagi, A1
Barisić, I1
Ljutić, D1
Vlak, T1
Bekavac, J1
Janković, S1
Regan, EA1
Bowler, RP1
Crapo, JD1
Zhou, HM1
Chen, SQ1
Sun, BG1
Yin, LR1
Ye, XY1
Chen, ZX1
Ayala-Guerrero, F1
Covarrubias-Gómez, A1
Torres-González, R1
Sarma, GR1
Acharyulu, GS1
Kannapiran, M1
Murthy, PV1
Gurumurthy, P1
Tripathy, SP1
Okuda, K1
Nakahama, H2
Miyakawa, H1
Shima, K1
Akerblom, HK1
Koivukangas, T1
Puukka, R1
Mononen, M1
Acheson, RM1
Villalon, CM1
Terron, JA2
Granados-Soto, V2
Castañeda-Hernández, G2
Villarreal, JE1
Flores-Murrieta, FJ2
Hong, E1
Andersson, HI1
Ejlertsson, G1
Leden, I1
Rosenberg, C1
Anderlini, P1
Przepiorka, D1
Seong, D1
Miller, P1
Sundberg, J1
Lichtiger, B1
Norfleet, F1
Chan, KW1
Champlin, R1
Körbling, M1
López Laur, JD1
Chiapetta Menéndez, J1
Shigenaga, T1
Kato, M1
Taguchi, K1
Banks, PA1
Hughes, M1
Ferrante, M1
Noordhoek, EC1
Ramagopal, V1
Slivka, A1
Wylie, LM1
Wisłowska, M1
Sypuła, S1
Kowalik, I1
Reyes, G1
Medina, R1
Castillo, EF1
Chaves, F1
Valdes, B1
Ventura, R2
Díaz, I1
Tost, D1
Cabré, F2
Mauleón, D2
Martin, JN1
May, WL1
Magann, EF1
Terrone, DA1
Rinehart, BK1
Blake, PG1
Bernard, R1
Dunn, LN1
Ozokutan, BH1
Küçükaydin, M1
Gündüz, Z1
Kabaklioğlu, M1
Okur, H1
Turan, C1
Díaz, MI1
Hernández, GP1
Domínguez, AM1
García, ML1
Revelo, MP1
Staffeld, C1
Copley, JB1
Fogo, AB1
Nuño Mateo, FJ1
Noval Menéndez, J1
Mazorra Iraculis, M1
Campoamor Serrano, M1
Martínez, RV1
Reval, M1
Campos, MD1
Domínguez, R1
Watanabe, T1
Zaloga, B1
Hughes, JL1
Hoda, RS1
Bogner, G1
Tilscher, H1
Horsfall, PA1
Plummer, J1
Allan, WG1
Girling, DJ1
Nunn, AJ1
Fox, W1
King, RS1
Wichman, BA1
Heuckenkamp, PU1
Abraham, WM1
Schumann, D1
Patterson, P1
Moxley, TE1
Royer, GL1
Hearron, MS1
Donovan, JF1
Levi, L1
Kyle, RA1
Giudicelli, Y1
Kaiser, JM1
Pecquery, R1
Remy, JM1
Doury, P1
Delahaye, RP1
Leguay, G1
Pattin, S1
Metges, PJ1
Montely, JM1
Duret, JC1
Salhi, A1
Forseth, KO1
Gran, JT1
Horowitz, MD1
Abbey, L1
Sirota, DK1
Spiera, H1
Strom, BL1
West, SL1
Sim, E1
Carson, JL1
Weil-Fugazza, J1
Godefroy, F1
Basbaum, AI1
Bradlow, A1
Mowat, AG1
Lacroix, C1
Guyonnaud, C1
Chaou, M1
Duwoos, H1
Lafont, O1
Coderre, TJ1
Wall, PD1
Abraham, PA1
Halstenson, CE1
Opsahl, JA1
Matzke, GR1
Keane, WF1
Dubinsky, B1
Gebre-Mariam, S1
Capetola, RJ1
Rosenthale, ME1
Inase, M1
Otsuki, T1
Fang, JZ1
Bodem, H1
Dormoy, O1
Ajzenberg, D1
Shiokawa, Y1
Riseman, JE1
Ostendorp, U1
Sonntag, RW1
Emmerson, BT1
Pasotti, C1
Barbieri, C1
Buniva, G1
Chierichetti, S2
Pavelka, K2
Susta, A1
Vojtísek, O2
Bremová, A2
Kanková, D2
Hándlová, D2
Malecek, J1
Huskisson, EC1
Wojtulewski, JA1
Berry, H1
Scott, J1
Hart, FD1
Balme, HW1
Borrie, P1
Slack, J1
Hutchison, JC1
Ghiringhelli, F1
Mazzi, C1
Sutton, J1
Coleman, MJ1
Millar, AP1
Lazarus, L1
Russo, P1
Fearnley, ME1
Vadasz, I1
Harkness, RA1
Nicol, AD1
van Arman, CG1
Carlson, RP1
Risley, EA1
Thomas, RH1
Nuss, GW1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 3 Randomized, Double-Blind, Multicenter, Placebo- Controlled Study to Assess the Efficacy and Safety of Lesinurad Monotherapy Compared to Placebo in Subjects With Gout and an Intolerance or Contraindication to a Xanthine Oxidase Inhibitor[NCT01508702]Phase 3214 participants (Actual)Interventional2012-01-31Completed
Long-term Allopurinol Safety Study Evaluating Outcomes in Gout Patients (LASSO)[NCT01391325]Phase 41,735 participants (Actual)Interventional2011-07-31Completed
A Phase 3 Randomized, Double-Blind, Multicenter, Placebo-Controlled, Combination Study to Evaluate the Efficacy and Safety of Lesinurad and Allopurinol Compared to Allopurinol Alone in Subjects With Gout Who Have Had an Inadequate Hypouricemic Response to[NCT01510158]Phase 3607 participants (Actual)Interventional2012-01-31Completed
A Phase 3 Randomized, Double-Blind, Multicenter, Placebo- Controlled, Combination Study to Evaluate the Efficacy and Safety of Lesinurad and Febuxostat Compared to Febuxostat Alone at Lowering Serum Uric Acid and Resolving Tophi in Subjects With Tophaceou[NCT01510769]Phase 3330 participants (Actual)Interventional2012-01-31Completed
A Phase 3 Randomized, Double-Blind, Multicenter, Placebo- Controlled, Combination Study to Evaluate the Efficacy and Safety of Lesinurad and Allopurinol Compared to Allopurinol Alone in Subjects With Gout Who Have Had an Inadequate Hypouricemic Response t[NCT01493531]Phase 3610 participants (Actual)Interventional2011-12-31Completed
A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among [NCT05170113]79 participants (Actual)Interventional2021-11-02Completed
Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544]76 participants (Actual)Interventional2019-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Subjects With an sUA Level That is < 6.0 mg/dL

(NCT01508702)
Timeframe: 6 months

InterventionNumber of Subjects (Number)
Lesinurad 400 mg32
Placebo2

Incidence of Gout Flares

Proportion of subjects who experienced at least one gout flare requiring treatment during the study. (NCT01391325)
Timeframe: Every month for 6 months.

Interventionpercentage of subjects (Number)
Allopurinol33.4

Proportion of Subjects With Serum Urate (sUA) Less Than 6.0 mg/dL

Proportion of subjects with serum urate (sUA) less than 6.0 mg/dL at Month 6 using Last Observation Carried Forward (LOCF) for subjects with missing values at Month 6. (NCT01391325)
Timeframe: Month 6

Interventionpercentage of subjects (Number)
Allopurinol43.4

Safety of Allopurinol

Proportion of subjects who experienced at least one Treatment Emergent Adverse Event (TEAE) during the study. (NCT01391325)
Timeframe: Every month for 6 months.

Interventionpercentage of subjects (Number)
Allopurinol55.1

Mean Change From Baseline to Month 6 in SF-36 PCS+MCS

The SF-36 is a short-form health survey with 36 questions that yields an 8-scale profile of functional health and well-being scores as well as psychometrically-based physical (PCS) and mental health (MCS) summary. Each scale is directly transformed into a 0-100 scale. The lower the score the more disability. The higher the score the less disability. The component scores (PCS and MCS) are norm-based to a standard population with a mean of 50 and a standard deviation of 10. (NCT01391325)
Timeframe: Month 6

Interventionunits on a scale (Mean)
SF-36 Physical Component SummarySF-36 Mental Health Component Summary
Allopurinol3.880.71

Gout Flares

Mean rate of gout flares requiring treatment for the 6-month period from the end of Month 6 to the end of Month 12 (NCT01510158)
Timeframe: 12 Months

InterventionGout Flares (Mean)
Lesinurad 200 mg + Allopurinol.60
Lesinurad 400 mg + Allopurinol.50
Placebo + Allopurinol.60

Proportion of Subjects With an sUA Level That is < 6.0 mg/dL

(NCT01510158)
Timeframe: 6 Months, analysis after all subjects complete 12 months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Allopurinol0.542
Lesinurad 400 mg + Allopurinol0.592
Placebo + Allopurinol0.279

Tophus

Proportion of subjects with ≥ 1 target tophus at Baseline who experience complete resolution of at least 1 target tophus by Month 12 (NCT01510158)
Timeframe: 12 Months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Allopurinol0
Lesinurad 400 mg + Allopurinol0.211
Placebo + Allopurinol0.294

Complete or Partial Response of at Least One Tophus

Proportion of subjects with a best tophus response on at least 1 target tophus of complete (disappearance of at least 1 target tophus) or partial (≥ 50% decrease in the area of at least 1 target tophus) resolution by Month 12 (NCT01510769)
Timeframe: 12 Months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Febuxostat 80 mg0.566
Lesinurad 400 mg + Febuxostat 80 mg0.587
Placebo + Febuxostat 80 mg0.505

Complete Resolution of at Least One Target Tophus

Proportion of subjects who experience complete resolution of at least 1 target tophus by Month 12 (NCT01510769)
Timeframe: 12 Months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Febuxostat 80 mg0.255
Lesinurad 400 mg + Febuxostat 80 mg0.303
Placebo + Febuxostat 80 mg0.211

Quality of Life

Proportion of subjects with an improvement from Baseline in Health Assessment Questionnaire - Disability Index (HAQ-DI) of at least 0.25 at Month 12. The HAQ-DI assesses a patient's level of functional ability with items scores ranging from 0-3 with 0 being the least disability. (NCT01510769)
Timeframe: 12 Months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Febuxostat 80 mg0.442
Lesinurad 400 mg + Febuxostat 80 mg0.333
Placebo + Febuxostat 80 mg0.525

Subjects With a Serum Urate (sUA) Level That is < 5.0 mg/dL by Month 6

Proportion of subjects with an sUA level that is < 5.0 mg/dL by Month 6 (NCT01510769)
Timeframe: 6 months, analysis after all subjects complete 12 months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Febuxostat 80 mg0.566
Lesinurad 400 mg + Febuxostat 80 mg0.761
Placebo + Febuxostat 80 mg0.468

Gout Flares

Mean rate of gout flares requiring treatment for the 6-month period from the end of Month 6 to the end of Month 12. (NCT01493531)
Timeframe: 12 Months

InterventionGout Flares (Mean)
Lesinurad 200 mg + Allopurinol0.7
Lesinurad 400 mg + Allopurinol0.8
Placebo + Allopurinol0.9

Subjects With ≥ 1 Target Tophus at Baseline Who Experience Complete Resolution of at Least 1 Target Tophus by Month 12

Proportion of subjects with ≥ 1 target tophus at Baseline who experience complete resolution of at least 1 target tophus by Month 12 (NCT01493531)
Timeframe: 12 months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Allopurinol0.314
Lesinurad 400 mg + Allopurinol0.276
Placebo + Allopurinol0.333

Subjects With a Serum Urate (sUA) < 6.0 mg/dL by Month 6.

Proportion of subjects with an sUA level that is < 6.0 mg/dL by Month 6. (NCT01493531)
Timeframe: 6 months

InterventionProportion of Subjects (Number)
Lesinurad 200 mg + Allopurinol0.554
Lesinurad 400 mg + Allopurinol0.665
Placebo + Allopurinol0.233

Reviews

6 reviews available for uric acid and Pain

ArticleYear
Efficacy of initiating urate-lowering therapy during an acute gout episode: a meta-analysis.
    Zeitschrift fur Rheumatologie, 2023, Volume: 82, Issue:9

    Topics: Arthritis, Gouty; Gout; Gout Suppressants; Humans; Pain; Uric Acid

2023
Herbal medicine for external use in acute gouty arthritis: A PRISMA-compliant systematic review and meta-analysis.
    Medicine, 2023, Sep-15, Volume: 102, Issue:37

    Topics: Arthritis, Gouty; Herbal Medicine; Humans; Pain; Plant Extracts; Plants, Medicinal; Randomized Contr

2023
Molecular mechanisms of pain in crystal-induced arthritis.
    Best practice & research. Clinical rheumatology, 2015, Volume: 29, Issue:1

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Calcium Pyrophosphate; Chondrocalc

2015
Gout: epitome of painful arthritis.
    Metabolism: clinical and experimental, 2010, Volume: 59 Suppl 1

    Topics: Arthritis; Female; Gout; Humans; Hyperuricemia; Immunity, Innate; Male; Pain; Uric Acid

2010
Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise in patients with or without renal hypouricemia.
    Nephron, 2002, Volume: 91, Issue:4

    Topics: Acute Kidney Injury; Adolescent; Adult; Exercise; Female; Humans; Ischemia; Kidney; Male; Pain; Tomo

2002
The antialgesic drugs: human therapeutic correlates of their potency in laboratory animal models of hyperalgesia.
    Agents and actions, 1987, Volume: 20, Issue:1-2

    Topics: Acetylcholine; Administration, Oral; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ar

1987

Trials

18 trials available for uric acid and Pain

ArticleYear
Efficacy and safety of Tibetan medicine Qingpeng ointment for acute gouty arthritis: protocol for a multi-center, randomized, double-blind, placebo-controlled trial.
    Trials, 2022, May-12, Volume: 23, Issue:1

    Topics: Adult; Arthralgia; Arthritis, Gouty; Double-Blind Method; Drugs, Chinese Herbal; Edema; Humans; Medi

2022
Immersion in Water Between 20-30
    Biological research for nursing, 2023, Volume: 25, Issue:2

    Topics: Biomarkers; Gout; Humans; Immersion; Indonesia; Inflammasomes; Inflammation; Pain; Pain Management;

2023
Allopurinol for fibromyalgia pain in adults: A randomized controlled trial.
    Pain practice : the official journal of World Institute of Pain, 2022, Volume: 22, Issue:1

    Topics: Allopurinol; Animals; Double-Blind Method; Female; Fibromyalgia; Gout Suppressants; Humans; Pain; Pr

2022
Dose range finding study for the efficacy of meloxicam administered prior to sodium urate-induced synovitis in cats.
    Veterinary anaesthesia and analgesia, 2011, Volume: 38, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cross-Over Studies; Dose-Response Relationsh

2011
Safety of intradermal injection of monosodium urate crystals as a vaccine carrier in volunteers.
    Nucleosides, nucleotides & nucleic acids, 2011, Volume: 30, Issue:12

    Topics: Adjuvants, Immunologic; Adult; Crystallization; Female; Humans; Inflammation; Injections, Intraderma

2011
Improved health-related quality of life and physical function in patients with refractory chronic gout following treatment with pegloticase: evidence from phase III randomized controlled trials.
    The Journal of rheumatology, 2012, Volume: 39, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Gout; Gout Suppressants; Humans; Male; Midd

2012
Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs.
    Veterinary therapeutics : research in applied veterinary medicine, 2002,Winter, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cyclooxygenase I

2002
Effects of non-steroidal anti-inflammatory drugs on pain-related behaviour in a model of articular pain in the domestic fowl.
    Research in veterinary science, 2005, Volume: 78, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chickens; Clonixin; Dose-Response Rela

2005
Comparative study on treatment of acute gouty arthritis by electroacupuncture with different frequency.
    Chinese journal of integrative medicine, 2006, Volume: 12, Issue:3

    Topics: Acupuncture Analgesia; Acute Disease; Adult; Aged; Arthritis, Gouty; Electroacupuncture; Female; Hum

2006
[A clinical research of Jiawei simiaosan oral administration combined with the external application of Sihuangshuimi in the treatment of acute gouty arthritis].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2007, Volume: 30, Issue:9

    Topics: Acute Disease; Administration, Oral; Administration, Topical; Adult; Aged; Arthritis, Gouty; Body Te

2007
Does allopurinol reduce pain of chronic pancreatitis?
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1997, Volume: 22, Issue:3

    Topics: Abdominal Pain; Activities of Daily Living; Adult; Allopurinol; Ankle; Blood Cell Count; Chronic Dis

1997
Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration.
    Tubercle, 1979, Volume: 60, Issue:1

    Topics: Adolescent; Adult; Aged; Allopurinol; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female

1979
Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial.
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:8

    Topics: Alanine Transaminase; Clinical Trials as Topic; Drug Evaluation; Humans; Ibuprofen; Osteoarthritis;

1975
Clinical trial of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370) in painful osteoarticular conditions.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; Blood Cell Count; Body Weight; Clinical Trials as Topic; Diur

1972
Double-blind comparison of ibuprofen and phenylbutazone in the short-term treatment of rheumatoid arthritis.
    Rheumatology and rehabilitation, 1973, Volume: 12, Issue:2

    Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Hematocrit; H

1973
Double-blind comparison of alclofenac and phenylbutazone in the short-term treatment of rheumatoid arthritis.
    Current medical research and opinion, 1973, Volume: 1, Issue:6

    Topics: Administration, Oral; Allyl Compounds; Anthropometry; Anti-Inflammatory Agents; Arthritis, Rheumatoi

1973
Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.
    British medical journal, 1974, Feb-02, Volume: 1, Issue:5900

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Body Temperature; Clinical Trials as Topic; Deafness;

1974
The hypotensive action of ethacrynic acid.
    Vascular diseases, 1968, Volume: 5, Issue:2

    Topics: Abdomen; Adult; Aged; Antihypertensive Agents; Black People; Blood Glucose; Blood Pressure Determina

1968

Other Studies

114 other studies available for uric acid and Pain

ArticleYear
Bee Venom Alleviated Edema and Pain in Monosodium Urate Crystals-Induced Gouty Arthritis in Rat by Inhibiting Inflammation.
    Toxins, 2021, 09-16, Volume: 13, Issue:9

    Topics: Animals; Arthritis, Gouty; Bee Venoms; Disease Models, Animal; Edema; Humans; Inflammation; Male; Pa

2021
Lipegfilgrastim may cause hyperleukocytosis.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:8

    Topics: Allopurinol; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Middle Aged; Pain; P

2022
Pegloticase causes prolonged improvement in multiple disease parameters in patients with chronic refractory gout who maintain low serum urate levels.
    Clinical and experimental rheumatology, 2022, Volume: 40, Issue:5

    Topics: Arthritis, Gouty; Chronic Disease; Gout; Gout Suppressants; Humans; Pain; Polyethylene Glycols; Trea

2022
Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022, Volume: 71, Issue:4

    Topics: Animals; Arthritis, Gouty; Calcium; Edema; Hyperalgesia; Mice; Pain; Transient Receptor Potential Ch

2022
RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.
    British journal of pharmacology, 2022, Volume: 179, Issue:18

    Topics: Animals; Arthritis, Gouty; Calcitonin Gene-Related Peptide; Docosahexaenoic Acids; Hyperalgesia; Inf

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Change in serum urate level with urate-lowering therapy initiation associates in the immediate term with patient-reported outcomes in people with gout.
    Seminars in arthritis and rheumatism, 2022, Volume: 56

    Topics: Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Observational Studies as To

2022
Plasma adsorption in refractory chronic gouty arthritis flare: A case report.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Cytokines; Gout; Humans; Infl

2022
Plasma adsorption in refractory chronic gouty arthritis flare: A case report.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Cytokines; Gout; Humans; Infl

2022
Plasma adsorption in refractory chronic gouty arthritis flare: A case report.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Cytokines; Gout; Humans; Infl

2022
Plasma adsorption in refractory chronic gouty arthritis flare: A case report.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Cytokines; Gout; Humans; Infl

2022
Dimethyl fumarate attenuates MSU-induced gouty arthritis by inhibiting NLRP3 inflammasome activation and oxidative stress.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:2

    Topics: Animals; Arthritis, Gouty; Caspases; Cytokines; Dimethyl Fumarate; Gout; Inflammasomes; Lipopolysacc

2023
Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model.
    Einstein (Sao Paulo, Brazil), 2023, Volume: 21

    Topics: Animals; Arthritis, Gouty; Edema; Humans; Inflammation; Male; Pain; Rats; Rats, Wistar; Uric Acid

2023
Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis.
    British journal of pharmacology, 2020, Volume: 177, Issue:9

    Topics: Animals; Eucalyptol; Gout; Humans; Inflammation; Macrophages; Mice; Pain; Quality of Life; Uric Acid

2020
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
    Pharmacology, 2020, Volume: 105, Issue:7-8

    Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Ca

2020
Characteristics of voltage-gated potassium currents in monosodium urate induced gouty arthritis in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020, Volume: 69, Issue:6

    Topics: Animals; Arthritis, Gouty; Ganglia, Spinal; Male; Mice, Inbred ICR; Neurons; Pain; Potassium Channel

2020
IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020, Volume: 69, Issue:12

    Topics: Animals; Arthritis, Gouty; Female; Humans; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Inte

2020
IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain.
    Theranostics, 2020, Volume: 10, Issue:26

    Topics: Animals; Disease Models, Animal; Gout; Humans; Injections, Intra-Articular; Interleukin-1 Receptor-L

2020
Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes : Secretome of synoviocytes induces chondrocyte damage.
    Clinical rheumatology, 2021, Volume: 40, Issue:8

    Topics: Cells, Cultured; Chondrocytes; Humans; Hydrogen Peroxide; Inflammation Mediators; Oxidative Stress;

2021
Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2021, Volume: 41, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbr

2021
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.
    Journal of neuroinflammation, 2017, 04-04, Volume: 14, Issue:1

    Topics: Animals; Ankle; Anti-Inflammatory Agents; Antioxidants; Colchicine; Cytokines; Gout; Grape Seed Extr

2017
Erding Formula in hyperuricaemia treatment: unfolding traditional Chinese herbal compatibility using modern pharmaceutical approaches.
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; Gene E

2018
Auricle Pain Due to Tophi.
    Internal medicine (Tokyo, Japan), 2019, Feb-01, Volume: 58, Issue:3

    Topics: Arthritis, Gouty; Ear Auricle; Febuxostat; Gout Suppressants; Humans; Male; Middle Aged; Pain; Uric

2019
15d-PGJ
    Scientific reports, 2018, 09-18, Volume: 8, Issue:1

    Topics: Animals; Antioxidants; Arthritis, Experimental; Arthritis, Gouty; Inflammation; Male; Mice; Mice, In

2018
Urate-lowering therapy (ULT) reduces non-episodic foot pain in patients who fail to meet ACR/EULAR 2015 gout classification criteria: an effect predicted by ultrasound and potential rationale for reclassification.
    Annals of the rheumatic diseases, 2019, Volume: 78, Issue:4

    Topics: Case-Control Studies; Female; Foot Joints; Gout; Gout Suppressants; Humans; Male; Middle Aged; Pain;

2019
Serum uric acid and leg ulcers.
    Anais brasileiros de dermatologia, 2019, 07-29, Volume: 94, Issue:3

    Topics: Biomarkers; Female; Humans; Leg Ulcer; Male; Middle Aged; Pain; Uric Acid; Wound Healing

2019
Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013, Volume: 62, Issue:5

    Topics: Acetic Acid; Acid Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; beta-Glu

2013
Anti-inflammatory and antinociceptive effects of Chinese medicine SQ gout capsules and its modulation of pro-inflammatory cytokines focusing on gout arthritis.
    Journal of ethnopharmacology, 2013, Dec-12, Volume: 150, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Capsules; Cells, Cultu

2013
Suppressive effect of modified Simiaowan on experimental gouty arthritis: an in vivo and in vitro study.
    Journal of ethnopharmacology, 2013, Dec-12, Volume: 150, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Gouty; Cell Surv

2013
The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 70

    Topics: Animals; Disease Models, Animal; Euonymus; Formaldehyde; Gardenia; Gout; Hyperuricemia; Nociception;

2014
The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:1

    Topics: Acute Disease; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin B1 Receptor Antagonists

2016
Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in gout.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Acetanilides; Animals; Cytokines; Disease Models, Animal; Gout; Inflammation; Mice; Mice, Knockout;

2015
Nociceptive Alteration by High Sucrose Diet in Hypoestrogenic Wistar Rats.
    Drug development research, 2016, Volume: 77, Issue:5

    Topics: Animals; Blood Glucose; Body Weight; Dietary Sucrose; Estrogens; Female; Glucose Tolerance Test; Ins

2016
Effects of denervation of the hip joint on results of clinical observations and instrumented gait analysis in dogs with sodium urate crystal-induced synovitis.
    American journal of veterinary research, 2016, Volume: 77, Issue:11

    Topics: Animals; Biomechanical Phenomena; Denervation; Dog Diseases; Dogs; Female; Gait; Hip Joint; Kinetics

2016
Gout: will the "King of Diseases" be the first rheumatic disease to be cured?
    BMC medicine, 2016, Nov-11, Volume: 14, Issue:1

    Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Gout; Gout Suppressants; Humans; Inflammation; Pain;

2016
The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 91, Issue:1

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dipyrone; Dose-Respon

2008
Oxidative imbalance in idiopathic renal hypouricemia.
    Pediatric nephrology (Berlin, Germany), 2009, Volume: 24, Issue:4

    Topics: Acute Kidney Injury; Anaerobiosis; Child; DNA Mutational Analysis; Exercise; Exercise Test; Female;

2009
A pilot study: sodium urate synovitis as an acute model of inflammatory response using objective and subjective criteria to evaluate arthritic pain in cats.
    Journal of veterinary pharmacology and therapeutics, 2008, Volume: 31, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Area Under Curve; Cats; Female; Infl

2008
Prednisolone and naproxen both work for pain relief in acute gout.
    Medscape journal of medicine, 2008, Volume: 10, Issue:9

    Topics: Anti-Inflammatory Agents; Arthritis, Gouty; Clinical Trials as Topic; Double-Blind Method; Female; H

2008
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
    British journal of pharmacology, 2009, Volume: 156, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor

2009
Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts.
    Planta medica, 2009, Volume: 75, Issue:5

    Topics: Analgesics; Animals; Arthritis; Chromatography, Gas; Male; Mass Spectrometry; Naloxone; Narcotic Ant

2009
Exercise-induced acute kidney injury with reversible posterior leukoencephalopathy syndrome.
    Clinical and experimental nephrology, 2010, Volume: 14, Issue:2

    Topics: Adolescent; Exercise; Humans; Kidney; Magnetic Resonance Imaging; Male; Pain; Posterior Leukoencepha

2010
Clinical manifestations and etiology of renal stones in children less than 14 years age.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2010, Volume: 21, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Citric Acid; Cystinuria; Dysuria; Female; Fever; Genetic Predis

2010
Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.
    Fitoterapia, 2010, Volume: 81, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Camellia; Drug Evaluation, Preclinical; Female; Infla

2010
Diagnosis of chronic gout: evaluating the american college of rheumatology proposal, European league against rheumatism recommendations, and clinical judgment.
    The Journal of rheumatology, 2010, Aug-01, Volume: 37, Issue:8

    Topics: Chronic Disease; Cohort Studies; Cross-Sectional Studies; Crystallization; European Union; Female; G

2010
Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray.
    Brain research, 2010, Aug-19, Volume: 1349

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Area Under Curve; Behavior, Animal; Diazepam; Disea

2010
Serum cortisol concentration and force plate analysis in the assessment of pain associated with sodium urate-induced acute synovitis in dogs.
    American journal of veterinary research, 2010, Volume: 71, Issue:8

    Topics: Animals; Biomarkers; Dog Diseases; Dogs; Female; Gait; Hydrocortisone; Male; Pain; Reproducibility o

2010
Disabling gout.
    Lancet (London, England), 2010, Sep-25, Volume: 376, Issue:9746

    Topics: Arthrodesis; Biomarkers; Foot; Gout; Hallux Valgus; Humans; Magnetic Resonance Imaging; Male; Metata

2010
Gout: nonsteroidal anti-inflammatory drugs and colchicine to prevent painful flares during early urate-lowering therapy.
    Journal of pain & palliative care pharmacotherapy, 2010, Volume: 24, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Gout; Gout Suppressants; Humans; Male; Pa

2010
An animal model for measuring the effect of common NICU procedures on ATP metabolism.
    Biological research for nursing, 2011, Volume: 13, Issue:3

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Biomarkers; Catheterization, Central Venous; Ener

2011
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B

2011
Unknown: Multiple painful nodules - what is the diagnosis? Chronic tophaceous gout.
    Dermatology online journal, 2011, Dec-15, Volume: 17, Issue:12

    Topics: Alcoholics; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Chronic Disease; Colch

2011
Procedural pain and oxidative stress in premature neonates.
    The journal of pain, 2012, Volume: 13, Issue:6

    Topics: Humans; Infant, Newborn; Infant, Premature; Malondialdehyde; Oxidative Stress; Pain; Pain Measuremen

2012
Evaluation of hyaluronic acid intra-articular injections in the treatment of primary and secondary osteoarthritis of the knee.
    Polish orthopedics and traumatology, 2012, Oct-22, Volume: 77

    Topics: Aged; Albumins; Bilirubin; Ceruloplasmin; Female; Humans; Hyaluronic Acid; Hydrogen Peroxide; Inject

2012
Evaluation of morphine analgesic activity in rats submitted to repetitive intra-articular injections of uric acid.
    Proceedings of the Western Pharmacology Society, 2003, Volume: 46

    Topics: Analgesics, Opioid; Animals; Arthritis; Injections, Intra-Articular; Male; Morphine; Pain; Pain Meas

2003
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
    Proceedings of the Western Pharmacology Society, 2003, Volume: 46

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxyge

2003
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
    European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Mod

2004
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
    Psychopharmacology, 2005, Volume: 180, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D

2005
Recurring exercise-induced acute renal failure with usual daily work.
    Nephrology (Carlton, Vic.), 2007, Volume: 12, Issue:1

    Topics: Acute Kidney Injury; Humans; Ischemia; Kidney; Male; Middle Aged; Pain; Physical Exertion; Recurrenc

2007
Laboratory and sonographic findings in dialyzed patients with bilateral chronic knee pain versus dialyzed asymptomatic patients.
    Collegium antropologicum, 2007, Volume: 31, Issue:2

    Topics: beta 2-Microglobulin; Biomarkers; C-Reactive Protein; Humans; Kidney Failure, Chronic; Knee Joint; P

2007
Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury.
    Osteoarthritis and cartilage, 2008, Volume: 16, Issue:4

    Topics: Age Factors; Cartilage, Articular; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Female;

2008
Effect of acute gouty arthritis on sleep patterns: a preclinical study.
    European journal of pain (London, England), 2009, Volume: 13, Issue:2

    Topics: Animals; Arousal; Arthritis, Gouty; Behavior, Animal; Electrodes, Implanted; Electroencephalography;

2009
Role of rifampicin in arthralgia induced by pyrazinamide.
    Tubercle, 1983, Volume: 64, Issue:2

    Topics: Drug Therapy, Combination; Humans; Joint Diseases; Pain; Pyrazinamide; Rifampin; Tuberculosis, Pulmo

1983
Arthritis induced in cat by sodium urate: a possible animal model for tonic pain.
    Pain, 1984, Volume: 18, Issue:3

    Topics: Animals; Arthritis; Behavior, Animal; Cat Diseases; Cats; Disease Models, Animal; Gait; Injections,

1984
The tolerance of increasing amounts of dietary xylitol in children.
    International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 1982, Volume: 22

    Topics: Abdomen; Administration, Oral; Adolescent; Child; Cholesterol; Diarrhea; Female; Flatulence; Humans;

1982
Heberden Oration 1981: epidemiology and the arthritides.
    Annals of the rheumatic diseases, 1982, Volume: 41, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Body Weight; Connecticut; Female; Gout; Hand; Humans; Male; Ma

1982
Analgesic interactions produced by combinations of dipyrone and morphine in the rat.
    Proceedings of the Western Pharmacology Society, 1994, Volume: 37

    Topics: Analgesics; Animals; Dipyrone; Female; Hindlimb; Morphine; Pain; Pain Measurement; Rats; Rats, Wista

1994
Characterization of the analgesic effect of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:7

    Topics: Acetaminophen; Administration, Oral; Animals; Caffeine; Drug Combinations; Drug Synergism; Female; H

1993
Comparison of the analgesic effects of ketorolac, morphine and aspirin in the rat.
    Proceedings of the Western Pharmacology Society, 1993, Volume: 36

    Topics: Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Female; Ketorolac; Morphine; Pain; P

1993
Analgesic effects of multiple combinations of morphine and aspirin in the rat.
    Proceedings of the Western Pharmacology Society, 1993, Volume: 36

    Topics: Analgesics; Animals; Aspirin; Drug Combinations; Female; Hindlimb; Injections, Intra-Articular; Morp

1993
Characteristics of subjects with chronic pain, in relation to local and widespread pain report. A prospective study of symptoms, clinical findings and blood tests in subgroups of a geographically defined population.
    Scandinavian journal of rheumatology, 1996, Volume: 25, Issue:3

    Topics: Adult; Aged; Chronic Disease; Female; Humans; Male; Middle Aged; Musculoskeletal Diseases; Pain; Ran

1996
Clinical toxicity and laboratory effects of granulocyte-colony-stimulating factor (filgrastim) mobilization and blood stem cell apheresis from normal donors, and analysis of charges for the procedures.
    Transfusion, 1996, Volume: 36, Issue:7

    Topics: Adolescent; Adult; Alkaline Phosphatase; Analgesics; Blood Transfusion, Autologous; Bone Marrow Tran

1996
Pain-related behaviour following sodium urate arthritis is expressed in decerebrate chickens.
    Physiology & behavior, 1997, Volume: 62, Issue:3

    Topics: Animals; Arthritis; Behavior, Animal; Chickens; Decerebrate State; Disease Models, Animal; Pain; Tel

1997
[Chronic orchialgia. A diagnostic and therapeutic hypothesis].
    Actas urologicas espanolas, 1997, Volume: 21, Issue:8

    Topics: Adolescent; Adult; Humans; Male; Middle Aged; Pain; Pain Management; Testicular Diseases; Uric Acid

1997
In vivo voltammetric studies of the effects of intrathecal morphine on noxious heat stimuli-induced serotonin release in the nucleus raphe magnus of anesthetized rats.
    Neuroscience research, 1997, Volume: 29, Issue:3

    Topics: Animals; Electrochemistry; Hot Temperature; Hydroxyindoleacetic Acid; Injections, Spinal; Male; Morp

1997
Feeding-induced tonic pain suppression in the chicken: reversal by naloxone.
    Physiology & behavior, 1998, Volume: 64, Issue:1

    Topics: Adaptation, Psychological; Analgesia; Animals; Arthritis, Gouty; Behavior, Animal; Chickens; Eating;

1998
Echocardiographic findings, 24-hour electrocardiographic Holter monitoring in patients with rheumatoid arthritis according to Steinbrocker's criteria, functional index, value of Waaler-Rose titre and duration of disease.
    Clinical rheumatology, 1998, Volume: 17, Issue:5

    Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Glucose; Echocardiography; Electrocardiography; Electrocar

1998
On the analgesic effect of sodium diclofenac in pain-induced functional impairment in the rat.
    Proceedings of the Western Pharmacology Society, 1998, Volume: 41

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Diclofenac; Dose-Response Re

1998
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise

1998
Early risk assessment of severe preeclampsia: admission battery of symptoms and laboratory tests to predict likelihood of subsequent significant maternal morbidity.
    American journal of obstetrics and gynecology, 1999, Volume: 180, Issue:6 Pt 1

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Creatinine; Female; HELLP Syndrome; Humans; L-Lac

1999
Evaluation of intraarticular opioid analgesia for the relief of articular pain in the domestic fowl.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:2

    Topics: Analgesia; Analgesics; Animals; Arthritis, Gouty; Buprenorphine; Chickens; Disease Models, Animal; F

1999
Urolithiasis in childhood.
    Pediatric surgery international, 2000, Volume: 16, Issue:1-2

    Topics: Adolescent; Calcium; Child; Child, Preschool; Female; Humans; Infant; Kidney Calculi; Male; Pain; Re

2000
Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:8

    Topics: Analgesics; Animals; Area Under Curve; Arthritis; Disease Models, Animal; Dose-Response Relationship

2000
A 26-year-old man with kidney allograft failure and foot pain.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:4

    Topics: Adult; Arthritis, Gouty; Foot Diseases; Graft Rejection; Humans; Kidney Transplantation; Male; Pain;

2001
[A 40-year-old man with left knee pain and tumefaction].
    Revista clinica espanola, 2001, Volume: 201, Issue:3

    Topics: Acute Disease; Adult; Arthritis, Gouty; Humans; Knee Joint; Male; Pain; Synovitis; Uric Acid

2001
Involvement of peripheral cyclooxygenase-1 and cyclooxygenase-2 in inflammatory pain.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:3

    Topics: Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Inflammation; Lactones

2002
Patchy renal vasoconstriction after exercise in a child without renal hypouricemia.
    Pediatric nephrology (Berlin, Germany), 2002, Volume: 17, Issue:4

    Topics: Abdomen; Acute Kidney Injury; Adolescent; Analgesics; Exercise; Female; Humans; Pain; Renal Circulat

2002
Pathologic quiz case: a soft tissue mass with bone destruction. Gouty tophus.
    Archives of pathology & laboratory medicine, 2002, Volume: 126, Issue:5

    Topics: Aged; Biopsy; Elbow Joint; Gout; Humans; Male; Pain; Radiography; Uric Acid

2002
[Spinal complaints of hyperuricemic patients].
    MMW, Munchener medizinische Wochenschrift, 1976, Jan-23, Volume: 118, Issue:4

    Topics: Back Pain; Female; Gout; Headache; Humans; Male; Neurologic Manifestations; Osteoarthritis; Pain; Sp

1976
Acute arthralgia (gout?) after tricrynafen.
    The New England journal of medicine, 1979, Nov-08, Volume: 301, Issue:19

    Topics: Glycolates; Gout; Humans; Hypertension; Joint Diseases; Male; Middle Aged; Pain; Ticrynafen; Uric Ac

1979
Comparison of glucose, fructose and xylitol for parenteral alimentation in metabolically healthy men.
    Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Beiheft, 1976, Volume: 15

    Topics: Abdomen; Fasting; Fructose; Glucose; Humans; Male; Pain; Parenteral Nutrition; Time Factors; Uric Ac

1976
Factors in delayed muscle soreness.
    Medicine and science in sports, 1977,Spring, Volume: 9, Issue:1

    Topics: Adult; Creatinine; Electromyography; Evoked Potentials; Female; Heart Rate; Humans; Hydroxyproline;

1977
Multiple myeloma.
    The American journal of nursing, 1975, Volume: 75, Issue:1

    Topics: Aged; Bacterial Infections; Bence Jones Protein; Blood Viscosity; Bone Diseases; Humans; Hypercalcem

1975
Multiple myeloma: review of 869 cases.
    Mayo Clinic proceedings, 1975, Volume: 50, Issue:1

    Topics: Adult; Aged; Bacterial Infections; Blood Cell Count; Blood Sedimentation; Bone and Bones; Calcium; C

1975
[Interference of noramidopyrin and its derivatives on the dosage of uric acid].
    Annales de biologie clinique, 1975, Volume: 33, Issue:2

    Topics: Adult; Aminopyrine; Dipyrone; Drug Interactions; Female; Humans; Hydrogen Peroxide; In Vitro Techniq

1975
[Diffuse articular chondrocalcinosis and Paget's disease].
    Revue du rhumatisme et des maladies osteo-articulaires, 1975, Volume: 42, Issue:10

    Topics: Adult; Aged; Alkaline Phosphatase; Chondrocalcinosis; Diabetes Complications; Female; Humans; Hydrox

1975
The prevalence of fibromyalgia among women aged 20-49 years in Arendal, Norway.
    Scandinavian journal of rheumatology, 1992, Volume: 21, Issue:2

    Topics: Adult; Blood Cell Count; Blood Chemical Analysis; Female; Fibromyalgia; Humans; Joints; Middle Aged;

1992
Intraarticular noninflammatory free urate suspension (urate milk) in 3 patients with painful joints.
    The Journal of rheumatology, 1990, Volume: 17, Issue:5

    Topics: Aged; Alcoholism; Crystallization; Exudates and Transudates; Female; Gout; Humans; Knee Joint; Neutr

1990
The epidemiology of the acute flank pain syndrome from suprofen.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:6

    Topics: Acute Kidney Injury; Adult; Asthma; Case-Control Studies; Exercise; Female; Humans; Incidence; Kidne

1989
Effect of deafferentation on the levels of uric acid in the spinal cord of the rat.
    Neuroscience letters, 1989, Apr-24, Volume: 99, Issue:1-2

    Topics: Afferent Pathways; Animals; Functional Laterality; Male; Neurons, Afferent; Pain; Rats; Spinal Cord;

1989
Alcohol consumption in arthritic patients: clinical and laboratory studies.
    Annals of the rheumatic diseases, 1985, Volume: 44, Issue:3

    Topics: Alcohol Drinking; Arthritis, Rheumatoid; Erythrocyte Volume; Female; Femur Head Necrosis; gamma-Glut

1985
Interaction between allopurinol and pyrazinamide.
    The European respiratory journal, 1988, Volume: 1, Issue:9

    Topics: Adult; Allopurinol; Drug Interactions; Drug Therapy, Combination; Humans; Joint Diseases; Male; Pain

1988
Effect of the forebrain on flexion reflexes in rats with ankle joint urate arthritis.
    Pain, 1988, Volume: 33, Issue:1

    Topics: Animals; Ankle Joint; Arthritis; Decerebrate State; Efferent Pathways; Frontal Lobe; Male; Pain; Rat

1988
Suprofen-induced uricosuria. A potential mechanism for acute nephropathy and flank pain.
    American journal of nephrology, 1988, Volume: 8, Issue:2

    Topics: Acute Disease; Adult; Humans; Kidney Concentrating Ability; Kidney Diseases; Male; Pain; Phenylpropi

1988
Analgesic effects of serotonin microinjection into nucleus raphe magnus and nucleus raphe dorsalis evaluated by the monosodium urate (MSU) tonic pain model in the rat.
    Brain research, 1987, Nov-24, Volume: 426, Issue:2

    Topics: Analgesia; Animals; Male; Microinjections; Naloxone; Organ Specificity; Pain; Raphe Nuclei; Rats; Ra

1987
[Arresting an acute attack of gout. Open pilot study in 98 patients].
    Fortschritte der Medizin, 1985, Feb-26, Volume: 103, Issue:SPEC NO 7A

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Gout; Humans; Male;

1985
[Familial encephalopathy with oligophrenia and congenital indifference to pain and Laurence-Moon-Bardet-Biedl syndrome].
    Annales medico-psychologiques, 1970, Volume: 2, Issue:4

    Topics: Alkaline Phosphatase; Brain Diseases; Child; Esterases; Female; Glucosephosphate Dehydrogenase; Huma

1970
[Pain of the joint].
    Saishin igaku. Modern medicine, 1969, Volume: 24, Issue:11

    Topics: Blood Sedimentation; Complement System Proteins; gamma-Globulins; Humans; Joint Diseases; Methods; N

1969
Diagnosis of angina pectoris at the present time.
    The Medical clinics of North America, 1974, Volume: 58, Issue:2

    Topics: Angina Pectoris; Cholesterol; Coronary Angiography; Coronary Circulation; Diagnosis, Differential; E

1974
[Juvenile gout of the hip-joints (author's transl)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1973, Volume: 111, Issue:5

    Topics: Adolescent; Age Factors; Child; Gout; Hip; Hip Joint; Humans; Male; Pain; Radiography; Uric Acid

1973
[General medical measures in neoplastic diseases and their complications].
    Praxis, 1967, Dec-14, Volume: 56, Issue:50

    Topics: Anemia; Central Nervous System Diseases; Humans; Hypercalcemia; Hyperinsulinism; Hyperparathyroidism

1967
Chronic lead nephropathy.
    Kidney international, 1973, Volume: 4, Issue:1

    Topics: Adult; Bone and Bones; Chelating Agents; Child; Child, Preschool; Edetic Acid; Environmental Exposur

1973
A clinical syndrome characteristic of primary Type IV-V hyperlipoproteinaemia.
    The British journal of dermatology, 1974, Volume: 90, Issue:3

    Topics: Abdomen; Adult; Cholesterol; Chylomicrons; Clofibrate; Diabetes Complications; Diet, Reducing; Elect

1974
Metabolic and clinical effects of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370).
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; Bilirubin; Blood Cell Count; Diuresis; Female; Hemoglobinomet

1972
The medical problems of mass participation in athletic competition. The "City-to-Surf" race.
    The Medical journal of Australia, 1972, Jul-15, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Aspartate Aminotransferases; Blood Glucose; Body Temperature; Creatinine; Dehydra

1972
Factors influencing the response of lesions of the rotator cuff of the shoulder to local steroid injection.
    Annals of physical medicine, 1969, Volume: 10, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Aged; Blood Sedimentation; Cervical Vertebrae; Female; Humans; Injec

1969
Plasma uric acid levels in children.
    Archives of disease in childhood, 1969, Volume: 44, Issue:238

    Topics: Abdomen; Adolescent; Child; Child, Preschool; Female; Growth; Humans; Infant; Infant, Newborn; Male;

1969
Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 175, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzopyrans; Carrageenan; Cellulose; Dogs; Indomethacin;

1970