Page last updated: 2024-08-08 00:36:48
Tyrosine-protein kinase JAK3
A tyrosine-protein kinase JAK3 that is encoded in the genome of mouse. [OMA:Q62137, PRO:DNx]
Synonyms
EC 2.7.10.2;
Janus kinase 3;
JAK-3
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| hc 030031 | Mus musculus (house mouse) | IC50 | 6.2000 | 1 | 1 |
| tofacitinib | Mus musculus (house mouse) | IC50 | 0.6640 | 5 | 5 |
| vx-509 | Mus musculus (house mouse) | IC50 | 0.0500 | 1 | 1 |
Hydrogen Peroxide Inducible JAK3 Covalent Inhibitor: Prodrug for the Treatment of RA with Enhanced Safety Profile.ACS medicinal chemistry letters, , Nov-12, Volume: 11, Issue:11, 2020
Design, synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors.European journal of medicinal chemistry, , Apr-01, Volume: 191, 2020
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors.Bioorganic & medicinal chemistry, , 01-01, Volume: 25, Issue:1, 2017
Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.Journal of medicinal chemistry, , Jan-13, Volume: 54, Issue:1, 2011