Page last updated: 2024-10-16

carbamates and Pain

carbamates has been researched along with Pain in 59 studies

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis."7.96Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020)
"Inhibitors of fatty acid amide hydrolase (FAAH) and anandamide (AEA) uptake, which limit the degradation of endogenous cannabinoids, have received interest as potential therapeutics for pain."7.78Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. ( Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD, 2012)
" Since, KCNQ/M-current is located in the visceral sensory system, we examined the anti-nociceptive effect of the KCNQ opener, retigabine, on visceral pain induced by an intracolonic injection of capsaicin in mice."7.74Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. ( Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N, 2007)
"The present study examines the effect of combinations of gabapentin (Neurontin) and a selective neurokinin (NK)(1) receptor antagonist, 1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amino]ethyl]-2-benzofuranylmethyl ester (CI-1021), in two models of neuropathic pain."7.71Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. ( Field, MJ; Gonzalez, MI; Singh, L; Tallarida, RJ, 2002)
"Local injection of OMDM-1 reduced hyperalgesia in vivo in mice with unilateral tumors in and around the calcaneous bone."5.39Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. ( Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA, 2013)
"N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents."5.34New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. ( Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF, 2007)
"To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis."3.96Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020)
"The pharmacological inhibition of anandamide (AEA) hydrolysis by fatty acid amide hydrolase (FAAH) attenuates pain in animal models of osteoarthritis (OA) but has failed in clinical trials."3.81A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. ( Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K, 2015)
" We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism of the endocannabinoid anandamide and related N-acylethanolamines, on expression of FCA and fear and pain related behaviour per se in rats."3.78Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. ( Butler, RK; Chapman, V; Doyle, KM; Finn, DP; Ford, GK; Hogan, M; Kelly, JP; Kendall, DA; Roche, M, 2012)
" In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner."3.78Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012)
"Inhibitors of fatty acid amide hydrolase (FAAH) and anandamide (AEA) uptake, which limit the degradation of endogenous cannabinoids, have received interest as potential therapeutics for pain."3.78Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. ( Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD, 2012)
" Since, KCNQ/M-current is located in the visceral sensory system, we examined the anti-nociceptive effect of the KCNQ opener, retigabine, on visceral pain induced by an intracolonic injection of capsaicin in mice."3.74Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. ( Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N, 2007)
"The analgesic and anti-hyperalgesic effects of cannabinoid- and vanilloid-like compounds, plus the fatty acid amide hydrolase (FAAH) inhibitor Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), and acetaminophen, were evaluated in the phenyl-p-quinone (PPQ) pain model, using different routes of administration in combination with opioid and cannabinoid receptor antagonists."3.73Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice. ( Cichewicz, DL; Haller, VL; Welch, SP, 2006)
"The present study examines the effect of combinations of gabapentin (Neurontin) and a selective neurokinin (NK)(1) receptor antagonist, 1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amino]ethyl]-2-benzofuranylmethyl ester (CI-1021), in two models of neuropathic pain."3.71Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. ( Field, MJ; Gonzalez, MI; Singh, L; Tallarida, RJ, 2002)
"We describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of MAGL and FAAH activities in the key regions of the PNS and CNS implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endoCBs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent MAGL and FAAH inhibitors which efficiently increase endoCBs levels."2.82Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. ( Della Pietra, A; Giniatullin, R; Savinainen, J, 2022)
"The decreased hyperalgesia was associated with a reduction in CGRP and cytokine gene expression levels in central and peripheral structures and reduced CGRP serum levels."1.62Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2021)
"Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients."1.56Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020)
"Adults with moderate-to-severe primary restless legs syndrome (RLS) often experience painful dysesthesias, which may lead to impaired quality of life."1.43The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials. ( Buchfuhrer, M; Ellenbogen, A; Hermanowicz, N; Irving, G; Jaros, MJ; Kim, R; Shang, G, 2016)
"Although inactive in acute seizure tests, repeated administration of SAR127303 delays the acquisition and decreases kindled seizures in mice, indicating that the drug slows down epileptogenesis, a finding deserving further investigation to evaluate the potential of MAGL inhibitors as antiepileptics."1.42Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. ( Arlt, H; Augé, F; Avenet, P; Beeské, S; Bergis, OE; Bert, L; Bertrand, T; Brittain, S; Didier, M; Escoubet, J; Even, L; Françon, D; George, P; Griebel, G; He, T; Houtmann, J; Jacquet, A; Leroy, T; Lopez-Grancha, M; Menet, V; Michot, N; Mikol, V; Pichat, P; Rak, A; Redon, N; Sun, F; Tolstykh, T; Vallée, F; Wiederschain, D; Yu, Q; Zhang, B, 2015)
"Using a rat model of bone cancer pain based on intratibial injection of MRMT-1 tumor cells, we observed a significant increase in C-fiber responses of dorsal horn WDR neurons in the MRMT-1 injected rats, indicating sensitization of spinal WDR neurons in bone cancer rats."1.42Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. ( Cai, J; Fang, D; Li, S; Liu, XD; Ren, J; Xing, GG, 2015)
"Local injection of OMDM-1 reduced hyperalgesia in vivo in mice with unilateral tumors in and around the calcaneous bone."1.39Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. ( Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA, 2013)
"Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat."1.39Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. ( Cai, J; Fang, D; Han, JS; Liu, M; Wan, Y; Xing, GG; Zheng, Q, 2013)
"Effects of pre-treatment with a single dose, versus 4 day repeated dosing with the selective FAAH inhibitor, URB597 (i."1.38Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. ( Alexander, SP; Barrett, DA; Bennett, AJ; Burston, J; Chapman, V; Kendall, DA; Norris, LM; Okine, BN; Patel, A; Woodhams, S, 2012)
"Cholestasis is associated with increased activity of the endogenous opioid system that results in analgesia."1.35Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis. ( Hasanein, P; Komaki, A; Mirazi, N; Shahidi, S, 2008)
"N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents."1.34New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. ( Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF, 2007)
"Carbamazepine (100 mg/kg) was weakly effective against all the responses."1.31Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain. ( Field, MJ; Gonzalez, MI; Hughes, J; Singh, L, 2000)

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19905 (8.47)18.7374
1990's1 (1.69)18.2507
2000's22 (37.29)29.6817
2010's25 (42.37)24.3611
2020's6 (10.17)2.80

Authors

AuthorsStudies
Greco, R1
Demartini, C1
Francavilla, M1
Zanaboni, AM1
Tassorelli, C1
Ferizovic, H1
Spasojevic, N1
Jankovic, M1
Stefanovic, B1
Dronjak, S1
Della Pietra, A2
Savinainen, J2
Giniatullin, R2
Krivoshein, G1
Ivanov, K1
Giniatullina, R1
Jyrkkänen, HK1
Leinonen, V1
Lehtonen, M1
van den Maagdenberg, AMJM1
Crivelaro do Nascimento, G1
Ferrari, DP1
Guimaraes, FS1
Del Bel, EA1
Bortolanza, M1
Ferreira-Junior, NC1
Zhang, F1
Liu, S1
Jin, L1
Tang, L1
Zhao, X1
Yang, T1
Wang, Y1
Huo, B1
Liu, R1
Li, H2
Rea, K2
McGowan, F1
Corcoran, L1
Roche, M2
Finn, DP3
Zignego, AL1
Monti, M1
Gragnani, L1
Khasabova, IA1
Holman, M1
Morse, T1
Burlakova, N1
Coicou, L1
Harding-Rose, C1
Simone, DA1
Seybold, VS1
Maione, S3
Costa, B1
Piscitelli, F1
Morera, E3
De Chiaro, M1
Comelli, F1
Boccella, S1
Guida, F1
Verde, R1
Ortar, G2
Di Marzo, V4
Anderson, WB1
Gould, MJ1
Torres, RD1
Mitchell, VA3
Vaughan, CW3
Fujishiro, H1
Hayashi, H1
Iwata, M1
Tsuchimori, N1
Matsumoto, T1
Kwilasz, AJ1
Abdullah, RA2
Poklis, JL2
Lichtman, AH4
Negus, SS1
Lau, BK1
Drew, GM1
Griebel, G1
Pichat, P1
Beeské, S1
Leroy, T1
Redon, N1
Jacquet, A1
Françon, D1
Bert, L1
Even, L1
Lopez-Grancha, M1
Tolstykh, T1
Sun, F1
Yu, Q1
Brittain, S1
Arlt, H1
He, T1
Zhang, B1
Wiederschain, D1
Bertrand, T1
Houtmann, J1
Rak, A1
Vallée, F1
Michot, N1
Augé, F1
Menet, V1
Bergis, OE1
George, P1
Avenet, P1
Mikol, V1
Didier, M1
Escoubet, J1
Cai, J2
Fang, D2
Liu, XD1
Li, S1
Ren, J1
Xing, GG2
Malek, N1
Mrugala, M1
Makuch, W1
Kolosowska, N1
Przewlocka, B1
Binkowski, M1
Czaja, M1
Starowicz, K1
Bogan, RK1
Lee, DO1
Buchfuhrer, MJ1
Jaros, MJ2
Kim, R2
Shang, G2
Wang, F1
Wang, X1
Sun, R1
Chen, J1
Chen, B1
Zhang, Y1
Hermanowicz, N1
Ellenbogen, A1
Irving, G1
Buchfuhrer, M1
Rivera-Arconada, I1
Vicente-Baz, J1
Lopez-Garcia, JA1
Hasanein, P1
Shahidi, S1
Komaki, A1
Mirazi, N1
Sagar, DR1
Kendall, DA4
Chapman, V5
Haller, VL2
Stevens, DL1
Welch, SP2
Feuerbach, D1
Lingenhoehl, K1
Olpe, HR1
Vassout, A1
Gentsch, C1
Chaperon, F1
Nozulak, J1
Enz, A1
Bilbe, G1
McAllister, K1
Hoyer, D1
Butler, RK2
Lang, Y1
Gavin, AM1
Naidu, PS1
Booker, L1
Cravatt, BF2
Kinsey, SG1
Long, JZ1
O'Neal, ST1
Boger, DL1
Macsari, I1
Sandberg, L1
Besidski, Y1
Gravenfors, Y1
Ginman, T1
Bylund, J1
Bueters, T1
Eriksson, AB1
Lund, PE1
Venyike, E1
Arvidsson, PI1
Ford, GK1
Hogan, M1
Doyle, KM1
Kelly, JP1
Linley, JE1
Pettinger, L1
Huang, D1
Gamper, N1
Chae, E1
Yi, H1
Choi, Y1
Cho, H1
Lee, K1
Moon, H1
Sasso, O1
Bertorelli, R1
Bandiera, T1
Scarpelli, R1
Colombano, G1
Armirotti, A1
Moreno-Sanz, G1
Reggiani, A1
Piomelli, D3
Miller, LL1
Picker, MJ1
Umberger, MD1
Schmidt, KT1
Dykstra, LA1
Okine, BN1
Norris, LM1
Woodhams, S1
Burston, J1
Patel, A1
Alexander, SP1
Barrett, DA2
Bennett, AJ1
Zheng, Q1
Liu, M1
Wan, Y1
Han, JS1
Devic, E1
Li, D1
Dauta, A1
Henriksen, P1
Codd, GA1
Marty, JL1
Fournier, D1
Field, MJ3
Gonzalez, MI2
Tallarida, RJ1
Singh, L3
Passmore, GM1
Selyanko, AA1
Mistry, M1
Al-Qatari, M1
Marsh, SJ1
Matthews, EA1
Dickenson, AH1
Brown, TA1
Burbidge, SA1
Main, M1
Brown, DA1
SPILBORGHS, G1
NEBO, F1
BLANK, KH1
STERN, FH1
Wua, YJ1
Dworetzky, SI1
Blackburn-Munro, G1
Dalby-Brown, W1
Mirza, NR1
Mikkelsen, JD1
Blackburn-Munro, RE1
Bisogno, T1
de Novellis, V2
Palazzo, E1
Cristino, L1
Valenti, M1
Petrosino, S1
Guglielmotti, V1
Rossi, F2
Jayamanne, A1
Greenwood, R1
Aslan, S1
Connell, K1
Bolton, N1
Olsen, D1
Hohmann, AG1
Cichewicz, DL1
Jhaveri, MD1
Richardson, D1
Hirano, K1
Kuratani, K1
Fujiyoshi, M1
Tashiro, N1
Hayashi, E1
Kinoshita, M1
Liberatore, AM1
Schulz, J1
Favre-Guilmard, C1
Pommier, J1
Lannoy, J1
Pawlowski, E1
Barthelemy, MA1
Huchet, M1
Auguet, M1
Chabrier, PE1
Bigg, D1
Cascio, MG1
De Petrocellis, L1
Schiano-Moriello, A1
Nalli, M1
Woodward, DF1
Belknap, SM1
Moore, H1
Lanzotti, SA1
Yarnold, PR1
Getz, M1
Deitrick, DL1
Peterson, A1
Akeson, J1
Maurer, T1
Soltysik, RC1
Storm, GA1
Brooks, I1
McCleary, S1
Boden, P1
Suman-Chauhan, N1
Hughes, J2
Atsumi, T2
Motomiya, T1
Isokane, N1
Shimamoto, T2
Maezawa, H1
Yamazaki, H1
Fujita, T1
Ishioka, T1
Sunaga, T1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms[NCT05142267]120 participants (Anticipated)Interventional2022-03-02Recruiting
Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716]600 participants (Anticipated)Interventional2018-07-06Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for carbamates and Pain

ArticleYear
Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain.
    International journal of molecular sciences, 2022, Apr-15, Volume: 23, Issue:8

    Topics: Amidohydrolases; Analgesics; Carbamates; Endocannabinoids; Enzyme Inhibitors; Humans; Hydrolysis; Io

2022
Sofosbuvir/Velpatasvir for the treatment of Hepatitis C Virus infection.
    Acta bio-medica : Atenei Parmensis, 2018, 10-08, Volume: 89, Issue:3

    Topics: Adult; Antiviral Agents; Carbamates; Clinical Trials as Topic; Drug Therapy, Combination; Fatigue; F

2018
Recent developments on KCNQ potassium channel openers.
    Current medicinal chemistry, 2005, Volume: 12, Issue:4

    Topics: Acrylamides; Aminopyridines; Benzamides; Carbamates; Epilepsy; Humans; Indoles; Ion Channel Gating;

2005
Retigabine: chemical synthesis to clinical application.
    CNS drug reviews, 2005,Spring, Volume: 11, Issue:1

    Topics: Animals; Anticonvulsants; Anxiety; Carbamates; Dose-Response Relationship, Drug; Epilepsy; Humans; K

2005

Trials

2 trials available for carbamates and Pain

ArticleYear
Treatment response to sleep, pain, and mood disturbance and their correlation with sleep disturbance in adult patients with moderate-to-severe primary restless legs syndrome: Pooled analyses from 3 trials of gabapentin enacarbil.
    Annals of medicine, 2015, Volume: 47, Issue:3

    Topics: Adult; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric

2015
Pyridinolcarbamate, a bradykinin antagonist in veins. A preliminary report on pharmacologic and clinical observations.
    American heart journal, 1966, Volume: 71, Issue:3

    Topics: Adams-Stokes Syndrome; Aged; Animals; Bradykinin; Carbamates; Coronary Disease; Electrocardiography;

1966

Other Studies

53 other studies available for carbamates and Pain

ArticleYear
Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine.
    Cells, 2021, 09-26, Volume: 10, Issue:10

    Topics: Animals; Behavior, Animal; Carbamates; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Male;

2021
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats.
    Pharmacology, 2022, Volume: 107, Issue:1-2

    Topics: Adrenal Medulla; Amidohydrolases; Animals; Benzamides; Carbamates; Catechol O-Methyltransferase; Cat

2022
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain.
    The journal of headache and pain, 2023, Apr-11, Volume: 24, Issue:1

    Topics: Aged; Amidohydrolases; Animals; Carbamates; Chromatography, Liquid; Endocannabinoids; Humans; Migrai

2023
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
    Neuropharmacology, 2020, Volume: 163

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecox

2020
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
    Pharmacology, 2020, Volume: 105, Issue:7-8

    Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Ca

2020
The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner.
    British journal of pharmacology, 2019, Volume: 176, Issue:10

    Topics: Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Ps

2019
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain.
    Neurobiology of disease, 2013, Volume: 58

    Topics: Animals; Arachidonic Acids; Benzamides; Brain Neoplasms; Cannabinoid Receptor Antagonists; Carbamate

2013
Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics.
    Pharmacological research, 2013, Volume: 76

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Carbamates; Edema; Endocannabinoids; Male;

2013
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
    Neuropharmacology, 2014, Volume: 81

    Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Benzamides; Ben

2014
Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with Lewy bodies.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2014, Volume: 14, Issue:2

    Topics: Aged; Carbamates; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Japan;

2014
Activation of peripheral KCNQ channels attenuates inflammatory pain.
    Molecular pain, 2014, Feb-21, Volume: 10

    Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stim

2014
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:2

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbam

2014
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
    British journal of pharmacology, 2014, Volume: 171, Issue:23

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Endocannabinoids

2014
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
    Scientific reports, 2015, Jan-06, Volume: 5

    Topics: Acetylcholine; Administration, Oral; Analgesics; Animals; Arachidonic Acids; Binding Sites; Brain; C

2015
Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain.
    Oncology reports, 2015, Volume: 33, Issue:3

    Topics: Acetylcholine; Animals; Anthracenes; Bone Neoplasms; Carbamates; Disease Models, Animal; Female; Hyp

2015
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
    Pain, 2015, Volume: 156, Issue:5

    Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides

2015
Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain.
    Pharmacology, 2015, Volume: 95, Issue:5-6

    Topics: Analgesics; Animals; Arthritis, Experimental; Behavior, Animal; Carbamates; Disease Models, Animal;

2015
The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials.
    CNS drugs, 2016, Volume: 30, Issue:5

    Topics: Adult; Aged; Carbamates; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; F

2016
Targeting Kv7 channels in pain pathways.
    Oncotarget, 2017, Feb-21, Volume: 8, Issue:8

    Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channe

2017
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis.
    European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cholestasis; Disease Models, Animal; Injections, I

2008
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
    British journal of pharmacology, 2008, Volume: 155, Issue:8

    Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; In

2008
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase.
    European journal of pharmacology, 2008, Dec-14, Volume: 600, Issue:1-3

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Mo

2008
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
    Neuropharmacology, 2009, Volume: 56, Issue:1

    Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbam

2009
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates.
    Pain, 2008, Volume: 140, Issue:3

    Topics: Amidohydrolases; Amygdala; Analgesia; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Ca

2008
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1

    Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac

2009
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3

    Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Ca

2009
A FAAH-fetched approach to treat osteoarthritis pain.
    Pain, 2011, Volume: 152, Issue:5

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Osteoarthritis; Pain

2011
Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Administration, Oral; Animals; Carbamates; Humans; Infusion Pumps; Inhibitory Concentration 50; Isox

2011
Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:1

    Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Re

2012
M channel enhancers and physiological M channel block.
    The Journal of physiology, 2012, Feb-15, Volume: 590, Issue:4

    Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia

2012
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.
    Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7

    Topics: Analgesics; Animals; Carbamates; Esters; Mice; Molecular Structure; Morphine; Pain; Pain Measurement

2012
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
    Pharmacological research, 2012, Volume: 65, Issue:5

    Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment

2012
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:1

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators

2012
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.
    British journal of pharmacology, 2012, Volume: 167, Issue:3

    Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disea

2012
Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.
    Pain, 2013, Volume: 154, Issue:3

    Topics: Animals; Anthracenes; Bone Neoplasms; Carbamates; Carcinoma; Down-Regulation; Female; Ganglia, Spina

2013
Detection of anatoxin-a(s) in environmental samples of cyanobacteria by using a biosensor with engineered acetylcholinesterases.
    Applied and environmental microbiology, 2002, Volume: 68, Issue:8

    Topics: Animals; Bacterial Toxins; Biological Assay; Biosensing Techniques; Carbamates; Cholinesterase Inhib

2002
Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Acetates; Amines; Animals; Benzofurans; Carbamates; Cyclohexanecarboxylic Acids; Diabetes Mellitus,

2002
KCNQ/M currents in sensory neurons: significance for pain therapy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Aug-06, Volume: 23, Issue:18

    Topics: Animals; Anthracenes; Anura; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Ani

2003
[3-Phenylpropyl carbamate in vertebral pain].
    Hospital (Rio de Janeiro, Brazil), 1962, Volume: 62

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Back Pain; Carbamates; Muscle Relaxants, Central

1962
[Treatment of painful neuromuscular conditions by a central muscle relaxant and its combinations].
    Die Medizinische Welt, 1963, Mar-16, Volume: 11

    Topics: Arthritis; Back Pain; Carbamates; Humans; Joint Diseases; Muscle Relaxants, Central; Osteochondritis

1963
A CONTROLLED COMPARISON OF THREE MUSCLE RELAXANT AGENTS.
    Clinical medicine (Northfield, Ill.), 1964, Volume: 71

    Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Antipyretics; Carbamates; Carisoprodol; G

1964
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 re
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carb

2006
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
    British journal of pharmacology, 2006, Volume: 147, Issue:3

    Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Chronic Disease; Disease Models, Animal; Enzyme In

2006
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.
    Neuroscience letters, 2006, Apr-24, Volume: 397, Issue:3

    Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators;

2006
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes;

2006
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Dec-20, Volume: 26, Issue:51

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Carbamates; Disease Models, Animal; Enzyme Inhibit

2006
Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice.
    Neuroscience letters, 2007, Feb-14, Volume: 413, Issue:2

    Topics: Animals; Anticonvulsants; Capsaicin; Carbamates; Colon; KCNQ2 Potassium Channel; Male; Mice; Mice, I

2007
Butyl 2-(4-[1.1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain.
    Bioorganic & medicinal chemistry letters, 2007, Mar-15, Volume: 17, Issue:6

    Topics: Animals; Batrachotoxins; Binding, Competitive; Carbamates; Carrageenan; Humans; Hyperalgesia; Imidaz

2007
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.
    Journal of medicinal chemistry, 2007, Dec-27, Volume: 50, Issue:26

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biphenyl Compounds; Brain; Calcium; Carbama

2007
Application of software design principles and debugging methods to an analgesia prescription reduces risk of severe injury from medical use of opioids.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Blood Glucose; Carbamates; Clinical

2008
Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:3

    Topics: Animals; Benzofurans; Carbamates; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophy

1998
Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2

    Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzofurans; Ca

2000
Treatment of atherosclerosis obliterans with pyridinolcarbamate.
    Japanese heart journal, 1971, Volume: 12, Issue:4

    Topics: Adult; Aged; Arteriosclerosis Obliterans; Carbamates; Cyanosis; Female; Femoral Artery; Follow-Up St

1971