carbamates has been researched along with Pain in 59 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Excerpt | Relevance | Reference |
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"To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis." | 7.96 | Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020) |
"Inhibitors of fatty acid amide hydrolase (FAAH) and anandamide (AEA) uptake, which limit the degradation of endogenous cannabinoids, have received interest as potential therapeutics for pain." | 7.78 | Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. ( Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD, 2012) |
" Since, KCNQ/M-current is located in the visceral sensory system, we examined the anti-nociceptive effect of the KCNQ opener, retigabine, on visceral pain induced by an intracolonic injection of capsaicin in mice." | 7.74 | Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. ( Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N, 2007) |
"The present study examines the effect of combinations of gabapentin (Neurontin) and a selective neurokinin (NK)(1) receptor antagonist, 1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amino]ethyl]-2-benzofuranylmethyl ester (CI-1021), in two models of neuropathic pain." | 7.71 | Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. ( Field, MJ; Gonzalez, MI; Singh, L; Tallarida, RJ, 2002) |
"Local injection of OMDM-1 reduced hyperalgesia in vivo in mice with unilateral tumors in and around the calcaneous bone." | 5.39 | Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. ( Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA, 2013) |
"N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents." | 5.34 | New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. ( Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF, 2007) |
"To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis." | 3.96 | Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020) |
"The pharmacological inhibition of anandamide (AEA) hydrolysis by fatty acid amide hydrolase (FAAH) attenuates pain in animal models of osteoarthritis (OA) but has failed in clinical trials." | 3.81 | A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. ( Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K, 2015) |
" We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism of the endocannabinoid anandamide and related N-acylethanolamines, on expression of FCA and fear and pain related behaviour per se in rats." | 3.78 | Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. ( Butler, RK; Chapman, V; Doyle, KM; Finn, DP; Ford, GK; Hogan, M; Kelly, JP; Kendall, DA; Roche, M, 2012) |
" In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner." | 3.78 | Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012) |
"Inhibitors of fatty acid amide hydrolase (FAAH) and anandamide (AEA) uptake, which limit the degradation of endogenous cannabinoids, have received interest as potential therapeutics for pain." | 3.78 | Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. ( Dykstra, LA; Miller, LL; Picker, MJ; Schmidt, KT; Umberger, MD, 2012) |
" Since, KCNQ/M-current is located in the visceral sensory system, we examined the anti-nociceptive effect of the KCNQ opener, retigabine, on visceral pain induced by an intracolonic injection of capsaicin in mice." | 3.74 | Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. ( Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N, 2007) |
"The analgesic and anti-hyperalgesic effects of cannabinoid- and vanilloid-like compounds, plus the fatty acid amide hydrolase (FAAH) inhibitor Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), and acetaminophen, were evaluated in the phenyl-p-quinone (PPQ) pain model, using different routes of administration in combination with opioid and cannabinoid receptor antagonists." | 3.73 | Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice. ( Cichewicz, DL; Haller, VL; Welch, SP, 2006) |
"The present study examines the effect of combinations of gabapentin (Neurontin) and a selective neurokinin (NK)(1) receptor antagonist, 1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amino]ethyl]-2-benzofuranylmethyl ester (CI-1021), in two models of neuropathic pain." | 3.71 | Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. ( Field, MJ; Gonzalez, MI; Singh, L; Tallarida, RJ, 2002) |
"We describe here: (i) migraine pain signaling pathways, which could serve as specific targets for antinociception; (ii) a divergent distribution of MAGL and FAAH activities in the key regions of the PNS and CNS implicated in migraine pain signaling; (iii) a complexity of anti-nociceptive effects of endoCBs mediated by cannabinoid receptors and through a direct modulation of ion channels in nociceptive neurons; and (iv) the spectrum of emerging potent MAGL and FAAH inhibitors which efficiently increase endoCBs levels." | 2.82 | Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain. ( Della Pietra, A; Giniatullin, R; Savinainen, J, 2022) |
"The decreased hyperalgesia was associated with a reduction in CGRP and cytokine gene expression levels in central and peripheral structures and reduced CGRP serum levels." | 1.62 | Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2021) |
"Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients." | 1.56 | Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020) |
"Adults with moderate-to-severe primary restless legs syndrome (RLS) often experience painful dysesthesias, which may lead to impaired quality of life." | 1.43 | The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials. ( Buchfuhrer, M; Ellenbogen, A; Hermanowicz, N; Irving, G; Jaros, MJ; Kim, R; Shang, G, 2016) |
"Although inactive in acute seizure tests, repeated administration of SAR127303 delays the acquisition and decreases kindled seizures in mice, indicating that the drug slows down epileptogenesis, a finding deserving further investigation to evaluate the potential of MAGL inhibitors as antiepileptics." | 1.42 | Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. ( Arlt, H; Augé, F; Avenet, P; Beeské, S; Bergis, OE; Bert, L; Bertrand, T; Brittain, S; Didier, M; Escoubet, J; Even, L; Françon, D; George, P; Griebel, G; He, T; Houtmann, J; Jacquet, A; Leroy, T; Lopez-Grancha, M; Menet, V; Michot, N; Mikol, V; Pichat, P; Rak, A; Redon, N; Sun, F; Tolstykh, T; Vallée, F; Wiederschain, D; Yu, Q; Zhang, B, 2015) |
"Using a rat model of bone cancer pain based on intratibial injection of MRMT-1 tumor cells, we observed a significant increase in C-fiber responses of dorsal horn WDR neurons in the MRMT-1 injected rats, indicating sensitization of spinal WDR neurons in bone cancer rats." | 1.42 | Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. ( Cai, J; Fang, D; Li, S; Liu, XD; Ren, J; Xing, GG, 2015) |
"Local injection of OMDM-1 reduced hyperalgesia in vivo in mice with unilateral tumors in and around the calcaneous bone." | 1.39 | Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. ( Burlakova, N; Coicou, L; Harding-Rose, C; Holman, M; Khasabova, IA; Morse, T; Seybold, VS; Simone, DA, 2013) |
"Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat." | 1.39 | Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. ( Cai, J; Fang, D; Han, JS; Liu, M; Wan, Y; Xing, GG; Zheng, Q, 2013) |
"Effects of pre-treatment with a single dose, versus 4 day repeated dosing with the selective FAAH inhibitor, URB597 (i." | 1.38 | Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. ( Alexander, SP; Barrett, DA; Bennett, AJ; Burston, J; Chapman, V; Kendall, DA; Norris, LM; Okine, BN; Patel, A; Woodhams, S, 2012) |
"Cholestasis is associated with increased activity of the endogenous opioid system that results in analgesia." | 1.35 | Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis. ( Hasanein, P; Komaki, A; Mirazi, N; Shahidi, S, 2008) |
"N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents." | 1.34 | New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. ( Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF, 2007) |
"Carbamazepine (100 mg/kg) was weakly effective against all the responses." | 1.31 | Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain. ( Field, MJ; Gonzalez, MI; Hughes, J; Singh, L, 2000) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (8.47) | 18.7374 |
1990's | 1 (1.69) | 18.2507 |
2000's | 22 (37.29) | 29.6817 |
2010's | 25 (42.37) | 24.3611 |
2020's | 6 (10.17) | 2.80 |
Authors | Studies |
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Greco, R | 1 |
Demartini, C | 1 |
Francavilla, M | 1 |
Zanaboni, AM | 1 |
Tassorelli, C | 1 |
Ferizovic, H | 1 |
Spasojevic, N | 1 |
Jankovic, M | 1 |
Stefanovic, B | 1 |
Dronjak, S | 1 |
Della Pietra, A | 2 |
Savinainen, J | 2 |
Giniatullin, R | 2 |
Krivoshein, G | 1 |
Ivanov, K | 1 |
Giniatullina, R | 1 |
Jyrkkänen, HK | 1 |
Leinonen, V | 1 |
Lehtonen, M | 1 |
van den Maagdenberg, AMJM | 1 |
Crivelaro do Nascimento, G | 1 |
Ferrari, DP | 1 |
Guimaraes, FS | 1 |
Del Bel, EA | 1 |
Bortolanza, M | 1 |
Ferreira-Junior, NC | 1 |
Zhang, F | 1 |
Liu, S | 1 |
Jin, L | 1 |
Tang, L | 1 |
Zhao, X | 1 |
Yang, T | 1 |
Wang, Y | 1 |
Huo, B | 1 |
Liu, R | 1 |
Li, H | 2 |
Rea, K | 2 |
McGowan, F | 1 |
Corcoran, L | 1 |
Roche, M | 2 |
Finn, DP | 3 |
Zignego, AL | 1 |
Monti, M | 1 |
Gragnani, L | 1 |
Khasabova, IA | 1 |
Holman, M | 1 |
Morse, T | 1 |
Burlakova, N | 1 |
Coicou, L | 1 |
Harding-Rose, C | 1 |
Simone, DA | 1 |
Seybold, VS | 1 |
Maione, S | 3 |
Costa, B | 1 |
Piscitelli, F | 1 |
Morera, E | 3 |
De Chiaro, M | 1 |
Comelli, F | 1 |
Boccella, S | 1 |
Guida, F | 1 |
Verde, R | 1 |
Ortar, G | 2 |
Di Marzo, V | 4 |
Anderson, WB | 1 |
Gould, MJ | 1 |
Torres, RD | 1 |
Mitchell, VA | 3 |
Vaughan, CW | 3 |
Fujishiro, H | 1 |
Hayashi, H | 1 |
Iwata, M | 1 |
Tsuchimori, N | 1 |
Matsumoto, T | 1 |
Kwilasz, AJ | 1 |
Abdullah, RA | 2 |
Poklis, JL | 2 |
Lichtman, AH | 4 |
Negus, SS | 1 |
Lau, BK | 1 |
Drew, GM | 1 |
Griebel, G | 1 |
Pichat, P | 1 |
Beeské, S | 1 |
Leroy, T | 1 |
Redon, N | 1 |
Jacquet, A | 1 |
Françon, D | 1 |
Bert, L | 1 |
Even, L | 1 |
Lopez-Grancha, M | 1 |
Tolstykh, T | 1 |
Sun, F | 1 |
Yu, Q | 1 |
Brittain, S | 1 |
Arlt, H | 1 |
He, T | 1 |
Zhang, B | 1 |
Wiederschain, D | 1 |
Bertrand, T | 1 |
Houtmann, J | 1 |
Rak, A | 1 |
Vallée, F | 1 |
Michot, N | 1 |
Augé, F | 1 |
Menet, V | 1 |
Bergis, OE | 1 |
George, P | 1 |
Avenet, P | 1 |
Mikol, V | 1 |
Didier, M | 1 |
Escoubet, J | 1 |
Cai, J | 2 |
Fang, D | 2 |
Liu, XD | 1 |
Li, S | 1 |
Ren, J | 1 |
Xing, GG | 2 |
Malek, N | 1 |
Mrugala, M | 1 |
Makuch, W | 1 |
Kolosowska, N | 1 |
Przewlocka, B | 1 |
Binkowski, M | 1 |
Czaja, M | 1 |
Starowicz, K | 1 |
Bogan, RK | 1 |
Lee, DO | 1 |
Buchfuhrer, MJ | 1 |
Jaros, MJ | 2 |
Kim, R | 2 |
Shang, G | 2 |
Wang, F | 1 |
Wang, X | 1 |
Sun, R | 1 |
Chen, J | 1 |
Chen, B | 1 |
Zhang, Y | 1 |
Hermanowicz, N | 1 |
Ellenbogen, A | 1 |
Irving, G | 1 |
Buchfuhrer, M | 1 |
Rivera-Arconada, I | 1 |
Vicente-Baz, J | 1 |
Lopez-Garcia, JA | 1 |
Hasanein, P | 1 |
Shahidi, S | 1 |
Komaki, A | 1 |
Mirazi, N | 1 |
Sagar, DR | 1 |
Kendall, DA | 4 |
Chapman, V | 5 |
Haller, VL | 2 |
Stevens, DL | 1 |
Welch, SP | 2 |
Feuerbach, D | 1 |
Lingenhoehl, K | 1 |
Olpe, HR | 1 |
Vassout, A | 1 |
Gentsch, C | 1 |
Chaperon, F | 1 |
Nozulak, J | 1 |
Enz, A | 1 |
Bilbe, G | 1 |
McAllister, K | 1 |
Hoyer, D | 1 |
Butler, RK | 2 |
Lang, Y | 1 |
Gavin, AM | 1 |
Naidu, PS | 1 |
Booker, L | 1 |
Cravatt, BF | 2 |
Kinsey, SG | 1 |
Long, JZ | 1 |
O'Neal, ST | 1 |
Boger, DL | 1 |
Macsari, I | 1 |
Sandberg, L | 1 |
Besidski, Y | 1 |
Gravenfors, Y | 1 |
Ginman, T | 1 |
Bylund, J | 1 |
Bueters, T | 1 |
Eriksson, AB | 1 |
Lund, PE | 1 |
Venyike, E | 1 |
Arvidsson, PI | 1 |
Ford, GK | 1 |
Hogan, M | 1 |
Doyle, KM | 1 |
Kelly, JP | 1 |
Linley, JE | 1 |
Pettinger, L | 1 |
Huang, D | 1 |
Gamper, N | 1 |
Chae, E | 1 |
Yi, H | 1 |
Choi, Y | 1 |
Cho, H | 1 |
Lee, K | 1 |
Moon, H | 1 |
Sasso, O | 1 |
Bertorelli, R | 1 |
Bandiera, T | 1 |
Scarpelli, R | 1 |
Colombano, G | 1 |
Armirotti, A | 1 |
Moreno-Sanz, G | 1 |
Reggiani, A | 1 |
Piomelli, D | 3 |
Miller, LL | 1 |
Picker, MJ | 1 |
Umberger, MD | 1 |
Schmidt, KT | 1 |
Dykstra, LA | 1 |
Okine, BN | 1 |
Norris, LM | 1 |
Woodhams, S | 1 |
Burston, J | 1 |
Patel, A | 1 |
Alexander, SP | 1 |
Barrett, DA | 2 |
Bennett, AJ | 1 |
Zheng, Q | 1 |
Liu, M | 1 |
Wan, Y | 1 |
Han, JS | 1 |
Devic, E | 1 |
Li, D | 1 |
Dauta, A | 1 |
Henriksen, P | 1 |
Codd, GA | 1 |
Marty, JL | 1 |
Fournier, D | 1 |
Field, MJ | 3 |
Gonzalez, MI | 2 |
Tallarida, RJ | 1 |
Singh, L | 3 |
Passmore, GM | 1 |
Selyanko, AA | 1 |
Mistry, M | 1 |
Al-Qatari, M | 1 |
Marsh, SJ | 1 |
Matthews, EA | 1 |
Dickenson, AH | 1 |
Brown, TA | 1 |
Burbidge, SA | 1 |
Main, M | 1 |
Brown, DA | 1 |
SPILBORGHS, G | 1 |
NEBO, F | 1 |
BLANK, KH | 1 |
STERN, FH | 1 |
Wua, YJ | 1 |
Dworetzky, SI | 1 |
Blackburn-Munro, G | 1 |
Dalby-Brown, W | 1 |
Mirza, NR | 1 |
Mikkelsen, JD | 1 |
Blackburn-Munro, RE | 1 |
Bisogno, T | 1 |
de Novellis, V | 2 |
Palazzo, E | 1 |
Cristino, L | 1 |
Valenti, M | 1 |
Petrosino, S | 1 |
Guglielmotti, V | 1 |
Rossi, F | 2 |
Jayamanne, A | 1 |
Greenwood, R | 1 |
Aslan, S | 1 |
Connell, K | 1 |
Bolton, N | 1 |
Olsen, D | 1 |
Hohmann, AG | 1 |
Cichewicz, DL | 1 |
Jhaveri, MD | 1 |
Richardson, D | 1 |
Hirano, K | 1 |
Kuratani, K | 1 |
Fujiyoshi, M | 1 |
Tashiro, N | 1 |
Hayashi, E | 1 |
Kinoshita, M | 1 |
Liberatore, AM | 1 |
Schulz, J | 1 |
Favre-Guilmard, C | 1 |
Pommier, J | 1 |
Lannoy, J | 1 |
Pawlowski, E | 1 |
Barthelemy, MA | 1 |
Huchet, M | 1 |
Auguet, M | 1 |
Chabrier, PE | 1 |
Bigg, D | 1 |
Cascio, MG | 1 |
De Petrocellis, L | 1 |
Schiano-Moriello, A | 1 |
Nalli, M | 1 |
Woodward, DF | 1 |
Belknap, SM | 1 |
Moore, H | 1 |
Lanzotti, SA | 1 |
Yarnold, PR | 1 |
Getz, M | 1 |
Deitrick, DL | 1 |
Peterson, A | 1 |
Akeson, J | 1 |
Maurer, T | 1 |
Soltysik, RC | 1 |
Storm, GA | 1 |
Brooks, I | 1 |
McCleary, S | 1 |
Boden, P | 1 |
Suman-Chauhan, N | 1 |
Hughes, J | 2 |
Atsumi, T | 2 |
Motomiya, T | 1 |
Isokane, N | 1 |
Shimamoto, T | 2 |
Maezawa, H | 1 |
Yamazaki, H | 1 |
Fujita, T | 1 |
Ishioka, T | 1 |
Sunaga, T | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms[NCT05142267] | 120 participants (Anticipated) | Interventional | 2022-03-02 | Recruiting | |||
Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716] | 600 participants (Anticipated) | Interventional | 2018-07-06 | Enrolling by invitation | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for carbamates and Pain
Article | Year |
---|---|
Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain.
Topics: Amidohydrolases; Analgesics; Carbamates; Endocannabinoids; Enzyme Inhibitors; Humans; Hydrolysis; Io | 2022 |
Sofosbuvir/Velpatasvir for the treatment of Hepatitis C Virus infection.
Topics: Adult; Antiviral Agents; Carbamates; Clinical Trials as Topic; Drug Therapy, Combination; Fatigue; F | 2018 |
Recent developments on KCNQ potassium channel openers.
Topics: Acrylamides; Aminopyridines; Benzamides; Carbamates; Epilepsy; Humans; Indoles; Ion Channel Gating; | 2005 |
Retigabine: chemical synthesis to clinical application.
Topics: Animals; Anticonvulsants; Anxiety; Carbamates; Dose-Response Relationship, Drug; Epilepsy; Humans; K | 2005 |
2 trials available for carbamates and Pain
Article | Year |
---|---|
Treatment response to sleep, pain, and mood disturbance and their correlation with sleep disturbance in adult patients with moderate-to-severe primary restless legs syndrome: Pooled analyses from 3 trials of gabapentin enacarbil.
Topics: Adult; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric | 2015 |
Pyridinolcarbamate, a bradykinin antagonist in veins. A preliminary report on pharmacologic and clinical observations.
Topics: Adams-Stokes Syndrome; Aged; Animals; Bradykinin; Carbamates; Coronary Disease; Electrocardiography; | 1966 |
53 other studies available for carbamates and Pain
Article | Year |
---|---|
Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine.
Topics: Animals; Behavior, Animal; Carbamates; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Male; | 2021 |
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats.
Topics: Adrenal Medulla; Amidohydrolases; Animals; Benzamides; Carbamates; Catechol O-Methyltransferase; Cat | 2022 |
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain.
Topics: Aged; Amidohydrolases; Animals; Carbamates; Chromatography, Liquid; Endocannabinoids; Humans; Migrai | 2023 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecox | 2020 |
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Ca | 2020 |
The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner.
Topics: Animals; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Ps | 2019 |
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain.
Topics: Animals; Arachidonic Acids; Benzamides; Brain Neoplasms; Cannabinoid Receptor Antagonists; Carbamate | 2013 |
Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Carbamates; Edema; Endocannabinoids; Male; | 2013 |
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
Topics: Amidohydrolases; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Benzamides; Ben | 2014 |
Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with Lewy bodies.
Topics: Aged; Carbamates; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Japan; | 2014 |
Activation of peripheral KCNQ channels attenuates inflammatory pain.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stim | 2014 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbam | 2014 |
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Carbamates; Endocannabinoids | 2014 |
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Topics: Acetylcholine; Administration, Oral; Analgesics; Animals; Arachidonic Acids; Binding Sites; Brain; C | 2015 |
Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain.
Topics: Acetylcholine; Animals; Anthracenes; Bone Neoplasms; Carbamates; Disease Models, Animal; Female; Hyp | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides | 2015 |
Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain.
Topics: Analgesics; Animals; Arthritis, Experimental; Behavior, Animal; Carbamates; Disease Models, Animal; | 2015 |
The Effect of Gabapentin Enacarbil on Pain Associated with Moderate-to-Severe Primary Restless Legs Syndrome in Adults: Pooled Analyses from Three Randomized Controlled Trials.
Topics: Adult; Aged; Carbamates; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; F | 2016 |
Targeting Kv7 channels in pain pathways.
Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channe | 2017 |
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on modulation of nociception in a rat model of cholestasis.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cholestasis; Disease Models, Animal; Injections, I | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; In | 2008 |
Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Mo | 2008 |
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbam | 2009 |
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates.
Topics: Amidohydrolases; Amygdala; Analgesia; Animals; Arachidonic Acids; Avoidance Learning; Benzamides; Ca | 2008 |
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac | 2009 |
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
Topics: Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Ca | 2009 |
A FAAH-fetched approach to treat osteoarthritis pain.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Osteoarthritis; Pain | 2011 |
Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.
Topics: Administration, Oral; Animals; Carbamates; Humans; Infusion Pumps; Inhibitory Concentration 50; Isox | 2011 |
Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Re | 2012 |
M channel enhancers and physiological M channel block.
Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia | 2012 |
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.
Topics: Analgesics; Animals; Carbamates; Esters; Mice; Molecular Structure; Morphine; Pain; Pain Measurement | 2012 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment | 2012 |
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators | 2012 |
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.
Topics: Amides; Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disea | 2012 |
Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.
Topics: Animals; Anthracenes; Bone Neoplasms; Carbamates; Carcinoma; Down-Regulation; Female; Ganglia, Spina | 2013 |
Detection of anatoxin-a(s) in environmental samples of cyanobacteria by using a biosensor with engineered acetylcholinesterases.
Topics: Animals; Bacterial Toxins; Biological Assay; Biosensing Techniques; Carbamates; Cholinesterase Inhib | 2002 |
Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain.
Topics: Acetates; Amines; Animals; Benzofurans; Carbamates; Cyclohexanecarboxylic Acids; Diabetes Mellitus, | 2002 |
KCNQ/M currents in sensory neurons: significance for pain therapy.
Topics: Animals; Anthracenes; Anura; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Ani | 2003 |
[3-Phenylpropyl carbamate in vertebral pain].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Back Pain; Carbamates; Muscle Relaxants, Central | 1962 |
[Treatment of painful neuromuscular conditions by a central muscle relaxant and its combinations].
Topics: Arthritis; Back Pain; Carbamates; Humans; Joint Diseases; Muscle Relaxants, Central; Osteochondritis | 1963 |
A CONTROLLED COMPARISON OF THREE MUSCLE RELAXANT AGENTS.
Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Antipyretics; Carbamates; Carisoprodol; G | 1964 |
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 re
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Carb | 2006 |
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Chronic Disease; Disease Models, Animal; Enzyme In | 2006 |
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; | 2006 |
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Carbamates; Disease Models, Animal; Enzyme Inhibit | 2006 |
Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice.
Topics: Animals; Anticonvulsants; Capsaicin; Carbamates; Colon; KCNQ2 Potassium Channel; Male; Mice; Mice, I | 2007 |
Butyl 2-(4-[1.1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain.
Topics: Animals; Batrachotoxins; Binding, Competitive; Carbamates; Carrageenan; Humans; Hyperalgesia; Imidaz | 2007 |
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biphenyl Compounds; Brain; Calcium; Carbama | 2007 |
Application of software design principles and debugging methods to an analgesia prescription reduces risk of severe injury from medical use of opioids.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Blood Glucose; Carbamates; Clinical | 2008 |
Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.
Topics: Animals; Benzofurans; Carbamates; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophy | 1998 |
Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzofurans; Ca | 2000 |
Treatment of atherosclerosis obliterans with pyridinolcarbamate.
Topics: Adult; Aged; Arteriosclerosis Obliterans; Carbamates; Cyanosis; Female; Femoral Artery; Follow-Up St | 1971 |