Page last updated: 2024-12-06

propinox

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

propinox: used as premedication when performing endoscopic retrograde cholangiopancreatography (ERCP) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID17700
CHEMBL ID1872101
CHEBI ID135433
SCHEMBL ID2111437
MeSH IDM0231218

Synonyms (35)

Synonym
pargeverinum [inn-latin]
pargeverina [inn-spanish]
be 50
2-(dimethylamino)ethyl diphenyl(2-propynyloxy)acetate
pargeverine
benzeneacetic acid, alpha-phenyl-alpha-(2-propynyloxy)-, 2-(dimethylamino)ethyl ester
propinox
brn 2226014
terisal
diphenyl(2-propynyloxy)acetic acid 2-(dimethylamino)ethyl ester
pargeverine [inn]
acetic acid, diphenyl(2-propynyloxy)-, 2-(dimethylamino)ethyl ester
NCGC00164558-01
CHEBI:135433
viadil (tn)
13479-13-5
pargeverine (inn)
D07466
pargeverinum
unii-uc61hm8fx0
pargeverina
uc61hm8fx0 ,
pargeverine hcl
pargeverine [who-dd]
pargeverin
CHEMBL1872101
viadil
benzeneacetic acid, .alpha.-phenyl-.alpha.-(2-propynyloxy)-, 2-(dimethylamino)ethyl ester
QNPHCSSJLHAKSA-UHFFFAOYSA-N
DTXSID1048386
SCHEMBL2111437
pargevarine hcl
2-(dimethylamino)ethyl 2,2-diphenyl-2-prop-2-ynoxyacetate
Q27291011
n,n-dimethyl-[2-(2,2-diphenyl)-2-prop-2-ynyloxyacetoxy]ethylamine

Research Excerpts

Overview

Propinox is an antispasmodic drug frequently used in the treatment of disorders of the gastrointestinal tract, the uterus and the gallbladders. Little is known about its relaxing activity in gallbladder tissue.

ExcerptReferenceRelevance
"Propinox is an antispasmodic drug frequently used in the treatment of disorders of the gastrointestinal tract, the uterus and the gallbladder, but little is known about its relaxing activity in gallbladder tissue. "( Antispasmodic action of propinox on the isolated human gallbladder: possible mechanism of action.
Baistrocchi, RL; de los Santos, AR; Di Girolamo, G; Marti, ML; Orti, E; Pico, JC, 1999
)
2.05

Dosage Studied

ExcerptRelevanceReference
", and establish a dose-response relation according to three dose levels (10, 20 and 30 mg), vs."( Propinox in biliary colic: a multicenter, randomized, prospective and parallel double-blind study of three doses of propinox versus placebo in acute biliary colic pain.
de los Santos, AR; Del Prete, C; Di Girolamo, G; Diego Espinosa, J; Martí, ML; Morano, MA; Tobar, JC, 1999
)
1.75
" and to establish a dose-response relationship according to three dose levels (10 mg, 20 mg and 30 mg), vs."( Propinox in intestinal colic: multicenter randomized prospective double-blind study of three doses of propinox vs. placebo in acute intestinal colic pain.
de los Santos, AR; Di Girolamo, G; Fandiño, D; Godoy, MI; Greggio, A; Martí, ML; Morano, MA; Palomino, G; Valdés Quintana, E, 2000
)
1.75
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's3 (42.86)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 62.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index62.64 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index99.39 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (62.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (57.14%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (42.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]