Page last updated: 2024-10-27

flecainide and Pain

flecainide has been researched along with Pain in 4 studies

Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"In a general population of patients with a working diagnosis of neuropathic pain, whether if flecainide produces enough of an improvement in pain to warrant further clinical study is determined."9.12Flecainide for the treatment of chronic neuropathic pain: a Phase II trial. ( Cella, D; Cleary, JF; Cleeland, C; Eappen, S; Moots, P; Regevik, N; Taylor, SG; von Gunten, CF, 2007)
"Flecainide was used to treat malignant neuropathic pain but despite using therapeutic doses, toxicity occurred resulting in paranoid psychosis."7.69Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain. ( Bennett, MI, 1997)
"In a general population of patients with a working diagnosis of neuropathic pain, whether if flecainide produces enough of an improvement in pain to warrant further clinical study is determined."5.12Flecainide for the treatment of chronic neuropathic pain: a Phase II trial. ( Cella, D; Cleary, JF; Cleeland, C; Eappen, S; Moots, P; Regevik, N; Taylor, SG; von Gunten, CF, 2007)
"Lidocaine and oral analogs were safe drugs in controlled clinical trials for neuropathic pain, were better than placebo, and were as effective as other analgesics."4.82Systemic administration of local anesthetic agents to relieve neuropathic pain. ( Carr, DB; Challapalli, V; Lau, J; McNicol, ED; Tremont-Lukats, IW, 2005)
"Flecainide was used to treat malignant neuropathic pain but despite using therapeutic doses, toxicity occurred resulting in paranoid psychosis."3.69Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain. ( Bennett, MI, 1997)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Challapalli, V1
Tremont-Lukats, IW1
McNicol, ED1
Lau, J1
Carr, DB1
von Gunten, CF1
Eappen, S1
Cleary, JF1
Taylor, SG1
Moots, P1
Regevik, N1
Cleeland, C1
Cella, D1
Bennett, MI1
Dunlop, R1
Davies, RJ1
Hockley, J1
Turner, P1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain : A Pilot Study[NCT02217267]Phase 329 participants (Actual)Interventional2014-08-01Completed
The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic[NCT04043624]Phase 480 participants (Anticipated)Interventional2019-08-01Recruiting
Flecainide for the Treatment of Chronic Neuropathic Pain: A Phase II Trial[NCT00002996]Phase 220 participants (Anticipated)Interventional1998-05-04Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for flecainide and Pain

ArticleYear
Systemic administration of local anesthetic agents to relieve neuropathic pain.
    The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4

    Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; M

2005
Systemic administration of local anesthetic agents to relieve neuropathic pain.
    The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4

    Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; M

2005
Systemic administration of local anesthetic agents to relieve neuropathic pain.
    The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4

    Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; M

2005
Systemic administration of local anesthetic agents to relieve neuropathic pain.
    The Cochrane database of systematic reviews, 2005, Oct-19, Issue:4

    Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; M

2005

Trials

1 trial available for flecainide and Pain

ArticleYear
Flecainide for the treatment of chronic neuropathic pain: a Phase II trial.
    Palliative medicine, 2007, Volume: 21, Issue:8

    Topics: Adult; Aged; Analgesics; Female; Flecainide; Humans; Male; Middle Aged; Neoplasms; Neuralgia; Pain;

2007

Other Studies

2 other studies available for flecainide and Pain

ArticleYear
Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain.
    Pain, 1997, Volume: 70, Issue:1

    Topics: Anti-Arrhythmia Agents; Brachial Plexus; Flecainide; Humans; Male; Middle Aged; Pain; Palliative Car

1997
Analgesic effects of oral flecainide.
    Lancet (London, England), 1988, Feb-20, Volume: 1, Issue:8582

    Topics: Administration, Oral; Flecainide; Humans; Nervous System Diseases; Pain

1988