Compounds > vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)-

vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)- and Pain

vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)- has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for vasotocin--desgly(nh2)(9)d(ch2)5-tyr(me)(2)-thr(4)-orn(8)- and Pain

Article	Year
Oxytocin in the periaqueductal grey regulates nociception in the rat. Regulatory peptides, 2011, Aug-08, Volume: 169, Issue:1-3 Studies have demonstrated that oxytocin (OXT) plays important roles in pain modulation in the central nervous system, and there are OXT receptors in the periaqueductal grey (PAG). The experiment was designed to investigate the effect of OXT in the PAG on antinociception. The results showed that (1) intra-PAG injection of OXT increased the pain threshold, whereas the local administration of the high specific OXT receptor antagonist, desGly-NH(2), d(CH(2))(5)[D-Tyr(2), Thr-sup-4]OVT decreased the pain threshold in a dose-dependent manner; (2) Pain stimulation could elevate OXT concentration in the PAG perfusion liquid. The data suggested that OXT in the PAG was involved in the antinociceptive process through the OXT receptor. Topics: Animals; Male; Microinjections; Ornipressin; Oxytocin; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin	2011

Article

Year

Oxytocin in the periaqueductal grey regulates nociception in the rat.

Regulatory peptides, 2011, Aug-08, Volume: 169, Issue:1-3

Studies have demonstrated that oxytocin (OXT) plays important roles in pain modulation in the central nervous system, and there are OXT receptors in the periaqueductal grey (PAG). The experiment was designed to investigate the effect of OXT in the PAG on antinociception. The results showed that (1) intra-PAG injection of OXT increased the pain threshold, whereas the local administration of the high specific OXT receptor antagonist, desGly-NH(2), d(CH(2))(5)[D-Tyr(2), Thr-sup-4]OVT decreased the pain threshold in a dose-dependent manner; (2) Pain stimulation could elevate OXT concentration in the PAG perfusion liquid. The data suggested that OXT in the PAG was involved in the antinociceptive process through the OXT receptor.

Topics: Animals; Male; Microinjections; Ornipressin; Oxytocin; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin

2011