| Assay ID | Title | Year | Journal | Article |
|---|
| AID1764390 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in spleens at 40 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 6.49%) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764380 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in colonic lamina proprias at 40 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.97%) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764389 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in spleens at 20 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 6.49%) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764379 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in colonic lamina proprias at 20 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.97%) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764396 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as increase in IL-10 mRNA level at 20 to 40 mg/kg, po administered for 10 consecutive days by Q-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764359 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of Foxp3 mRNA expression at 3 to 30 uM measured after 72 hrs by Q-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764364 | Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as reduction in DAI score a 20 to 40 mg/kg, po administered for 10 consecutive days | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764373 | Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as protection against colon destruction at 20 to 40 mg/kg, po administered for 10 consecutive days by HE staining based histopathological analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764356 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as number of Treg cells at 30 uM measured after 72 hrs by flow cytometry analysis (Rvb = 24 %) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764376 | Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as protection against inflammation of colons at 20 to 40 mg/kg, po administered for 10 consecutive days by HE staining based histopathological analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764348 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of CD4+ CD25+ cell frequency at 10 uM measured after 72 hrs by flow cytometry analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764370 | Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as reduction in MPO activity at 20 to 40 mg/kg, po administered for 10 consecutive days | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764394 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as increase in Foxp3 mRNA level at 20 to 40 mg/kg, po administered for 10 consecutive days by Q-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764355 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as number of Treg cells at 10 uM measured after 72 hrs by flow cytometry analysis (Rvb = 24 %) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764385 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in mesenteric lymph nodes at 40 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.52%) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764384 | Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in mesenteric lymph nodes at 20 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.52%) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764367 | Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as rescue of colon length shortening at 20 to 40 mg/kg, po administered for 10 consecutive days | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764346 | Cytotoxicity against mouse EL4 cells assessed as effect on cell viability at 1 to 10 uM measured after 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764362 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of IL-10 mRNA expression at 3 to 30 uM measured after 72 hrs by Q-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764354 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as number of Treg cells at 3 uM measured after 72 hrs by flow cytometry analysis (Rvb = 24 %) | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| AID1764351 | Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of Foxp3 expression at 10 uM measured after 72 hrs by Q-PCR analysis | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Synthesis of norisoboldine derivatives and bioactivity assay for inducing the generation of regulatory T cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |