Page last updated: 2024-11-13

phosphomannopentaose sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phosphomannopentaose sulfate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID53321097
CHEMBL ID1627122
MeSH IDM0333350

Synonyms (3)

Synonym
phosphomannopentaose sulfate
muparfostat sodium
CHEMBL1627122 ,

Research Excerpts

Overview

Phosphomannopentaose sulfate (PI-88) is a highly sulfonated oligosaccharide. It inhibits heparanase activity and competes with heparin sulfate binding to growth factors.

ExcerptReferenceRelevance
"Phosphomannopentaose sulfate (PI-88) is a highly sulfonated oligosaccharide which inhibits heparanase activity and competes with heparan sulfate binding to growth factors."( Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat.
Hu, J; Luo, Y; Ma, H; Ma, P; Tang, S; Zhu, X, 2009
)
2.52

Toxicity

ExcerptReferenceRelevance
" Treatment-related adverse effects included cytopenia, injection site hemorrhage, PT prolongation, etc."( Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage.
Chang, SS; Chen, PJ; Ho, MC; Hu, RH; Jeng, LB; Lai, KL; Lee, CC; Lee, PH; Lee, WC; Lin, DY; Lin, PW; Liu, CJ; Mok, KT; Peng, CY; Wu, CC; Yang, SS; Yeh, HZ; Yu, MC, 2009
)
0.35

Pharmacokinetics

ExcerptReferenceRelevance
"The aim of this study was to investigate typical population pharmacokinetic (PK) parameters, potential covariates, and interindividual and residual variabilities of PI-88, a heparanase endoglycosidase enzyme inhibitor being developed for the treatment of cancer."( Population pharmacokinetic model of PI-88, a heparanase inhibitor.
Eckhardt, SG; Gustafson, DL; Hicks, B; Hudachek, SF, 2010
)
0.36

Compound-Compound Interactions

ExcerptReferenceRelevance
"We conducted a multicentre open-label phase I/II trial of PI-88 in combination with docetaxel."( Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer.
Begbie, S; Boyce, A; de Souza, P; Harvie, R; Khasraw, M; Lim, V; Marx, G; McCowatt, S; Parnis, F; Pavlakis, N; Underhill, C, 2010
)
0.36

Bioavailability

ExcerptReferenceRelevance
"Population PK analysis of the data-set showed that apparent clearance (CL/F) and apparent volume of distribution (V/F) of PI-88 were positively correlated with body surface area and the absorption rate constant (KA) was positively correlated with body mass index."( Population pharmacokinetic model of PI-88, a heparanase inhibitor.
Eckhardt, SG; Gustafson, DL; Hicks, B; Hudachek, SF, 2010
)
0.36

Dosage Studied

ExcerptRelevanceReference
" All agents were supplemented to the citrated-pooled plasma prepared from 10 healthy volunteers at a graded dosage of 0 to 100 microg/ml."( Ecarin clotting time is sensitive to heparinoids: comparison of two different techniques.
Demir, M; Fareed, J; Gaikwad, BS; Hoppensteadt, DA; Iqbal, O; Untch, B, 2001
)
0.31
" PI-88 gave a more linear APTT dose-response curve and displayed less patient-to-patient variation than UFH, with its activity being neutralised by protamine sulfate."( Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides.
Cowden, W; Douglas, S; Ferro, V; Parish, C; Wall, D, 2001
)
0.31
" This phase II/stage 1 multi-center, randomized trial investigated the safety, optimal dosage and preliminary efficacy of PI-88, a novel heparanase inhibitor, in the setting of post-operative recurrence of HCC according to a Simon's 2-stage design."( Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage.
Chang, SS; Chen, PJ; Ho, MC; Hu, RH; Jeng, LB; Lai, KL; Lee, CC; Lee, PH; Lee, WC; Lin, DY; Lin, PW; Liu, CJ; Mok, KT; Peng, CY; Wu, CC; Yang, SS; Yeh, HZ; Yu, MC, 2009
)
0.35
" Safety and optimal dosage were assessed."( Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage.
Chang, SS; Chen, PJ; Ho, MC; Hu, RH; Jeng, LB; Lai, KL; Lee, CC; Lee, PH; Lee, WC; Lin, DY; Lin, PW; Liu, CJ; Mok, KT; Peng, CY; Wu, CC; Yang, SS; Yeh, HZ; Yu, MC, 2009
)
0.35
"This population PK model indicates that the PK variability of PI-88 can be significantly reduced by taking BSA into account when dosing this drug SC."( Population pharmacokinetic model of PI-88, a heparanase inhibitor.
Eckhardt, SG; Gustafson, DL; Hicks, B; Hudachek, SF, 2010
)
0.36
" Further evaluation of different scheduling and dosing of PI-88 and docetaxel may be warranted to optimise efficacy with a more manageable safety profile."( Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer.
Begbie, S; Boyce, A; de Souza, P; Harvie, R; Khasraw, M; Lim, V; Marx, G; McCowatt, S; Parnis, F; Pavlakis, N; Underhill, C, 2010
)
0.36
" Preliminary pharmacokinetic analyses also revealed significant increases in half-life following iv dosing, ultimately supporting less frequent dosing regimens in preclinical tumor models compared with other HS mimetics."( Discovery of PG545: a highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis.
Bytheway, I; Davis, K; Dredge, K; Ferro, V; Hammond, E; Handley, P; Harenberg, J; Johnstone, KD; Karoli, T; Li, CP; Liu, L; Rowley, J; Sarimaa, L; Wimmer, N, 2012
)
0.38
"Administering PI-88 at 160 mg/d is a safe and well-tolerated dosage that may confer significant clinical benefits for patients with HCC."( Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence.
Chang, J; Chang, SS; Chen, PJ; Ho, MC; Hu, RH; Jeng, LB; Lai, KL; Lee, PH; Lee, WC; Lin, DY; Lin, YJ; Liu, CJ; Mok, KT; Peng, CY; Wu, CC; Yang, MD; Yang, SS; Yeh, HZ; Yu, MC, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
HeparanaseHomo sapiens (human)Ki0.00790.00610.00700.0079AID672592
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Fibroblast growth factor 1Homo sapiens (human)Kd0.24000.00800.12400.2400AID459627
Fibroblast growth factor 2Homo sapiens (human)Kd0.06100.06100.22550.3900AID459628
Vascular endothelial growth factor AHomo sapiens (human)Kd0.00220.00220.16490.4760AID459629
HeparanaseHomo sapiens (human)Kd0.24000.24000.24000.2400AID459626
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (198)

Processvia Protein(s)Taxonomy
positive regulation of cell population proliferationFibroblast growth factor 1Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayFibroblast growth factor 1Homo sapiens (human)
angiogenesisFibroblast growth factor 1Homo sapiens (human)
organ inductionFibroblast growth factor 1Homo sapiens (human)
signal transductionFibroblast growth factor 1Homo sapiens (human)
positive regulation of cell population proliferationFibroblast growth factor 1Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayFibroblast growth factor 1Homo sapiens (human)
anatomical structure morphogenesisFibroblast growth factor 1Homo sapiens (human)
positive regulation of endothelial cell migrationFibroblast growth factor 1Homo sapiens (human)
lung developmentFibroblast growth factor 1Homo sapiens (human)
positive regulation of cell migrationFibroblast growth factor 1Homo sapiens (human)
activation of protein kinase B activityFibroblast growth factor 1Homo sapiens (human)
cellular response to heatFibroblast growth factor 1Homo sapiens (human)
wound healingFibroblast growth factor 1Homo sapiens (human)
positive regulation of MAP kinase activityFibroblast growth factor 1Homo sapiens (human)
positive regulation of cholesterol biosynthetic processFibroblast growth factor 1Homo sapiens (human)
positive regulation of angiogenesisFibroblast growth factor 1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIFibroblast growth factor 1Homo sapiens (human)
epithelial cell proliferationFibroblast growth factor 1Homo sapiens (human)
positive regulation of cell divisionFibroblast growth factor 1Homo sapiens (human)
branch elongation involved in ureteric bud branchingFibroblast growth factor 1Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeFibroblast growth factor 1Homo sapiens (human)
mesonephric epithelium developmentFibroblast growth factor 1Homo sapiens (human)
regulation of endothelial tube morphogenesisFibroblast growth factor 1Homo sapiens (human)
positive regulation of intracellular signal transductionFibroblast growth factor 1Homo sapiens (human)
positive regulation of sprouting angiogenesisFibroblast growth factor 1Homo sapiens (human)
positive regulation of hepatocyte proliferationFibroblast growth factor 1Homo sapiens (human)
regulation of endothelial cell chemotaxis to fibroblast growth factorFibroblast growth factor 1Homo sapiens (human)
cell differentiationFibroblast growth factor 1Homo sapiens (human)
positive regulation of gene expressionFibroblast growth factor 1Homo sapiens (human)
animal organ morphogenesisFibroblast growth factor 1Homo sapiens (human)
regulation of cell migrationFibroblast growth factor 1Homo sapiens (human)
negative regulation of gene expressionFibroblast growth factor 2Homo sapiens (human)
negative regulation of fibroblast growth factor receptor signaling pathwayFibroblast growth factor 2Homo sapiens (human)
regulation of cell migration involved in sprouting angiogenesisFibroblast growth factor 2Homo sapiens (human)
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisFibroblast growth factor 2Homo sapiens (human)
regulation of endothelial cell chemotaxis to fibroblast growth factorFibroblast growth factor 2Homo sapiens (human)
positive regulation of cell population proliferationFibroblast growth factor 2Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayFibroblast growth factor 2Homo sapiens (human)
positive regulation of cell fate specificationFibroblast growth factor 2Homo sapiens (human)
osteoblast differentiationFibroblast growth factor 2Homo sapiens (human)
branching involved in ureteric bud morphogenesisFibroblast growth factor 2Homo sapiens (human)
organ inductionFibroblast growth factor 2Homo sapiens (human)
endothelial cell proliferationFibroblast growth factor 2Homo sapiens (human)
positive regulation of endothelial cell proliferationFibroblast growth factor 2Homo sapiens (human)
cell migration involved in sprouting angiogenesisFibroblast growth factor 2Homo sapiens (human)
positive regulation of neuroblast proliferationFibroblast growth factor 2Homo sapiens (human)
transcription by RNA polymerase IIFibroblast growth factor 2Homo sapiens (human)
chemotaxisFibroblast growth factor 2Homo sapiens (human)
signal transductionFibroblast growth factor 2Homo sapiens (human)
Ras protein signal transductionFibroblast growth factor 2Homo sapiens (human)
nervous system developmentFibroblast growth factor 2Homo sapiens (human)
neuroblast proliferationFibroblast growth factor 2Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayFibroblast growth factor 2Homo sapiens (human)
embryo development ending in birth or egg hatchingFibroblast growth factor 2Homo sapiens (human)
glial cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of endothelial cell migrationFibroblast growth factor 2Homo sapiens (human)
negative regulation of fibroblast migrationFibroblast growth factor 2Homo sapiens (human)
growth factor dependent regulation of skeletal muscle satellite cell proliferationFibroblast growth factor 2Homo sapiens (human)
substantia nigra developmentFibroblast growth factor 2Homo sapiens (human)
cerebellar granule cell precursor proliferationFibroblast growth factor 2Homo sapiens (human)
positive regulation of cerebellar granule cell precursor proliferationFibroblast growth factor 2Homo sapiens (human)
hyaluronan catabolic processFibroblast growth factor 2Homo sapiens (human)
lung developmentFibroblast growth factor 2Homo sapiens (human)
paracrine signalingFibroblast growth factor 2Homo sapiens (human)
wound healingFibroblast growth factor 2Homo sapiens (human)
inner ear auditory receptor cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of MAP kinase activityFibroblast growth factor 2Homo sapiens (human)
positive regulation of MAPK cascadeFibroblast growth factor 2Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transductionFibroblast growth factor 2Homo sapiens (human)
positive regulation of blood vessel endothelial cell migrationFibroblast growth factor 2Homo sapiens (human)
negative regulation of blood vessel endothelial cell migrationFibroblast growth factor 2Homo sapiens (human)
positive regulation of inner ear auditory receptor cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of osteoblast differentiationFibroblast growth factor 2Homo sapiens (human)
regulation of angiogenesisFibroblast growth factor 2Homo sapiens (human)
positive regulation of angiogenesisFibroblast growth factor 2Homo sapiens (human)
positive regulation of DNA-templated transcriptionFibroblast growth factor 2Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIFibroblast growth factor 2Homo sapiens (human)
regulation of retinal cell programmed cell deathFibroblast growth factor 2Homo sapiens (human)
embryonic morphogenesisFibroblast growth factor 2Homo sapiens (human)
response to axon injuryFibroblast growth factor 2Homo sapiens (human)
stem cell developmentFibroblast growth factor 2Homo sapiens (human)
positive chemotaxisFibroblast growth factor 2Homo sapiens (human)
release of sequestered calcium ion into cytosolFibroblast growth factor 2Homo sapiens (human)
regulation of cell cycleFibroblast growth factor 2Homo sapiens (human)
positive regulation of cell divisionFibroblast growth factor 2Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionFibroblast growth factor 2Homo sapiens (human)
positive regulation of cardiac muscle cell proliferationFibroblast growth factor 2Homo sapiens (human)
canonical Wnt signaling pathwayFibroblast growth factor 2Homo sapiens (human)
corticotropin hormone secreting cell differentiationFibroblast growth factor 2Homo sapiens (human)
thyroid-stimulating hormone-secreting cell differentiationFibroblast growth factor 2Homo sapiens (human)
chondroblast differentiationFibroblast growth factor 2Homo sapiens (human)
mammary gland epithelial cell differentiationFibroblast growth factor 2Homo sapiens (human)
angiogenesis involved in coronary vascular morphogenesisFibroblast growth factor 2Homo sapiens (human)
negative regulation of wound healingFibroblast growth factor 2Homo sapiens (human)
ERK1 and ERK2 cascadeFibroblast growth factor 2Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeFibroblast growth factor 2Homo sapiens (human)
cellular response to mechanical stimulusFibroblast growth factor 2Homo sapiens (human)
stem cell proliferationFibroblast growth factor 2Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesisFibroblast growth factor 2Homo sapiens (human)
positive regulation of canonical Wnt signaling pathwayFibroblast growth factor 2Homo sapiens (human)
positive regulation of lens fiber cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of miRNA transcriptionFibroblast growth factor 2Homo sapiens (human)
positive regulation of neuroepithelial cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of sprouting angiogenesisFibroblast growth factor 2Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferationFibroblast growth factor 2Homo sapiens (human)
lymphatic endothelial cell migrationFibroblast growth factor 2Homo sapiens (human)
positive regulation of epithelial tube formationFibroblast growth factor 2Homo sapiens (human)
positive regulation of vascular endothelial cell proliferationFibroblast growth factor 2Homo sapiens (human)
regulation of endothelial cell chemotaxis to fibroblast growth factorFibroblast growth factor 2Homo sapiens (human)
positive regulation of endothelial cell chemotaxis to fibroblast growth factorFibroblast growth factor 2Homo sapiens (human)
positive regulation of DNA biosynthetic processFibroblast growth factor 2Homo sapiens (human)
negative regulation of stem cell proliferationFibroblast growth factor 2Homo sapiens (human)
positive regulation of stem cell proliferationFibroblast growth factor 2Homo sapiens (human)
positive regulation of stem cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of endothelial cell chemotaxisFibroblast growth factor 2Homo sapiens (human)
regulation of cell migrationFibroblast growth factor 2Homo sapiens (human)
positive regulation of gene expressionFibroblast growth factor 2Homo sapiens (human)
animal organ morphogenesisFibroblast growth factor 2Homo sapiens (human)
cell differentiationFibroblast growth factor 2Homo sapiens (human)
positive regulation of cell population proliferationFibroblast growth factor 2Homo sapiens (human)
positive regulation of receptor signaling pathway via STATVascular endothelial growth factor AHomo sapiens (human)
negative regulation of miRNA transcriptionVascular endothelial growth factor AHomo sapiens (human)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisVascular endothelial growth factor AHomo sapiens (human)
branching involved in blood vessel morphogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of endothelial cell proliferationVascular endothelial growth factor AHomo sapiens (human)
regulation of nitric oxide mediated signal transductionVascular endothelial growth factor AHomo sapiens (human)
cellular response to hypoxiaVascular endothelial growth factor AHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIVascular endothelial growth factor AHomo sapiens (human)
angiogenesisVascular endothelial growth factor AHomo sapiens (human)
ovarian follicle developmentVascular endothelial growth factor AHomo sapiens (human)
branching involved in blood vessel morphogenesisVascular endothelial growth factor AHomo sapiens (human)
vasculogenesisVascular endothelial growth factor AHomo sapiens (human)
response to hypoxiaVascular endothelial growth factor AHomo sapiens (human)
in utero embryonic developmentVascular endothelial growth factor AHomo sapiens (human)
kidney developmentVascular endothelial growth factor AHomo sapiens (human)
positive regulation of protein phosphorylationVascular endothelial growth factor AHomo sapiens (human)
endothelial cell proliferationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of endothelial cell proliferationVascular endothelial growth factor AHomo sapiens (human)
lymphangiogenesisVascular endothelial growth factor AHomo sapiens (human)
cell migration involved in sprouting angiogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of neuroblast proliferationVascular endothelial growth factor AHomo sapiens (human)
epithelial cell maturationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of receptor internalizationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of leukocyte migrationVascular endothelial growth factor AHomo sapiens (human)
heart morphogenesisVascular endothelial growth factor AHomo sapiens (human)
outflow tract morphogenesisVascular endothelial growth factor AHomo sapiens (human)
coronary vein morphogenesisVascular endothelial growth factor AHomo sapiens (human)
apoptotic processVascular endothelial growth factor AHomo sapiens (human)
nervous system developmentVascular endothelial growth factor AHomo sapiens (human)
neuroblast proliferationVascular endothelial growth factor AHomo sapiens (human)
mesoderm developmentVascular endothelial growth factor AHomo sapiens (human)
lactationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cell population proliferationVascular endothelial growth factor AHomo sapiens (human)
regulation of cell shapeVascular endothelial growth factor AHomo sapiens (human)
positive regulation of endothelial cell migrationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of gene expressionVascular endothelial growth factor AHomo sapiens (human)
negative regulation of gene expressionVascular endothelial growth factor AHomo sapiens (human)
negative regulation of epithelial to mesenchymal transitionVascular endothelial growth factor AHomo sapiens (human)
monocyte differentiationVascular endothelial growth factor AHomo sapiens (human)
macrophage differentiationVascular endothelial growth factor AHomo sapiens (human)
lung developmentVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cell migrationVascular endothelial growth factor AHomo sapiens (human)
epithelial cell differentiationVascular endothelial growth factor AHomo sapiens (human)
post-embryonic camera-type eye developmentVascular endothelial growth factor AHomo sapiens (human)
retinal ganglion cell axon guidanceVascular endothelial growth factor AHomo sapiens (human)
positive regulation of protein-containing complex assemblyVascular endothelial growth factor AHomo sapiens (human)
tube formationVascular endothelial growth factor AHomo sapiens (human)
endothelial cell chemotaxisVascular endothelial growth factor AHomo sapiens (human)
cellular response to vascular endothelial growth factor stimulusVascular endothelial growth factor AHomo sapiens (human)
lymph vessel morphogenesisVascular endothelial growth factor AHomo sapiens (human)
vascular endothelial growth factor receptor-2 signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
vascular endothelial growth factor signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
VEGF-activated neuropilin signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
vasodilationVascular endothelial growth factor AHomo sapiens (human)
eye photoreceptor cell developmentVascular endothelial growth factor AHomo sapiens (human)
negative regulation of apoptotic processVascular endothelial growth factor AHomo sapiens (human)
positive regulation of vascular permeabilityVascular endothelial growth factor AHomo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionVascular endothelial growth factor AHomo sapiens (human)
surfactant homeostasisVascular endothelial growth factor AHomo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic processVascular endothelial growth factor AHomo sapiens (human)
positive regulation of MAPK cascadeVascular endothelial growth factor AHomo sapiens (human)
positive regulation of blood vessel endothelial cell migrationVascular endothelial growth factor AHomo sapiens (human)
negative regulation of fat cell differentiationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of osteoblast differentiationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of angiogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cell adhesionVascular endothelial growth factor AHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIVascular endothelial growth factor AHomo sapiens (human)
vascular endothelial growth factor receptor signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
cell maturationVascular endothelial growth factor AHomo sapiens (human)
camera-type eye morphogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of axon extension involved in axon guidanceVascular endothelial growth factor AHomo sapiens (human)
artery morphogenesisVascular endothelial growth factor AHomo sapiens (human)
homeostasis of number of cells within a tissueVascular endothelial growth factor AHomo sapiens (human)
positive regulation of epithelial cell proliferationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationVascular endothelial growth factor AHomo sapiens (human)
positive chemotaxisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of positive chemotaxisVascular endothelial growth factor AHomo sapiens (human)
induction of positive chemotaxisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cell divisionVascular endothelial growth factor AHomo sapiens (human)
positive regulation of focal adhesion assemblyVascular endothelial growth factor AHomo sapiens (human)
cardiac muscle cell developmentVascular endothelial growth factor AHomo sapiens (human)
primitive erythrocyte differentiationVascular endothelial growth factor AHomo sapiens (human)
bone trabecula formationVascular endothelial growth factor AHomo sapiens (human)
lung vasculature developmentVascular endothelial growth factor AHomo sapiens (human)
mammary gland alveolus developmentVascular endothelial growth factor AHomo sapiens (human)
cardiac vascular smooth muscle cell developmentVascular endothelial growth factor AHomo sapiens (human)
coronary artery morphogenesisVascular endothelial growth factor AHomo sapiens (human)
vascular wound healingVascular endothelial growth factor AHomo sapiens (human)
cellular response to hypoxiaVascular endothelial growth factor AHomo sapiens (human)
dopaminergic neuron differentiationVascular endothelial growth factor AHomo sapiens (human)
commissural neuron axon guidanceVascular endothelial growth factor AHomo sapiens (human)
positive regulation of protein kinase C signalingVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of branching involved in ureteric bud morphogenesisVascular endothelial growth factor AHomo sapiens (human)
motor neuron migrationVascular endothelial growth factor AHomo sapiens (human)
cellular stress response to acid chemicalVascular endothelial growth factor AHomo sapiens (human)
cell-cell adhesionVascular endothelial growth factor AHomo sapiens (human)
positive regulation of cold-induced thermogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of p38MAPK cascadeVascular endothelial growth factor AHomo sapiens (human)
positive regulation of vascular endothelial growth factor signaling pathwayVascular endothelial growth factor AHomo sapiens (human)
positive regulation of trophoblast cell migrationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of lymphangiogenesisVascular endothelial growth factor AHomo sapiens (human)
regulation of hematopoietic progenitor cell differentiationVascular endothelial growth factor AHomo sapiens (human)
negative regulation of establishment of endothelial barrierVascular endothelial growth factor AHomo sapiens (human)
negative regulation of adherens junction organizationVascular endothelial growth factor AHomo sapiens (human)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of sprouting angiogenesisVascular endothelial growth factor AHomo sapiens (human)
negative regulation of blood-brain barrier permeabilityVascular endothelial growth factor AHomo sapiens (human)
negative regulation of cell-cell adhesion mediated by cadherinVascular endothelial growth factor AHomo sapiens (human)
positive regulation of endothelial cell chemotaxisVascular endothelial growth factor AHomo sapiens (human)
sprouting angiogenesisVascular endothelial growth factor AHomo sapiens (human)
positive regulation of mast cell chemotaxisVascular endothelial growth factor AHomo sapiens (human)
proteoglycan metabolic processHeparanaseHomo sapiens (human)
cell-matrix adhesionHeparanaseHomo sapiens (human)
response to organic substanceHeparanaseHomo sapiens (human)
positive regulation of vascular endothelial growth factor productionHeparanaseHomo sapiens (human)
positive regulation of blood coagulationHeparanaseHomo sapiens (human)
heparan sulfate proteoglycan catabolic processHeparanaseHomo sapiens (human)
heparin metabolic processHeparanaseHomo sapiens (human)
positive regulation of osteoblast proliferationHeparanaseHomo sapiens (human)
regulation of hair follicle developmentHeparanaseHomo sapiens (human)
positive regulation of hair follicle developmentHeparanaseHomo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionHeparanaseHomo sapiens (human)
establishment of endothelial barrierHeparanaseHomo sapiens (human)
vascular wound healingHeparanaseHomo sapiens (human)
protein transmembrane transportHeparanaseHomo sapiens (human)
angiogenesis involved in wound healingHeparanaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (25)

Processvia Protein(s)Taxonomy
fibroblast growth factor receptor bindingFibroblast growth factor 1Homo sapiens (human)
integrin bindingFibroblast growth factor 1Homo sapiens (human)
protein bindingFibroblast growth factor 1Homo sapiens (human)
growth factor activityFibroblast growth factor 1Homo sapiens (human)
heparin bindingFibroblast growth factor 1Homo sapiens (human)
Hsp70 protein bindingFibroblast growth factor 1Homo sapiens (human)
S100 protein bindingFibroblast growth factor 1Homo sapiens (human)
fibroblast growth factor receptor bindingFibroblast growth factor 2Homo sapiens (human)
cytokine activityFibroblast growth factor 2Homo sapiens (human)
integrin bindingFibroblast growth factor 2Homo sapiens (human)
protein bindingFibroblast growth factor 2Homo sapiens (human)
growth factor activityFibroblast growth factor 2Homo sapiens (human)
heparin bindingFibroblast growth factor 2Homo sapiens (human)
chemokine bindingFibroblast growth factor 2Homo sapiens (human)
nuclear receptor coactivator activityFibroblast growth factor 2Homo sapiens (human)
chemoattractant activityFibroblast growth factor 2Homo sapiens (human)
identical protein bindingFibroblast growth factor 2Homo sapiens (human)
receptor-receptor interactionFibroblast growth factor 2Homo sapiens (human)
fibronectin bindingVascular endothelial growth factor AHomo sapiens (human)
cytokine activityVascular endothelial growth factor AHomo sapiens (human)
platelet-derived growth factor receptor bindingVascular endothelial growth factor AHomo sapiens (human)
vascular endothelial growth factor receptor bindingVascular endothelial growth factor AHomo sapiens (human)
protein bindingVascular endothelial growth factor AHomo sapiens (human)
growth factor activityVascular endothelial growth factor AHomo sapiens (human)
heparin bindingVascular endothelial growth factor AHomo sapiens (human)
transmembrane receptor protein tyrosine kinase activator activityVascular endothelial growth factor AHomo sapiens (human)
chemoattractant activityVascular endothelial growth factor AHomo sapiens (human)
identical protein bindingVascular endothelial growth factor AHomo sapiens (human)
protein homodimerization activityVascular endothelial growth factor AHomo sapiens (human)
vascular endothelial growth factor receptor 1 bindingVascular endothelial growth factor AHomo sapiens (human)
vascular endothelial growth factor receptor 2 bindingVascular endothelial growth factor AHomo sapiens (human)
receptor ligand activityVascular endothelial growth factor AHomo sapiens (human)
extracellular matrix bindingVascular endothelial growth factor AHomo sapiens (human)
beta-glucuronidase activityHeparanaseHomo sapiens (human)
protein bindingHeparanaseHomo sapiens (human)
heparanase activityHeparanaseHomo sapiens (human)
syndecan bindingHeparanaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (22)

Processvia Protein(s)Taxonomy
extracellular regionFibroblast growth factor 1Homo sapiens (human)
extracellular spaceFibroblast growth factor 1Homo sapiens (human)
nucleoplasmFibroblast growth factor 1Homo sapiens (human)
cytosolFibroblast growth factor 1Homo sapiens (human)
cell cortexFibroblast growth factor 1Homo sapiens (human)
extracellular matrixFibroblast growth factor 1Homo sapiens (human)
cytoplasmFibroblast growth factor 1Homo sapiens (human)
extracellular spaceFibroblast growth factor 1Homo sapiens (human)
nucleusFibroblast growth factor 1Homo sapiens (human)
extracellular regionFibroblast growth factor 2Homo sapiens (human)
extracellular spaceFibroblast growth factor 2Homo sapiens (human)
extracellular spaceFibroblast growth factor 2Homo sapiens (human)
cytoplasmFibroblast growth factor 2Homo sapiens (human)
nucleusFibroblast growth factor 2Homo sapiens (human)
extracellular regionVascular endothelial growth factor AHomo sapiens (human)
extracellular spaceVascular endothelial growth factor AHomo sapiens (human)
nucleusVascular endothelial growth factor AHomo sapiens (human)
cytoplasmVascular endothelial growth factor AHomo sapiens (human)
endoplasmic reticulumVascular endothelial growth factor AHomo sapiens (human)
Golgi apparatusVascular endothelial growth factor AHomo sapiens (human)
adherens junctionVascular endothelial growth factor AHomo sapiens (human)
cell surfaceVascular endothelial growth factor AHomo sapiens (human)
membraneVascular endothelial growth factor AHomo sapiens (human)
secretory granuleVascular endothelial growth factor AHomo sapiens (human)
extracellular matrixVascular endothelial growth factor AHomo sapiens (human)
platelet alpha granule lumenVascular endothelial growth factor AHomo sapiens (human)
VEGF-A complexVascular endothelial growth factor AHomo sapiens (human)
extracellular spaceVascular endothelial growth factor AHomo sapiens (human)
extracellular regionHeparanaseHomo sapiens (human)
nucleusHeparanaseHomo sapiens (human)
nucleoplasmHeparanaseHomo sapiens (human)
lysosomeHeparanaseHomo sapiens (human)
lysosomal membraneHeparanaseHomo sapiens (human)
specific granule lumenHeparanaseHomo sapiens (human)
lysosomal lumenHeparanaseHomo sapiens (human)
intracellular membrane-bounded organelleHeparanaseHomo sapiens (human)
membrane raftHeparanaseHomo sapiens (human)
extracellular spaceHeparanaseHomo sapiens (human)
extracellular matrixHeparanaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID459633Cytotoxicity against HUVEC2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459636Toxicity in rat aortic endothelium assessed as microvessel sprouts at 10 and 50 uM after 6 or 7 days2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459629Binding affinity to VEGF by surface plasmon-based solution affinity assay2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459627Binding affinity to FGF1 by surface plasmon-based solution affinity assay2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459632Antiangiogenic activity against HUVEC assessed as inhibition of endothelial cell tube formation on ECM-derived protein matrix at 100 uM by phase contrast microscopy2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459628Binding affinity to FGF2 by surface plasmon-based solution affinity assay2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459630Anticoagulant activity in human plasma assessed as activated partial thromboplastin time2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459626Inhibition of human recombinant heparanase2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID459631Anticoagulant activity in human plasma by heptest2010Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
AID672592Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assay2012Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
Discovery of PG545: a highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (61)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (3.28)18.2507
2000's36 (59.02)29.6817
2010's19 (31.15)24.3611
2020's4 (6.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.79 (24.57)
Research Supply Index4.25 (2.92)
Research Growth Index6.04 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials8 (13.11%)5.53%
Reviews7 (11.48%)6.00%
Case Studies0 (0.00%)4.05%
Observational1 (1.64%)0.25%
Other45 (73.77%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]