Page last updated: 2024-10-15

histogranin

Description

histogranin: NMDA receptor antagonist isolated from bovine adrenal medulla; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16131189
MeSH IDM0219366

Synonyms (4)

Synonym
150045-04-8
histogranin
histogranin (ox)
DTXSID80164457

Research Excerpts

Overview

Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. It exhibits NMDA receptor antagonist activity.

ExcerptReference
"Histogranin is a 15-amino acid peptide that exhibits NMDA receptor antagonist activity."( NMDA antagonist peptide supplementation enhances pain alleviation by adrenal medullary transplants.
NasiriNezhad, F; Sagen, J, 2005
)
"Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. "( Histogranin, a modified histone H4 fragment endowed with N-methyl-D-aspartate antagonist and immunostimulatory activities.
Dumont, M; Lapierre, C; Lemaire, I; Lemaire, S; Prasad, J; Rogers, C; Shukla, VK, 1995
)
"Histogranin is a 15-amino acid peptide possessing NMDA receptor antagonist activity that has been isolated from adrenal medullary tissue."( NMDA-induced spinal hypersensitivity is reduced by naturally derived peptide analog [Ser1]histogranin.
Hama, AT; Herzberg, U; Sagen, J; Siegan, JB, 1999
)

Treatment

ExcerptReference
"Histogranin pretreatment reduced the volume of cerebral infarction and the caspase-3 immunoreactivity in the stroke animals."( Histogranin reduced brain injury after transient focal ischemia in rats.
Chen, GJ; Chiang, YH; Chou, J; Shen, H; Wang, Y, 2006
)

Dosage Studied

ExcerptReference
" A U-shaped dose-response curve was obtained."( A natural peptide with NMDA inhibitory activity reduces tonic pain in the formalin model.
Sagen, J; Siegan, JB, 1997
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's13 (46.43)18.2507
2000's12 (42.86)29.6817
2010's3 (10.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (96.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]