UDP-glucuronosyltransferase 1A5

A UDP-glucuronosyltransferase 1A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35504]

UGT1A5;
EC 2.4.1.17;
UDP-glucuronosyltransferase 1-5;
UDPGT 1-5;
UGT1*5;
UGT1-05;
UGT1.5;
UDP-glucuronosyltransferase 1-E;
UGT-1E;
UGT1E

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezogabine	Homo sapiens (human)	EC50	3.9000	1	1

This protein enables 4 target(s):

Target	Category	Definition
glucuronosyltransferase activity	molecular function	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

This protein is involved in 1 target(s):

Target	Category	Definition
cellular glucuronidation	biological process	The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]