KiSS-1 receptor

A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8]

KiSS-1R;
G-protein coupled receptor 54;
G-protein coupled receptor OT7T175;
hOT7T175;
Hypogonadotropin-1;
Kisspeptins receptor;
Metastin receptor

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzethonium chloride	Homo sapiens (human)	Ki	3.6000	1	1
kisspeptin-10 protein, human	Homo sapiens (human)	IC50	1.7021	5	5
kisspeptin-10 protein, human	Homo sapiens (human)	Ki	0.0004	4	4
tak-683	Homo sapiens (human)	Ki	0.0000	1	1
RF9	Homo sapiens (human)	IC50	0.8300	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
kisspeptin-10 protein, human	Homo sapiens (human)	EC50	0.0028	7	7
tak-683	Homo sapiens (human)	EC50	0.0003	2	2

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
neuropeptide receptor activity	molecular function	Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]
G protein-coupled peptide receptor activity	molecular function	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cilium	cellular component	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 2 target(s):

Target	Category	Definition
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]