| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID414715 | Intrinsic activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assay relative to (-)nicotine | 2009 | Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
| Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. |
| AID146786 | Binding affinity against human Nicotinic acetylcholine receptor alpha-7 was determined | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors. |
| AID146611 | Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 8, Issue:19
| Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. |
| AID146788 | Compound was evaluated for its ability to displace [125I]alpha-bungarotoxin (alpha-BgT) from K28 cells expressing human Nicotinic acetylcholine receptor alpha7 | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID146322 | In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortical membrane using [3H]cytisine as radioligand | 2000 | Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11
| Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis. |
| AID710185 | Agonist activity at human alpha7 nAChR | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID414714 | Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assay | 2009 | Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
| Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. |
| AID1143254 | Agonist activity at alpha4beta2 nAChR (unknown origin) | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. |
| AID91540 | Maximal response of compound was determined in an in vitro [86Rb+] release assay using IMR-32 cells | 1998 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 8, Issue:19
| Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. |
| AID231913 | Ratio between the binding affinities towards rat alpha3-beta4 and forebrain nACh Receptor using [3H]EB | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID710188 | Binding affinity to human alpha7 nAChR in human brain | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID710186 | Agonist activity at ganglionic nAChR | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID94464 | Compound was evaluated for functional activation to [86Rb+] efflux from human K177 cells expressing recombinant alpha4-beta2 receptors. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID146779 | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID145983 | Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID242876 | Maximal response against Nicotinic acetylcholine receptor alpha3-beta4 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
| AID132950 | Analgesic activity in a mouse hot plate assay | 1998 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 8, Issue:19
| Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. |
| AID91525 | Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID710189 | Binding affinity to muscle type alpha1beta1gammadelta-nAChR | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID1179362 | Binding affinity to human brain alpha4beta2* nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID700124 | Agonist activity at human alpha4beta2 nACHR expressed in SH-EP1 cells at 10 uM by 86Rb+ efflux assay | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. |
| AID1179363 | Binding affinity to human brain alpha3beta4* nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID220120 | Binding affinity for alpha4 beta-2 nAChR using [3H]epibatidine in rat brain | 1998 | Journal of medicinal chemistry, Sep-10, Volume: 41, Issue:19
| 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. |
| AID176047 | compound was evaluated for functional potencies and efficacies at rat nAChR subtype DA release | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID225720 | Binding affinity towards rat alpha2-beta4 nACh receptor expressed in HEK293 cells using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID145685 | Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID242877 | Maximal response against Nicotinic acetylcholine receptor alpha4-beta2 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
| AID146301 | Compound was evaluated for its ability to displace [3H]cytisine from K177 cells expressing human Nicotinic acetylcholine receptor alpha4-beta2 | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID132955 | Compound was evaluated for the analgesic activity by mouse hotplate assay at the doses of 0.62 and 6.2; No significant effect observed at the doses tested | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID146772 | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID146300 | Binding affinity against human Nicotinic acetylcholine receptor alpha4-beta2 | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors. |
| AID146486 | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID1179366 | Agonist activity at human alpha4beta2 nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID145682 | Binding affinity against Nicotinic Acetylcholine Receptor was determined by measuring the displacement of [3H]cytisine from a preparation of whole rat brain. | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID242872 | Maximal response against Nicotinic acetylcholine receptor alpha 7 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
| AID225721 | Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID91534 | Maximum efficacy relative to 100(uM) (S)-nicotine for cell preparations containing alpha3-betaX IMR32 cells | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID1179365 | Binding affinity to rat brain alpha4beta2* nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID145688 | Binding affinity towards nicotinic acetylcholine receptor using [3H]nicotine as radioligand in rat brain homogenates | 2002 | Bioorganic & medicinal chemistry letters, Aug-05, Volume: 12, Issue:15
| A comparison of the binding of three series of nicotinic ligands. |
| AID146006 | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID94463 | Maximum efficacy relative to 100(uM) (S)-nicotine for cell preparations containing alpha4-beta2 K177 cells | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID1179364 | Binding affinity to human brain alpha7* nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID700118 | Displacement of [3H]epibatidine from rat alpha4beta2 nACHR | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. |
| AID231915 | Ratio between the binding affinities towards rat alpha4-beta4 and alpha4-beta2 nACh receptor using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID414713 | Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in HEK293 cells | 2009 | Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
| Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. |
| AID1179333 | Antagonist activity at human alpha1beta1gammadelta nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID146162 | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID146778 | Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID1143255 | Agonist activity at alpha7 nAChR (unknown origin) | 2014 | Journal of medicinal chemistry, May-22, Volume: 57, Issue:10
| Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. |
| AID231912 | Ratio between the binding affinities towards rat alpha3-beta4 and alpha3-beta2 nACh receptor using [3H]EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID1179367 | Agonist activity at human alpha3beta4* nAChR | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. |
| AID145686 | Compound was evaluated for its ability to displace [3H]-cytisine binding from high-affinity Nicotinic acetylcholine receptor in rat brain (principally the alpha4-beta2 nAChR subtype) | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID231911 | Ratio between the binding affinities towards rat alpha2-beta4 and alpha2-beta2 nACh receptor using [3H]-EB as radioligand | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8
| Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. |
| AID219643 | Compound was evaluated for its ability to displace [125 I]alpha-bungarotoxin (alpha-BgT) from torpedo alpha1-beta1-gamma1 electroplax | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID146297 | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID710187 | Agonist activity at human alpha4beta2 nAChR | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID710191 | Binding affinity to alpha4beta2 nAChR in rat brain | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID710190 | Binding affinity to alpha4beta2 nAChR in human brain | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
| AID94460 | Ability to stimulate Rb+ efflux from human K177 cell preparations containing human alpha4-beta2 receptors | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID225722 | Intrinsic activity against human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID145356 | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic) | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |