| Assay ID | Title | Year | Journal | Article |
|---|
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID149286 | Compound was evaluated for binding affinity towards kappa opioid receptor using [3H](-)-U-69,593 in guinea pig ileum | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
| AID1781406 | Displacement of [3H]DPDPE from rat delta opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting method | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID1781407 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting method | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID157446 | Compound was evaluated for binding affinity towards Phencyclidine receptor using [3H]TCP in guinea pig ileum; No inhibition at 10000 nM | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
| AID1781417 | Antinociceptive activity in ip dosed Kunming mouse by hot plate test | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID1255661 | Intrinsic activity at kappa opioid receptor in human HEK293 cells at 1 uM after 30 mins by [35S]GTPgammaS binding assay relative to U-69593 | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
| AID232473 | Selectivity ratio for affinities determined by using [3H]BREM and [3H]-(+)-3-PPP in guinea pig ileum | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
| AID1781418 | Antinociceptive activity in ip dosed Kunming mouse assessed as reduction in acetic acid induced writhing signs measured after 15 mins by abdominal constriction test | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID259399 | Functional activity at human kappa opioid receptor expressed CHO cells by [35S]GTPgammaS binding assay | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID1506425 | Agonist activity at mouse MOR expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 90 mins by scintillation spectroscopy relative to DAMGO | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception. |
| AID1781414 | Agonist activity at human kappa opioid receptor expressed in CHO cell membrane at 1 uM incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation counting method relative to control | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID1781409 | Selectivity ratio of Ki for displacement of [3H]DPDPE from rat delta opioid receptor expressed in CHO cell membrane to Ki for displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID259400 | Activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. |
| AID1506427 | Agonist activity at mouse KOR expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 90 mins by scintillation spectroscopy relative to U50488H | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception. |
| AID1781413 | Agonist activity at human kappa opioid receptor expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation counting method | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID1255653 | Displacement of [3H]-DPDPE from delta opioid receptor in rat brain membrane after 120 mins by scintillation counting | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
| AID1191372 | Displacement of [3H]U69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies. |
| AID1781424 | Induction of conditioned place aversion in mouse at 5 mg/kg, ip treated for 15 mins in the afternoon session of preconditioning phase by placing in preferred side for 30 mins followed by test phase after 24 hrs | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID749675 | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding at 500 nM after 3 hrs by liquid scintillation counting analysis relative to control | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. |
| AID1506426 | Agonist activity at mouse KOR expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 90 mins by scintillation spectroscopy | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception. |
| AID1191374 | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in HEK cells after 60 mins | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies. |
| AID595992 | Antinociceptive activity in Sprague-Dawley rat assessed as mean AUC of thermal-stimulus induced tail flick latency for 60 mins at 5 mg/kg, sc | 2011 | Journal of medicinal chemistry, May-26, Volume: 54, Issue:10
| Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties. |
| AID592373 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting relative to control | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID1781408 | Selectivity ratio of Ki for displacement of [3H]DAMGO from rat mu opioid receptor expressed in CHO cell membrane to Ki for displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID1255660 | Agonist activity at kappa opioid receptor in human HEK293 cells after 30 mins by [35S]GTPgammaS binding assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
| AID203996 | Compound was evaluated for binding affinity towards sigma opioid receptor using [3H](+)-3-PPP in guinea pig ileum | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
| AID1506424 | Agonist activity at mouse MOR expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 90 mins by scintillation spectroscopy | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception. |
| AID1781405 | Displacement of [3H]DAMGO from rat mu opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting method | 2021 | Journal of medicinal chemistry, 08-26, Volume: 64, Issue:16
| Discovery of an |
| AID1191373 | Displacement of [3H]diprenorphine from human recombinant mu opioid receptor expressed in HEK cells after 60 mins | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies. |
| AID749676 | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 3 hrs by liquid scintillation counting analysis | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. |
| AID1255651 | Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
| AID1255650 | Binding affinity to kappa opioid receptor (unknown origin) | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
| AID592433 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting | 2011 | Journal of medicinal chemistry, Mar-24, Volume: 54, Issue:6
| Aminothiazolomorphinans with mixed κ and μ opioid activity. |
| AID149287 | Compound was evaluated for binding affinity towards kappa opioid receptor using [3H]-BREM in guinea pig ileum | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
| AID65265 | Compound was evaluated for binding affinity towards Dopamine receptor D2 using [3H]SULP in rat; No inhibition at 10000 nM | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. |
| AID1255652 | Displacement of [3H]-DAMGO from mu opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |