Page last updated: 2024-12-07

cyclo(prolylglycyl)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cyclo(prolylglycyl): RN given is for 17O-labeled cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID126154
CHEMBL ID360216
SCHEMBL ID4247464
MeSH IDM0172340

Synonyms (51)

Synonym
smr000386902
MLS001049064
97011-16-0
gio ,
cyclo-(glycine-l-proline) inhibitor
(8ar)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(s)-hexahydropyrrolo(1,2-a)pyrazine-1,4-dione-4-17o
DB04541
1W1P
cyclo(pro-o-gly)
cyclo(prolylglycyl)
CGP ,
3705-27-9
(8as)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(8as)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
traneurocin
cyclic glycine-proline
CHEMBL360216
na 831
na831
na-831
NCGC00246192-01
AKOS006273250
cyclo(-gly-pro)
MLS004714430
HMS2270J17
unii-w7o69j5f2b
pyrrolo(1,2-a)pyrazine-1,4-dione-4-17o, hexahydro-, (s)-
w7o69j5f2b ,
pyrrolo(1,2-a)pyrazine-1,4-dione-4-170, hexahydro-, (s)-
cyclo-glycyl-l-proline
cyclo-gp
cyclo-gly-pro
(s)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
OWOHLURDBZHNGG-YFKPBYRVSA-N
SCHEMBL4247464
(8as)-octahydropyrrolo[1,2-a]piperazine-1,4-dione
AC-31820
1,4-dioxo
1-hydroxy-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-4(3h)-one
DTXSID60914215
CS-0053108
na 831 [who-dd]
(r,s)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
AS-34882
Q27095302
SB11360
AMY5682
STL570274
EN300-7691430
Z1198149427

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Cyclic-glycine-proline (cGP), a metabolite of IGF-1, normalizes IGF-1 function under pathological conditions by regulating the bioavailability of IGF-1."( Cyclic-glycine-proline accelerates mammary involution by promoting apoptosis and inhibiting IGF-1 function.
Guan, J; McMahon, CD; Singh, K; Singh-Mallah, G, 2017
)
0.46
" As a neuropeptide, cyclic glycine-proline (cGP) improves IGF-1 function in brain and regulates IGF-1 bioavailability in plasma."( Cyclic glycine-proline administration normalizes high-fat diet-induced synaptophysin expression in obese rats.
Guan, J; Harris, PWR; Li, F; Liu, K; Vickers, MH; Wang, A, 2019
)
0.51
" It involves receptor-mediated mechanisms, for example, N-a-PGP acts as CXCR1/2 receptor ligand, whereas cGP regulates IGF-1 bioavailability by modifying the IGF-1 binding to the IGF-1 binding protein-3."( Proline-containing peptides-New insight and implications: A Review.
Miltyk, W; Misiura, M, 2019
)
0.51
" Thus, cGP and IGFBP-3 collectively regulate the bioavailability of IGF-1."( Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions.
Anderson, T; Dalrymple-Alford, J; Guan, J; Kang, D; Li, F; Pitcher, T; Shorten, P; Singh-Mallah, G, 2023
)
0.91
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1265333Inhibition of LPS-induced TNF-alpha mRNA level in mouse RAW264.7 cells in presence of 1 ug/ml LPS for 6 hrs by qRT-PCR analysis2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID1265334Toxicity in mouse RAW264.7 cells assessed as effect on NO production by Griess method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID403316Antimicrobial activity against Escherichia coli2004Journal of natural products, Jul, Volume: 67, Issue:7
Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.
AID1265327Inhibition of LPS-induced IL-6 mRNA level in mouse RAW264.7 cells in presence of 1 ug/ml LPS for 6 hrs by qRT-PCR analysis2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID1082823Toxicity in Artemia salina (brine shrimp) at 28 degC after 48 hr2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID403315Antimicrobial activity against Bacillus subtilis subsp. spizizenii2004Journal of natural products, Jul, Volume: 67, Issue:7
Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.
AID403317Antimicrobial activity against Saccharomyces cerevisiae2004Journal of natural products, Jul, Volume: 67, Issue:7
Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.
AID1265326Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell viability pretreated at 50 uM for 1 hr followed by addition of LPS incubated for 24 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID659559Induction of IFN-gamma secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages.
AID252783Cell aggregates after incubation of compound with Saccharomyces cerevisiae strains as measure of chitinase inhibitory activity2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Structure-based exploration of cyclic dipeptide chitinase inhibitors.
AID1265335Toxicity in mouse RAW264.7 cells assessed as effect on TNF-alpha mRNA level by qRT-PCR analysis2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID659558Induction of IL10 secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages.
AID1265332Inhibition of LPS-induced NO production in mouse RAW264.7 cells at 100 ug/ml cotreated with 1 ug/ml LPS for 16 hrs by Griess reagent method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID1265330Inhibition of LPS-induced TNF-alpha production in mouse RAW264.7 cells pretreated with compound for 1 hr followed by addition of 1 ug/ml LPS for 6 hrs by ELISA2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
AID252784Cell aggregates after mild sonication of compound with Saccharomyces cerevisiae strains as measure of chitinase inhibitory activity2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Structure-based exploration of cyclic dipeptide chitinase inhibitors.
AID659561Induction of TNF-alpha secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages.
AID659560Induction of MCP-1 secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control2012Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9
The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages.
AID1265328Inhibition of LPS-induced IL-1beta mRNA level in mouse RAW264.7 cells in presence of 1 ug/ml LPS for 6 hrs by qRT-PCR analysis2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (45)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (2.22)18.7374
1990's3 (6.67)18.2507
2000's8 (17.78)29.6817
2010's23 (51.11)24.3611
2020's10 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.38 (24.57)
Research Supply Index3.89 (2.92)
Research Growth Index5.28 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other46 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]