Page last updated: 2024-12-07
cyclo(prolylglycyl)
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
cyclo(prolylglycyl): RN given is for 17O-labeled cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 126154 |
CHEMBL ID | 360216 |
SCHEMBL ID | 4247464 |
MeSH ID | M0172340 |
Synonyms (51)
Synonym |
---|
smr000386902 |
MLS001049064 |
97011-16-0 |
gio , |
cyclo-(glycine-l-proline) inhibitor |
(8ar)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
(s)-hexahydropyrrolo(1,2-a)pyrazine-1,4-dione-4-17o |
DB04541 |
1W1P |
cyclo(pro-o-gly) |
cyclo(prolylglycyl) |
CGP , |
3705-27-9 |
(8as)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
(8as)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
traneurocin |
cyclic glycine-proline |
CHEMBL360216 |
na 831 |
na831 |
na-831 |
NCGC00246192-01 |
AKOS006273250 |
cyclo(-gly-pro) |
MLS004714430 |
HMS2270J17 |
unii-w7o69j5f2b |
pyrrolo(1,2-a)pyrazine-1,4-dione-4-17o, hexahydro-, (s)- |
w7o69j5f2b , |
pyrrolo(1,2-a)pyrazine-1,4-dione-4-170, hexahydro-, (s)- |
cyclo-glycyl-l-proline |
cyclo-gp |
cyclo-gly-pro |
(s)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
OWOHLURDBZHNGG-YFKPBYRVSA-N |
SCHEMBL4247464 |
(8as)-octahydropyrrolo[1,2-a]piperazine-1,4-dione |
AC-31820 |
1,4-dioxo |
1-hydroxy-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-4(3h)-one |
DTXSID60914215 |
CS-0053108 |
na 831 [who-dd] |
(r,s)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione |
AS-34882 |
Q27095302 |
SB11360 |
AMY5682 |
STL570274 |
EN300-7691430 |
Z1198149427 |
Research Excerpts
Bioavailability
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (29)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID1265333 | Inhibition of LPS-induced TNF-alpha mRNA level in mouse RAW264.7 cells in presence of 1 ug/ml LPS for 6 hrs by qRT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID1265334 | Toxicity in mouse RAW264.7 cells assessed as effect on NO production by Griess method | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID403316 | Antimicrobial activity against Escherichia coli | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula. |
AID1265327 | Inhibition of LPS-induced IL-6 mRNA level in mouse RAW264.7 cells in presence of 1 ug/ml LPS for 6 hrs by qRT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID1082823 | Toxicity in Artemia salina (brine shrimp) at 28 degC after 48 hr | 2012 | Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13 | Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities. |
AID403315 | Antimicrobial activity against Bacillus subtilis subsp. spizizenii | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula. |
AID403317 | Antimicrobial activity against Saccharomyces cerevisiae | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula. |
AID1265326 | Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell viability pretreated at 50 uM for 1 hr followed by addition of LPS incubated for 24 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID659559 | Induction of IFN-gamma secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages. |
AID252783 | Cell aggregates after incubation of compound with Saccharomyces cerevisiae strains as measure of chitinase inhibitory activity | 2004 | Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23 | Structure-based exploration of cyclic dipeptide chitinase inhibitors. |
AID1265335 | Toxicity in mouse RAW264.7 cells assessed as effect on TNF-alpha mRNA level by qRT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID659558 | Induction of IL10 secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages. |
AID1265332 | Inhibition of LPS-induced NO production in mouse RAW264.7 cells at 100 ug/ml cotreated with 1 ug/ml LPS for 16 hrs by Griess reagent method | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID1265330 | Inhibition of LPS-induced TNF-alpha production in mouse RAW264.7 cells pretreated with compound for 1 hr followed by addition of 1 ug/ml LPS for 6 hrs by ELISA | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
AID252784 | Cell aggregates after mild sonication of compound with Saccharomyces cerevisiae strains as measure of chitinase inhibitory activity | 2004 | Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23 | Structure-based exploration of cyclic dipeptide chitinase inhibitors. |
AID659561 | Induction of TNF-alpha secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages. |
AID659560 | Induction of MCP-1 secretion in mouse J774A1 cells at 5 ug/mL after 48 hrs by ELISA relative to control | 2012 | Bioorganic & medicinal chemistry letters, May-01, Volume: 22, Issue:9 | The effects of diketopiperazines from Callyspongia sp. on release of cytokines and chemokines in cultured J774A.1 macrophages. |
AID1265328 | Inhibition of LPS-induced IL-1beta mRNA level in mouse RAW264.7 cells in presence of 1 ug/ml LPS for 6 hrs by qRT-PCR analysis | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Attenuation of TNF-α secretion by L-proline-based cyclic dipeptides produced by culture broth of Pseudomonas aeruginosa. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (45)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (2.22) | 18.7374 |
1990's | 3 (6.67) | 18.2507 |
2000's | 8 (17.78) | 29.6817 |
2010's | 23 (51.11) | 24.3611 |
2020's | 10 (22.22) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.38
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.38) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 2 (4.17%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 46 (95.83%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |